Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0212 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.7618 | 0.7618 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.7618 | 0.7618 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.1216 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0212 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7618 | 0.7566 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.7618 | 0.7566 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.1216 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.1216 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7618 | 0.7566 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.7618 | 0.7566 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.1216 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1216 | 0.1025 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0212 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7618 | 0.7566 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.7618 | 0.7618 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0212 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.7618 | 0.7566 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0212 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7618 | 0.7566 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0212 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.1216 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0212 | 0.0212 |
Brugia malayi | hypothetical protein | 0.0027 | 0.1216 | 0.1216 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.1216 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.7618 | 0.7566 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.1216 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.1216 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.7618 | 0.7566 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0212 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.7618 | 0.7566 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0212 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4125 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.