Detailed information for compound 1188569

Basic information

Technical information
  • TDR Targets ID: 1188569
  • Name: 1-[(2R,3S,5S)-3-hydroxy-5-(hydroxymethyl)oxol an-2-yl]-5-methylpyrimidine-2,4-dione
  • MW: 242.229 | Formula: C10H14N2O5
  • H donors: 3 H acceptors: 4 LogP: -1.51 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cn([C@@H]2O[C@@H](C[C@@H]2O)CO)c(=O)[nH]c1=O
  • InChi: 1S/C10H14N2O5/c1-5-3-12(10(16)11-8(5)15)9-7(14)2-6(4-13)17-9/h3,6-7,9,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7-,9+/m0/s1
  • InChiKey: UYUWZFRYAAHPDN-ACLDMZEESA-N  

Network

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Synonyms

  • 1-[(2R,3S,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
  • 1-[(2R,3S,5S)-3-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-5-methylpyrimidine-2,4-dione
  • 1-[(2R,3S,5S)-3-hydroxy-5-methylol-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-quinone
  • 1-[(2R,3S,5S)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
  • 114672-74-1
  • 1-(3-Deoxy-B-D-arabinofuranosyl)thymine
  • 2,4(1H,3H)-Pyrimidinedione, 1-(3-deoxy-.beta.-D-threo-pentofuranosyl)-5-methyl-
  • 3'-Deoxy-araT
  • AIDS-001000
  • AIDS001000
  • 2,4(1H,3H)-Pyrimidinedione, 1-(3-deoxy-beta-D-threo-pentofuranosyl)-5-methyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) peptidase family M1 containing protein 0.0097 0.0455 0.1304
Echinococcus granulosus GPCR family 2 0.0016 0.0018 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0043 0.0109
Brugia malayi ADAM-TS Spacer 1 family protein 0.0014 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0112 0.0541 0.1422
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0094 0.0442 0.0398
Echinococcus multilocularis thioredoxin glutathione reductase 0.0272 0.1408 0.1598
Schistosoma mansoni nuclear hormone receptor 0.002 0.0043 0.0117
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0047 0.0009
Mycobacterium ulcerans hypothetical protein 0.0025 0.0068 0.003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.0045
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0038 0.0108
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0068 0.2694
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0442 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0141 0.0261
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0066 0.0026
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0367 0.1919 0.4808
Entamoeba histolytica Ran family GTPase 0.0025 0.0066 0.2553
Brugia malayi Pax transcription factor protein 2 0.0242 0.1244 0.356
Leishmania major hypothetical protein, conserved 0.0028 0.0083 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0439 0.1198
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0094 0.0442 0.1083
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0043 0.0049
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0161 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0087
Leishmania major trypanothione reductase 0.0272 0.1405 0.3659
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0141 0.039
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0122
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0094 0.0442 0.116
Loa Loa (eye worm) hypothetical protein 0.0235 0.1206 0.3459
Toxoplasma gondii thioredoxin reductase 0.0272 0.1405 0.137
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.0256 0.0218
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0047 0.0053
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0068 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0043 0.0122
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0094 0.0442 0.0404
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0019 0.0032 0.0037
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0132 0.0251
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0122 0.0307
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0025 0.0068 0.003
Plasmodium vivax ferrodoxin reductase, putative 0.0025 0.0068 0.0027
Loa Loa (eye worm) hypothetical protein 0.0102 0.0482 0.1382
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0114 0.0289
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0137 0.0156
Trypanosoma brucei unspecified product 0.002 0.0038 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0043 0.0122
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0141 0.0352
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.004 0.0102
Schistosoma mansoni sodium/solute symporter 0.0038 0.0137 0.0375
Brugia malayi ADAMTS-like protease 0.0014 0.0007 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0095 0.0445 0.1217
Loa Loa (eye worm) doublecortin family protein 0.002 0.004 0.0114
Mycobacterium ulcerans hypothetical protein 0.0036 0.013 0.0092
Schistosoma mansoni hypothetical protein 0.0074 0.0335 0.0916
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0007 0.0017
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0272 0.1405 0.1372
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0161 0.0126
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0069 0.0307 0.0868
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.0021
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0068 0.0075
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.013 0.033
Brugia malayi beta-lactamase family protein 0.0036 0.013 0.0359
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0141 0.016
Brugia malayi Pre-SET motif family protein 0.0656 0.3487 1
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0088 0.0407 0.1156
Trypanosoma brucei NADH dehydrogenase 0.0025 0.0068 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0043 0.0122
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.004 0.0101
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0094 0.0442 0.0377
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0043 0.0049
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0132 0.0092
Echinococcus multilocularis high affinity choline transporter 1 0.0038 0.0137 0.0156
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0083 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0541 0.0514
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0094 0.0442 0.0404
Loa Loa (eye worm) matrixin family protein 0.0244 0.1253 0.3594
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0402
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0426 0.036
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.156 0.1555
Schistosoma mansoni ran 0.0025 0.0066 0.0181
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0075 0.0337 0.0954
Echinococcus multilocularis adam 17 protease 0.0186 0.0938 0.1065
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0235 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0667 0.1822
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0043 0.0107
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0043 0.0096
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.013 0.037
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0095 0.0445 0.0506
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0025 0.0068 0.2694
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0025 0.0068 0.0079
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.026 0.0223
Echinococcus multilocularis muscleblind protein 0.0303 0.1572 0.1785
Onchocerca volvulus Matrilysin homolog 0.0224 0.1144 0.2868
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.0618 0.0702
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0038 0.0087
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0068 0.0075
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.1206 0.3023
Onchocerca volvulus 0.0021 0.0044 0.0098
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0141 0.0384
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0426 0.0389
Loa Loa (eye worm) matrix metalloproteinase 0.0101 0.0479 0.1372
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0321 0.1671 0.1639
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.3659 0.4154
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0083 0.0384 0.1048
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.039 0.2045 0.2015
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0094 0.0442 0.1083
Brugia malayi angiogenesis inhibito 0.0014 0.0007 0.0006
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0069 0.0308 0.0843
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0088 0.0407 0.0462
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0439 0.1257
Echinococcus granulosus endothelin converting enzyme 1 0.0285 0.1476 0.37
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0141 0.0352
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0111 0.0043
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0025 0.0068 0.0169
Leishmania major trypanothione synthetase-like protein 0.0112 0.0541 0.1346
Toxoplasma gondii NADPH-glutathione reductase 0.0094 0.0442 0.0404
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0051
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0303 0.1572 0.4508
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0008
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0106 0.0507 0.0463
Onchocerca volvulus 0.0119 0.0578 0.1444
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0122 0.0226
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0083 0.0043
Plasmodium falciparum ferrodoxin reductase-like protein 0.0025 0.0068 0.0028
Schistosoma mansoni hypothetical protein 0.0074 0.0335 0.0916
Loa Loa (eye worm) glutamate receptor 0.0083 0.0379 0.1086
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0123 0.0598 0.1703
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0106 0.0507 0.1333
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.0256 0.029
Entamoeba histolytica disulphide oxidoreductase, putative 0.0025 0.0068 0.2694
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0442 0.0413
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0106 0.0507 0.048
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0043 0.0122
Brugia malayi Peptidase family M1 containing protein 0.0035 0.0122 0.0338
Echinococcus multilocularis adam 0.0032 0.0107 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0043 0.0109
Brugia malayi Thioredoxin reductase 0.0272 0.1405 0.4021
Mycobacterium tuberculosis Probable oxidoreductase 0.039 0.2045 0.2015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0442 0.0413
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.004 0.0046
Onchocerca volvulus 0.0021 0.0044 0.0098
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0426 0.0387
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0068 0.003
Schistosoma mansoni cpg binding protein 0.0035 0.0124 0.0338
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0038 0.0087
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0094 0.0442 0.0413
Schistosoma mansoni survival motor neuron protein 0.0048 0.0192 0.0525
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.037
Echinococcus granulosus tar DNA binding protein 0.0136 0.0667 0.1671
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0122 0.0307
Mycobacterium ulcerans zinc metalloprotease 0.0285 0.1476 0.1444
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0047 0.0009
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0426 0.0387
Toxoplasma gondii selenide, water dikinase 0.0025 0.0068 0.0028
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.004 0.0006
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0043 0.0109
Brugia malayi PXA domain containing protein 0.0038 0.0141 0.039
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0141 0.039
Onchocerca volvulus 0.002 0.004 0.009
Onchocerca volvulus 0.0143 0.0707 0.1768
Toxoplasma gondii ABC1 family protein 0.0036 0.013 0.009
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0132 0.0149
Echinococcus multilocularis GPCR, family 2 0.0016 0.0018 0.0021
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0359 0.1874 0.5376
Trypanosoma brucei trypanothione synthetase 0.0351 0.1833 0.4849
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0087
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0102 0.0062
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.005
Plasmodium vivax SET domain protein, putative 0.0095 0.0445 0.0407
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0141 0.0384
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0133
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0043 0.0107
Brugia malayi hypothetical protein 0.0038 0.0141 0.039
Loa Loa (eye worm) hypothetical protein 0.0095 0.0445 0.1276
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0068 0.0077
Onchocerca volvulus Matrilysin homolog 0.0101 0.0479 0.1193
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0132 0.0094
Brugia malayi hypothetical protein 0.0038 0.0141 0.039
Brugia malayi Disintegrin family protein 0.0019 0.0032 0.008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0445 0.1217
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0161 0.0126
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0285 0.1476 0.4035
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0066 0.0166
Echinococcus granulosus thioredoxin glutathione reductase 0.0272 0.1408 0.3527
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0789 0.0754
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0114
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.1826 0.9821 1
Echinococcus granulosus lamin 0.0027 0.0079 0.0198
Onchocerca volvulus Cell death protein 3 homolog 0.003 0.0094 0.0226
Schistosoma mansoni loxhd1 0.002 0.004 0.011
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0087
Schistosoma mansoni hypothetical protein 0.0021 0.0044 0.0119
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0038 0.0087
Brugia malayi Pre-SET motif family protein 0.0095 0.0445 0.1266
Schistosoma mansoni hypothetical protein 0.0359 0.1874 0.5122
Leishmania major GTP-binding protein, putative 0.0025 0.0066 0.0075
Onchocerca volvulus 0.0027 0.0079 0.0187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0439 0.0498
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0132 0.0238
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0112 0.0541 0.1346
Loa Loa (eye worm) reprolysin 0.0019 0.0032 0.0092
Schistosoma mansoni hypothetical protein 0.0476 0.2513 0.6868
Schistosoma mansoni disulfide oxidoreductase 0.0025 0.0068 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0141 0.0261
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0402
Echinococcus multilocularis lamin dm0 0.0027 0.0079 0.009
Schistosoma mansoni hypothetical protein 0.002 0.004 0.011
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0122
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0122
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0132 0.0238
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0122 0.0307
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.026 0.0223
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0144 0.0711 0.1944
Echinococcus granulosus microtubule associated protein 2 0.0688 0.3659 0.9169
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0141 0.0352
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0066 0.0029
Mycobacterium ulcerans leucyl aminopeptidase 0.0106 0.0507 0.0471
Loa Loa (eye worm) hypothetical protein 0.0038 0.0137 0.0393
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0141 0.016
Echinococcus granulosus caspase 2 0.003 0.0094 0.0237
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0025 0.0068 0.2694
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0038 0.0043
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0141 0.0352
Echinococcus multilocularis muscleblind protein 1 0.0303 0.1572 0.1785
Loa Loa (eye worm) hypothetical protein 0.0285 0.1476 0.4234
Echinococcus granulosus RUN 0.002 0.004 0.0101
Onchocerca volvulus 0.0101 0.0479 0.1193
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0025 0.0068 0.0077
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.0108
Trichomonas vaginalis glutathione reductase, putative 0.0094 0.0442 0.1027
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0113 0.0324
Schistosoma mansoni rab6-interacting 0.002 0.004 0.011
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0069 0.0307 0.0348
Trypanosoma brucei trypanothione reductase 0.0272 0.1405 0.3714
Mycobacterium ulcerans ferredoxin reductase 0.0025 0.0068 0.003
Leishmania major trypanothione synthetase, putative 0.0351 0.1833 0.4804
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.004 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.027
Trypanosoma brucei cysteine peptidase, Clan CA, family C51, putative 0.0112 0.0541 0.1422
Loa Loa (eye worm) TAR-binding protein 0.0136 0.0667 0.1911
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0137 0.0344
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0141 0.0384
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0083 0.0208
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0025 0.0068 0.0075
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0141 0.0261
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.013 0.0359
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.0256 0.0218
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0068 0.0027
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0046 0.0116
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0031 0.0102 0.0035
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0025 0.0068 0.0169
Onchocerca volvulus 0.0035 0.0122 0.0296
Mycobacterium ulcerans NADH dehydrogenase 0.0025 0.0068 0.003
Leishmania major NADH dehydrogenase, putative 0.0025 0.0068 0.0079
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0068 0.0166
Mycobacterium tuberculosis Conserved protein 0.0036 0.013 0.0092
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0035 0.0122 0.0086
Leishmania major importin beta-1 subunit, putative 0.0027 0.008 0.0112
Schistosoma mansoni metabotropic glutamate receptor 0.004 0.015 0.041
Entamoeba histolytica hypothetical protein 0.0038 0.0141 0.9322
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0043 0.0109
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0141 0.0384
Echinococcus granulosus cpg binding protein 0.0035 0.0124 0.031
Echinococcus granulosus solute carrier family 5 0.0148 0.0736 0.1845
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0066 0.0695
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0068 0.0166
Schistosoma mansoni ap endonuclease 0.0021 0.0046 0.0126
Plasmodium vivax hypothetical protein, conserved 0.0036 0.013 0.009
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.005
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.013 0.0092
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0043 0.0107
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0006 0.0004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0148 0.0168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0439 0.1198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0439 0.0498
Brugia malayi Bloom's syndrome protein homolog 0.002 0.004 0.0102
Mycobacterium tuberculosis Conserved protein 0.0036 0.013 0.0092
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0112 0.0541 0.0514
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.013 0.0092
Loa Loa (eye worm) hypothetical protein 0.009 0.0419 0.12
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0141 0.0402
Trypanosoma cruzi trypanothione synthetase 0.0351 0.1833 0.1835
Schistosoma mansoni lamin 0.0027 0.0079 0.0216
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0122 0.0139
Leishmania major hypothetical protein, conserved 0.0025 0.0068 0.0079
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0021 0.0047 0.0133
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0094 0.0442 0.0404
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0046 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0083 0.0046
Trichomonas vaginalis ran, putative 0.0025 0.0066 0.0071
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0094 0.0442 0.116
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0025 0.0068 0.003
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0043 0.0109
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0019 0.0032 0.0089
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0118 0.0325
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.013 0.0232
Giardia lamblia Thioredoxin reductase 0.0025 0.0068 0.0733
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0043 0.0049
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0011 0.0018
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0137 0.0098
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0066 0.0162
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0106 0.0507 0.1257
Echinococcus multilocularis RUN 0.002 0.004 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0122
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0321 0.1671 0.1639
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0018 0.0039
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.0141 0.016
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0046 0.0021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0656 0.3487 1
Loa Loa (eye worm) hypothetical protein 0.0211 0.1073 0.3078
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0667 0.1822
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0068 0.0075
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0709 0.3774 0.3819
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0402
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0132 0.0086
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0141 0.016
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0204 0.0572
Loa Loa (eye worm) beta-lactamase 0.0036 0.013 0.037
Toxoplasma gondii leucyl aminopeptidase LAP 0.0106 0.0507 0.0469
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0043 0.0107
Leishmania major mitochondrial DNA polymerase beta 0.03 0.156 0.4073
Schistosoma mansoni importin beta-1 0.0034 0.0114 0.0312
Onchocerca volvulus 0.0036 0.013 0.0314
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0083 0.0046
Mycobacterium ulcerans lipase LipD 0.0036 0.013 0.0092
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0007 0.0008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0043 0.0107
Mycobacterium ulcerans hydrolase 0.0123 0.0598 0.0562
Echinococcus multilocularis aminopeptidase N 0.0119 0.0578 0.0657
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0106 0.0507 0.0469
Echinococcus granulosus sodium:glucose cotransporter 2 0.0148 0.0736 0.1845
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0025 0.0068 0.0733
Trypanosoma brucei Polypeptide deformylase 1 0.0709 0.3774 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0043 0.0109
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0141 0.039
Brugia malayi Muscle positioning protein 4 0.0021 0.0044 0.0112
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0141 0.0402
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0094 0.0442 0.0406
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0439 0.1246
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0094 0.0442 0.1083
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0122 0.0139
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0426 0.036
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0141 0.016
Brugia malayi Matrixin family protein 0.0101 0.0479 0.1361
Onchocerca volvulus 0.0027 0.0079 0.0187
Brugia malayi Doublecortin family protein 0.002 0.004 0.0102
Trypanosoma brucei glutathionylspermidine synthetase, putative 0.0112 0.0541 0.1422
Echinococcus multilocularis geminin 0.0342 0.1787 0.2029
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0043 0.0107
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0043 0.0049
Schistosoma mansoni hypothetical protein 0.004 0.0148 0.0405
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0068 0.003
Onchocerca volvulus 0.0036 0.013 0.0314
Echinococcus granulosus disintegrin and metalloproteinase 0.0019 0.0032 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0114
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.0667 0.1911
Onchocerca volvulus 0.0021 0.0044 0.0098
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0068 0.003
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0122 0.0139
Brugia malayi RNA, U transporter 1 0.0096 0.045 0.1278
Mycobacterium ulcerans monoxygenase 0.0025 0.0068 0.003
Brugia malayi Inositol-1 0.0037 0.0132 0.0365
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0402
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.005
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.013 0.0092
Trypanosoma cruzi trypanothione synthetase-like protein, putative 0.0112 0.0541 0.0514
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0043 0.0117
Schistosoma mansoni thyroid hormone receptor 0.0147 0.0729 0.1992
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0094 0.0442 0.0404
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0091 0.0426 0.0387
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1639 0.8809 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0046 0.0008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0018 0.0051
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0094 0.0442 0.0404
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.013 0.0092
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0112 0.0541 0.0514
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0011 0.003
Schistosoma mansoni rab6-interacting 0.002 0.004 0.011
Schistosoma mansoni lamin 0.0027 0.0079 0.0216
Onchocerca volvulus 0.0095 0.0445 0.1109
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0047 0.0053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0018
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0068 0.0075
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0038 0.0096
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0144 0.0711 0.1944
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0043 0.0122
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0132 0.0336
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0068 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0043 0.0109
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0046 0.0022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0043 0.0122
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0025 0.0068 0.003
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0112 0.0541 0.0514
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0141 0.0261
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.0055 0.0152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0439 0.1099
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0132 0.0096
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0321 0.1671 0.1639
Echinococcus granulosus histone lysine methyltransferase setb 0.0095 0.0445 0.1116
Onchocerca volvulus 0.003 0.0094 0.0226
Mycobacterium ulcerans dehydrogenase 0.0025 0.0068 0.003
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0025 0.0068 0.0077
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0114
Schistosoma mansoni hypothetical protein 0.003 0.0094 0.0258
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0442 0.0413
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.1206 0.137
Onchocerca volvulus 0.0021 0.0044 0.0098
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0038 0.0096
Echinococcus granulosus sodium:glucose cotransporter 0.0148 0.0736 0.1845
Trichomonas vaginalis esterase, putative 0.0036 0.013 0.0232
Echinococcus multilocularis bloom syndrome protein 0.002 0.004 0.0046
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0025 0.0068 0.0027
Echinococcus granulosus lamin dm0 0.0027 0.0079 0.0198
Brugia malayi peptidase family M13 containing protein 0.0069 0.0308 0.0872
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0043 0.0117
Loa Loa (eye worm) programmed cell death 8 0.0025 0.0068 0.0193
Onchocerca volvulus Matrix metalloproteinase homolog 0.0224 0.1144 0.2868
Onchocerca volvulus 0.0747 0.3977 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0046 0.0204
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0068 0.0075
Echinococcus granulosus expressed protein 0.0749 0.3991 1
Schistosoma mansoni hypothetical protein 0.0342 0.1787 0.4884
Schistosoma mansoni hypothetical protein 0.0034 0.0118 0.0322
Loa Loa (eye worm) hypothetical protein 0.0211 0.1073 0.3078
Treponema pallidum oxidoreductase 0.0025 0.0068 0.0021
Entamoeba histolytica hypothetical protein 0.0038 0.0141 0.9322
Schistosoma mansoni dihydroceramide desaturase 0.0019 0.0032 0.0089
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0442 0.0413
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0137 0.0381
Schistosoma mansoni glutamate synthase 0.0025 0.0068 0.0185
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0066 0.0075
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0019 0.0032 0.0081
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0068 0.0166
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0038 0.0087
Echinococcus multilocularis solute carrier family 5 0.0148 0.0736 0.0836
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0046 0.0008
Brugia malayi hypothetical protein 0.002 0.004 0.0102
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0141 0.0352
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0094 0.0442 0.0406
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0043 0.0049
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0025 0.0068 0.0021
Schistosoma mansoni inositol monophosphatase 0.0037 0.0132 0.036
Brugia malayi ecdysteroid receptor 0.002 0.0043 0.0109
Echinococcus granulosus peptidase Clp S14 family 0.006 0.0256 0.064
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0667 0.1822
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0124
Echinococcus granulosus bloom syndrome protein 0.002 0.004 0.0101
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0021 0.0047 0.0121
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0122 0.0139
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0025 0.0068 0.003
Leishmania major hypothetical protein, conserved 0.0025 0.0068 0.0079
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0068 0.003
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0031 0.0102 0.0056
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.039 0.2045 0.1991
Schistosoma mansoni high-affinity choline transporter 0.0038 0.0137 0.0375
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.3659 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0043 0.0109
Onchocerca volvulus 0.0021 0.0044 0.0098
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0018 0.0039
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0132 0.0238
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0114 0.0289
Schistosoma mansoni ran 0.0025 0.0066 0.0181
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0132 0.0096
Plasmodium falciparum importin beta, putative 0.0034 0.0114 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0043 0.0109
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0294 0.0255
Brugia malayi RNA binding protein 0.0136 0.0667 0.1901
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0043 0.0096
Entamoeba histolytica hypothetical protein 0.004 0.0148 1
Echinococcus multilocularis dna polymerase eta 0.002 0.0038 0.0043
Toxoplasma gondii hypothetical protein 0.0048 0.0195 0.0155
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0043 0.0117
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0068 0.0169
Giardia lamblia NADH oxidase lateral transfer candidate 0.0094 0.0442 1
Schistosoma mansoni hypothetical protein 0.0074 0.0335 0.0916
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0035 0.0122 0.0334
Brugia malayi hypothetical protein 0.0032 0.0107 0.0294
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0123 0.0598 0.0562
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0068 0.0075
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.004 0.0046
Schistosoma mansoni hypothetical protein 0.0342 0.1787 0.4884
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0047 0.0024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0402
Brugia malayi intermediate filament protein 0.0027 0.0079 0.0214
Loa Loa (eye worm) glutathione reductase 0.0272 0.1405 0.4028
Loa Loa (eye worm) pax transcription factor protein 2 0.0242 0.1244 0.3567
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0088 0.0407 0.1113
Leishmania major D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative 0.0112 0.0541 0.1346
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0043 0.0109
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0335 0.0916
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0204 0.0584
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0025 0.0068 0.003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0141 0.0402
Brugia malayi SEA domain containing protein 0.0021 0.0044 0.0112
Echinococcus multilocularis musashi 0.0027 0.0079 0.009
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.037
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0367 0.1919 0.2178
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.026 0.0711
Schistosoma mansoni cpg binding protein 0.0033 0.0113 0.031
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0032 0.0107 0.0293
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.013 0.0232
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0043 0.0049
Plasmodium falciparum glutathione reductase 0.0272 0.1405 0.137
Echinococcus multilocularis dna polymerase kappa 0.002 0.0038 0.0043
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0042 0.0157 0.043
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0235 0.0588
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.004 0.0101
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.013 0.0232
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0066 0.0026
Loa Loa (eye worm) hypothetical protein 0.0034 0.0118 0.0337
Schistosoma mansoni glutamate synthase 0.0025 0.0068 0.0185
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0079 0.0226
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.026 0.0595
Loa Loa (eye worm) hypothetical protein 0.0107 0.0511 0.1466
Treponema pallidum NADH oxidase 0.0094 0.0442 0.0398
Echinococcus granulosus geminin 0.0342 0.1787 0.4478
Mycobacterium leprae probable zinc metalloprotease 0.0285 0.1476 0.1418
Onchocerca volvulus 0.0025 0.0068 0.0158
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0069 0.0308 0.0843
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.004 0.0006
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.0426 0.1163
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0117 0.0564 0.064
Trypanosoma cruzi aminopeptidase, putative 0.0035 0.0122 0.0086
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0069 0.0308 0.0843
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0193
Echinococcus multilocularis tar DNA binding protein 0.0136 0.0667 0.0757
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0091 0.0426 0.0381
Brugia malayi hypothetical protein 0.004 0.0148 0.0412
Schistosoma mansoni intermediate filament proteins 0.0027 0.0079 0.0216
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0021 0.0047 0.0133
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.013 0.0354
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0122 0.0311
Loa Loa (eye worm) peptidase family M13 containing protein 0.0211 0.1073 0.3078
Echinococcus granulosus metabotropic glutamate receptor 5 0.0102 0.0482 0.1209
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.004 0.0101
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0068 0.0075
Trypanosoma brucei aminopeptidase, putative 0.0021 0.0047 0.0111
Onchocerca volvulus 0.002 0.0043 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0087
Entamoeba histolytica thioredoxin reductase, putative 0.0025 0.0068 0.2694
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0094 0.0237
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0111 0.0073
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0047 0.0111
Mycobacterium leprae PROBABLE HYDROLASE 0.0123 0.0598 0.0534
Echinococcus multilocularis dnaJ subfamily B 0.0476 0.2513 0.2853
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0122 0.0214
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0141 0.0384
Plasmodium vivax importin-beta 2, putative 0.0034 0.0114 0.0074
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.0141 0.0352
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0117 0.0564 0.1412
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0021 0.0047 0.0133
Schistosoma mansoni lipoxygenase 0.0056 0.0235 0.0642
Trichomonas vaginalis set domain proteins, putative 0.0747 0.3977 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0087
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0025 0.0068 0.0028
Trypanosoma cruzi trypanothione synthetase, putative 0.0112 0.0541 0.0514
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0141 0.039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.008 0.0106
Loa Loa (eye worm) hypothetical protein 0.0123 0.06 0.1721
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0025 0.0068 0.003
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0068 0.0028
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0043 0.0049
Leishmania major hypothetical protein, conserved 0.0112 0.0541 0.1346
Brugia malayi hypothetical protein 0.0235 0.1206 0.3451
Loa Loa (eye worm) hypothetical protein 0.005 0.0204 0.0584
Loa Loa (eye worm) hypothetical protein 0.0216 0.11 0.3155
Echinococcus granulosus FTZ F1 alpha 0.002 0.0043 0.0107
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0321 0.1671 0.1639
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.008 0.0106
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0043 0.0117
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0019 0.0032 0.0089
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0068 0.0185
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0122
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0192 0.0538
Onchocerca volvulus 0.0038 0.0137 0.0334
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0069 0.0307 0.0868
Plasmodium falciparum thioredoxin reductase 0.0272 0.1405 0.137
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0141 0.0352
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0094 0.0442 0.1209
Echinococcus granulosus high affinity choline transporter 1 0.0038 0.0137 0.0344
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0021 0.0047 0.0133
Trichomonas vaginalis mercuric reductase, putative 0.0094 0.0442 0.1027
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0025 0.0068 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0148 0.0371
Plasmodium vivax thioredoxin reductase, putative 0.0272 0.1405 0.137
Echinococcus granulosus metabotropic glutamate receptor 2 0.0069 0.0307 0.0768
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0025 0.0068 0.0028
Brugia malayi GH02984p 0.0038 0.0137 0.0381
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.0045
Echinococcus granulosus GPCR family 3 C terminal 0.0013 0.0005 0.0012
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0091 0.0426 0.0387
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0043 0.0117
Echinococcus granulosus adam 17 protease 0.0204 0.1039 0.2603
Loa Loa (eye worm) hypothetical protein 0.0211 0.1073 0.3078
Schistosoma mansoni hypothetical protein 0.0013 0.0005 0.0013
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0141 0.016
Loa Loa (eye worm) hypothetical protein 0.003 0.0094 0.027
Loa Loa (eye worm) hypothetical protein 0.0084 0.0388 0.1112
Loa Loa (eye worm) hypothetical protein 0.0216 0.11 0.3155
Trypanosoma cruzi trypanothione reductase, putative 0.0272 0.1405 0.1397
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0094 0.0442 0.1109
Mycobacterium leprae Probable lipase LipE 0.0036 0.013 0.0062
Loa Loa (eye worm) aminopeptidase N 0.0035 0.0122 0.035
Trypanosoma cruzi Peptide deformylase 2, putative 0.0709 0.3774 0.3819
Echinococcus multilocularis endothelin converting enzyme 1 0.0285 0.1476 0.1676
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0074 0.0335 0.0916
Trypanosoma brucei Peptide deformylase 2 0.0709 0.3774 1
Brugia malayi metabotropic glutamate receptor type 2 0.004 0.015 0.0417
Brugia malayi Importin beta-1 subunit 0.0034 0.0114 0.0314
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0141 0.0384
Brugia malayi Cell death protein 3 precursor 0.003 0.0094 0.0258
Schistosoma mansoni DNA helicase recq1 0.002 0.004 0.011
Schistosoma mansoni lipoxygenase 0.002 0.004 0.011
Echinococcus multilocularis expressed protein 0.0749 0.3991 0.453
Loa Loa (eye worm) DOMON domain-containing protein 0.0021 0.0044 0.0124
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0025 0.0068 0.003
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.004 0.0114
Brugia malayi Matrixin family protein 0.0101 0.0479 0.1361
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0003 0.0004
Brugia malayi Matrixin family protein 0.0101 0.0479 0.1361
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.1193 0.116
Entamoeba histolytica aminopeptidase, putative 0.0035 0.0122 0.7667
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.004 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0087
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0141 0.0384
Schistosoma mansoni thyroid hormone receptor 0.0147 0.0729 0.1992
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0094 0.0442 0.1083
Toxoplasma gondii exonuclease III APE 0.0021 0.0046 0.0006
Brugia malayi beta-lactamase 0.0036 0.013 0.0359
Onchocerca volvulus 0.0141 0.0697 0.1743
Schistosoma mansoni hypothetical protein 0.0074 0.0335 0.0916
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0046 0.0021
Schistosoma mansoni hypothetical protein 0.0024 0.006 0.0165
Schistosoma mansoni inositol transporter 0.0148 0.0736 0.2012
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0141 0.0352
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0066 0.0188
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0025 0.0068 0.003
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0141 0.0384
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0025 0.0068 0.0028
Schistosoma mansoni DNA polymerase eta 0.002 0.0038 0.0104
Onchocerca volvulus 0.0242 0.1244 0.312
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0038 0.0104
Loa Loa (eye worm) matrixin family protein 0.0224 0.1144 0.3281
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0087
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.0729 0.0828
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0141 0.0384
Trypanosoma cruzi trypanothione synthetase 0.0351 0.1833 0.1835
Loa Loa (eye worm) hypothetical protein 0.0123 0.0598 0.1713
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0132 0.851
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0025 0.0068 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0141 0.0261
Brugia malayi hypothetical protein 0.003 0.0094 0.0258
Echinococcus granulosus sodium:myo inositol cotransporter 0.0148 0.0736 0.1845
Echinococcus multilocularis disintegrin and metalloproteinase 0.0019 0.0032 0.0037
Brugia malayi TAR-binding protein 0.0136 0.0667 0.1901
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0079 0.0226
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.004 0.0102
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0046 0.0052
Onchocerca volvulus 0.0033 0.0113 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0439 0.1198
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0068 0.0077
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.013 0.0092
Treponema pallidum thioredoxin reductase (trxB) 0.0025 0.0068 0.0021
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0035 0.0122 0.0139
Schistosoma mansoni hypothetical protein 0.0074 0.0335 0.0916
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0068 0.0181
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.0141 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0087
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.004 0.0006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.004 0.0000000000494
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0114 0.0074
Echinococcus granulosus intermediate filament protein 0.0027 0.0079 0.0198
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0094 0.0442 0.116
Schistosoma mansoni endothelin-converting enzyme-related 0.0069 0.0308 0.0843
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0043 0.0109
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0094 0.0442 0.0398
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0112 0.0541 0.0514
Leishmania major polypeptide deformylase-like protein, putative 0.0709 0.3774 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.026 0.0295
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0102 0.0482 0.0548
Trypanosoma brucei amidase, putative 0.0112 0.0541 0.1422
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0087 0.0401 0.1097
Brugia malayi hypothetical protein 0.0018 0.003 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0087
Schistosoma mansoni neprilysin-2 (M13 family) 0.0144 0.0711 0.1944
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0035 0.0122 0.0311
Toxoplasma gondii peptidase family M13 protein 0.0285 0.1476 0.1442
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0025 0.0068 0.2694
Brugia malayi Matrixin family protein 0.0244 0.1253 0.3586
Brugia malayi hypothetical protein 0.002 0.004 0.0102
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0094 0.0442 0.1257
Entamoeba histolytica hypothetical protein 0.0038 0.0141 0.9322
Onchocerca volvulus 0.0036 0.013 0.0314
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0066 0.0176
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0141 0.0384
Mycobacterium tuberculosis Conserved protein 0.0036 0.013 0.0092
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0025 0.0068 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0141 0.0261
Brugia malayi nuclear hormone receptor 0.002 0.0043 0.0109
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0068 0.0185
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0025 0.0068 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0043 0.0122
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0043 0.0107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0124
Brugia malayi Receptor family ligand binding region containing protein 0.0021 0.0047 0.0121
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.0426 0.0381
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0442 0.0413
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0442 0.0413
Trichomonas vaginalis apoptosis inducing factor, putative 0.0025 0.0068 0.0075
Loa Loa (eye worm) RecQ helicase 0.002 0.004 0.0114
Chlamydia trachomatis cytosol aminopeptidase 0.0106 0.0507 0.0443
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0068 0.003
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.004 0.0093
Schistosoma mansoni metabotropic glutamate receptor 0.0069 0.0307 0.0838
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0106 0.0507 0.048
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.1372
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.026 0.0223
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0043 0.0117
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0321 0.1671 0.1614
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.0141 0.0402
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.013 0.0092
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0047 0.0117
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.1372
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.013 0.0092
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0094 0.044 0.1203
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0025 0.0068 0.0193
Schistosoma mansoni hypothetical protein 0.0074 0.0335 0.0916
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0083 0.0043
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0141 0.039
Loa Loa (eye worm) hypothetical protein 0.0135 0.0666 0.1908
Brugia malayi Probable ClpP-like protease 0.0091 0.0426 0.1209
Schistosoma mansoni caspase-7 (C14 family) 0.003 0.0094 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0445 0.1217
Echinococcus multilocularis glutamate synthase 0.0025 0.0068 0.0077
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0068 0.0075
Loa Loa (eye worm) RNA binding protein 0.0136 0.0667 0.1911
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.037
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0047 0.0024
Loa Loa (eye worm) hypothetical protein 0.0303 0.1572 0.4508
Echinococcus granulosus importin subunit beta 1 0.0034 0.0114 0.0286
Mycobacterium ulcerans hypothetical protein 0.0158 0.0789 0.0754
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0043 0.0109
Mycobacterium ulcerans aminopeptidase N PepN 0.0035 0.0122 0.0085
Schistosoma mansoni hypothetical protein 0.0025 0.0068 0.0185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0439 0.1099
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0046 0.0006
Entamoeba histolytica hypothetical protein 0.004 0.0148 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0046 0.0751
Schistosoma mansoni cpg binding protein 0.0035 0.0124 0.0338
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0158
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0043 0.0117
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0007 0.0019
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0066 0.0026
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.013 0.0092
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.005
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0068 0.0166
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0132 0.033
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0068 0.2694
Schistosoma mansoni glutamate synthase 0.0025 0.0068 0.0185
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0047 0.0117
Trypanosoma cruzi Aminopeptidase M1, putative 0.0035 0.0122 0.0086
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0025 0.0068 0.0169
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.013 0.0354
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0068 0.0075
Entamoeba histolytica hypothetical protein 0.004 0.0148 1
Echinococcus multilocularis lamin 0.0027 0.0079 0.009
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0063 0.0169
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.013 0.0092
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.0426 0.036
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.039 0.2045 0.2015
Schistosoma mansoni neprilysin 0.0074 0.0335 0.0916
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0068 0.0181
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0144 0.0711 0.1944
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0141 0.0384
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0445 0.1217
Toxoplasma gondii hypothetical protein 0.0031 0.0102 0.0062
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0141 0.0384
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0043 0.0096
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0091 0.0426 0.0389
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.026 0.0711
Leishmania major trypanothione synthetase, putative 0.0112 0.0541 0.1346
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0094 0.0442 0.0406
Loa Loa (eye worm) hypothetical protein 0.0091 0.0426 0.122
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0043 0.0109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0158
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0068 0.0079
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.0445 0.0407
Loa Loa (eye worm) hypothetical protein 0.0141 0.0697 0.1999
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0141 0.016
Loa Loa (eye worm) hypothetical protein 0.0285 0.1476 0.4234
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.026 0.0223
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.156 0.4125
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0068 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0043 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0068 0.003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0046 0.0131
Leishmania major hypothetical protein, conserved 0.0025 0.0068 0.0079
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0702 0.1779
Plasmodium falciparum thioredoxin reductase 0.0094 0.0442 0.0404
Schistosoma mansoni inositol monophosphatase 0.0037 0.0132 0.036
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0079 0.0214
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.013 0.0147
Echinococcus multilocularis leucine aminopeptidase protein 0.0106 0.0507 0.0576
Echinococcus granulosus dna polymerase eta 0.002 0.0038 0.0095
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0068 0.003
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0025 0.0068 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0038 0.0087
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0043 0.0117
Onchocerca volvulus 0.0048 0.0192 0.0472
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.013 0.0094
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0021 0.0047 0.0121
Plasmodium falciparum M17 leucyl aminopeptidase 0.0106 0.0507 0.0469
Echinococcus granulosus leucine aminopeptidase protein 0.0106 0.0507 0.1271
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.0141 0.039
Trypanosoma cruzi cysteine peptidase, Clan CA, family C51, putative 0.0112 0.0541 0.0514
Schistosoma mansoni DNA helicase recq5 0.002 0.004 0.011
Brugia malayi Peptidase family M1 containing protein 0.0119 0.0578 0.1647
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0122
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0148 0.0736 0.0836
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0046 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0043 0.0049
Entamoeba histolytica recQ family helicase, putative 0.002 0.004 0.0203
Mycobacterium tuberculosis Probable dehydrogenase 0.0321 0.1671 0.1639
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.013 0.0094
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0068 0.0075
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0047 0.0111
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.0426 0.0483
Schistosoma mansoni polycystin 1-related 0.002 0.004 0.011
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.004 0.0046
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.004 0.0046
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.026 0.0652
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0423 0.1059
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0094 0.0107
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.013 0.0232
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0141 0.0384
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0106 0.0507 0.0471
Brugia malayi glutamate synthase 0.0025 0.0068 0.0181
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0025 0.0068 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0141 0.0261
Mycobacterium ulcerans glutamate synthase subunit beta 0.0025 0.0068 0.003
Echinococcus multilocularis caspase 2 0.003 0.0094 0.0107
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0122 0.0139
Echinococcus granulosus muscleblind protein 0.0303 0.1572 0.3939
Brugia malayi steroid hormone receptor 0.002 0.0043 0.0109
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0702 0.185
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0141 0.0402
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0122
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0141 0.0352
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0141 0.0384
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.0667 0.1901
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0038 0.0104
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.013 0.0232
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0031 0.0102 0.0062
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0025 0.0068 0.0075
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.0226
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0008 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0043 0.0109
Giardia lamblia Glutamate synthase 0.0025 0.0068 0.0733
Echinococcus multilocularis GPCR, family 3, C terminal 0.0013 0.0005 0.0005
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0068 0.003
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.004 0.0006
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0025 0.0068 0.0021
Brugia malayi hypothetical protein 0.0028 0.0083 0.0226
Schistosoma mansoni leucine aminopeptidase 0.0021 0.0047 0.0128
Mycobacterium leprae conserved hypothetical protein 0.0036 0.013 0.0062
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.0618 0.155
Echinococcus multilocularis cpg binding protein 0.0035 0.0124 0.014
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0285 0.1476 0.4227
Loa Loa (eye worm) hypothetical protein 0.0034 0.0114 0.0326
Loa Loa (eye worm) inositol-1 0.0037 0.0132 0.0376
Schistosoma mansoni hypothetical protein 0.0143 0.0707 0.1932
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0144 0.0711 0.1944
Schistosoma mansoni hypothetical protein 0.0127 0.0618 0.169
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0122
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0094 0.0442 0.0502
Schistosoma mansoni ap endonuclease 0.0021 0.0046 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0043 0.0122
Echinococcus granulosus snurportin 1 0.0359 0.1874 0.4697
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0025 0.0068 0.003
Echinococcus granulosus aminopeptidase N 0.0119 0.0578 0.1449
Brugia malayi CXXC zinc finger family protein 0.0033 0.0113 0.0312
Trypanosoma cruzi trypanothione synthetase, putative 0.0112 0.0541 0.0514
Trypanosoma cruzi Peptide deformylase 2, putative 0.0709 0.3774 0.3819
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0025 0.0068 0.0021
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.004 0.0101
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0047 0.0024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0702 0.0679
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0003 0.0008
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.008 0.0043
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0025 0.0068 0.0181
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0043 0.0117
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0021 0.0047 0.0117
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0083 0.0043
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0238
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0066 0.0029
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0025 0.0068 0.0028
Brugia malayi cytosol aminopeptidase 0.0021 0.0047 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0667 0.1822
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0141 0.016
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0667 0.1822
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0018
Trypanosoma brucei trypanothione synthetase, putative 0.0351 0.1833 0.4849
Loa Loa (eye worm) hypothetical protein 0.0285 0.1476 0.4234
Onchocerca volvulus 0.002 0.004 0.009
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0122 0.0226
Echinococcus granulosus glutamate synthase 0.0025 0.0068 0.0169
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.026 0.0221
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0038 0.0095
Brugia malayi beta-lactamase family protein 0.0036 0.013 0.0359
Leishmania major hypothetical protein, conserved 0.0036 0.013 0.0245
Echinococcus granulosus dna polymerase kappa 0.002 0.0038 0.0095
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0122 0.0307
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.0256 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0043 0.0109
Loa Loa (eye worm) peptidase family M13 containing protein 0.0211 0.1073 0.3078
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0122 0.0214
Loa Loa (eye worm) hypothetical protein 0.0216 0.11 0.3155
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0122 0.0311
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0216 0.11 0.3155
Loa Loa (eye worm) thioredoxin reductase 0.0272 0.1405 0.4028
Brugia malayi Peptidase family M13 containing protein 0.0285 0.1476 0.4227
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0069 0.0308 0.0843
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0106 0.0507 0.0443
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0161 0.0414
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0047 0.0053
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0141 0.016
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.0445 0.0506
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0046 0.0119
Brugia malayi glutathione reductase 0.0272 0.1405 0.4021
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0094 0.0442 0.0413
Brugia malayi Muscleblind-like protein 0.0303 0.1572 0.4502
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0285 0.1476 0.1444
Echinococcus multilocularis snurportin 1 0.0359 0.1874 0.2128
Loa Loa (eye worm) hypothetical protein 0.0038 0.0137 0.0393
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0046 0.0008
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0023 0.0055 0.0018
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0709 0.3774 0.3819
Trypanosoma brucei CHAP domain containing protein, putative 0.0112 0.0541 0.1422
Loa Loa (eye worm) hypothetical protein 0.0211 0.1073 0.3078
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.0055 0.0063
Brugia malayi Hemopexin family protein 0.0143 0.0707 0.2017
Loa Loa (eye worm) hypothetical protein 0.039 0.2047 0.5869
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.004 0.0055
Plasmodium falciparum LCCL domain-containing protein 0.002 0.004 0.0000057584
Echinococcus granulosus adam 0.0032 0.0107 0.0268
Mycobacterium ulcerans beta-lactamase 0.0036 0.013 0.0092
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0211 0.0177
Brugia malayi hypothetical protein 0.0035 0.0122 0.0338
Loa Loa (eye worm) glutamate receptor 0.0032 0.0108 0.0308
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0148 0.0405
Plasmodium falciparum glutathione reductase 0.0094 0.0442 0.0404
Brugia malayi nuclear receptor NHR-88 0.002 0.0043 0.0109
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0046 0.0109
Schistosoma mansoni hypothetical protein 0.0048 0.0192 0.0525
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0088 0.0407 0.1021
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0094 0.0442 0.116
Loa Loa (eye worm) hypothetical protein 0.0216 0.11 0.3155
Schistosoma mansoni coup transcription factor 0.002 0.0043 0.0117
Plasmodium vivax glutathione reductase, putative 0.0272 0.1405 0.137
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.0426 0.1066
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.1372
Loa Loa (eye worm) hypothetical protein 0.0036 0.013 0.037
Trichomonas vaginalis importin beta-1, putative 0.0027 0.008 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.156 0.1555
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0141 0.016
Loa Loa (eye worm) zinc metallopeptidase 4 0.0069 0.0308 0.0883
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.0218
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0186 0.0938 0.2564
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0114 0.013
Mycobacterium tuberculosis Probable reductase 0.0321 0.1671 0.1639
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.013 0.0325
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0148 0.0736 0.0836
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0025 0.0068 0.0077
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0132 0.0648 0.0736
Schistosoma mansoni inositol transporter 0.0148 0.0736 0.2012
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0204 0.0572
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0094 0.0442 0.0406
Entamoeba histolytica hypothetical protein 0.004 0.0148 1
Echinococcus granulosus dnaJ subfamily B 0.0476 0.2513 0.6297
Brugia malayi PXA domain containing protein 0.0038 0.0141 0.039
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0021 0.0047 0.0128
Entamoeba histolytica hypothetical protein 0.0027 0.008 0.3791
Loa Loa (eye worm) hypothetical protein 0.0216 0.11 0.3155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.0021
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0068 0.003
Brugia malayi Matrixin family protein 0.0101 0.0479 0.1361
Brugia malayi Metabotropic glutamate receptor precursor. 0.0083 0.0379 0.1075
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0043 0.0107
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0069 0.0308 0.0843
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0025 0.0068 0.003
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0101 0.0479 0.1308

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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