Detailed information for compound 1189955

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 353.265 | Formula: C13H8F5NO3S
  • H donors: 2 H acceptors: 3 LogP: 3.18 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1c(F)cc(cc1F)NS(=O)(=O)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C13H8F5NO3S/c14-10-5-8(6-11(15)12(10)20)19-23(21,22)9-3-1-7(2-4-9)13(16,17)18/h1-6,19-20H
  • InChiKey: QIUNEKHJCQVTGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0041 0.029 0.0313
Loa Loa (eye worm) glutaminase 0.0294 0.2992 0.3336
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.0777 0.0873
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.021 0.2094 0.6996
Loa Loa (eye worm) hypothetical protein 0.0178 0.1753 0.1954
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0086 0.0777 0.0857
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0552 0.182
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0392 0.079
Loa Loa (eye worm) hypothetical protein 0.005 0.0392 0.0437
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0277 0.2817 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0041 0.029 0.0323
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0835 0.2771
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0835 0.0827
Brugia malayi ecdysone receptor 0.0041 0.029 0.0313
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.003 0.0021
Giardia lamblia Fructose-bisphosphate aldolase 0.095 1 1
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0178 0.1753 1
Brugia malayi mbt repeat family protein 0.003 0.0179 0.0189
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0082 0.0073
Loa Loa (eye worm) hypothetical protein 0.0035 0.0224 0.025
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0086 0.0777 0.0936
Brugia malayi nuclear receptor RXR 0.0046 0.0342 0.0371
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.1029 0.1137
Schistosoma mansoni hypothetical protein 0.0039 0.0268 0.0313
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0012 0.001
Schistosoma mansoni phosphoglycerate kinase 0.0178 0.1753 0.2131
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0124 0.1178 0.144
Echinococcus multilocularis histone acetyltransferase MYST2 0.0035 0.0224 0.0252
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0552 0.182
Brugia malayi hypothetical protein 0.0041 0.029 0.0313
Loa Loa (eye worm) MBCTL1 0.0035 0.0224 0.025
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0082 0.0145
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.003 0.0179 0.0512
Schistosoma mansoni Smad4 0.0016 0.003 0.0021
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0035 0.0224 0.0274
Schistosoma mansoni tar DNA-binding protein 0.0269 0.2732 0.3328
Brugia malayi nuclear receptor NHR-88 0.0041 0.029 0.0313
Schistosoma mansoni cpg binding protein 0.003 0.017 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0086 0.0777 0.0857
Schistosoma mansoni tar DNA-binding protein 0.0269 0.2732 0.3328
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0016 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0086 0.0777 0.0857
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.1029 0.1147
Onchocerca volvulus 0.0028 0.0153 0.0433
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.0866
Onchocerca volvulus 0.0015 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0038 0.0256 0.0285
Loa Loa (eye worm) mucolipin 1 0.0074 0.0642 0.0715
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0342 0.0371
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.027 0.0291
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0041 0.029 0.034
Onchocerca volvulus 0.0028 0.0156 0.0441
Echinococcus multilocularis neuropeptide s receptor 0.0507 0.5272 0.5922
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.0777 0.0857
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0835 0.2771
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0398 0.1303
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0392 0.1283
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0086 0.0777 0.0857
Echinococcus granulosus phosphoglycerate kinase 1 0.0178 0.1753 0.2143
Toxoplasma gondii hypothetical protein 0.0047 0.036 0.1999
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0012 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0194 0.0223
Schistosoma mansoni sex comb on midleg homolog 0.003 0.0179 0.0204
Schistosoma mansoni myelin transcription factor 1 myt1 0.0035 0.0224 0.0259
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1338 0.446
Loa Loa (eye worm) hypothetical protein 0.0854 0.8971 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Brugia malayi glutaminase DH11.1 0.0294 0.2992 0.3329
Echinococcus granulosus cpg binding protein 0.003 0.017 0.0208
Loa Loa (eye worm) hypothetical protein 0.0046 0.0342 0.0381
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0041 0.029 0.0326
Brugia malayi AMP-binding enzyme family protein 0.005 0.0392 0.0427
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.0866
Treponema pallidum phosphoglycerate kinase 0.0178 0.1753 0.1685
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.0777 0.0857
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0268 0.0313
Echinococcus granulosus nuclear receptor nhr 48 0.0041 0.029 0.0354
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.029 0.0326
Loa Loa (eye worm) ICD-1 protein 0.0146 0.1411 0.1572
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0226 0.0254
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1338 0.446
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0835 0.0922
Loa Loa (eye worm) nuclear receptor NHR-67 0.0041 0.029 0.0323
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0021
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0392 0.1283
Echinococcus multilocularis ecdysone induced protein 78C 0.0086 0.0777 0.0873
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0277 0.2817 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.1725 0.1923
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0234 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1411 0.1403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0086 0.0777 0.0866
Echinococcus granulosus GPCR family 2 0.0035 0.0226 0.0276
Echinococcus multilocularis neuropeptide receptor A26 0.0507 0.5272 0.5922
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0086 0.0777 0.0936
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0012 0.001
Brugia malayi nuclear hormone receptor family member odr-7 0.0041 0.029 0.0313
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0178 0.1753 0.1746
Trypanosoma brucei polo-like protein kinase 0.0092 0.0835 0.2771
Echinococcus granulosus tar DNA binding protein 0.0269 0.2732 0.3338
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.003 0.0037
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0012 0.0014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0086 0.0777 0.0873
Echinococcus granulosus thyroid hormone receptor alpha 0.0041 0.029 0.0354
Brugia malayi nuclear receptor RXR 0.0041 0.029 0.0313
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0392 0.0383
Echinococcus granulosus FTZ F1 alpha 0.0086 0.0777 0.095
Echinococcus multilocularis SAM and MBT domain containing protein 0.003 0.0179 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0086 0.0777 0.0866
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0086 0.0777 0.0936
Brugia malayi hypothetical protein 0.0325 0.3325 0.3699
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0082 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0835 0.0827
Schistosoma mansoni glutaminase 0.0294 0.2992 0.3647
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0086 0.0777 0.0866
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.095 1 1
Brugia malayi nuclear receptor NHR-88 0.0086 0.0777 0.0857
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.027 0.0261
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0012 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0342 0.0371
Schistosoma mansoni tar DNA-binding protein 0.0269 0.2732 0.3328
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0398 0.2213
Toxoplasma gondii NAC domain-containing protein 0.0146 0.1411 0.8031
Loa Loa (eye worm) hypothetical protein 0.0028 0.015 0.0167
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0012 0.0003
Onchocerca volvulus 0.005 0.0392 0.1153
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0014
Schistosoma mansoni smad 0.0016 0.003 0.0021
Loa Loa (eye worm) hypothetical protein 0.005 0.0392 0.0437
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.001
Brugia malayi tailless protein 0.0041 0.029 0.0313
Loa Loa (eye worm) RNA binding protein 0.0269 0.2732 0.3045
Loa Loa (eye worm) hypothetical protein 0.0046 0.0342 0.0381
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0082 0.0243
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0268 0.0328
Loa Loa (eye worm) Smad1 0.0016 0.003 0.0033
Treponema pallidum fructose-bisphosphate aldolase 0.095 1 1
Schistosoma mansoni hypothetical protein 0.0398 0.41 0.5003
Entamoeba histolytica hypothetical protein 0.0039 0.0268 0.0259
Treponema pallidum hypothetical protein 0.0277 0.2817 0.2758
Onchocerca volvulus 0.003 0.0179 0.0512
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0392 0.079
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0082 0.0081
Echinococcus granulosus ecdysone induced protein 78C 0.0086 0.0777 0.095
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0156 0.0174
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.1029 0.1137
Leishmania major hypothetical protein, conserved 0.0051 0.0398 0.1303
Loa Loa (eye worm) mbt repeat family protein 0.003 0.0179 0.02
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.027 0.0261
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0835 0.0827
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0086 0.0777 0.095
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0176 0.0215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0185 0.0211
Schistosoma mansoni nuclear receptor 0.0041 0.029 0.034
Loa Loa (eye worm) hypothetical protein 0.011 0.1029 0.1147
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.299 1
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0065 0.0552 0.182
Loa Loa (eye worm) glutaminase 2 0.0294 0.2992 0.3336
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0156 0.0163
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0178 0.1753 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Schistosoma mansoni hypothetical protein 0.0035 0.0226 0.0262
Brugia malayi intermediate filament protein 0.0028 0.0156 0.0163
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0552 0.182
Schistosoma mansoni hypothetical protein 0.0035 0.0226 0.0262
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0082 0.0247
Schistosoma mansoni sex comb on midleg homolog 0.003 0.0179 0.0204
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0012 0.001
Brugia malayi RNA binding protein 0.0269 0.2732 0.3037
Schistosoma mansoni lamin 0.0028 0.0156 0.0175
Trypanosoma brucei glucosidase, putative 0.0039 0.027 0.0874
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.0023
Schistosoma mansoni lamin 0.0028 0.0156 0.0175
Echinococcus granulosus geminin 0.0721 0.755 0.9226
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.029 0.0326
Echinococcus multilocularis mucolipin 3 0.0074 0.0642 0.0721
Schistosoma mansoni alpha glucosidase 0.0039 0.027 0.0315
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0835 0.1007
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.0866
Loa Loa (eye worm) steroid hormone receptor 0.0086 0.0777 0.0866
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.027 0.0261
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0012 0.0014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0082 0.01
Echinococcus multilocularis smad 0.0016 0.003 0.0034
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0086 0.0777 0.0936
Schistosoma mansoni ap endonuclease 0.0021 0.0082 0.0085
Onchocerca volvulus 0.0019 0.0053 0.013
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.029 0.0354
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0392 0.1284
Schistosoma mansoni nuclear hormone receptor 0.0041 0.029 0.034
Schistosoma mansoni tar DNA-binding protein 0.0269 0.2732 0.3328
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.029 0.0354
Trypanosoma brucei phosphoglycerate kinase 0.0065 0.0552 0.182
Loa Loa (eye worm) hypothetical protein 0.0028 0.0156 0.0174
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.027 0.0874
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0269 0.2732 0.3328
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.095 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.034 0.0331
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0098 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0086 0.0777 0.0866
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0185 0.0211
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0194 0.1045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0499 0.0596
Brugia malayi hypothetical protein 0.0046 0.0342 0.0371
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0082 0.0091
Schistosoma mansoni retinoic acid receptor RXR 0.0086 0.0777 0.0936
Brugia malayi Pre-SET motif family protein 0.0032 0.0194 0.0206
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0082 0.0243
Onchocerca volvulus 0.0248 0.2504 0.7524
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0046 0.0342 0.0404
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0012 0.0014
Echinococcus multilocularis transcription factor btf3 0.0146 0.1411 0.1585
Echinococcus granulosus lamin dm0 0.0028 0.0156 0.019
Brugia malayi MH1 domain containing protein 0.0016 0.003 0.0023
Echinococcus multilocularis geminin 0.0721 0.755 0.8482
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.0866
Schistosoma mansoni cpg binding protein 0.003 0.017 0.0193
Loa Loa (eye worm) hypothetical protein 0.0038 0.0256 0.0285
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0194 0.0223
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.027 0.0261
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0086 0.0777 0.0873
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0392 0.079
Echinococcus granulosus transcription factor btf3 0.0146 0.1411 0.1724
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0031 0.0185 0.0206
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0178 0.1753 0.3628
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0031 0.0185 0.0196
Onchocerca volvulus 0.0028 0.0156 0.0441
Brugia malayi nuclear hormone receptor family member nhr-6 0.0041 0.029 0.0313
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0012 0.0015
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0552 0.182
Schistosoma mansoni hypothetical protein 0.0721 0.755 0.9225
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0268 0.0301
Schistosoma mansoni hypothetical protein 0.0035 0.0226 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0086 0.0777 0.0857
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0464 0.4811 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0086 0.0777 0.0866
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.027 0.0874
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.0777 0.0857
Echinococcus multilocularis transcription factor Dp 1 0.0121 0.1151 0.1293
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0086 0.0777 0.2316
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.029 0.0846
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0178 0.1753 0.3628
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.1725 0.1938
Brugia malayi AMP-binding enzyme family protein 0.005 0.0392 0.0427
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0226 0.0242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0185 0.0208
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0398 0.1303
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0835 0.2491
Schistosoma mansoni hypothetical protein 0.0075 0.0657 0.0789
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.1725 0.2108
Loa Loa (eye worm) hypothetical protein 0.0325 0.3325 0.3706
Entamoeba histolytica hypothetical protein 0.0146 0.1411 0.1403
Mycobacterium ulcerans glutaminase 0.0294 0.2992 0.6211
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0296 0.096
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0392 0.079
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.021 0.2094 0.6996
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.029 0.0846
Brugia malayi AMP-binding enzyme family protein 0.005 0.0392 0.0427
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1411 0.1403
Schistosoma mansoni transcription factor btf3 0.0146 0.1411 0.1711
Echinococcus granulosus dnaJ subfamily B 0.0398 0.41 0.501
Loa Loa (eye worm) hypothetical protein 0.0046 0.0342 0.0381
Brugia malayi conserved hypotetical protein 0.0041 0.029 0.0313
Schistosoma mansoni thyroid hormone receptor 0.0086 0.0777 0.0936
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.0777 0.095
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0835 0.0938
Plasmodium vivax SET domain protein, putative 0.0032 0.0194 0.0649
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0185 0.0226
Plasmodium vivax basic transcription factor 3b, putative 0.0146 0.1411 0.4986
Brugia malayi nuclear hormone receptor 0.0041 0.029 0.0313
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0086 0.0777 0.0936
Brugia malayi MH2 domain containing protein 0.0241 0.2426 0.2696
Brugia malayi orphan nuclear receptor NR2E1 0.0041 0.029 0.0313
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.2426 0.2704
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0012 0.0003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.027 0.0261
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0256 0.0507
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0012 0.0003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.095 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0194 0.0223
Brugia malayi nuclear hormone receptor 0.0086 0.0777 0.0857
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0392 0.0383
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0035 0.0224 0.0239
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0392 0.079
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0086 0.0777 0.095
Mycobacterium ulcerans phosphoglycerate kinase 0.0178 0.1753 0.3628
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0012 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.0777 0.0857
Trichomonas vaginalis conserved hypothetical protein 0.0146 0.1411 0.1403
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.0866
Mycobacterium ulcerans hypothetical protein 0.0155 0.1506 0.3113
Chlamydia trachomatis phosphoglycerate kinase 0.0178 0.1753 1
Mycobacterium ulcerans hypothetical protein 0.005 0.0392 0.079
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0226 0.0242
Loa Loa (eye worm) hypothetical protein 0.0032 0.0194 0.0217
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0082 0.0243
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.021 0.2094 0.6996
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0392 0.079
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0082 0.0243
Plasmodium falciparum basic transcription factor 3b, putative 0.0146 0.1411 0.4986
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0086 0.0777 0.095
Brugia malayi RNA recognition motif domain containing protein 0.0269 0.2732 0.3037
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.003 0.0033
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.027 0.0261
Schistosoma mansoni smad1 5 8 and 0.0016 0.003 0.0021
Schistosoma mansoni nuclear receptor nhr-48 0.0041 0.029 0.034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0185 0.0226
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0035 0.0224 0.0252
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0226 0.0276
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.095 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0179 0.02
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0086 0.0777 0.0857
Plasmodium vivax phosphoglycerate kinase, putative 0.0178 0.1753 0.6208
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.027 0.0301
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.2426 0.2704
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0277 0.2817 0.5844
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0012 0.001
Schistosoma mansoni microtubule-associated protein tau 0.078 0.8184 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.029 0.0354
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.021 0.2094 0.2559
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0296 0.096
Onchocerca volvulus 0.0015 0.0012 0.0009
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0082 0.0247
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.027 0.0261
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0012 0.0003
Onchocerca volvulus 0.0041 0.029 0.0846
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.027 0.0261
Brugia malayi MH1 domain containing protein 0.0016 0.003 0.0023
Brugia malayi steroid hormone receptor 0.0086 0.0777 0.0857
Loa Loa (eye worm) hypothetical protein 0.0038 0.0256 0.0285
Brugia malayi hypothetical protein 0.0046 0.0342 0.0371
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.003 0.0034
Trypanosoma brucei transcription factor BTF3, putative 0.0146 0.1411 0.4702
Echinococcus granulosus neuropeptide s receptor 0.0507 0.5272 0.6441
Echinococcus multilocularis FTZ F1 alpha 0.0086 0.0777 0.0873
Brugia malayi Pre-SET motif family protein 0.0218 0.2183 0.2425
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0234 0.0462
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0046 0.0342 0.0418
Schistosoma mansoni phosphoglycerate kinase 0.0178 0.1753 0.2131
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.021 0.2094 0.2327
Toxoplasma gondii exonuclease III APE 0.0021 0.0082 0.0399
Brugia malayi Nuclear hormone receptor E75 0.0041 0.029 0.0313
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0082 0.0073
Echinococcus multilocularis cpg binding protein 0.003 0.017 0.0191
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0296 0.096
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0342 0.0404
Schistosoma mansoni ap endonuclease 0.0021 0.0082 0.0085
Giardia lamblia Kinase, PLK 0.0092 0.0835 0.076
Schistosoma mansoni alpha-glucosidase 0.0151 0.1464 0.1777
Schistosoma mansoni coup transcription factor 0.0086 0.0777 0.0936
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0185 0.0211
Echinococcus granulosus mucolipin 3 0.0074 0.0642 0.0784
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.027 0.0261
Loa Loa (eye worm) TAR-binding protein 0.0269 0.2732 0.3045
Echinococcus multilocularis Smad4 0.0016 0.003 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0012 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0086 0.0777 0.0857
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.299 1
Schistosoma mansoni thyroid hormone receptor 0.0086 0.0777 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.0777 0.0857
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Echinococcus granulosus SAM and MBT domain containing protein 0.003 0.0179 0.0219
Echinococcus multilocularis lamin 0.0028 0.0156 0.0175
Leishmania major basic transcription factor 3a, putative 0.0146 0.1411 0.4702
Loa Loa (eye worm) oxidoreductase 0.0015 0.0012 0.0014
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.027 0.0874
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0046 0.0342 0.0381
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.299 1
Schistosoma mansoni zinc finger protein 0.0041 0.029 0.034
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0156 0.0174
Brugia malayi Nuclear hormone receptor E75 0.0041 0.029 0.0313
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Loa Loa (eye worm) hypothetical protein 0.0075 0.0657 0.0733
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0046 0.0342 0.0384
Brugia malayi nuclear receptor NHR-67 0.0041 0.029 0.0313
Loa Loa (eye worm) hypothetical protein 0.0038 0.0256 0.0285
Brugia malayi Phosphoglycerate kinase 0.0065 0.0552 0.0605
Leishmania major phosphoglycerate kinase B, cytosolic 0.0178 0.1753 0.5852
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0432 0.2409
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0012 0.0003
Brugia malayi hypothetical protein 0.0051 0.0398 0.0433
Echinococcus granulosus Smad4 0.0016 0.003 0.0037
Schistosoma mansoni nuclear receptor 0.0041 0.029 0.034
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0012 0.001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0086 0.0777 0.0873
Brugia malayi photoreceptor-specific nuclear receptor 0.0854 0.8971 1
Schistosoma mansoni hypothetical protein 0.0721 0.755 0.9225
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.003 0.0033
Echinococcus granulosus histone acetyltransferase MYST2 0.0035 0.0224 0.0274
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0041 0.029 0.034
Onchocerca volvulus 0.0101 0.0936 0.2796
Onchocerca volvulus 0.0032 0.0194 0.0558
Trichomonas vaginalis glutaminase, putative 0.0294 0.2992 0.2986
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.027 0.0261
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0012 0.001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0086 0.0777 0.095
Echinococcus granulosus microtubule associated protein 2 0.078 0.8184 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0226 0.0252
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0178 0.1753 0.5852
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0098 0.011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.2183 0.2433
Schistosoma mansoni mucolipin 0.0068 0.0576 0.069
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0835 0.2771
Trypanosoma brucei phosphoglycerate kinase 0.0178 0.1753 0.5852
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0398 0.1374
Trichomonas vaginalis set domain proteins, putative 0.0248 0.2504 0.2497
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.299 1
Brugia malayi hypothetical protein 0.0039 0.0268 0.0289
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0398 0.1374
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0178 0.1753 0.5852
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0234 0.0462
Schistosoma mansoni hypothetical protein 0.0035 0.0226 0.0262
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.034 0.0331
Echinococcus multilocularis phosphoglycerate kinase 1 0.0178 0.1753 0.197
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0657 0.0723
Brugia malayi ecdysteroid receptor 0.0086 0.0777 0.0857
Trypanosoma cruzi transcription factor btf3, putative 0.0146 0.1411 0.4702
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0041 0.029 0.0326
Brugia malayi hypothetical protein 0.0041 0.029 0.0313
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0256 0.0507
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0398 0.1303
Brugia malayi hypothetical protein 0.0033 0.0205 0.0219
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0082 0.0145
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.021 0.2094 0.2087
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.027 0.0303
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.003 0.0037
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0392 0.0383
Schistosoma mansoni hypothetical protein 0.0023 0.0098 0.0105
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0269 0.2732 0.3045
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0323
Onchocerca volvulus Bile acid receptor homolog 0.0086 0.0777 0.2316
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0256 0.0868
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0082 0.0073
Loa Loa (eye worm) hypothetical protein 0.0046 0.0342 0.0381
Echinococcus granulosus lamin 0.0028 0.0156 0.019
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0178 0.1753 0.1746
Entamoeba histolytica phosphoglycerate kinase, putative 0.0178 0.1753 0.1746
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0835 0.0827
Brugia malayi Steroid receptor seven-up type 2 0.0086 0.0777 0.0857
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0392 0.079
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0226 0.0254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.095 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.0777 0.0857
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0392 0.079
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0835 0.0827
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0835 0.0827
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0277 0.2817 0.5844
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.027 0.1478
Echinococcus multilocularis musashi 0.0028 0.0156 0.0175
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0124 0.1178 0.1324
Echinococcus multilocularis microtubule associated protein 2 0.078 0.8184 0.9194
Leishmania major phosphoglycerate kinase C, glycosomal 0.0178 0.1753 0.5852
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0185 0.0208
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.0777 0.0873
Loa Loa (eye worm) hypothetical protein 0.005 0.0392 0.0437
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0194 0.0218
Loa Loa (eye worm) hypothetical protein 0.0038 0.0256 0.0285
Giardia lamblia Phosphoglycerate kinase 0.0178 0.1753 0.1685
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0041 0.029 0.0354
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0464 0.4811 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0086 0.0777 0.0873
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0012 0.0003
Brugia malayi mbt repeat family protein 0.003 0.0179 0.0189
Onchocerca volvulus 0.0086 0.0777 0.2316
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0277 0.2817 0.5844
Brugia malayi beta-NAC-like protein 0.0146 0.1411 0.1564
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0398 0.1374
Loa Loa (eye worm) DR-78 0.0041 0.029 0.0323
Plasmodium falciparum phosphoglycerate kinase 0.0178 0.1753 0.6208
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0835 0.0827
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0016 0.0018
Echinococcus multilocularis thyroid hormone receptor alpha 0.0086 0.0777 0.0873
Entamoeba histolytica hypothetical protein 0.0039 0.0268 0.0259
Echinococcus granulosus smad 0.0016 0.003 0.0037
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.021 0.2094 0.2353
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.0866
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.003 0.0034
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0392 0.079
Onchocerca volvulus Protein ultraspiracle homolog 0.0086 0.0777 0.2316
Loa Loa (eye worm) hypothetical protein 0.0051 0.0398 0.0443
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.027 0.0261
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0464 0.4811 1
Echinococcus granulosus polycomb protein SCMH1 0.003 0.0179 0.0219
Schistosoma mansoni cpg binding protein 0.0028 0.0153 0.0172
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0086 0.0777 0.0936
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.1506 0.3113
Brugia malayi Smad1 0.0016 0.003 0.0023
Schistosoma mansoni steroid hormone receptor ad4bp 0.0086 0.0777 0.0936
Onchocerca volvulus 0.0325 0.3325 1
Echinococcus multilocularis polycomb protein SCMH1 0.003 0.0179 0.0201
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.1725 0.1938
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0194 0.0218
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1338 0.446
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.021 0.2094 0.2548
Entamoeba histolytica hypothetical protein 0.0039 0.0268 0.0259
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0296 0.096
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.003 0.0179 0.0204
Echinococcus multilocularis GPCR, family 2 0.0035 0.0226 0.0254
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.41 0.4607
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.1725 0.1914
Trypanosoma cruzi transcription factor btf3, putative 0.0146 0.1411 0.4702
Loa Loa (eye worm) hypothetical protein 0.0046 0.0342 0.0381
Brugia malayi Coelomocyte uptake defective protein 5 0.0074 0.0642 0.0706
Schistosoma mansoni nuclear hormone receptor 0.0041 0.029 0.034
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0392 0.079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.0777 0.095
Echinococcus multilocularis nuclear receptor nhr 48 0.0041 0.029 0.0326
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0552 0.182
Schistosoma mansoni kinase 0.0047 0.0353 0.0417
Echinococcus granulosus transcription factor Dp 1 0.0121 0.1151 0.1407
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0256 0.0868
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.095 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.0777 0.0857
Schistosoma mansoni alpha-glucosidase 0.0151 0.1464 0.1777
Schistosoma mansoni mucolipin 0.0074 0.0642 0.077
Loa Loa (eye worm) nuclear hormone receptor 0.0041 0.029 0.0323
Onchocerca volvulus 0.0015 0.0012 0.0009
Onchocerca volvulus 0.0041 0.029 0.0846
Trypanosoma brucei phosphoglycerate kinase, putative 0.0065 0.0552 0.182
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0012 0.001
Schistosoma mansoni intermediate filament proteins 0.0028 0.0156 0.0175
Echinococcus granulosus intermediate filament protein 0.0028 0.0156 0.019
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0835 0.1021
Echinococcus granulosus neuropeptide receptor A26 0.0507 0.5272 0.6441
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.095 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0194 0.0237
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.021 0.2094 0.6996
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0835 0.0827
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0086 0.0777 0.0866
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0847 0.8901 1
Echinococcus multilocularis tar DNA binding protein 0.0269 0.2732 0.3069
Loa Loa (eye worm) hypothetical protein 0.0086 0.0777 0.0866
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.095 1 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.021 0.2094 0.2335
Brugia malayi Phosphoglycerate kinase 0.0178 0.1753 0.1946
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0226 0.0276
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0835 0.0931
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0194 0.0223
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0234 0.0462
Schistosoma mansoni nuclear hormone receptor 0.0086 0.0777 0.0936
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0012 0.0003
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0178 0.1753 1
Schistosoma mansoni hypothetical protein 0.0189 0.1872 0.2275
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0392 0.1283
Brugia malayi TAR-binding protein 0.0269 0.2732 0.3037
Entamoeba histolytica transcription factor BTF3, putative 0.0146 0.1411 0.1403
Entamoeba histolytica hypothetical protein 0.0039 0.0268 0.0259
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.0023
Schistosoma mansoni RAR-like nuclear receptor 0.0086 0.0777 0.0936
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0392 0.079
Trypanosoma brucei phosphoglycerate kinase 0.0178 0.1753 0.5852
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.027 0.033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.095 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0086 0.0777 0.095
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0153 0.017
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.029 0.0326
Brugia malayi CXXC zinc finger family protein 0.0028 0.0153 0.016
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0086 0.0777 0.0866
Echinococcus multilocularis lamin dm0 0.0028 0.0156 0.0175

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 91.5 uM Inhibition of Fischer-344 rat lens ALR2 by least-square analysis ChEMBL. 20936791
IC50 (binding) = 105.2 uM Inhibition of Fischer-344 rat kidney AK1A1 ChEMBL. 20936791
Inhibition (binding) = 50.65 % Inhibition of Fischer-344 rat kidney AK1A1 at 100 uM ChEMBL. 20936791
Inhibition (binding) = 55.8 % Inhibition of Fischer-344 rat lens ALR2 at 100 uM ChEMBL. 20936791

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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