Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Pre-SET motif family protein | 0.0229 | 0.6563 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.3338 | 0.3338 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.3316 | 0.5022 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.3338 | 0.5055 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0229 | 0.6563 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0332 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.3338 | 0.5055 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0566 | 0.1594 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3338 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.3338 | 0.3311 |
Onchocerca volvulus | 0.0049 | 0.0566 | 0.0694 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 0.7615 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.004 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3338 | 1 |
Onchocerca volvulus | 0.0261 | 0.7615 | 1 | |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.004 | 0.004 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3338 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.3338 | 0.5055 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0566 | 0.0806 |
Brugia malayi | RNA binding protein | 0.0132 | 0.3338 | 0.5055 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.3316 | 0.5022 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.3338 | 0.5055 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3338 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.004 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.3338 | 0.5055 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.3316 | 0.5022 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.