Detailed information for compound 1190568

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 385.443 | Formula: C17H19N7O2S
  • H donors: 2 H acceptors: 6 LogP: 1.53 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1ncc2c1nc(nc2NCCCS(=O)(=O)C)c1cccc2c1c[nH]n2
  • InChi: 1S/C17H19N7O2S/c1-24-17-13(10-20-24)15(18-7-4-8-27(2,25)26)21-16(22-17)11-5-3-6-14-12(11)9-19-23-14/h3,5-6,9-10H,4,7-8H2,1-2H3,(H,19,23)(H,18,21,22)
  • InChiKey: YZTXAMRYFBNCHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0026 0.0043 0.0138
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0076 0.0231 0.0292
Toxoplasma gondii hypothetical protein 0.0026 0.0042 0.0137
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0286 0.1032 0.3313
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0286 0.1032 0.1303
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0076 0.0231 0.0292
Giardia lamblia Glutamate synthase 0.0076 0.0231 0.2073
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0086 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0427 0.0427
Trypanosoma cruzi hypothetical protein, conserved 0.0253 0.0905 0.2931
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0893 0.4822
Echinococcus multilocularis lamin dm0 0.0026 0.0043 0.0071
Brugia malayi nuclear hormone receptor 0.002 0.0017 0.0057
Echinococcus granulosus GPCR family 2 0.0124 0.0414 0.1328
Loa Loa (eye worm) Smad1 0.0016 0.0003 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0286 0.1032 0.3342
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0252 0.0252
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0076 0.0231 0.0749
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.004 0.0092 0.0497
Plasmodium vivax ataxin-2 like protein, putative 0.01 0.0322 0.104
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0017 0.0057
Brugia malayi Pre-SET motif family protein 0.0441 0.1619 0.5246
Loa Loa (eye worm) acetyltransferase 0.0142 0.0484 0.1567
Schistosoma mansoni importin beta-1 0.0029 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0086 0.0277
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0076 0.0231 0.1247
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0076 0.0231 0.2073
Entamoeba histolytica hypothetical protein 0.0071 0.0213 0.542
Leishmania major GTP-binding protein, putative 0.0021 0.0022 0.0071
Echinococcus multilocularis beta LACTamase domain containing family member 0.0253 0.0905 0.1503
Brugia malayi Importin beta-1 subunit 0.0029 0.0051 0.0164
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0076 0.0231 0.0384
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0076 0.0231 0.0747
Schistosoma mansoni hypothetical protein 0.0448 0.1647 0.1647
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0076 0.0231 0.0292
Brugia malayi Bromodomain containing protein 0.0082 0.0253 0.082
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0076 0.0231 0.2241
Echinococcus multilocularis Smad4 0.0016 0.0003 0.0005
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0286 0.1032 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0007 0.0007
Brugia malayi hypothetical protein 0.0064 0.0187 0.0606
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0233 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0057
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0076 0.0231 0.1247
Echinococcus granulosus glutamate synthase 0.0076 0.0231 0.0742
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0233 0.0755
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0022 0.007
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0233 0.226
Entamoeba histolytica Ran family GTPase 0.0021 0.0022 0.0546
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0076 0.0231 0.0749
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0138
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0076 0.0231 0.0747
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0042 0.0103 0.013
Leishmania major cytochrome p450-like protein 0.0025 0.0035 0.0115
Brugia malayi glutathione reductase 0.0827 0.3087 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1617 0.6094 0.7697
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0124 0.0414 0.1328
Schistosoma mansoni apoferritin-2 0.0042 0.0103 0.0103
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0017 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0893 0.4822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0017 0.0057
Leishmania major trypanothione reductase 0.0827 0.3087 1
Echinococcus granulosus geminin 0.0184 0.0641 0.2057
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0022 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0187 0.0187
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0392 0.1433 0.4641
Loa Loa (eye worm) phosphatidylinositol 3 0.0198 0.0696 0.2256
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0057
Brugia malayi RNA, U transporter 1 0.0081 0.0251 0.0813
Toxoplasma gondii NADPH-glutathione reductase 0.0286 0.1032 0.3342
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0028 0.0047 0.025
Echinococcus granulosus Smad4 0.0016 0.0003 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0253 0.0905 0.1143
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.0112 0.0186
Schistosoma mansoni thyroid hormone receptor 0.002 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0071 0.0213 0.542
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0071
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0286 0.1032 0.3342
Schistosoma mansoni glutamate synthase 0.0076 0.0231 0.0231
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0028 0.0091
Mycobacterium tuberculosis Probable dehydrogenase 0.1886 0.7117 0.8989
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0173 0.0555
Schistosoma mansoni hypothetical protein 0.0124 0.0414 0.0414
Schistosoma mansoni ferritin 0.0042 0.0103 0.0103
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0007 0.0022
Entamoeba histolytica disulphide oxidoreductase, putative 0.0076 0.0231 0.5894
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0427 0.1384
Brugia malayi MH1 domain containing protein 0.0016 0.0003 0.0009
Mycobacterium ulcerans bacterioferritin BfrB 0.0042 0.0103 0.1001
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0076 0.0231 0.2241
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0017 0.0057
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0118 0.0392 1
Leishmania major hypothetical protein, conserved 0.0253 0.0905 0.2931
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0057
Loa Loa (eye worm) latrophilin receptor protein 2 0.0124 0.0414 0.134
Trichomonas vaginalis D-aminoacylase, putative 0.0253 0.0905 0.4888
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0022 0.0069
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0108 0.0347
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0015 0.0001 0.0002
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0076 0.0231 0.5894
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0286 0.1032 0.3341
Loa Loa (eye worm) beta-lactamase 0.0253 0.0905 0.2931
Loa Loa (eye worm) hypothetical protein 0.0253 0.0905 0.2931
Schistosoma mansoni zinc finger protein 0.0026 0.0042 0.0042
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0286 0.1032 0.3341
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0076 0.0231 0.2241
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0043 0.0138
Echinococcus multilocularis ferritin 0.0042 0.0103 0.0172
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0007 0.0011
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0286 0.1032 0.3342
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0566 0.3055
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0108 0.0579
Loa Loa (eye worm) hypothetical protein 0.0044 0.011 0.0356
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0076 0.0231 0.0384
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.004 0.0092 0.2348
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0017 0.0057
Echinococcus granulosus cpg binding protein 0.0066 0.0192 0.0617
Brugia malayi intermediate filament protein 0.0026 0.0043 0.0138
Loa Loa (eye worm) hypothetical protein 0.0268 0.0961 0.3113
Echinococcus multilocularis GPCR, family 2 0.0124 0.0414 0.0687
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0086 0.0829
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.2096 0.7917 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0017 0.0029
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0003 0.0009
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.1102 0.357
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0076 0.0231 0.0384
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0286 0.1032 0.3342
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0076 0.0231 0.1247
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0008 0.0013
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0286 0.1032 0.1032
Brugia malayi Thioredoxin reductase 0.0827 0.3087 1
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0076 0.0231 0.0749
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0076 0.0231 0.1247
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.002 0.0066
Schistosoma mansoni cpg binding protein 0.0066 0.0192 0.0192
Schistosoma mansoni lamin 0.0026 0.0043 0.0043
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0071
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0017 0.0057
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0076 0.0231 0.0749
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0187 0.031
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.0322 0.104
Echinococcus granulosus lamin dm0 0.0026 0.0043 0.0137
Onchocerca volvulus 0.0064 0.0187 0.0924
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0124 0.0414 0.0414
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0015 0.0001 0.0002
Loa Loa (eye worm) thioredoxin reductase 0.0827 0.3087 1
Trypanosoma cruzi hypothetical protein, conserved 0.0253 0.0905 0.2931
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0015 0.0001 0.0001
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0041 0.0131
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0172 0.0557
Treponema pallidum oxidoreductase 0.0076 0.0231 0.1909
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0286 0.1032 0.1714
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0566 0.3055
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0086 0.063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0284
Brugia malayi Cytochrome P450 family protein 0.0077 0.0236 0.0765
Plasmodium falciparum glutathione reductase 0.0827 0.3087 1
Entamoeba histolytica hypothetical protein 0.0071 0.0213 0.542
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0104 0.0338 0.1096
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0233 0.0755
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0478 0.176 0.57
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0086 0.0277
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0566 0.2991
Loa Loa (eye worm) hypothetical protein 0.0253 0.0905 0.2931
Schistosoma mansoni smad 0.0016 0.0003 0.0003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0159
Echinococcus granulosus ferritin 0.0042 0.0103 0.0332
Mycobacterium leprae Probable lipase LipE 0.0253 0.0905 0.1143
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0017 0.0029
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0076 0.0231 0.0749
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0213 0.0353
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0286 0.1032 0.3342
Schistosoma mansoni Smad4 0.0016 0.0003 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.0253 0.0905 0.2931
Trypanosoma cruzi NADH dehydrogenase, putative 0.0076 0.0231 0.0749
Brugia malayi ecdysteroid receptor 0.002 0.0017 0.0057
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0253 0.0905 0.1143
Onchocerca volvulus 0.0253 0.0905 0.4841
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0017 0.0057
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.2552 0.4238
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0042 0.0103 0.013
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0086 0.0277
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0076 0.0231 0.0384
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0017 0.0057
Loa Loa (eye worm) hypothetical protein 0.0081 0.0252 0.0815
Mycobacterium ulcerans hypothetical protein 0.0253 0.0905 0.8769
Loa Loa (eye worm) hypothetical protein 0.0076 0.0231 0.0749
Loa Loa (eye worm) hypothetical protein 0.0077 0.0233 0.0756
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0076 0.0231 0.0749
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0438 0.0438
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0076 0.0231 0.2241
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0017 0.0057
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0076 0.0231 0.0742
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.0252 0.0418
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.0252 0.0252
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0076 0.0231 0.0749
Mycobacterium tuberculosis Conserved protein 0.0253 0.0905 0.1143
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.2096 0.7917 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0124 0.0414 0.1328
Brugia malayi Pre-SET motif family protein 0.0064 0.0187 0.0605
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.066 0.066
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0286 0.1032 0.3342
Mycobacterium tuberculosis Putative ferredoxin reductase 0.1886 0.7117 0.8989
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0042 0.0103 0.013
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0015 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.066 0.066
Echinococcus granulosus importin subunit beta 1 0.0029 0.0051 0.0162
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0827 0.3087 0.3899
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0086 0.0275
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.1886 0.7117 0.8989
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0286 0.1032 0.3342
Brugia malayi TAR-binding protein 0.0128 0.0427 0.1384
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0286 0.1032 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0834 0.3115 0.5172
Echinococcus granulosus tar DNA binding protein 0.0128 0.0427 0.1372
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0108 0.0579
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0253 0.0905 0.0905
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.066 0.2138
Treponema pallidum bacterioferrin (TpF1) 0.0042 0.0103 0.0617
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0057
Brugia malayi nuclear receptor NHR-88 0.002 0.0017 0.0057
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.003 0.0097
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0118 0.0392 0.127
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0133 0.0168
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0253 0.0905 0.2931
Plasmodium falciparum glutathione reductase 0.0286 0.1032 0.3341
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0286 0.1032 1
Leishmania major hypothetical protein, conserved 0.0076 0.0231 0.0749
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0286 0.1032 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0566 0.3055
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0076 0.0231 0.2241
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0042 0.0135
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.0195 0.0324
Schistosoma mansoni ap endonuclease 0.0038 0.0086 0.0086
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0036 0.0079 0.0256
Schistosoma mansoni hypothetical protein 0.0184 0.0641 0.0641
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0078 0.013
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0076 0.0231 0.1247
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0566 0.3055
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.2096 0.7917 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0017 0.0057
Schistosoma mansoni cpg binding protein 0.0066 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0253 0.0905 0.2931
Trichomonas vaginalis esterase, putative 0.0253 0.0905 0.4888
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0233 0.0756
Entamoeba histolytica thioredoxin reductase, putative 0.0076 0.0231 0.5894
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0392 0.1433 0.4641
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0286 0.1032 0.3342
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0233 0.0754
Giardia lamblia NADH oxidase lateral transfer candidate 0.0286 0.1032 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0015 0.0001 0.0001
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0118 0.0392 0.2116
Entamoeba histolytica hypothetical protein 0.0094 0.03 0.7652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0017 0.0057
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0076 0.0231 0.1539
Schistosoma mansoni hypothetical protein 0.0268 0.0961 0.0961
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0421
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.0141 0.3601
Plasmodium vivax SET domain protein, putative 0.0064 0.0187 0.0604
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0076 0.0231 0.1247
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0076 0.0231 0.0747
Trichomonas vaginalis glutamate synthase, putative 0.0076 0.0231 0.1247
Mycobacterium tuberculosis Conserved protein 0.0253 0.0905 0.1143
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0017 0.0056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0017 0.0017
Echinococcus multilocularis lamin 0.0026 0.0043 0.0071
Mycobacterium ulcerans bacterioferritin BfrA 0.0042 0.0103 0.1001
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0017 0.0029
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0233 0.0233
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0076 0.0231 0.1247
Entamoeba histolytica hypothetical protein 0.0023 0.003 0.0754
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0003 0.0009
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0286 0.1032 0.3341
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0076 0.0231 0.0742
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0286 0.1032 0.3342
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0051 0.0164
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0076 0.0231 0.2241
Brugia malayi glutamate synthase 0.0076 0.0231 0.0749
Onchocerca volvulus 0.0253 0.0905 0.4841
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0164
Schistosoma mansoni intermediate filament proteins 0.0026 0.0043 0.0043
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0115 0.0379 0.966
Onchocerca volvulus 0.006 0.0172 0.0842
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0017 0.0056
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0427 0.1384
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0222 0.0788 0.2531
Treponema pallidum NADH oxidase 0.0286 0.1032 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.1886 0.7117 0.8989
Trichomonas vaginalis ferritin, putative 0.0042 0.0103 0.0555
Leishmania major hypothetical protein, conserved 0.0076 0.0231 0.0749
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0057
Schistosoma mansoni coup transcription factor 0.002 0.0017 0.0017
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0286 0.1032 0.3342
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.0835 0.2705
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.066 0.212
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0076 0.0231 0.0749
Loa Loa (eye worm) hypothetical protein 0.0124 0.0414 0.134
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0008 0.0025
Echinococcus granulosus thioredoxin glutathione reductase 0.0834 0.3115 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.004 0.0092 0.03
Loa Loa (eye worm) hypothetical protein 0.0253 0.0905 0.2931
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0017 0.0017
Schistosoma mansoni thyroid hormone receptor 0.002 0.0017 0.0017
Mycobacterium ulcerans esterase/lipase LipP 0.0253 0.0905 0.8769
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0086 0.0275
Echinococcus multilocularis glutamate synthase 0.0076 0.0231 0.0384
Brugia malayi latrophilin 2 splice variant baaae 0.0268 0.0961 0.3113
Brugia malayi CXXC zinc finger family protein 0.006 0.0172 0.0557
Echinococcus multilocularis expressed protein 0.0042 0.0103 0.0172
Trypanosoma cruzi NADH dehydrogenase, putative 0.0076 0.0231 0.0749
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0124 0.0414 0.134
Plasmodium vivax thioredoxin reductase, putative 0.0827 0.3087 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0015 0.0001 0.0002
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0003 0.0009
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0076 0.0231 0.0292
Echinococcus multilocularis Zinc finger, PHD finger 0.0015 0.0001 0.0001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0233 0.0754
Echinococcus multilocularis snurportin 1 0.0305 0.1102 0.183
Mycobacterium tuberculosis Probable lipase LipE 0.0253 0.0905 0.1143
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0124 0.0414 0.0687
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.004 0.0092 0.0497
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.0392 0.127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0017 0.0057
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0069
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.021 0.0743 0.2405
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0286 0.1032 0.3341
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0017 0.0017
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0076 0.0231 0.1247
Leishmania major importin beta-1 subunit, putative 0.0023 0.003 0.0097
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0484 0.0484
Echinococcus granulosus intermediate filament protein 0.0026 0.0043 0.0137
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0286 0.1032 0.3342
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0017 0.0017
Brugia malayi hypothetical protein 0.0071 0.0213 0.0689
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0124 0.0414 0.0687
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0253 0.0905 0.0905
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0094 0.03 0.7652
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0076 0.0231 0.0742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0017 0.0057
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0076 0.0231 0.0749
Giardia lamblia Thioredoxin reductase 0.0076 0.0231 0.2073
Brugia malayi MH2 domain containing protein 0.0016 0.0003 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0017 0.0057
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0076 0.0231 0.0749
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0076 0.0231 0.0749
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.0322 0.104
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0076 0.0231 0.0749
Loa Loa (eye worm) hypothetical protein 0.0253 0.0905 0.2931
Loa Loa (eye worm) hypothetical protein 0.0253 0.0905 0.2931
Echinococcus granulosus expressed protein 0.0042 0.0103 0.0332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0017 0.0057
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0017 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0017 0.0056
Trichomonas vaginalis glutamate synthase, putative 0.0076 0.0231 0.1247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.066 0.066
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0017 0.0017
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0035 0.0343
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0076 0.0231 0.2241
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0057 0.0159 0.1358
Toxoplasma gondii ABC1 family protein 0.0253 0.0905 0.2931
Echinococcus granulosus snurportin 1 0.0305 0.1102 0.3538
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.0322 0.1042
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0017 0.0017
Leishmania major hypothetical protein, conserved 0.01 0.0322 0.1042
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0253 0.0905 0.1143
Brugia malayi beta-lactamase family protein 0.0253 0.0905 0.2931
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0076 0.0231 0.0292
Trichomonas vaginalis importin beta-1, putative 0.0023 0.003 0.0159
Plasmodium vivax glutathione reductase, putative 0.0827 0.3087 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0042 0.01 0.0325
Schistosoma mansoni glutamate synthase 0.0076 0.0231 0.0231
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0022 0.0036
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0118 0.0392 0.2116
Brugia malayi Cytochrome P450 family protein 0.0025 0.0035 0.0115
Schistosoma mansoni zinc finger protein 0.0015 0.0000057672 0.0000057672
Trichomonas vaginalis glutathione reductase, putative 0.0286 0.1032 0.5575
Brugia malayi MH2 domain containing protein 0.0235 0.0835 0.2705
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0008 0.0008
Toxoplasma gondii exonuclease III APE 0.0038 0.0086 0.0277
Echinococcus multilocularis geminin 0.0184 0.0641 0.1064
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0233 0.156
Schistosoma mansoni sulfide quinone reductase 0.0076 0.0231 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0017 0.0057
Onchocerca volvulus 0.0502 0.1851 1
Loa Loa (eye worm) RNA binding protein 0.0128 0.0427 0.1384
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0017 0.0017
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0427 0.0709
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0076 0.0231 0.0292
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0071 0.0213 0.0213
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.0392 0.127
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.1886 0.7117 0.8989
Loa Loa (eye worm) hypothetical protein 0.0392 0.1433 0.4641
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0017 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0427 0.0427
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.066 0.212
Onchocerca volvulus 0.0026 0.0043 0.0138
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0078 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0017 0.0057
Mycobacterium tuberculosis Probable lipase LipD 0.0253 0.0905 0.1143
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0286 0.1032 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0233 0.0295
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0017 0.0029
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0035 0.0115
Mycobacterium ulcerans monoxygenase 0.0076 0.0231 0.2241
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0022 0.007
Mycobacterium ulcerans glutamate synthase subunit beta 0.0076 0.0231 0.2241
Schistosoma mansoni nuclear hormone receptor 0.002 0.0017 0.0017
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0071
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0015 0.0001 0.0002
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0076 0.0231 0.0742
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0008 0.0013
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0286 0.1032 1
Leishmania major NADH dehydrogenase, putative 0.0076 0.0231 0.0749
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.0233 0.0388
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.0322 0.1042
Plasmodium vivax hypothetical protein, conserved 0.0253 0.0905 0.293
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0286 0.1032 0.3342
Brugia malayi hypothetical protein 0.01 0.0322 0.1042
Brugia malayi Calcitonin receptor-like protein seb-1 0.0392 0.1433 0.4641
Schistosoma mansoni sulfide quinone reductase 0.0076 0.0231 0.0231
Schistosoma mansoni smad1 5 8 and 0.0016 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0305 0.1102 0.1102
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0076 0.0231 0.0749
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0076 0.0231 0.5894
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0043 0.0138
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0076 0.0231 0.0749
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0086 0.0459
Trichomonas vaginalis D-aminoacylase, putative 0.0253 0.0905 0.4888
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0007 0.0007
Plasmodium falciparum ferrodoxin reductase-like protein 0.0076 0.0231 0.0747
Mycobacterium tuberculosis Probable reductase 0.1886 0.7117 0.8989
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0035 0.0115
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.021 0.0743 0.2405
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0222 0.0788 0.0788
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0076 0.0231 0.0292
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0893 0.4822
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0484 0.0803
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0076 0.0231 0.0742
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0133 0.0427
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0253 0.0905 0.8769
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0017 0.0057
Treponema pallidum thioredoxin reductase (trxB) 0.0076 0.0231 0.1909
Trichomonas vaginalis penicillin-binding protein, putative 0.0253 0.0905 0.4888
Schistosoma mansoni ran 0.0021 0.0022 0.0022
Mycobacterium ulcerans NADH dehydrogenase 0.0076 0.0231 0.2241
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0017 0.0057
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0076 0.0231 0.0384
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0233 0.1929
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0108 0.0346
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0015 0.0001 0.0002
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.0112 0.036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0286 0.1032 0.3342
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0108 0.0349
Brugia malayi Cytochrome P450 family protein 0.0025 0.0035 0.0115
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0041 0.0041
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0086 0.0459
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0086 0.0275
Trypanosoma brucei NADH dehydrogenase 0.0076 0.0231 0.0749
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0017 0.0057
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0118 0.0392 0.2116
Trypanosoma cruzi trypanothione reductase, putative 0.0286 0.1032 0.3342
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0187 0.0187
Trichomonas vaginalis ran, putative 0.0021 0.0022 0.0115
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0015 0.0001 0.0002
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0427 0.1384
Schistosoma mansoni hypothetical protein 0.0124 0.0414 0.0414
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0079 0.0256
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.0893 0.2891
Toxoplasma gondii selenide, water dikinase 0.0076 0.0231 0.0749
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0081 0.0251 0.1354
Toxoplasma gondii LsmAD domain-containing protein 0.01 0.0322 0.1042
Loa Loa (eye worm) glutathione reductase 0.0827 0.3087 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0051 0.0162
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0076 0.0231 0.0292
Plasmodium vivax ferrodoxin reductase, putative 0.0076 0.0231 0.0747
Brugia malayi Latrophilin receptor protein 2 0.0124 0.0414 0.134
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.0233 0.0749
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0076 0.0231 0.5894
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0222 0.0788 0.1309
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0076 0.0231 0.0292
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1598 0.6022 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0133 0.0221
Mycobacterium tuberculosis Probable hydrolase 0.0253 0.0905 0.1143
Schistosoma mansoni smad1 5 8 and 0.0016 0.0003 0.0003
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0086 0.063
Schistosoma mansoni ferritin 0.0042 0.0103 0.0103
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0022 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0017 0.0057
Leishmania major hypothetical protein, conserved 0.0076 0.0231 0.0749
Trichomonas vaginalis D-aminoacylase, putative 0.0253 0.0905 0.4888
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0017 0.0017
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0076 0.0231 0.0749
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0086 0.2172
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0015 0.0001 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.0448 0.1647 0.2735
Brugia malayi MH2 domain containing protein 0.0016 0.0003 0.0009
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0076 0.0231 0.0292
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0092 0.03
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.046 0.1476
Plasmodium falciparum importin beta, putative 0.0029 0.0051 0.0162
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0076 0.0231 0.1539
Schistosoma mansoni apoferritin-2 0.0042 0.0103 0.0103
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0599 0.3236
Echinococcus multilocularis musashi 0.0026 0.0043 0.0071
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0076 0.0231 0.0749
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0233 0.226
Schistosoma mansoni ferritin light chain 0.0042 0.0103 0.0103
Loa Loa (eye worm) programmed cell death 8 0.0076 0.0231 0.0749
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0286 0.1032 0.3342
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0003 0.0005
Schistosoma mansoni lamin 0.0026 0.0043 0.0043
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0035 0.0115
Schistosoma mansoni ferritin light chain 0.0042 0.0103 0.0103
Schistosoma mansoni bromodomain containing protein 0.007 0.0209 0.0209
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0086 0.0437
Schistosoma mansoni cpg binding protein 0.006 0.0172 0.0172
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0017 0.0029
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0017 0.0056
Schistosoma mansoni smad1 5 8 and 0.0016 0.0003 0.0003
Toxoplasma gondii thioredoxin reductase 0.0827 0.3087 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0427 0.0427
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0035 0.0115
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0051 0.0164
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0022 0.0036
Mycobacterium ulcerans beta-lactamase 0.0253 0.0905 0.8769
Schistosoma mansoni disulfide oxidoreductase 0.0076 0.0231 0.0231
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.0408 0.1323
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0086 0.0277
Schistosoma mansoni ferritin 0.0042 0.0103 0.0103
Echinococcus granulosus beta LACTamase domain containing family member 0.0253 0.0905 0.2905
Onchocerca volvulus 0.0253 0.0905 0.4841
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.004 0.0092 0.03
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0015 0.0001 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0827 0.3087 1
Echinococcus granulosus FTZ F1 alpha 0.002 0.0017 0.0056
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0233 0.0749
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0071
Mycobacterium ulcerans ferredoxin reductase 0.0076 0.0231 0.2241
Brugia malayi RNA binding protein 0.0128 0.0427 0.1384
Plasmodium falciparum thioredoxin reductase 0.0827 0.3087 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0017 0.0057
Brugia malayi steroid hormone receptor 0.002 0.0017 0.0057
Loa Loa (eye worm) hypothetical protein 0.01 0.0322 0.1042
Schistosoma mansoni hypothetical protein 0.0045 0.0112 0.0112
Echinococcus multilocularis cpg binding protein 0.0066 0.0192 0.0319
Trypanosoma brucei PAB1-binding protein , putative 0.01 0.0322 0.1042
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0893 0.4822
Schistosoma mansoni hypothetical protein 0.0124 0.0414 0.0414
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0017 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0231 0.0749
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.0195 0.0626
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0076 0.0231 0.0749
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.004 0.0092 0.0092
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0017 0.0056
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0042 0.0103 0.0188
Mycobacterium ulcerans hypothetical protein 0.0076 0.0231 0.2241
Brugia malayi beta-lactamase 0.0253 0.0905 0.2931
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0253 0.0905 0.2931
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0076 0.0231 0.1539
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.0835 0.2705
Brugia malayi Probable ClpP-like protease 0.0077 0.0233 0.0755
Plasmodium falciparum thioredoxin reductase 0.0286 0.1032 0.3341
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0076 0.0231 0.0384
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0076 0.0231 0.0749
Onchocerca volvulus 0.0076 0.0231 0.1166
Echinococcus granulosus dnaJ subfamily B 0.0448 0.1647 0.5287
Mycobacterium ulcerans lipase LipD 0.0253 0.0905 0.8769
Trichomonas vaginalis set domain proteins, putative 0.0502 0.1851 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0253 0.0905 0.4888
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0251 0.1354
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0076 0.0231 0.1247
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0076 0.0231 0.0742
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.2552 0.2552
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0253 0.0905 0.1143
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0017 0.0057
Brugia malayi MH1 domain containing protein 0.0016 0.0003 0.0009
Mycobacterium tuberculosis Probable esterase LipL 0.0253 0.0905 0.1143
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0076 0.0231 0.0749
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.066 0.1096
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0566 0.3055
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0427 0.0427
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0286 0.1032 0.3342
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0566 0.3055
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0076 0.0231 0.0747
Mycobacterium tuberculosis Conserved protein 0.0253 0.0905 0.1143
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.004 0.0092 0.2348
Brugia malayi Bromodomain containing protein 0.0042 0.01 0.0326
Echinococcus granulosus lamin 0.0026 0.0043 0.0137
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0017 0.0029
Mycobacterium tuberculosis Probable oxidoreductase 0.2096 0.7917 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0043 0.0138
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0231 0.0749
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0017 0.0056
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0076 0.0231 0.0749
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0015 0.0001 0.0002
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.004 0.0092 0.0497
Trichomonas vaginalis mercuric reductase, putative 0.0286 0.1032 0.5575
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0213 0.0683
Echinococcus granulosus microtubule associated protein 2 0.0686 0.2552 0.8194
Echinococcus multilocularis zinc finger protein 0.0026 0.0042 0.0071
Brugia malayi Smad1 0.0016 0.0003 0.0009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0017 0.0017
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.0893 0.2891
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0008 0.0025
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0051 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0566 0.3055
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0086 0.2172
Schistosoma mansoni ferritin 0.0042 0.0103 0.0103
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0599 0.3236
Echinococcus multilocularis smad 0.0016 0.0003 0.0005
Entamoeba histolytica hypothetical protein 0.0071 0.0213 0.542
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0003 0.0009
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0086 0.0275
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.066 0.2138
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0233 0.0387
Brugia malayi follicle stimulating hormone receptor 0.0478 0.176 0.57
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.1619 0.5246
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0893 0.4822
Loa Loa (eye worm) hypothetical protein 0.0077 0.0233 0.0755
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0076 0.0231 0.5894
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0108 0.0349
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0233 0.0024
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0086 0.0142
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0133 0.0168
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0076 0.0231 0.5894
Brugia malayi beta-lactamase family protein 0.0253 0.0905 0.2931
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0051 0.0164
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0003 0.0003
Trypanosoma brucei trypanothione reductase 0.0827 0.3087 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0086 0.0277
Loa Loa (eye worm) hypothetical protein 0.0071 0.0211 0.0682
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0035 0.0115
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0022 0.0072
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0086 0.0277
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0286 0.1032 0.3342
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0042 0.0135
Schistosoma mansoni ap endonuclease 0.0038 0.0086 0.0086
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0076 0.0231 0.1247
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0017 0.0029
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0484 0.1567
Echinococcus granulosus smad 0.0016 0.0003 0.0009
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.0893 0.4822
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.0252 0.0808
Schistosoma mansoni glutamate synthase 0.0076 0.0231 0.0231
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0035 0.0115
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0041 0.0068
Schistosoma mansoni ran 0.0021 0.0022 0.0022
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0213 0.0213
Schistosoma mansoni hypothetical protein 0.0184 0.0641 0.0641
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0231 0.0749
Trichomonas vaginalis apoptosis inducing factor, putative 0.0076 0.0231 0.1247
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0015 0.0001 0.0002
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0042 0.0053
Echinococcus granulosus zinc finger protein 0.0026 0.0042 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.066 0.1096
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0017 0.0057
Schistosoma mansoni hypothetical protein 0.0076 0.0231 0.0231
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0286 0.1032 0.3342
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0017 0.0057
Mycobacterium ulcerans dehydrogenase 0.0076 0.0231 0.2241
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0187 0.0605
Brugia malayi PHD-finger family protein 0.0032 0.0063 0.0203
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0236 0.0765
Schistosoma mansoni hypothetical protein 0.0015 0.0000057672 0.0000057672
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.1886 0.7117 0.8989
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0286 0.1032 0.3342
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0133 0.0168

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.403 uM Cytotoxicity against human MCF7 cells ChEMBL. 20822905
IC50 (binding) = 0.0014 uM Inhibition of PI3Kalpha ChEMBL. 20822905

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20822905

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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