Detailed information for compound 1189708

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 378.378 | Formula: C21H18N2O5
  • H donors: 2 H acceptors: 3 LogP: 3.21 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)cc(n2CC(=O)O)CNC(=O)c1cc2c(o1)cccc2
  • InChi: 1S/C21H18N2O5/c1-27-16-6-7-17-14(9-16)8-15(23(17)12-20(24)25)11-22-21(26)19-10-13-4-2-3-5-18(13)28-19/h2-10H,11-12H2,1H3,(H,22,26)(H,24,25)
  • InChiKey: CYMXZVQAGCGDHU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum pantoate--beta-alanine ligase, putative Get druggable targets OG5_129569 All targets in OG5_129569
Mycobacterium ulcerans pantoate--beta-alanine ligase Get druggable targets OG5_129569 All targets in OG5_129569
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) Get druggable targets OG5_129569 All targets in OG5_129569
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) Get druggable targets OG5_129569 All targets in OG5_129569
Toxoplasma gondii pantoate-beta-alanine ligase Get druggable targets OG5_129569 All targets in OG5_129569
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.1472 0.5656
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.034 0.456
Loa Loa (eye worm) hypothetical protein 0.0041 0.034 0.034
Leishmania major hypothetical protein, conserved 0.0041 0.034 0.4153
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.1082 0.1339
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0172 0.1105
Echinococcus granulosus importin 5 0.0017 0.0096 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.034 0.403
Echinococcus granulosus translational activator gcn1 0.0017 0.0096 0.0096
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0041 0.034 0.034
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.034 0.1306
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.1472 0.1472
Brugia malayi kap beta 3 protein 0.0017 0.0096 0.0369
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.097 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0041 0.034 0.034
Echinococcus multilocularis translational activator gcn1 0.0017 0.0096 0.0096
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0292 0.3337
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0032 0.0032
Onchocerca volvulus Huntingtin homolog 0.0119 0.116 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0292 0.3337
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0108 0.0108
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0292 0.3197
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1007 0.3866
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.034 0.034
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0298 0.344
Loa Loa (eye worm) beta-lactamase 0.0041 0.034 0.034
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0065 0.0065
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0074 0.0683 1
Trichomonas vaginalis ran, putative 0.0067 0.0613 0.8879
Plasmodium vivax hypothetical protein, conserved 0.0041 0.034 0.3184
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0067 0.0613 0.877
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1007 0.1007
Mycobacterium ulcerans hypothetical protein 0.0041 0.034 0.0315
Brugia malayi Importin beta-1 subunit 0.0091 0.0862 0.3311
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0108 0.0158
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0172 0.0172
Brugia malayi MH2 domain containing protein 0.0116 0.1128 0.4334
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.034 0.456
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.034 0.0315
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.034 0.456
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0067 0.0613 0.0701
Leishmania major GTP-binding protein, putative 0.0067 0.0613 0.8795
Trichomonas vaginalis importin beta-1, putative 0.0074 0.0683 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0298 0.2638
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0292 0.2558
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0292 0.025
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0292 0.38
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0298 0.3897
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0292 0.2683
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0662 0.2543
Echinococcus multilocularis snurportin 1 0.097 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.034 0.0315
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0298 0.0298
Onchocerca volvulus 0.0057 0.0512 0.2099
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0067 0.0613 1
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0298 0.3302
Schistosoma mansoni hypothetical protein 0.0359 0.365 0.365
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1128 0.1128
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0298 0.3302
Toxoplasma gondii exonuclease III APE 0.0018 0.0108 0.0016
Loa Loa (eye worm) hypothetical protein 0.0119 0.116 0.116
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0262 0.1007
Mycobacterium leprae Probable lipase LipE 0.0041 0.034 0.0167
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0725 0.746 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0108 0.0206
Schistosoma mansoni ran 0.0067 0.0613 0.0613
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0262 0.0262
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0793 0.9106
Schistosoma mansoni hypothetical protein 0.0359 0.365 0.365
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0292 0.38
Brugia malayi CXXC zinc finger family protein 0.0057 0.0512 0.1967
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.034 0.0315
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0492 0.0522
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0298 0.0298
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.034 0.0315
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.034 0.0315
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0067 0.0613 0.6744
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0292 0.0266
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0074 0.0683 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0298 0.3765
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0298 0.0298
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0065 0.0065
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0492 0.0376
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0108 0.0206
Loa Loa (eye worm) hypothetical protein 0.0105 0.1007 0.1007
Echinococcus granulosus importin subunit beta 1 0.0091 0.0862 0.0862
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.034 0.3184
Schistosoma mansoni importin-beta 2 0.0017 0.0096 0.0096
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0065 0.0065
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0262 0.0262
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0337 0.4096
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0067 0.0613 0.6744
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0375 0.3638
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0492 0.0522
Leishmania major importin beta-1 subunit, putative 0.0074 0.0683 1
Toxoplasma gondii HEAT repeat-containing protein 0.0091 0.0862 0.104
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0067 0.0613 0.6744
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0003 0.0003
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0725 0.746 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0172 0.1105
Schistosoma mansoni cpg binding protein 0.006 0.0546 0.0546
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0108 0.0887
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0793 0.0947
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1128 0.1128
Loa Loa (eye worm) hypothetical protein 0.0041 0.034 0.034
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0032 0.0032
Brugia malayi hypothetical protein 0.0119 0.116 0.4456
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0298 0.344
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0793 0.0793
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.034 0.456
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0219 0.1608
Brugia malayi hypothetical protein 0.0024 0.0172 0.066
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0793 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0298 0.0298
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0067 0.0613 0.0613
Loa Loa (eye worm) importin-beta domain-containing protein 0.0017 0.0096 0.0096
Schistosoma mansoni inositol monophosphatase 0.0036 0.0292 0.0292
Echinococcus granulosus dnaJ subfamily B 0.0397 0.4043 0.4043
Echinococcus granulosus GTP binding nuclear protein Ran 0.0067 0.0613 0.0613
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0793 0.0793
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0172 0.0988
Toxoplasma gondii pantoate-beta-alanine ligase 0.0725 0.746 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.1429 0.1429
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0793 0.0947
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.034 0.034
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0793 0.9106
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0298 0.0298
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0219 0.1608
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0492 0.0492
Mycobacterium tuberculosis Possible penicillin-binding protein 0.026 0.2617 0.3412
Loa Loa (eye worm) inositol-1 0.0036 0.0292 0.0292
Brugia malayi beta-lactamase 0.0041 0.034 0.1306
Mycobacterium leprae conserved hypothetical protein 0.0041 0.034 0.0167
Echinococcus multilocularis transportin 1 0.0017 0.0096 0.0096
Schistosoma mansoni cpg binding protein 0.0057 0.0512 0.0512
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0298 0.0298
Toxoplasma gondii hypothetical protein 0.0029 0.0219 0.0167
Schistosoma mansoni ap endonuclease 0.0018 0.0108 0.0108
Schistosoma mansoni importin beta-1 0.0091 0.0862 0.0862
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0292 0.0292
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0298 0.0298
Mycobacterium tuberculosis Conserved protein 0.0041 0.034 0.0315
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0101 0.0101
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0793 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.034 0.0315
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0101 0.0101
Trypanosoma brucei importin beta-1 subunit, putative 0.0091 0.0862 1
Mycobacterium ulcerans beta-lactamase 0.0041 0.034 0.0315
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0108 0.0416
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0375 0.511
Echinococcus granulosus cpg binding protein 0.006 0.0546 0.0546
Schistosoma mansoni ran 0.0067 0.0613 0.0613
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0262 0.1007
Mycobacterium tuberculosis Conserved protein 0.0041 0.034 0.0315
Trichomonas vaginalis esterase, putative 0.0041 0.034 0.456
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0108 0.0108
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0219 0.1621
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0793 1
Loa Loa (eye worm) kap beta 3 protein 0.0017 0.0096 0.0096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.034 0.034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.034 0.034
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0172 0.0103
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0262 0.0262
Plasmodium falciparum importin beta, putative 0.0091 0.0862 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0298 0.1145
Echinococcus granulosus geminin 0.0359 0.365 0.365
Loa Loa (eye worm) acetyltransferase 0.015 0.1472 0.1472
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0725 0.746 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0253 0.0197
Brugia malayi beta-lactamase family protein 0.0041 0.034 0.1306
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.034 0.456
Loa Loa (eye worm) hypothetical protein 0.0084 0.0793 0.0793
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0298 0.0298
Brugia malayi RNA, U transporter 1 0.0258 0.2603 1
Echinococcus multilocularis importin subunit beta 1 0.0091 0.0862 0.0862
Trichomonas vaginalis hypothetical protein 0.0017 0.0096 0.0696
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0298 0.3897
Loa Loa (eye worm) hypothetical protein 0.0072 0.0662 0.0662
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0793 0.0932
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0375 0.0378
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0108 0.0158
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0375 0.511
Onchocerca volvulus Huntingtin homolog 0.0119 0.116 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0262 0.0262
Echinococcus multilocularis importin 5 0.0017 0.0096 0.0096
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0067 0.0613 0.2353
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0793 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0172 0.0988
Mycobacterium tuberculosis Conserved protein 0.0041 0.034 0.0315
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0298 0.3897
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0065 0.0065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1007 0.3866
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0033 0.0262 0.0262
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.034 0.403
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0172 0.0988
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0375 0.0378
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.034 0.0315
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0375 0.0375
Leishmania major hypothetical protein, conserved 0.0024 0.0172 0.1288
Echinococcus multilocularis cpg binding protein 0.006 0.0546 0.0546
Loa Loa (eye worm) hypothetical protein 0.0041 0.034 0.034
Brugia malayi hypothetical protein 0.0016 0.0082 0.0314
Loa Loa (eye worm) hypothetical protein 0.0041 0.034 0.034
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0067 0.0613 0.0613
Brugia malayi Probable ClpP-like protease 0.0084 0.0793 0.3048
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0292 0.3197
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0793 0.0793
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0099 0.0381
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0101 0.0101
Entamoeba histolytica Ran family GTPase 0.0067 0.0613 0.8795
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0492 0.0492
Entamoeba histolytica hypothetical protein 0.0074 0.0683 1
Schistosoma mansoni ap endonuclease 0.0018 0.0108 0.0108
Plasmodium vivax importin-beta 2, putative 0.0091 0.0862 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0091 0.0862 1
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.4043 0.4043
Echinococcus multilocularis GPCR, family 2 0.0033 0.0262 0.0262
Schistosoma mansoni hypothetical protein 0.0397 0.4043 0.4043
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0512 0.0512
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0337 0.314
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0298 0.0298
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0292 0.38
Toxoplasma gondii ABC1 family protein 0.0041 0.034 0.0331
Brugia malayi Inositol-1 0.0036 0.0292 0.1122
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0108 0.0887
Loa Loa (eye worm) hypothetical protein 0.0119 0.116 0.116
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0172 0.0988
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0108 0.0158
Schistosoma mansoni hypothetical protein 0.0011 0.0032 0.0032
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0337 0.4528
Brugia malayi beta-lactamase family protein 0.0041 0.034 0.1306
Echinococcus multilocularis geminin 0.0359 0.365 0.365
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0262 0.0262
Mycobacterium ulcerans lipase LipD 0.0041 0.034 0.0315
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1179 0.1179
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.034 0.0315
Loa Loa (eye worm) hypothetical protein 0.0091 0.0862 0.0862
Schistosoma mansoni hypothetical protein 0.0072 0.0662 0.0662
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0253 0.0046
Schistosoma mansoni cpg binding protein 0.006 0.0546 0.0546
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0793 0.0932
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0108 0.0108
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.097 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0074 0.0683 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0793 0.0793
Echinococcus granulosus GPCR family 2 0.0033 0.0262 0.0262
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.034 0.0315
Schistosoma mansoni inositol monophosphatase 0.0036 0.0292 0.0292
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0067 0.0613 0.877
Echinococcus granulosus transportin 1 0.0017 0.0096 0.0096
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.1472 0.1472

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 860 nM Binding affinity to Mycobacterium tuberculosis Pantothenate synthetase ChEMBL. 21235241

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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