Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.2378 | 0.2604 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0401 | 0.0502 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2516 | 0.2786 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.2516 | 0.4715 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.2516 | 0.3148 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.2516 | 0.4715 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2516 | 0.2786 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2516 | 0.2786 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0209 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0081 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0401 | 0.0621 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.2516 | 0.3148 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0401 | 0.0621 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0401 | 0.0502 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.2516 | 0.4715 |
Mycobacterium tuberculosis | Conserved protein | 0.0024 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0081 | 0.0081 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0401 | 0.0502 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.2378 | 0.4447 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.4081 | 0.7745 |
Brugia malayi | RNA binding protein | 0.0071 | 0.2516 | 0.4715 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0401 | 0.0502 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.2516 | 0.4715 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.7991 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2516 | 0.2786 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0401 | 0.0502 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.5246 | 1 |
Echinococcus granulosus | geminin | 0.0172 | 0.7991 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.7991 | 1 |
Echinococcus multilocularis | geminin | 0.0172 | 0.7991 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0401 | 0.0502 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.5246 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0209 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.2516 | 0.4715 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0401 | 0.0621 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.4081 | 0.7745 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2516 | 0.2786 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.4081 | 0.7745 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.5246 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2378 | 0.4447 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0209 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0081 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0081 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.4081 | 0.7745 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0081 | 0.5 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0024 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0401 | 0.0621 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 22 uM | Antiproliferative activity against human HaCaT cells after 48 hrs by phase contrast microscopy | ChEMBL. | 20828887 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.