TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 392.468 | Formula: C23H20O4S
H donors: 0 H acceptors: 3 LogP: 4.53 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)/C=C(\C(=O)c1ccc(cc1)S(=O)(=O)C)/c1ccccc1
InChi: 1S/C23H20O4S/c1-27-20-12-8-17(9-13-20)16-22(18-6-4-3-5-7-18)23(24)19-10-14-21(15-11-19)28(2,25)26/h3-16H,1-2H3/b22-16-
InChiKey: PSPGWQBSEPDIST-JWGURIENSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Ovis aries	Cyclooxygenase-2	Starlite/ChEMBL	References
Ovis aries	Cyclooxygenase-1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0325	1	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.2754	0.3996
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0159	0.4595	1
Brugia malayi	Animal haem peroxidase family protein	0.0095	0.2532	0.3674
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0031	0.5
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0233	0.0443
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Loa Loa (eye worm)	animal heme peroxidase	0.0095	0.2532	0.3674
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0027	0.032	0.0448
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0233	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1241	0.18
Leishmania major	hypothetical protein, conserved	0.0236	0.7125	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0095	0.2532	0.3674
Giardia lamblia	PHD finger protein 15	0.0032	0.0488	0.0361
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0132	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Entamoeba histolytica	hypothetical protein	0.0037	0.0647	0.0522
Trypanosoma brucei	beta lactamase	0.007	0.1717	0.2409
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Schistosoma mansoni	hypothetical protein	0.0042	0.0807	0.1568
Brugia malayi	hypothetical protein	0.0095	0.2532	0.3674
Treponema pallidum	fructose-bisphosphate aldolase	0.0325	1	0.5
Brugia malayi	jmjC domain containing protein	0.0106	0.2886	0.4187
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0488	0.9687
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0132	0.0185
Plasmodium falciparum	phd finger protein, putative	0.0032	0.0488	1
Schistosoma mansoni	tar DNA-binding protein	0.007	0.1704	0.331
Schistosoma mansoni	DNA polymerase eta	0.0021	0.0132	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Echinococcus multilocularis	peroxidasin	0.0095	0.2532	0.4918
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.0488	0.0708
Plasmodium vivax	SET domain protein, putative	0.0033	0.0504	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0233	0.0443
Onchocerca volvulus	Dual oxidase homolog	0.0095	0.2532	0.2989
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Brugia malayi	CHE-14 protein	0.0044	0.0859	0.1246
Loa Loa (eye worm)	animal heme peroxidase	0.0095	0.2532	0.3674
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	1	1
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0027	0.032	0.0632
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0027	0.032	0.0621
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0233	0.0443
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0229	0.6892	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0233	0.0328
Schistosoma mansoni	hypothetical protein	0.0032	0.0488	0.0948
Echinococcus multilocularis	Niemann Pick C1 protein	0.0146	0.4179	0.8117
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0027	0.032	0.0695
Brugia malayi	jmjC domain containing protein	0.0039	0.071	0.103
Brugia malayi	Animal haem peroxidase family protein	0.0095	0.2532	0.3674
Trypanosoma brucei	unspecified product	0.0021	0.0132	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0045
Echinococcus granulosus	jumonji domain containing protein	0.0045	0.0901	0.1749
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.0132	0.0185
Echinococcus granulosus	PHD finger protein rhinoceros	0.0032	0.0488	0.0948
Trypanosoma cruzi	hypothetical protein, conserved	0.0236	0.7125	1
Echinococcus granulosus	peregrin	0.0032	0.0488	0.0948
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Onchocerca volvulus		0.0095	0.2532	0.2989
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	1	1
Brugia malayi	Bromodomain containing protein	0.0032	0.0488	0.0708
Onchocerca volvulus	Peroxidasin homolog	0.0095	0.2532	0.2989
Echinococcus granulosus	sterol regulatory element binding protein	0.0044	0.0859	0.1668
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0233	0.0339
Mycobacterium ulcerans	lipoprotein LpqF	0.007	0.1717	0.3692
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0504	0.0978
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.007	0.1704	0.2472
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0159	0.4595	1
Echinococcus granulosus	geminin	0.0176	0.5148	1
Echinococcus multilocularis	tar DNA binding protein	0.007	0.1704	0.331
Onchocerca volvulus		0.0033	0.0504	0.0351
Loa Loa (eye worm)	jmjC domain-containing protein	0.0067	0.161	0.2336
Schistosoma mansoni	hypothetical protein	0.0042	0.0807	0.1568
Mycobacterium ulcerans	hypothetical protein	0.0027	0.032	0.0632
Schistosoma mansoni	hypothetical protein	0.0042	0.0807	0.1568
Trypanosoma cruzi	hypothetical protein, conserved	0.0236	0.7125	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Echinococcus granulosus	expressed conserved protein	0.0096	0.2553	0.4958
Brugia malayi	RNA binding protein	0.007	0.1704	0.2472
Schistosoma mansoni	peroxidasin	0.0095	0.2532	0.4918
Onchocerca volvulus	Peroxidase homolog	0.0095	0.2532	0.2989
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0647	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0132	0.0185
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0647	0.1257
Echinococcus granulosus	citrate lyase subunit beta protein	0.0027	0.032	0.0621
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0159	0.4595	1
Schistosoma mansoni	hypothetical protein	0.0176	0.5148	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0132	0.0255
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0039	0.071	0.103
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	1	1
Brugia malayi	Pre-SET motif family protein	0.0229	0.6892	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0104	0.2805	0.5449
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0027	0.032	0.019
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0031	0.062
Brugia malayi	TAR-binding protein	0.007	0.1704	0.2472
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Brugia malayi	Pre-SET motif family protein	0.0033	0.0504	0.0731
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0132	0.022
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0233	0.0103
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0233	0.0508
Trichomonas vaginalis	set domain proteins, putative	0.0261	0.7922	0.7895
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0233	0.0339
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0859	0.0737
Schistosoma mansoni	jumonji domain containing protein	0.0084	0.2176	0.4227
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Mycobacterium ulcerans	hypothetical protein	0.0027	0.032	0.0632
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0233	0.0443
Entamoeba histolytica	hypothetical protein	0.0037	0.0647	0.0522
Schistosoma mansoni	peroxidasin	0.0095	0.2532	0.4918
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0464	0.0902
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0102	0.2754	0.2657
Onchocerca volvulus	Alhambra homolog	0.0032	0.0488	0.0331
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0504	0.0978
Echinococcus multilocularis	geminin	0.0176	0.5148	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0325	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0233	0.0443
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0132	0.0255
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0233	0.0328
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0504	0.0978
Echinococcus granulosus	lysine specific demethylase 5A	0.0039	0.071	0.1378
Loa Loa (eye worm)	animal heme peroxidase	0.0095	0.2532	0.3674
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	1	1
Schistosoma mansoni	tar DNA-binding protein	0.007	0.1704	0.331
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0031	0.0068
Echinococcus granulosus	Protein patched homolog 1	0.0044	0.0859	0.1668
Schistosoma mansoni	patched 1	0.0044	0.0859	0.1668
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0132	0.0191
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0027	0.032	0.0448
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0032	0.0488	0.0948
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0031	0.064
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0233	0.0103
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0647	0.1257
Echinococcus granulosus	tar DNA binding protein	0.007	0.1704	0.331
Brugia malayi	PHD-finger family protein	0.0032	0.0488	0.0708
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0044	0.0859	0.1246
Schistosoma mansoni	hypothetical protein	0.0042	0.0807	0.1568
Echinococcus multilocularis	protein patched	0.0044	0.0859	0.1668
Loa Loa (eye worm)	RNA binding protein	0.007	0.1704	0.2472
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0132	0.0255
Echinococcus granulosus	Niemann Pick C1 protein	0.0102	0.2754	0.5349
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0132	0.0191
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0504	0.0978
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.007	0.1717	0.3735
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0132	0.0185
Brugia malayi	Niemann-Pick C1 protein precursor	0.0102	0.2754	0.3996
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0146	0.4189	0.911
Onchocerca volvulus	Peroxidasin homolog	0.0095	0.2532	0.2989
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	1	1
Onchocerca volvulus		0.0261	0.7922	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0233	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0045
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0132	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0045
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0132	0.0185
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	1	1
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0146	0.4189	0.9116
Loa Loa (eye worm)	TAR-binding protein	0.007	0.1704	0.2472
Onchocerca volvulus	Peroxidase homolog	0.0095	0.2532	0.2989
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0233	0.0339
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0106	0.2886	0.5606
Schistosoma mansoni	tar DNA-binding protein	0.007	0.1704	0.331
Echinococcus multilocularis	lysine specific demethylase 5A	0.0039	0.071	0.1378
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0504	0.0978
Brugia malayi	Animal haem peroxidase family protein	0.0095	0.2532	0.3674
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0504	1
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0132	0.0255
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0027	0.032	0.0448
Echinococcus multilocularis	peregrin	0.0032	0.0488	0.0948
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0233	0.0508
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0132	0.0255
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0233	0.0339
Leishmania major	DNA polymerase eta, putative	0.0021	0.0132	0.0185
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0233	0.0443
Schistosoma mansoni	tar DNA-binding protein	0.007	0.1704	0.331
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0132	0.0286
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.071	0.1378
Echinococcus multilocularis	expressed conserved protein	0.0096	0.2553	0.4958
Schistosoma mansoni	tar DNA-binding protein	0.007	0.1704	0.331
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0132	0.0255
Schistosoma mansoni	hypothetical protein	0.0176	0.5148	1
Echinococcus multilocularis	protein dispatched 1	0.005	0.106	0.2059
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0504	0.0978
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0504	0.0978
Echinococcus multilocularis	jumonji domain containing protein	0.0045	0.0901	0.1749
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0106	0.2886	0.5606
Onchocerca volvulus	Chorion peroxidase homolog	0.0095	0.2532	0.2989
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0504	0.0731
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Mycobacterium tuberculosis	Conserved protein	0.0027	0.032	0.0695
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0233	0.0328
Loa Loa (eye worm)	animal heme peroxidase	0.0095	0.2532	0.3674
Onchocerca volvulus		0.0095	0.2532	0.2989
Toxoplasma gondii	PHD-finger domain-containing protein	0.0032	0.0488	0.9687
Schistosoma mansoni	hypothetical protein	0.0037	0.0647	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0031	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0233	0.0339
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0032	0.0488	0.0948
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0132	0.022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0325	1	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0132	0.0191
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0488	0.9687
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0233	0.0339
Echinococcus multilocularis	Niemann Pick C1 protein	0.0102	0.2754	0.5349
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0859	0.1246
Echinococcus granulosus	dna polymerase eta	0.0021	0.0132	0.0255
Entamoeba histolytica	hypothetical protein	0.0037	0.0647	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0488	0.0708
Brugia malayi	Animal haem peroxidase family protein	0.0095	0.2532	0.3674
Brugia malayi	hypothetical protein	0.0037	0.0647	0.0939
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Echinococcus multilocularis	dna polymerase eta	0.0021	0.0132	0.0255
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0027	0.032	0.0632
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0027	0.032	0.0632
Echinococcus granulosus	Niemann Pick C1 protein	0.0146	0.4179	0.8117
Brugia malayi	Peroxidasin	0.0095	0.2532	0.3674
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0132	0.0191
Echinococcus multilocularis	sterol regulatory element binding protein	0.0044	0.0859	0.1668
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1179	0.1711
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0233	0.0103
Brugia malayi	Animal haem peroxidase family protein	0.0095	0.2532	0.3674
Trypanosoma brucei	hypothetical protein, conserved	0.0236	0.7125	1
Brugia malayi	Blistered cuticle protein 3	0.0095	0.2532	0.3674
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2532	0.3674
Brugia malayi	RNA recognition motif domain containing protein	0.007	0.1704	0.2472
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.007	0.1717	0.34
Echinococcus granulosus	peroxidasin	0.0095	0.2532	0.4918
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0132	0.0185
Onchocerca volvulus		0.0095	0.2532	0.2989
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.071	0.1378
Entamoeba histolytica	hypothetical protein	0.0037	0.0647	0.0522

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.21 uM	Inhibition of ovine COX2 by chemiluminescence assay	ChEMBL.	20691338
IC50 (binding)	= 18.38 uM	Inhibition of ovine COX1 by chemiluminescence assay	ChEMBL.	20691338

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1243177

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1191326