Detailed information for compound 1187965

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 357.405 | Formula: C22H19N3O2
  • H donors: 1 H acceptors: 4 LogP: 5.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c(c(c1)C(=O)c1cnc2c(c1)c(C)nn2c1ccccc1)O
  • InChi: 1S/C22H19N3O2/c1-13-9-14(2)20(26)19(10-13)21(27)16-11-18-15(3)24-25(22(18)23-12-16)17-7-5-4-6-8-17/h4-12,26H,1-3H3
  • InChiKey: LTWAJDVBZNSQGY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans monoamine oxidase 0.0043 0.0142 0.0343
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0295 0.0295
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0037 0.0147
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0102 0.0153
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0126 0.0715 0.0715
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0465 0.1215
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0191 0.0312
Schistosoma mansoni hypothetical protein 0.0051 0.0191 0.0191
Trypanosoma brucei C-8 sterol isomerase, putative 0.0389 0.2544 1
Schistosoma mansoni phosphatidylserine receptor 0.0056 0.0227 0.0227
Brugia malayi Cation transporter family protein 0.0105 0.0572 0.0974
Brugia malayi Smad1 0.0025 0.0013 0.0022
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0025 0.0356
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0056 0.0227 0.318
Schistosoma mansoni acetylcholinesterase 0.0046 0.0159 0.0159
Onchocerca volvulus 0.0105 0.0572 0.0853
Loa Loa (eye worm) hypothetical protein 0.0043 0.0142 0.0231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0046 0.0159 0.026
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.002 0.0295
Echinococcus multilocularis lysine specific demethylase 6a 0.0056 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Trichomonas vaginalis set domain proteins, putative 0.0988 0.6708 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0043 0.0142 0.1996
Echinococcus granulosus biogenic amine 5HT receptor 0.0173 0.104 0.104
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0105 0.0572 0.0934
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0049 0.0177 0.0302
Brugia malayi putative neuropeptide receptor 0.0051 0.0191 0.0325
Loa Loa (eye worm) hypothetical protein 0.0057 0.0234 0.0382
Loa Loa (eye worm) hypothetical protein 0.0272 0.1732 0.2829
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0082 0.014
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0114 0.0186
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0051 0.0191 0.0191
Echinococcus granulosus geminin 0.0681 0.4572 0.4572
Schistosoma mansoni smad 0.0025 0.0013 0.0013
Echinococcus multilocularis nAChR subunit 0.0105 0.0572 0.0572
Onchocerca volvulus 0.0043 0.0142 0.0211
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0142 0.0556
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0025 0.0356
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0365 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0171 0.0171
Onchocerca volvulus 0.0051 0.0191 0.0285
Onchocerca volvulus 0.0051 0.0191 0.0285
Loa Loa (eye worm) hypothetical protein 0.0389 0.2544 0.4155
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0043 0.0142 0.0231
Echinococcus granulosus orexin receptor type 2 0.0051 0.0191 0.0191
Schistosoma mansoni biogenic amine receptor 0.0051 0.0191 0.0191
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0102 0.0102
Schistosoma mansoni inositol monophosphatase 0.004 0.0115 0.0115
Schistosoma mansoni smad1 5 8 and 0.0025 0.0013 0.0013
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0049 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0122 0.0689 0.1125
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0191 0.0312
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0105 0.0572 0.0572
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0316 0.0316
Brugia malayi Carboxylesterase family protein 0.0046 0.0159 0.0271
Trypanosoma cruzi C-14 sterol reductase, putative 0.0093 0.0485 0.1907
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0082 0.0215
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0135
Echinococcus granulosus neuropeptide s receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Echinococcus granulosus acetylcholinesterase 0.0272 0.1732 0.1732
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0043 0.0142 0.0343
Loa Loa (eye worm) hypothetical protein 0.0213 0.1322 0.2159
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0293 0.1151
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0105 0.0572 0.0974
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0235 0.1471 0.1471
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0025 0.0096
Trypanosoma cruzi UDP-galactopyranose mutase 0.0043 0.0142 0.0556
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0142 0.1996
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0465 0.1215
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0105 0.0572 0.0572
Schistosoma mansoni nAChR subunit 0.0105 0.0572 0.0572
Schistosoma mansoni ap endonuclease 0.0038 0.0102 0.0102
Trypanosoma cruzi C-14 sterol reductase, putative 0.0093 0.0485 0.1907
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0082 0.0215
Loa Loa (eye worm) hypothetical protein 0.0057 0.0234 0.0382
Schistosoma mansoni neuropeptide receptor 0.0051 0.0191 0.0191
Brugia malayi Pre-SET motif family protein 0.0125 0.0709 0.1207
Echinococcus granulosus glycine receptor subunit beta 0.0105 0.0572 0.0572
Echinococcus granulosus neuropeptide receptor A26 0.0051 0.0191 0.0191
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0082 0.0082
Toxoplasma gondii PHD-finger domain-containing protein 0.0122 0.0689 0.964
Schistosoma mansoni smad1 5 8 and 0.0025 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Loa Loa (eye worm) acetylcholine receptor protein 0.0049 0.0177 0.029
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0272 0.1732 0.1732
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0292 0.1148
Leishmania major sterol C-24 reductase, putative 0.0093 0.0485 0.1907
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0105 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Echinococcus granulosus neuropeptide receptor 0.0051 0.0191 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0292 0.1148
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0142 0.0142
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0715 0.0715
Brugia malayi Carboxylesterase family protein 0.0272 0.1732 0.2949
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0572 0.0974
Schistosoma mansoni phd/f-box containing protein 0.0056 0.0227 0.0227
Brugia malayi MH2 domain containing protein 0.0025 0.0013 0.0022
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.024 0.024
Schistosoma mansoni myosin xvIII 0.0051 0.0191 0.0191
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0102 0.3497
Schistosoma mansoni alpha-glucosidase 0.0146 0.0856 0.0856
Echinococcus granulosus lamin dm0 0.0028 0.0031 0.0031
Onchocerca volvulus 0.0051 0.0191 0.0285
Echinococcus granulosus small conductance calcium activated potassium 0.0474 0.3135 0.3135
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0101 0.0399
Echinococcus multilocularis geminin 0.0681 0.4572 0.4572
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.0173 0.104 0.1698
Toxoplasma gondii exonuclease III APE 0.0038 0.0102 0.1433
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus granulosus glycine receptor subunit beta 0.0105 0.0572 0.0572
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0051 0.0191 0.0325
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0037 0.0037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0184 0.048
Echinococcus multilocularis lamin 0.0028 0.0031 0.0031
Brugia malayi hypothetical protein 0.0049 0.0177 0.0302
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0115 0.0453
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0013 0.0013
Brugia malayi amine oxidase, flavin-containing family protein 0.0043 0.0142 0.0241
Echinococcus multilocularis glycine receptor subunit beta 0.0105 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0057 0.0234 0.0382
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0105 0.0572 0.0572
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0543 0.3611 0.5897
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.0535 0.1397
Brugia malayi hypothetical protein 0.0051 0.0191 0.0325
Leishmania major cathepsin L-like protease 0.0065 0.0292 0.1148
Echinococcus granulosus alpha 1A adrenergic receptor 0.0051 0.0191 0.0191
Schistosoma mansoni nAChR subunit 0.0049 0.0177 0.0177
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0305 0.0305
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0082 0.1208
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0365 0.5292
Onchocerca volvulus 0.0051 0.0191 0.0285
Echinococcus multilocularis acetylcholinesterase 0.0272 0.1732 0.1732
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0056 0.0227 0.0893
Onchocerca volvulus 0.0988 0.6708 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Echinococcus multilocularis lysine specific demethylase 5A 0.0209 0.1294 0.1294
Schistosoma mansoni amine GPCR 0.0051 0.0191 0.0191
Brugia malayi Dopamine receptor protein 2 0.0051 0.0191 0.0325
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0114 0.0297
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0126 0.0715 0.1867
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0037 0.0147
Echinococcus multilocularis lamin dm0 0.0028 0.0031 0.0031
Brugia malayi PHD-finger family protein 0.0122 0.0689 0.1173
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0086 0.0226
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0031 0.0053
Onchocerca volvulus 0.0058 0.024 0.0358
Plasmodium falciparum JmjC domain-containing protein, putative 0.0056 0.0227 0.3299
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0293 0.0478
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0292 0.1148
Echinococcus multilocularis neuropeptide s receptor 0.0051 0.0191 0.0191
Brugia malayi Carboxylesterase family protein 0.0046 0.0159 0.0271
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0365 1
Schistosoma mansoni opsin-like receptor 0.0051 0.0191 0.0191
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0129 0.1827
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0715 0.173
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0135
Loa Loa (eye worm) hypothetical protein 0.0474 0.3135 0.5119
Loa Loa (eye worm) acetylcholinesterase 1 0.0272 0.1732 0.2829
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0365 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0051 0.0191 0.0191
Schistosoma mansoni calcium-activated potassium channel 0.0474 0.3135 0.3135
Echinococcus granulosus neuropeptide FF receptor 2 0.0051 0.0191 0.0191
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.0159 0.0385
Loa Loa (eye worm) hypothetical protein 0.0047 0.0165 0.0269
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0102 0.0248
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus granulosus phd:f box containing protein 0.0056 0.0227 0.0227
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.004 0.0117 0.1637
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0086 0.1285
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0056 0.0227 0.0227
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0302 0.4228
Loa Loa (eye worm) hypothetical protein 0.0066 0.0295 0.0482
Schistosoma mansoni jumonji domain containing protein 0.0056 0.0227 0.0227
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0172 0.0256
Loa Loa (eye worm) hypothetical protein 0.0057 0.0234 0.0382
Onchocerca volvulus 0.0046 0.0159 0.0237
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0049 0.0177 0.0302
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.024 0.024
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0082 0.0123
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0049 0.0177 0.0302
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0101 0.0151
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Schistosoma mansoni gliotactin 0.0046 0.0159 0.0159
Echinococcus granulosus neuropeptide receptor 0.0051 0.0191 0.0191
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0105 0.0572 0.0572
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0115 0.0495
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0102 0.0402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0292 0.1148
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0045
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0101 0.142
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0082 0.0215
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0051 0.0191 0.0312
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0049 0.0177 0.029
Brugia malayi jmjC domain containing protein 0.0056 0.0227 0.0387
Echinococcus granulosus lysine specific demethylase 6a 0.0056 0.0227 0.0227
Schistosoma mansoni lamin 0.0028 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0101 0.0151
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0235 0.1471 0.1471
Echinococcus multilocularis JmjC domain containing protein 4 0.0056 0.0227 0.0227
Echinococcus multilocularis somatostatin receptor 0.0051 0.0191 0.0191
Mycobacterium ulcerans oxidoreductase 0.0043 0.0142 0.0343
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0191 0.0191
Echinococcus granulosus g protein coupled receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0041 0.0121 0.0198
Toxoplasma gondii ABC1 family protein 0.0035 0.0082 0.1154
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0082 0.0123
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0122 0.0689 0.0689
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0103 0.0103
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0929 0.0929
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0043 0.0142 0.0142
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0715 0.173
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0929 0.0929
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.2385 0.3895
Brugia malayi larval opioid receptor 0.0051 0.0191 0.0325
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0253 0.0993
Loa Loa (eye worm) hypothetical protein 0.0272 0.1732 0.2829
Mycobacterium tuberculosis Conserved protein 0.0035 0.0082 0.0215
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0191 0.0312
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0105 0.0572 0.0572
Echinococcus multilocularis sex peptide receptor 0.0051 0.0191 0.0191
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0191 0.0191
Echinococcus granulosus g-protein coupled receptor 0.0051 0.0191 0.0191
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0184 0.048
Schistosoma mansoni hypothetical protein 0.0304 0.1954 0.1954
Brugia malayi putative neuropeptide receptor NPR1 0.0051 0.0191 0.0325
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0159 0.0416
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0102 0.0402
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0101 0.0166
Brugia malayi hypothetical protein 0.0049 0.0177 0.0302
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0051 0.0191 0.0325
Brugia malayi hypothetical protein 0.0246 0.1548 0.2635
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0125 0.0709 0.0709
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0059 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0057 0.0234 0.0382
Brugia malayi Dopamine receptor protein 1 0.0051 0.0191 0.0325
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0191 0.0191
Onchocerca volvulus 0.0046 0.0159 0.0237
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0171 0.0171
Loa Loa (eye worm) PHD-finger family protein 0.0122 0.0689 0.1125
Schistosoma mansoni hypothetical protein 0.0681 0.4572 0.4572
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0117 0.0117
Brugia malayi Pre-SET motif family protein 0.0868 0.5874 1
Onchocerca volvulus 0.0105 0.0572 0.0853
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0101 0.0399
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0051 0.0191 0.0191
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0013 0.0013
Leishmania major hypothetical protein, conserved 0.0027 0.0025 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0191 0.0191
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0082 0.1164
Echinococcus multilocularis G protein coupled receptor 139 0.0051 0.0191 0.0191
Loa Loa (eye worm) GABA receptor subunit 0.0057 0.0234 0.0382
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0057 0.0234 0.0398
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0051 0.0191 0.0191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0191 0.0191
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0289 0.0492
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0043 0.0142 0.1996
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0082 0.0135
Schistosoma mansoni protein phosphatase 2C 0.0056 0.0227 0.0227
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0057 0.0234 0.0382
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.1548 0.1548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0292 0.1148
Brugia malayi Bromodomain containing protein 0.0128 0.0733 0.1247
Schistosoma mansoni amine GPCR 0.0051 0.0191 0.0191
Brugia malayi jmjC domain containing protein 0.0213 0.132 0.2247
Mycobacterium ulcerans aldehyde dehydrogenase 0.0126 0.0715 0.173
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0295 0.0295
Schistosoma mansoni cpg binding protein 0.0033 0.0069 0.0069
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0462 0.3048 0.3048
Schistosoma mansoni acetylcholine receptor subunit beta 0.0049 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0105 0.0572 0.0572
Leishmania major C-8 sterol isomerase-like protein 0.0389 0.2544 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0115 0.0279
Loa Loa (eye worm) jmjC domain-containing protein 0.0213 0.132 0.2155
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0172 0.0172
Brugia malayi beta-lactamase family protein 0.0035 0.0082 0.014
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0389 0.2544 0.4331
Echinococcus multilocularis orexin receptor type 2 0.0051 0.0191 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0292 0.1148
Loa Loa (eye worm) MBCTL1 0.0066 0.0295 0.0482
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0102 0.0402
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0191 0.0191
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0191 0.0191
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0105 0.0572 0.0974
Echinococcus granulosus G protein coupled receptor 139 0.0051 0.0191 0.0191
Loa Loa (eye worm) glutathione reductase 0.0039 0.0114 0.0186
Echinococcus granulosus serotonin receptor 0.0051 0.0191 0.0191
Brugia malayi ORL1-like opioid receptor 0.0051 0.0191 0.0325
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0184 0.0184
Brugia malayi Carboxylesterase family protein 0.0046 0.0159 0.0271
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0142 0.1996
Echinococcus granulosus g protein coupled receptor 0.0051 0.0191 0.0191
Brugia malayi PHD-finger family protein 0.0044 0.0143 0.0243
Echinococcus granulosus allatostatin A receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0082 0.0215
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0049 0.0177 0.029
Schistosoma mansoni hypothetical protein 0.0474 0.3135 0.3135
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0191 0.0191
Brugia malayi mbt repeat family protein 0.0058 0.024 0.0408
Onchocerca volvulus 0.0105 0.0572 0.0853
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0105 0.0572 0.0974
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0171 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0115 0.0115
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0128 0.1863
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0051 0.0191 0.0191
Brugia malayi sulfakinin receptor protein 0.0051 0.0191 0.0325
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0929 0.1581
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0105 0.0572 0.0572
Echinococcus multilocularis smad 0.0025 0.0013 0.0013
Brugia malayi jmjC domain containing protein 0.0056 0.0227 0.0387
Schistosoma mansoni nAChR subunit 0.0105 0.0572 0.0572
Schistosoma mansoni importin beta-1 0.0028 0.0037 0.0037
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0365 0.5102
Mycobacterium ulcerans hypothetical protein 0.0035 0.0082 0.02
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Brugia malayi MH2 domain containing protein 0.0366 0.2385 0.406
Loa Loa (eye worm) hypothetical protein 0.0046 0.0159 0.026
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0043 0.0142 0.2054
Brugia malayi glutaminase DH11.1 0.0268 0.17 0.2893
Plasmodium falciparum protoporphyrinogen oxidase 0.0043 0.0142 0.2054
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0227 0.0893
Onchocerca volvulus 0.0051 0.0191 0.0285
Onchocerca volvulus 0.0046 0.0159 0.0237
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0049 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Brugia malayi Serotonin receptor 0.0051 0.0191 0.0325
Plasmodium falciparum phd finger protein, putative 0.0122 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Onchocerca volvulus 0.0057 0.0234 0.0349
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0289 0.0472
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0159 0.0159
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.1021 0.1021
Echinococcus granulosus acetylcholinesterase 0.0272 0.1732 0.1732
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0159 0.0237
Schistosoma mansoni nAChR subunit 0.0049 0.0177 0.0177
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0105 0.0572 0.0974
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.1021 0.1021
Echinococcus granulosus nAChR subunit 0.0105 0.0572 0.0572
Brugia malayi Serotonin receptor 0.0051 0.0191 0.0325
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0082 0.0082
Onchocerca volvulus 0.0125 0.0709 0.1057
Brugia malayi Bromodomain containing protein 0.0085 0.0428 0.0729
Brugia malayi hypothetical protein 0.0043 0.0142 0.0241
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0292 0.1148
Echinococcus granulosus nAChR subunit 0.0057 0.0234 0.0234
Brugia malayi Thioredoxin reductase 0.0039 0.0114 0.0193
Leishmania major UDP-galactopyranose mutase 0.0043 0.0142 0.0556
Schistosoma mansoni biogenic amine (5HT) receptor 0.0173 0.104 0.104
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.024 0.0358
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0574 0.3828 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0359 0.0586
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.004 0.0117 0.046
Echinococcus granulosus jumonji domain containing protein 0.017 0.1022 0.1022
Schistosoma mansoni calcium-activated potassium channel 0.0451 0.2974 0.2974
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0101 0.0151
Loa Loa (eye worm) hypothetical protein 0.0199 0.1222 0.1995
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0292 0.1148
Brugia malayi MH1 domain containing protein 0.0025 0.0013 0.0022
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0125 0.0709 0.9919
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0293 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Loa Loa (eye worm) hypothetical protein 0.0043 0.0142 0.0231
Giardia lamblia PHD finger protein 15 0.0122 0.0689 1
Echinococcus multilocularis musashi 0.0028 0.0031 0.0031
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0293 0.0293
Echinococcus multilocularis neuropeptide receptor A26 0.0051 0.0191 0.0191
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0159 0.0159
Onchocerca volvulus 0.0049 0.0177 0.0264
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0051 0.0191 0.0312
Toxoplasma gondii aldehyde dehydrogenase 0.0126 0.0715 1
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0191 0.0191
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0365 0.0365
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0051 0.0191 0.0191
Echinococcus granulosus glycine receptor subunit alpha 1 0.0105 0.0572 0.0572
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.1021 0.1737
Loa Loa (eye worm) carboxylesterase 0.0046 0.0159 0.026
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0159 0.0416
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0082 0.0123
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Loa Loa (eye worm) ACC-1 protein 0.0105 0.0572 0.0934
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0159 0.0159
Schistosoma mansoni nAChR subunit 0.0105 0.0572 0.0572
Leishmania major cathepsin L-like protease 0.0065 0.0292 0.1148
Loa Loa (eye worm) LGC-31 protein 0.0105 0.0572 0.0934
Echinococcus multilocularis zinc finger protein 0.0026 0.0021 0.0021
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.0535 0.1397
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0013 0.0021
Onchocerca volvulus 0.0051 0.0191 0.0285
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.0535 0.1397
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0135
Toxoplasma gondii hypothetical protein 0.0026 0.002 0.0284
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0311
Brugia malayi Carboxylesterase family protein 0.0046 0.0159 0.0271
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0082 0.0324
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.002 0.0286
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0128 0.1863
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0102 0.0402
Echinococcus granulosus hypothetical protein 0.0051 0.0191 0.0191
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0102 0.0102
Onchocerca volvulus 0.0051 0.0191 0.0285
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0105 0.0572 0.0974
Brugia malayi follicle stimulating hormone receptor 0.0543 0.3611 0.6148
Echinococcus granulosus peptide allatostatin:somatostatin 0.0051 0.0191 0.0191
Echinococcus multilocularis 0.0043 0.0142 0.0142
Schistosoma mansoni smad1 5 8 and 0.0025 0.0013 0.0013
Brugia malayi F/Y-rich N-terminus family protein 0.0056 0.0225 0.0384
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0191 0.0191
Brugia malayi hypothetical protein 0.0051 0.0191 0.0325
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.0535 1
Schistosoma mansoni survival motor neuron protein 0.005 0.0188 0.0188
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0159 0.0237
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0114 0.0447
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0191 0.0191
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0051
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Schistosoma mansoni amine GPCR 0.0051 0.0191 0.0191
Echinococcus multilocularis serotonin receptor 0.0173 0.104 0.104
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0868 0.5874 0.9593
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0365 0.6691
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0101 0.0151
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0289 0.0289
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Plasmodium falciparum thioredoxin reductase 0.0039 0.0114 0.1649
Onchocerca volvulus 0.0028 0.0031 0.0047
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0105 0.0572 0.0572
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0082 0.0123
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Plasmodium vivax JmjC domain containing protein 0.0056 0.0227 0.3206
Echinococcus granulosus somatostatin receptor 0.0051 0.0191 0.0191
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0105 0.0572 0.0572
Schistosoma mansoni inositol monophosphatase 0.004 0.0115 0.0115
Onchocerca volvulus 0.0057 0.0234 0.0349
Brugia malayi neuropeptide F receptor 0.0051 0.0191 0.0325
Brugia malayi hypothetical protein 0.0049 0.0177 0.0302
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0051 0.0191 0.0191
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0105 0.0572 0.0572
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0051 0.0191 0.0312
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0102 0.0102
Plasmodium vivax glutathione reductase, putative 0.0039 0.0114 0.1603
Brugia malayi Cation transporter family protein 0.0105 0.0572 0.0974
Mycobacterium ulcerans glutaminase 0.0268 0.17 0.4115
Loa Loa (eye worm) hypothetical protein 0.0238 0.1491 0.2436
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.0159 0.0416
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0126 0.0715 0.2808
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0191 0.0191
Onchocerca volvulus Alhambra homolog 0.0122 0.0689 0.1027
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0365 0.5102
Trypanosoma cruzi sterol C-24 reductase, putative 0.0093 0.0485 0.1907
Onchocerca volvulus Neuropeptide F receptor homolog 0.0051 0.0191 0.0285
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0105 0.0572 0.0974
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0172 0.0256
Echinococcus granulosus sex peptide receptor 0.0051 0.0191 0.0191
Brugia malayi RNA, U transporter 1 0.0081 0.0403 0.0685
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0082 0.0082
Echinococcus multilocularis acetylcholinesterase 0.0272 0.1732 0.1732
Schistosoma mansoni nAChR subunit 0.0105 0.0572 0.0572
Echinococcus multilocularis glycine receptor subunit beta 0.0105 0.0572 0.0572
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0135
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0101 0.0151
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Toxoplasma gondii PHD-finger domain-containing protein 0.0122 0.0689 0.964
Echinococcus multilocularis jumonji domain containing 1A 0.0056 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus multilocularis PHD finger protein rhinoceros 0.0122 0.0689 0.0689
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0159 0.0159
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0191 0.0191
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0102 0.0153
Brugia malayi G-protein coupled receptor 0.0051 0.0191 0.0325
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0105 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0191 0.0191
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0115 0.1614
Echinococcus granulosus carboxylesterase 5A 0.0272 0.1732 0.1732
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0159 0.0159
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.024 0.0392
Loa Loa (eye worm) melatonin receptor type 1A 0.0051 0.0191 0.0312
Echinococcus multilocularis jumonji domain containing protein 0.017 0.1022 0.1022
Onchocerca volvulus 0.0051 0.0191 0.0285
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0051 0.0191 0.0191
Brugia malayi hypothetical protein 0.0049 0.0177 0.0302
Plasmodium falciparum glutathione reductase 0.0039 0.0114 0.1649
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0365 0.0883
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0293 0.1151
Brugia malayi Cation transporter family protein 0.0105 0.0572 0.0974
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0025 0.0346
Leishmania major hypothetical protein, conserved 0.0035 0.0082 0.0324
Schistosoma mansoni cpg binding protein 0.0033 0.0069 0.0069
Echinococcus granulosus tachykinin peptides receptor 99D 0.0051 0.0191 0.0191
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0017 0.0017
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0191 0.0191
Echinococcus granulosus dro:myosuppressin receptor 0.0051 0.0191 0.0191
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0057 0.0234 0.0234
Schistosoma mansoni histamine h1 receptor 0.0051 0.0191 0.0191
Onchocerca volvulus 0.0051 0.0191 0.0285
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Echinococcus granulosus tar DNA binding protein 0.0065 0.0289 0.0289
Onchocerca volvulus 0.0051 0.0191 0.0285
Loa Loa (eye worm) hypothetical protein 0.0043 0.0142 0.0231
Leishmania major trypanothione reductase 0.0039 0.0114 0.0447
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0101 0.0151
Schistosoma mansoni aldehyde dehydrogenase 0.0126 0.0715 0.0715
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0295 0.0295
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0101 0.0151
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0105 0.0572 0.0974
Schistosoma mansoni jumonji/arid domain-containing protein 0.0213 0.132 0.132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0191 0.0191
Echinococcus granulosus lamin b receptor 0.0093 0.0485 0.0485
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.024 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0465 0.1215
Schistosoma mansoni acetylcholine receptor-related 0.0049 0.0177 0.0177
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0105 0.0572 0.0572
Leishmania major C-14 sterol reductase, putative 0.0093 0.0485 0.1907
Schistosoma mansoni alpha-glucosidase 0.0146 0.0856 0.0856
Loa Loa (eye worm) carboxylesterase 0.0046 0.0159 0.026
Echinococcus granulosus glycine receptor subunit alpha 1 0.0105 0.0572 0.0572
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0462 0.3048 0.3048
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.0117
Schistosoma mansoni opsin-like receptor 0.0051 0.0191 0.0191
Echinococcus multilocularis nAChR subunit 0.0057 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0191 0.0191
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0013 0.0013
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0115 0.0453
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0101 0.0151
Echinococcus granulosus glycine receptor subunit alpha 1 0.0105 0.0572 0.0572
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0082 0.02
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0159 0.0159
Onchocerca volvulus 0.0046 0.0159 0.0237
Loa Loa (eye worm) hypothetical protein 0.0046 0.0159 0.026
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0051 0.0191 0.0191
Brugia malayi hypothetical protein 0.0051 0.0191 0.0325
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0191 0.0191
Onchocerca volvulus 0.0098 0.0523 0.0779
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0191 0.0191
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0102 0.2385
Brugia malayi beta-lactamase 0.0035 0.0082 0.014
Schistosoma mansoni amine GPCR 0.0051 0.0191 0.0191
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0102 0.0167
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0031 0.0051
Schistosoma mansoni lamin 0.0028 0.0031 0.0031
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0293 0.0293
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0101 0.0173
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0049 0.0177 0.0302
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Brugia malayi jmjC domain containing protein 0.0462 0.3048 0.5189
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0115 0.0172
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0191 0.0191
Brugia malayi jmjC domain containing protein 0.0056 0.0227 0.0387
Brugia malayi jmjC domain containing protein 0.0056 0.0227 0.0387
Brugia malayi hypothetical protein 0.0051 0.0191 0.0325
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Schistosoma mansoni neuropeptide receptor 0.0051 0.0191 0.0191
Echinococcus granulosus fmrfamide receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0143 0.0834 0.1362
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0105 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0184 0.0184
Brugia malayi SWIRM domain containing protein 0.0043 0.0142 0.0241
Echinococcus granulosus lysine specific histone demethylase 1A 0.0043 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Loa Loa (eye worm) hypothetical protein 0.0056 0.0227 0.0371
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0037 0.0523
Echinococcus multilocularis phd:f box containing protein 0.0056 0.0227 0.0227
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0188 0.032
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0102 0.0174
Onchocerca volvulus 0.0105 0.0572 0.0853
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.0881 0.0881
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Mycobacterium tuberculosis Possible oxidoreductase 0.0043 0.0142 0.037
Brugia malayi G protein-coupled receptor F59B2.13 0.0051 0.0191 0.0325
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0057 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0681 0.4572 0.4572
Schistosoma mansoni neurotransmitter gated ion channel 0.0049 0.0177 0.0177
Onchocerca volvulus 0.0028 0.0031 0.0047
Loa Loa (eye worm) RNA binding protein 0.0065 0.0289 0.0472
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus granulosus importin subunit beta 1 0.0028 0.0037 0.0037
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0105 0.0572 0.0572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0292 0.1148
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0049 0.0177 0.0177
Echinococcus multilocularis G-protein coupled receptor, putative 0.0051 0.0191 0.0191
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0191 0.0191
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus granulosus lysine specific demethylase 5A 0.0213 0.132 0.132
Brugia malayi Inositol-1 0.004 0.0115 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0292 0.1148
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0051 0.0191 0.0191
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Schistosoma mansoni alpha glucosidase 0.0038 0.0101 0.0101
Brugia malayi intermediate filament protein 0.0028 0.0031 0.0053
Schistosoma mansoni neurotransmitter gated ion channel 0.0049 0.0177 0.0177
Echinococcus multilocularis Smad4 0.0025 0.0013 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0031 0.0051
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0105 0.0572 0.0934
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0105 0.0572 0.0934
Brugia malayi hypothetical protein 0.0051 0.0191 0.0325
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0191 0.0191
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0025 0.0096
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.012 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0049 0.0177 0.0177
Echinococcus granulosus g protein coupled receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Echinococcus granulosus zinc finger protein 0.0026 0.0021 0.0021
Schistosoma mansoni nAChR subunit 0.0105 0.0572 0.0572
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0172 0.2407
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.1548 0.1548
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0115 0.0172
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0056 0.0227 0.0893
Loa Loa (eye worm) hypothetical protein 0.0044 0.0143 0.0233
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0105 0.0572 0.0934
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Loa Loa (eye worm) jmjC domain-containing protein 0.0252 0.1593 0.2602
Loa Loa (eye worm) glutaminase 2 0.0268 0.17 0.2775
Plasmodium vivax SET domain protein, putative 0.0125 0.0709 1
Brugia malayi beta-lactamase family protein 0.0035 0.0082 0.014
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0051 0.0191 0.0191
Onchocerca volvulus 0.0049 0.0177 0.0264
Echinococcus multilocularis peregrin 0.0128 0.0733 0.0733
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0171 0.0279
Loa Loa (eye worm) Smad1 0.0025 0.0013 0.0021
Echinococcus granulosus 7tm_1 domain containing protein 0.0051 0.0191 0.0191
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0101 0.3466
Brugia malayi TAR-binding protein 0.0065 0.0289 0.0492
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0042 0.0129 0.1879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0572 0.0974
Onchocerca volvulus 0.0105 0.0572 0.0853
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0292 0.1148
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0365 0.0365
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0044 0.0071
Echinococcus multilocularis carboxylesterase 5A 0.0272 0.1732 0.1732
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.1954 0.3191
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0295 0.0295
Brugia malayi MH2 domain containing protein 0.0025 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0246 0.1548 0.2527
Loa Loa (eye worm) inositol-1 0.004 0.0115 0.0188
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0295 0.0503
Loa Loa (eye worm) hypothetical protein 0.0046 0.0159 0.026
Echinococcus multilocularis g-protein coupled receptor 0.0051 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0358 0.2327 0.2327
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Loa Loa (eye worm) hypothetical protein 0.0904 0.6124 1
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0051 0.0191 0.0191
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0128 0.4383
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0051 0.0191 0.0312
Schistosoma mansoni zinc finger protein 0.0026 0.0021 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0143 0.0834 0.0834
Echinococcus multilocularis cpg binding protein 0.0033 0.0069 0.0069
Brugia malayi G protein-coupled receptor 0.0051 0.0191 0.0325
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0051 0.0191 0.0325
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0191 0.0191
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0101 0.0101
Loa Loa (eye worm) acetyltransferase 0.0157 0.0929 0.1517
Loa Loa (eye worm) hypothetical protein 0.0057 0.0234 0.0382
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0105 0.0572 0.0572
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0043 0.0142 0.2356
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0293 0.0293
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0105 0.0572 0.0934
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0143 0.0834 0.0834
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0191 0.0191
Echinococcus granulosus JmjC domain containing protein 4 0.0056 0.0227 0.0227
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0101 0.0151
Schistosoma mansoni amine oxidase 0.0043 0.0142 0.0142
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0051 0.0191 0.0191
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.024 0.024
Brugia malayi hypothetical protein 0.0051 0.0191 0.0325
Schistosoma mansoni biogenic amine receptor 0.0051 0.0191 0.0191
Schistosoma mansoni biogenic amine receptor 0.0051 0.0191 0.0191
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0013 0.0013
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0191 0.0191
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0046 0.0159 0.026
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0572 0.0974
Echinococcus granulosus 7TM GPCR rhodopsin 0.0051 0.0191 0.0191
Echinococcus granulosus neuroligin 0.0046 0.0159 0.0159
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0142 0.037
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0617 0.413 1
Brugia malayi Dopamine receptor 0.0051 0.0191 0.0325
Brugia malayi mbt repeat family protein 0.0058 0.024 0.0408
Loa Loa (eye worm) hypothetical protein 0.0226 0.141 0.2302
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Plasmodium falciparum importin beta, putative 0.0028 0.0037 0.0543
Mycobacterium tuberculosis Conserved protein 0.0035 0.0082 0.0215
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0101 0.3466
Schistosoma mansoni alpha-1 adrenergic receptor 0.0051 0.0191 0.0191
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0572 0.0974
Onchocerca volvulus 0.0051 0.0191 0.0285
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0043 0.0142 0.0231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0135
Brugia malayi hypothetical protein 0.0046 0.0159 0.0271
Brugia malayi hypothetical protein 0.0051 0.0191 0.0325
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Schistosoma mansoni ap endonuclease 0.0038 0.0102 0.0102
Schistosoma mansoni opsin-like receptor 0.0051 0.0191 0.0191
Toxoplasma gondii PHD-finger domain-containing protein 0.004 0.0117 0.1637
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0617 0.413 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0051 0.0191 0.0191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.0392
Schistosoma mansoni neurotransmitter gated ion channel 0.0057 0.0234 0.0234
Brugia malayi excitatory GABA receptor EXP-1A 0.0105 0.0572 0.0974
Toxoplasma gondii histone lysine-specific demethylase 0.0043 0.0142 0.198
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0293 0.1151
Onchocerca volvulus Putative nachr subunit 0.0105 0.0572 0.0853
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0056 0.0227 0.318
Entamoeba histolytica hypothetical protein 0.0057 0.0234 0.7994
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Onchocerca volvulus 0.0035 0.0082 0.0123
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0191 0.0191
Brugia malayi Melatonin receptor type 1A 0.0051 0.0191 0.0325
Loa Loa (eye worm) hypothetical protein 0.0046 0.0159 0.026
Schistosoma mansoni nAChR subunit 0.0105 0.0572 0.0572
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0105 0.0572 0.0572
Brugia malayi Probable ClpP-like protease 0.0076 0.0365 0.0621
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0057 0.0234 0.0398
Onchocerca volvulus 0.0051 0.0191 0.0285
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0293 0.0498
Echinococcus granulosus jumonji domain containing 1A 0.0056 0.0227 0.0227
Brugia malayi Carboxylesterase family protein 0.0272 0.1732 0.2949
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0057 0.0234 0.0398
Echinococcus multilocularis protoporphyrinogen oxidase 0.0043 0.0142 0.0142
Brugia malayi MH1 domain containing protein 0.0025 0.0013 0.0022
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0043 0.0142 0.0142
Onchocerca volvulus 0.0049 0.0177 0.0264
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0191 0.0191
Brugia malayi RNA binding protein 0.0065 0.0289 0.0492
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Mycobacterium tuberculosis Probable reductase 0.009 0.0465 0.1215
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0082 0.0215
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0049 0.0177 0.0302
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0061
Echinococcus multilocularis small conductance calcium activated potassium 0.0474 0.3135 0.3135
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0191 0.0191
Echinococcus granulosus intermediate filament protein 0.0028 0.0031 0.0031
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0102 0.1486
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0126 0.0715 0.0715
Brugia malayi CXXC zinc finger family protein 0.0029 0.0044 0.0074
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Trypanosoma brucei trypanothione reductase 0.0039 0.0114 0.0447
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0105 0.0572 0.0974
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0051 0.0191 0.0191
Toxoplasma gondii thioredoxin reductase 0.0039 0.0114 0.159
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0172 0.2426
Echinococcus multilocularis lamin b receptor 0.0093 0.0485 0.0485
Schistosoma mansoni bromodomain containing protein 0.0072 0.0342 0.0342
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0117 0.0117
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0389 0.2544 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0031 0.0031
Echinococcus multilocularis neuroligin 0.0046 0.0159 0.0159
Brugia malayi Bromodomain containing protein 0.0044 0.0147 0.025
Schistosoma mansoni hypothetical protein 0.0051 0.0191 0.0191
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1393 0.3638
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0101 0.0399
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0082 0.0215
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0572 0.0974
Echinococcus granulosus Smad4 0.0025 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0051 0.0191 0.0285
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0171 0.0291
Onchocerca volvulus 0.0035 0.0082 0.0123
Echinococcus multilocularis serotonin receptor 0.0173 0.104 0.104
Trypanosoma brucei glucosidase, putative 0.0038 0.0101 0.0399
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.0465 0.8643
Schistosoma mansoni nAChR subunit 0.0105 0.0572 0.0572
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0191 0.0191
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0043 0.0142 0.2054
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0105 0.0572 0.0572
Schistosoma mansoni jumonji/arid domain-containing protein 0.0213 0.132 0.132
Schistosoma mansoni hypothetical protein 0.005 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0057 0.0234 0.0382
Onchocerca volvulus 0.0051 0.0191 0.0285
Mycobacterium leprae Probable lipase LipE 0.0035 0.0082 0.1208
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0365 0.0883
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0082 0.0324
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0365 0.0365
Onchocerca volvulus 0.0035 0.0082 0.0123
Echinococcus granulosus lamin 0.0028 0.0031 0.0031
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0172 0.2407
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0191 0.0191
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0105 0.0572 0.0974
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0115 0.0453
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0115 0.0115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0191 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0289 0.0289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0191 0.0191
Loa Loa (eye worm) carboxylesterase 0.0272 0.1732 0.2829
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0572 0.0974
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0082 0.0123
Loa Loa (eye worm) hypothetical protein 0.0076 0.0365 0.0595
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0105 0.0572 0.0974
Schistosoma mansoni amine oxidase 0.0043 0.0142 0.0142
Echinococcus granulosus cpg binding protein 0.0033 0.0069 0.0069
Loa Loa (eye worm) glutaminase 0.0268 0.17 0.2775
Onchocerca volvulus 0.0029 0.0044 0.0065
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0184 0.3174
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0191 0.0191
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0102 0.1445
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0195 0.0767
Brugia malayi Importin beta-1 subunit 0.0028 0.0037 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0171 0.0171
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0227 0.0371
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0051 0.0191 0.0325
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.1021 0.1667
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0292 0.1148
Schistosoma mansoni adenoreceptor 0.0051 0.0191 0.0191
Plasmodium vivax importin-beta 2, putative 0.0028 0.0037 0.0528
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0292 0.1148
Trypanosoma brucei C-14 sterol reductase, putative 0.0093 0.0485 0.1907
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0115 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0292 0.1148
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0465 0.1215
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Schistosoma mansoni neuropeptide receptor 0.0051 0.0191 0.0191
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0289 0.0472
Schistosoma mansoni glutaminase 0.0268 0.17 0.17
Brugia malayi hypothetical protein 0.0049 0.0177 0.0302
Loa Loa (eye worm) hypothetical protein 0.0173 0.104 0.1698
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0045 0.0154 0.2155
Onchocerca volvulus 0.0051 0.0191 0.0285
Schistosoma mansoni amine GPCR 0.0051 0.0191 0.0191
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0316 0.0316
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0025 0.0096
Trichomonas vaginalis glutaminase, putative 0.0268 0.17 0.2534
Echinococcus granulosus snurportin 1 0.0304 0.1954 0.1954
Plasmodium vivax hypothetical protein, conserved 0.0122 0.0689 0.9719
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0052 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0043 0.0142 0.0231
Echinococcus granulosus PHD finger protein rhinoceros 0.0122 0.0689 0.0689
Loa Loa (eye worm) TYRA-2 protein 0.0051 0.0191 0.0312
Echinococcus multilocularis snurportin 1 0.0304 0.1954 0.1954
Echinococcus granulosus peregrin 0.0128 0.0733 0.0733
Onchocerca volvulus 0.0105 0.0572 0.0853
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0709 0.0709
Brugia malayi hypothetical protein 0.0027 0.0025 0.0042
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0365 0.5144
Schistosoma mansoni cpg binding protein 0.0029 0.0044 0.0044
Brugia malayi hypothetical protein 0.0051 0.0191 0.0325
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0105 0.0572 0.0572
Schistosoma mansoni Lamin B receptor (ERG24) 0.0093 0.0485 0.0485
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Onchocerca volvulus 0.0046 0.0159 0.0237
Brugia malayi AKH receptor 0.0051 0.0191 0.0325
Trichomonas vaginalis esterase, putative 0.0035 0.0082 0.0123
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0105 0.0572 0.0934
Schistosoma mansoni hypothetical protein 0.0051 0.0191 0.0191
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0057 0.0234 0.0398
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0191 0.0191
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0465 0.1215
Echinococcus multilocularis allatostatin A receptor 0.0051 0.0191 0.0191
Brugia malayi hypothetical protein 0.0051 0.0191 0.0325
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0191 0.0191
Brugia malayi G-protein coupled receptor 0.0051 0.0191 0.0325
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0159 0.0159
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0191 0.0191
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0102 0.0267
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0115 0.394
Leishmania major hypothetical protein, conserved 0.0056 0.0227 0.0893
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0082 0.02
Mycobacterium ulcerans lipase LipD 0.0035 0.0082 0.02
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Brugia malayi glutathione reductase 0.0039 0.0114 0.0193
Brugia malayi PHD-finger family protein 0.0032 0.006 0.0103
Leishmania major cathepsin L-like protease 0.0065 0.0292 0.1148
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0059 0.0253 0.0253
Mycobacterium ulcerans beta-lactamase 0.0035 0.0082 0.02
Brugia malayi neuropeptide F receptor 0.0051 0.0191 0.0325
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0082 0.0082
Trypanosoma cruzi sterol C-24 reductase, putative 0.0093 0.0485 0.1907
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0293 0.1151
Onchocerca volvulus 0.0051 0.0191 0.0285
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0082 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0082 0.0324
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.2385 0.3895
Brugia malayi hypothetical protein 0.0051 0.0191 0.0325
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0049 0.0177 0.0177
Schistosoma mansoni neuropeptide receptor 0.0051 0.0191 0.0191
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0105 0.0572 0.0572
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0171 0.0171
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0105 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0046 0.0159 0.026
Loa Loa (eye worm) ACC-1 protein 0.0105 0.0572 0.0934
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus granulosus smad 0.0025 0.0013 0.0013
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0191 0.0312
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0365 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0051 0.0191 0.0325
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0125 0.0709 0.0709
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0105 0.0572 0.0572
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0105 0.0572 0.0934
Echinococcus granulosus histone lysine methyltransferase setb 0.0143 0.0834 0.0834
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0114 0.1603
Schistosoma mansoni hypothetical protein 0.0122 0.0689 0.0689
Onchocerca volvulus 0.005 0.0188 0.028
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.004 0.0117 0.046
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0025 0.0343
Brugia malayi RE15519p 0.0051 0.0191 0.0325
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0159 0.0159
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.024 0.024
Brugia malayi GnHR receptor homolog 0.0051 0.0191 0.0325
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0191 0.0191
Schistosoma mansoni Smad4 0.0025 0.0013 0.0013
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0105 0.0572 0.0572
Schistosoma mansoni growth hormone secretagogue receptor 0.0051 0.0191 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0292 0.1148
Loa Loa (eye worm) hypothetical protein 0.0051 0.0191 0.0312
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0105 0.0572 0.0572
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0191 0.0191
Mycobacterium ulcerans dehydrogenase 0.0043 0.0142 0.0343
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0115 0.0453
Schistosoma mansoni jumonji domain containing protein 0.0379 0.2476 0.2476
Loa Loa (eye worm) hypothetical protein 0.0049 0.0177 0.029
Loa Loa (eye worm) beta-lactamase 0.0035 0.0082 0.0135
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0227 0.0371
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0043 0.0142 0.0142
Brugia malayi AF-10 protein 0.004 0.0117 0.0199
Onchocerca volvulus 0.0051 0.0191 0.0285
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0056 0.0227 0.0371
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0289 0.0289
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0227 0.0371
Loa Loa (eye worm) hypothetical protein 0.0057 0.0234 0.0382
Onchocerca volvulus 0.0051 0.0191 0.0285
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0049 0.0177 0.0302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0171 0.0171
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0102 0.1486
Mycobacterium tuberculosis Conserved protein 0.0035 0.0082 0.0215
Brugia malayi Tachykinin-like peptides receptor 99D 0.0051 0.0191 0.0325
Echinococcus multilocularis neuropeptide FF receptor 2 0.0051 0.0191 0.0191
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0143 0.0834 0.0834

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNFalpha at 10 uM by ELISA ChEMBL. 18625560
Inhibition (functional) = 14 % Cytotoxicity against human THP1 cells at 10 uM ChEMBL. 18625560
Inhibition (functional) = 44 % Antiinflammatory activity in human THP1 cells assessed as inhibition of IL6 at 10 uM by ELISA ChEMBL. 18625560

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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