Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.042 | 0.0832 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.5045 | 0.5045 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.1637 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.1637 | 0.1637 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.042 | 0.4422 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0671 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.0966 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.042 | 0.042 |
Brugia malayi | RNA binding protein | 0.0062 | 0.5045 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0671 | 0.5 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.1201 | 0.238 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.5045 | 0.5045 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.1637 | 0.2632 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.5045 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.042 | 0.0832 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.5045 | 0.5045 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5045 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5045 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0949 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.1637 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0005 | 0.0000000003529 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.5045 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.5045 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5045 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5045 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.1637 | 0.2632 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.042 | 0.4422 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.5045 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.1637 | 0.2632 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.001 | 0.042 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.5045 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0671 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.1385 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0671 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.042 | 0.042 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.