Detailed information for compound 1188884

Basic information

Technical information
  • TDR Targets ID: 1188884
  • Name: N-[2-(trifluoromethyl)phenyl]acetamide
  • MW: 203.161 | Formula: C9H8F3NO
  • H donors: 1 H acceptors: 1 LogP: 1.98 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccccc1C(F)(F)F
  • InChi: 1S/C9H8F3NO/c1-6(14)13-8-5-3-2-4-7(8)9(10,11)12/h2-5H,1H3,(H,13,14)
  • InChiKey: OXDTZGRSCDEKGO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(trifluoromethyl)phenyl]ethanamide
  • 344-62-7
  • ST5407000
  • ZINC00126903
  • .alpha.,.alpha.,.alpha.-Trifluoro-o-acetotoluidide
  • NCIOpen2_005228
  • Acetamide, N-[2-(trifluoromethyl)phenyl]-
  • NSC88329
  • WLN: FXFFVMR B1
  • o-Acetotoluidide, .alpha.,.alpha.,.alpha.-trifluoro-
  • 2'-(Trifluoromethyl)acetanilide
  • 3-12-00-01909 (Beilstein Handbook Reference)
  • Acetamide, N-(2-(trifluoromethyl)phenyl)- (9CI)
  • Acetanilide, 2-trifluoromethyl-
  • BRN 2106815
  • EINECS 206-453-2
  • N-(2-(Trifluoromethyl)phenyl)acetamide
  • NSC 88329
  • alpha,alpha,alpha-Trifluoro-o-acetotoluidide
  • o-Acetotoluidide, alpha,alpha,alpha-trifluoro-
  • MLS000835009
  • N1-[2-(trifluoromethyl)phenyl]acetamide
  • SMR000461625
  • Maybridge1_008684
  • 2-Trifluoromethylacetanilide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.1356 0.1563
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.1078 0.7875
Schistosoma mansoni tar DNA-binding protein 0.0201 0.258 0.2573
Schistosoma mansoni ferritin light chain 0.0016 0.0032 0.0024
Loa Loa (eye worm) hypothetical protein 0.0112 0.1356 0.1563
Loa Loa (eye worm) MH2 domain-containing protein 0.0485 0.651 0.7501
Entamoeba histolytica hypothetical protein 0.0113 0.1368 1
Schistosoma mansoni smad 0.0033 0.0262 0.0253
Mycobacterium tuberculosis Conserved protein 0.0112 0.1356 0.1367
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.1356 0.1563
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0045 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.0468 0.054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0201 0.258 0.2573
Brugia malayi RNA binding protein 0.0201 0.258 0.2972
Schistosoma mansoni thyroid hormone receptor 0.0133 0.1642 0.1634
Loa Loa (eye worm) nuclear factor I 0.0018 0.0057 0.0066
Brugia malayi Smad1 0.0033 0.0262 0.0301
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0524 0.3655
Schistosoma mansoni hypothetical protein 0.0205 0.2631 0.2625
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1356 0.1348
Echinococcus multilocularis cysteine protease 0.0017 0.0045 0.0036
Brugia malayi beta-lactamase family protein 0.0112 0.1356 0.1563
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0009 0.001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0045 0.0036
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.1356 0.1367
Schistosoma mansoni Smad4 0.0033 0.0262 0.0253
Schistosoma mansoni apoferritin-2 0.0016 0.0032 0.0024
Brugia malayi RNA recognition motif domain containing protein 0.0201 0.258 0.2972
Onchocerca volvulus 0.0092 0.1078 0.108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0013
Onchocerca volvulus 0.0112 0.1356 0.1361
Entamoeba histolytica hypothetical protein 0.0113 0.1368 1
Brugia malayi MH1 domain containing protein 0.0018 0.0057 0.0066
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0009 0.001
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0468 0.046
Brugia malayi hypothetical protein 0.0113 0.1368 0.1576
Onchocerca volvulus 0.0017 0.0045 0.0036
Leishmania major cathepsin L-like protease 0.0066 0.072 0.515
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0262 0.0253
Leishmania major cathepsin L-like protease 0.0066 0.072 0.515
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.1368 0.136
Plasmodium vivax hypothetical protein, conserved 0.0112 0.1356 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0262 0.0253
Onchocerca volvulus 0.0112 0.1356 0.1361
Brugia malayi intermediate filament protein 0.0026 0.0169 0.0195
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.001
Loa Loa (eye worm) fibroinase 0.0017 0.0045 0.0052
Echinococcus granulosus smad 0.0033 0.0262 0.0253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0485 0.651 0.7501
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0045 0.0036
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0009 0.001
Echinococcus multilocularis survival motor neuron protein 1 0.0257 0.3357 0.3351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0045 0.0036
Schistosoma mansoni smad1 5 8 and 0.0033 0.0262 0.0253
Echinococcus multilocularis musashi 0.0026 0.0169 0.016
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.072 0.515
Loa Loa (eye worm) hypothetical protein 0.0112 0.1356 0.1563
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.1356 1
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1356 0.1341
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.1078 0.107
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0045 0.0036
Loa Loa (eye worm) TAR-binding protein 0.0201 0.258 0.2972
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.1078 0.107
Schistosoma mansoni tar DNA-binding protein 0.0201 0.258 0.2573
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.1078 0.107
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0262 0.0301
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0169 0.0195
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1356 0.1341
Leishmania major hypothetical protein, conserved 0.0112 0.1356 1
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.1356 0.1367
Echinococcus multilocularis Smad4 0.0033 0.0262 0.0253
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.1368 0.136
Echinococcus granulosus cathepsin l1 0.0017 0.0045 0.0036
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.1356 0.1367
Onchocerca volvulus 0.0048 0.0468 0.0464
Loa Loa (eye worm) hypothetical protein 0.0112 0.1356 0.1563
Entamoeba histolytica hypothetical protein 0.0113 0.1368 1
Schistosoma mansoni apoferritin-2 0.0016 0.0032 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0045 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1356 0.1341
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1356 0.1341
Loa Loa (eye worm) hypothetical protein 0.0112 0.1356 0.1563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Loa Loa (eye worm) hypothetical protein 0.0112 0.1356 0.1563
Echinococcus multilocularis lamin 0.0026 0.0169 0.016
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1505 0.1498
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0045 0.0052
Echinococcus multilocularis lamin dm0 0.0026 0.0169 0.016
Brugia malayi hypothetical protein 0.0257 0.3357 0.3868
Brugia malayi Pre-SET motif family protein 0.0092 0.1078 0.1242
Brugia malayi MH2 domain containing protein 0.0033 0.0262 0.0301
Brugia malayi MH1 domain containing protein 0.0018 0.0057 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0201 0.258 0.2573
Schistosoma mansoni smad1 5 8 and 0.0033 0.0262 0.0253
Mycobacterium tuberculosis Conserved protein 0.0112 0.1356 0.1367
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0045 0.0036
Echinococcus multilocularis thyroid hormone receptor alpha 0.0133 0.1642 0.1634
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.1356 0.1367
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0052
Schistosoma mansoni hypothetical protein 0.0123 0.1505 0.1498
Loa Loa (eye worm) hypothetical protein 0.0026 0.0169 0.0195
Echinococcus granulosus intermediate filament protein 0.0026 0.0169 0.016
Schistosoma mansoni ferritin 0.0016 0.0032 0.0024
Onchocerca volvulus 0.0017 0.0045 0.0036
Onchocerca volvulus 0.0017 0.0045 0.0036
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0045 0.0036
Brugia malayi MH2 domain containing protein 0.0485 0.651 0.7501
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.1356 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.1356 0.1367
Schistosoma mansoni lamin 0.0026 0.0169 0.016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0642 0.8678 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.1078 0.107
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0045 0.0036
Schistosoma mansoni ferritin 0.0016 0.0032 0.0024
Echinococcus granulosus lamin 0.0026 0.0169 0.016
Schistosoma mansoni tar DNA-binding protein 0.0201 0.258 0.2573
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Brugia malayi MH2 domain containing protein 0.0033 0.0262 0.0301
Schistosoma mansoni smad1 5 8 and 0.0033 0.0262 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0013
Plasmodium vivax SET domain protein, putative 0.0092 0.1078 0.7875
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.1356 0.1348
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0262 0.0253
Brugia malayi TAR-binding protein 0.0201 0.258 0.2972
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0045 0.0036
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.1356 1
Onchocerca volvulus 0.0731 0.9904 1
Mycobacterium leprae Probable lipase LipE 0.0112 0.1356 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.1078 0.107
Onchocerca volvulus 0.0017 0.0045 0.0036
Brugia malayi MH2 domain containing protein 0.0015 0.0009 0.001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0201 0.258 0.2972
Echinococcus multilocularis tar DNA binding protein 0.0201 0.258 0.2573
Onchocerca volvulus 0.0026 0.0169 0.0162
Schistosoma mansoni hypothetical protein 0.0113 0.1368 0.136
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0052
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0045 0.0052
Echinococcus granulosus survival motor neuron protein 1 0.0257 0.3357 0.3351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.1031 0.1023
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0045 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0045 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0169 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Trichomonas vaginalis esterase, putative 0.0112 0.1356 0.1341
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0045 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.072 0.515
Echinococcus granulosus tar DNA binding protein 0.0201 0.258 0.2573
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0045 0.0052
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0262 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1356 0.1341
Brugia malayi MH1 domain containing protein 0.0033 0.0262 0.0301
Schistosoma mansoni ferritin light chain 0.0016 0.0032 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0013
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0052
Echinococcus multilocularis smad 0.0033 0.0262 0.0253
Mycobacterium ulcerans lipase LipD 0.0112 0.1356 1
Echinococcus granulosus lamin dm0 0.0026 0.0169 0.016
Mycobacterium leprae conserved hypothetical protein 0.0112 0.1356 1
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.1368 0.136
Onchocerca volvulus 0.0112 0.1356 0.1361
Echinococcus granulosus tumor protein p63 0.0328 0.4338 0.4333
Schistosoma mansoni hypothetical protein 0.0205 0.2631 0.2625
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0718 0.9717 1
Schistosoma mansoni hypothetical protein 0.0052 0.0529 0.0521
Loa Loa (eye worm) beta-lactamase 0.0112 0.1356 0.1563
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0013
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.1356 0.1367
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0262 0.0301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Echinococcus granulosus Smad4 0.0033 0.0262 0.0253
Trichomonas vaginalis set domain proteins, putative 0.0731 0.9904 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0045 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.1078 0.107
Onchocerca volvulus 0.0052 0.0529 0.0526
Echinococcus granulosus ferritin 0.0016 0.0032 0.0024
Echinococcus multilocularis ferritin 0.0016 0.0032 0.0024
Loa Loa (eye worm) cysteine protease 0.0017 0.0045 0.0052
Onchocerca volvulus 0.0017 0.0045 0.0036
Schistosoma mansoni lamin 0.0026 0.0169 0.016
Loa Loa (eye worm) RNA binding protein 0.0201 0.258 0.2972
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.1078 0.107
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0262 0.0253
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.1356 0.1367
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0045 0.0036
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1505 0.1498
Mycobacterium ulcerans beta-lactamase 0.0112 0.1356 1
Echinococcus multilocularis expressed protein 0.0016 0.0032 0.0024
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0045 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0187
Entamoeba histolytica hypothetical protein 0.0113 0.1368 1
Schistosoma mansoni survival motor neuron protein 0.0052 0.0529 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0529 0.061
Loa Loa (eye worm) hypothetical protein 0.0257 0.3357 0.3868
Brugia malayi beta-lactamase family protein 0.0112 0.1356 0.1563
Loa Loa (eye worm) hypothetical protein 0.0112 0.1356 0.1563
Echinococcus granulosus expressed protein 0.0016 0.0032 0.0024
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0016 0.0032 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.072 0.515
Schistosoma mansoni ferritin 0.0016 0.0032 0.0024
Onchocerca volvulus 0.0017 0.0045 0.0036
Brugia malayi Pre-SET motif family protein 0.0642 0.8678 1
Echinococcus multilocularis cysteine protease 0.0017 0.0045 0.0036
Treponema pallidum bacterioferrin (TpF1) 0.0016 0.0032 0.5
Echinococcus granulosus geminin 0.0205 0.2631 0.2625
Onchocerca volvulus 0.0017 0.0045 0.0036
Brugia malayi beta-lactamase 0.0112 0.1356 0.1563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0013
Loa Loa (eye worm) ctsf protein 0.0017 0.0045 0.0052
Echinococcus multilocularis tumor protein p63 0.0328 0.4338 0.4333
Loa Loa (eye worm) Smad1 0.0033 0.0262 0.0301
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0052
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0169 0.0195
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1356 0.1348
Mycobacterium ulcerans hypothetical protein 0.0112 0.1356 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.1078 0.1242
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.072 0.515
Toxoplasma gondii ABC1 family protein 0.0112 0.1356 1
Schistosoma mansoni thyroid hormone receptor 0.0133 0.1642 0.1634
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1356 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0641 0.4544
Leishmania major cathepsin L-like protease 0.0066 0.072 0.515
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1356 1
Schistosoma mansoni ferritin 0.0016 0.0032 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0013
Onchocerca volvulus 0.0026 0.0169 0.0162
Brugia malayi MH1 domain containing protein 0.0033 0.0262 0.0301
Mycobacterium tuberculosis Conserved protein 0.0112 0.1356 0.1367
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.1356 0.1348
Echinococcus multilocularis geminin 0.0205 0.2631 0.2625
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0045 0.5
Schistosoma mansoni intermediate filament proteins 0.0026 0.0169 0.016

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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