Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0134 | 0.9161 | 0.9161 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0788 | 0.0718 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.9161 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.9161 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.9161 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.9161 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0075 | 0.0075 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0134 | 0.9161 | 0.9161 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0224 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0224 | 0.0163 |
Echinococcus granulosus | tar DNA binding protein | 0.0134 | 0.9161 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0788 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0224 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.26 | 0.2779 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0224 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0134 | 0.9161 | 0.9155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.9161 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1829 | 0.1829 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0224 | 0.0224 |
Brugia malayi | RNA binding protein | 0.0134 | 0.9161 | 0.9161 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0224 | 0.0149 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0788 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0075 | 0.0075 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0224 | 0.0163 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3339 | 0.3339 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0788 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0134 | 0.9161 | 0.9155 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.26 | 0.2779 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3339 | 0.3289 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3339 | 0.3339 |
Echinococcus multilocularis | tar DNA binding protein | 0.0134 | 0.9161 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.26 | 0.2779 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0788 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0224 | 0.0163 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0224 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0788 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1829 | 0.1767 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1829 | 0.193 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.26 | 0.2779 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0224 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.26 | 0.2779 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0788 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.26 | 0.2779 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0224 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3339 | 0.3289 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.26 | 0.26 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.26 | 0.2544 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0224 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0224 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0224 | 0.0163 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0788 | 0.0788 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0788 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.26 | 0.2779 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0788 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0134 | 0.9161 | 0.9155 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.