Detailed information for compound 1191923

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.391 | Formula: C21H16N6O
  • H donors: 0 H acceptors: 4 LogP: 2.86 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nn(Cc2ccccc2)c(=O)c2c1c1cc(nn1nn2)c1ccccc1
  • InChi: 1S/C21H16N6O/c1-14-19-18-12-17(16-10-6-3-7-11-16)24-27(18)25-22-20(19)21(28)26(23-14)13-15-8-4-2-5-9-15/h2-12H,13H2,1H3
  • InChiKey: PLLAZQGXPJPXTC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0085 0.0971 0.5203
Schistosoma mansoni hypothetical protein 0.004 0.0372 0.0372
Brugia malayi Isocitrate dehydrogenase 0.0053 0.055 0.0808
Brugia malayi intermediate filament protein 0.003 0.024 0.0352
Trypanosoma cruzi PAB1-binding protein , putative 0.0085 0.0971 0.5203
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0549 0.0549
Echinococcus multilocularis geminin 0.0568 0.7427 0.7427
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.014 0.014
Echinococcus multilocularis dnaJ subfamily B 0.0451 0.5863 0.5863
Loa Loa (eye worm) hypothetical protein 0.0522 0.6804 1
Schistosoma mansoni hypothetical protein 0.0106 0.1263 0.1263
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1523 0.3663
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0053 0.055 0.3756
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.014 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0167 0.2074 0.3048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0053 0.055 0.055
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0373 0.0227
Echinococcus multilocularis lamin 0.003 0.024 0.024
Echinococcus granulosus lamin 0.003 0.024 0.024
Echinococcus multilocularis Smad4 0.0027 0.0207 0.0207
Schistosoma mansoni lamin 0.003 0.024 0.024
Brugia malayi hypothetical protein 0.0507 0.6606 0.971
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3644 1
Trypanosoma brucei PAB1-binding protein , putative 0.0085 0.0971 0.5203
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0053 0.055 0.055
Schistosoma mansoni microtubule-associated protein tau 0.0761 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0373 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.014 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3644 1
Schistosoma mansoni smad1 5 8 and 0.0027 0.0207 0.0207
Echinococcus multilocularis musashi 0.003 0.024 0.024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0516 0.0516
Brugia malayi isocitrate dehydrogenase 0.0053 0.055 0.0808
Loa Loa (eye worm) hypothetical protein 0.003 0.024 0.0352
Loa Loa (eye worm) hypothetical protein 0.0085 0.0971 0.1427
Entamoeba histolytica hypothetical protein 0.004 0.0372 0.0618
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.1523 0.1523
Loa Loa (eye worm) hypothetical protein 0.0022 0.014 0.0206
Brugia malayi hypothetical protein 0.004 0.0372 0.0547
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0065
Echinococcus granulosus mothers against decapentaplegic 6 0.0012 0.0006 0.0006
Brugia malayi nuclear hormone receptor 0.0022 0.014 0.0206
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0549 0.0549
Echinococcus multilocularis isocitrate dehydrogenase 0.0053 0.055 0.055
Echinococcus multilocularis GPCR, family 2 0.0053 0.0549 0.0549
Trichomonas vaginalis esterase, putative 0.004 0.0373 0.0227
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0053 0.055 0.1541
Schistosoma mansoni cpg binding protein 0.0033 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.004
Brugia malayi hypothetical protein 0.0522 0.6804 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0207 0.0207
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.014 0.014
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0207 0.0304
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0297 0.5
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1523 0.2238
Schistosoma mansoni intermediate filament proteins 0.003 0.024 0.024
Loa Loa (eye worm) MH2 domain-containing protein 0.04 0.5186 0.7623
Loa Loa (eye worm) hypothetical protein 0.004 0.0373 0.0548
Echinococcus granulosus geminin 0.0568 0.7427 0.7427
Loa Loa (eye worm) hypothetical protein 0.004 0.0373 0.0548
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0053 0.055 0.055
Onchocerca volvulus 0.003 0.024 0.0355
Brugia malayi Smad1 0.0027 0.0207 0.0304
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0008
Brugia malayi mothers against decapentaplegic homolog 3 0.0012 0.0006 0.0008
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.1368 0.2011
Loa Loa (eye worm) hypothetical protein 0.0022 0.014 0.0206
Schistosoma mansoni smad 0.0027 0.0207 0.0207
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2471 0.6496
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.014 0.014
Loa Loa (eye worm) nuclear factor I 0.0015 0.0044 0.0065
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0373 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.014 0.0206
Brugia malayi beta-lactamase family protein 0.004 0.0373 0.0548
Loa Loa (eye worm) hypothetical protein 0.0022 0.014 0.0206
Plasmodium falciparum ataxin-2 like protein, putative 0.0085 0.0971 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0373 0.0548
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.3229 1
Echinococcus granulosus FTZ F1 alpha 0.0022 0.014 0.014
Onchocerca volvulus 0.003 0.024 0.0355
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.014 0.014
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0207 0.0304
Brugia malayi MH2 domain containing protein 0.0027 0.0207 0.0304
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.1263 0.1856
Loa Loa (eye worm) hypothetical protein 0.0053 0.0549 0.0807
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0053 0.055 0.1541
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0549 0.0807
Echinococcus granulosus mothers against decapentaplegic 2 0.0012 0.0006 0.0006
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0038 0.0349 0.0349
Loa Loa (eye worm) RNA binding protein 0.0216 0.2725 0.4005
Onchocerca volvulus 0.004 0.0373 0.0556
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.014 0.0204
Trypanosoma cruzi PAB1-binding protein , putative 0.0085 0.0971 0.5203
Echinococcus granulosus smad 0.0027 0.0207 0.0207
Echinococcus granulosus Smad4 0.0027 0.0207 0.0207
Brugia malayi hypothetical protein 0.0055 0.0571 0.0839
Brugia malayi MH2 domain containing protein 0.04 0.5186 0.7623
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0516 0.0516
Brugia malayi 6-phosphofructokinase 0.0126 0.1523 0.2238
Echinococcus multilocularis cpg binding protein 0.0033 0.029 0.029
Loa Loa (eye worm) isocitrate dehydrogenase 0.0053 0.055 0.0808
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.014 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0516 0.0516
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0373 0.0373
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3644 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0053 0.055 0.0621
Loa Loa (eye worm) hypothetical protein 0.004 0.0373 0.0548
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1523 1
Schistosoma mansoni tar DNA-binding protein 0.0216 0.2725 0.2725
Schistosoma mansoni hypothetical protein 0.0053 0.0549 0.0549
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2337 0.6095
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3644 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.014 0.014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0568 0.7427 0.7427
Entamoeba histolytica hypothetical protein 0.004 0.0372 0.0618
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.1523 0.1523
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0038 0.0349 0.0349
Schistosoma mansoni cpg binding protein 0.0033 0.029 0.029
Toxoplasma gondii ABC1 family protein 0.004 0.0373 0.1129
Echinococcus multilocularis smad 0.0027 0.0207 0.0207
Brugia malayi RNA recognition motif domain containing protein 0.0216 0.2725 0.4005
Schistosoma mansoni thyroid hormone receptor 0.0022 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0053 0.0549 0.0549
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0053 0.0549 0.0549
Onchocerca volvulus 0.0507 0.6606 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0373 0.0227
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0266 0.039
Echinococcus multilocularis tar DNA binding protein 0.0216 0.2725 0.2725
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0373 0.0373
Brugia malayi phosphofructokinase 0.0126 0.1523 0.2238
Brugia malayi MH1 domain containing protein 0.0015 0.0044 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2337 0.6095
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1523 0.1523
Loa Loa (eye worm) hypothetical protein 0.004 0.0373 0.0548
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.014 0.014
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.024 0.0352
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0053 0.055 0.1541
Schistosoma mansoni hypothetical protein 0.0114 0.1368 0.1368
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2337 0.6095
Schistosoma mansoni tar DNA-binding protein 0.0216 0.2725 0.2725
Echinococcus multilocularis mothers against decapentaplegic 6 0.0012 0.0006 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0549 0.0549
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0053 0.055 0.1541
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3644 1
Onchocerca volvulus Glucosylceramidase homolog 0.0187 0.2337 0.3532
Loa Loa (eye worm) MH2 domain-containing protein 0.0012 0.0006 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.014 0.0206
Schistosoma mansoni nuclear hormone receptor 0.0022 0.014 0.014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0516 0.0516
Echinococcus multilocularis lamin dm0 0.003 0.024 0.024
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.014 0.0206
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.014 0.014
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.014 0.014
Schistosoma mansoni smad1 5 8 and 0.0027 0.0207 0.0207
Echinococcus granulosus GPCR family 2 0.0053 0.0549 0.0549
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.014 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.014 0.0206
Echinococcus multilocularis microtubule associated protein 2 0.0761 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.014 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.014 0.0206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0516 0.0516
Schistosoma mansoni smad1 5 8 and 0.0027 0.0207 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.014 0.0206
Loa Loa (eye worm) hypothetical protein 0.0167 0.2074 0.3048
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.014 0.0206
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.014 0.014
Schistosoma mansoni tar DNA-binding protein 0.0216 0.2725 0.2725
Schistosoma mansoni survival motor neuron protein 0.0106 0.1263 0.1263
Entamoeba histolytica hypothetical protein 0.004 0.0372 0.0618
Onchocerca volvulus 0.0032 0.0266 0.0394
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0207 0.0207
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0516 0.0759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.014 0.0206
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.014 0.014
Echinococcus granulosus lamin dm0 0.003 0.024 0.024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0549 0.0807
Loa Loa (eye worm) intermediate filament protein 0.003 0.024 0.0352
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0051
Schistosoma mansoni Smad4 0.0012 0.0006 0.0006
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0285 0.3644 0.5356
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0207 0.0207
Brugia malayi Calcitonin receptor-like protein seb-1 0.0167 0.2074 0.3048
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0373 0.0548
Schistosoma mansoni Smad4 0.0027 0.0207 0.0207
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0034 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0549 0.0807
Brugia malayi MH1 domain containing protein 0.0015 0.0044 0.0065
Schistosoma mansoni lamin 0.003 0.024 0.024
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0297 0.5
Entamoeba histolytica hypothetical protein 0.004 0.0372 0.0618
Schistosoma mansoni tar DNA-binding protein 0.0216 0.2725 0.2725
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.014 0.0206
Brugia malayi Pax transcription factor protein 2 0.0265 0.3385 0.4975
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.014 0.0206
Brugia malayi CXXC zinc finger family protein 0.0032 0.0266 0.039
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.1523 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.014 0.014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0516 0.0759
Loa Loa (eye worm) hypothetical protein 0.0114 0.1368 0.2011
Schistosoma mansoni hypothetical protein 0.0053 0.0549 0.0549
Loa Loa (eye worm) MH1 domain-containing protein 0.0012 0.0006 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0285 0.3644 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0373 0.0548
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.014 0.0204
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0372 0.0372
Onchocerca volvulus 0.004 0.0373 0.0556
Loa Loa (eye worm) transcription factor SMAD2 0.04 0.5186 0.7623
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.1523 1
Toxoplasma gondii isocitrate dehydrogenase 0.0053 0.055 0.3756
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.014 0.014
Schistosoma mansoni cpg binding protein 0.0032 0.0266 0.0266
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1523 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.014 0.014
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1523 1
Loa Loa (eye worm) TAR-binding protein 0.0216 0.2725 0.4005
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.1523 1
Plasmodium vivax ataxin-2 like protein, putative 0.0085 0.0971 1
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2337 0.6095
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1523 0.3663
Loa Loa (eye worm) hypothetical protein 0.0022 0.014 0.0206
Echinococcus multilocularis mothers against decapentaplegic 2 0.0012 0.0006 0.0006
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.014 0.014
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.014 0.014
Brugia malayi nuclear receptor NHR-88 0.0022 0.014 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.014 0.0206
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0207 0.0207
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.014 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2337 0.6095
Loa Loa (eye worm) hypothetical protein 0.0507 0.6606 0.971
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0053 0.055 0.055
Brugia malayi MH2 domain containing protein 0.0027 0.0207 0.0304
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0549 0.0549
Schistosoma mansoni coup transcription factor 0.0022 0.014 0.014
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.1523 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.014 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0216 0.2725 0.2725
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0373 0.0227
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.1523 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0053 0.055 0.1541
Schistosoma mansoni thyroid hormone receptor 0.0022 0.014 0.014
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0373 0.0373
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0034 0.0034
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0207 0.0207
Schistosoma mansoni hypothetical protein 0.0568 0.7427 0.7427
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.014 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0516 0.0516
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.014 0.0206
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.024 0.0352
Brugia malayi steroid hormone receptor 0.0022 0.014 0.0206
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.014 0.0206
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.014 0.014
Onchocerca volvulus 0.0022 0.014 0.0204
Plasmodium vivax hypothetical protein, conserved 0.004 0.0373 0.1129
Toxoplasma gondii LsmAD domain-containing protein 0.0085 0.0971 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0516 0.0516
Echinococcus granulosus tar DNA binding protein 0.0216 0.2725 0.2725
Loa Loa (eye worm) hypothetical protein 0.0022 0.014 0.0206
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0053 0.055 0.3756
Brugia malayi RNA binding protein 0.0216 0.2725 0.4005
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0055 0.0082
Echinococcus granulosus intermediate filament protein 0.003 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0022 0.014 0.0206
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1523 0.3663
Schistosoma mansoni Smad4 0.0012 0.0006 0.0006
Onchocerca volvulus 0.004 0.0373 0.0556
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.014 0.014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.014 0.0206
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.014 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2337 0.6095
Loa Loa (eye worm) hypothetical protein 0.004 0.0373 0.0548
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.014 0.014
Echinococcus granulosus dnaJ subfamily B 0.0451 0.5863 0.5863
Brugia malayi TAR-binding protein 0.0216 0.2725 0.4005
Schistosoma mansoni smad 0.0012 0.0006 0.0006
Onchocerca volvulus 0.0265 0.3385 0.512
Loa Loa (eye worm) hypothetical protein 0.0029 0.0232 0.0342
Echinococcus multilocularis survival motor neuron protein 1 0.0522 0.6804 0.6804
Onchocerca volvulus 0.0106 0.1263 0.1904
Loa Loa (eye worm) hypothetical protein 0.0022 0.014 0.0206
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0053 0.055 0.055
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.1523 1
Brugia malayi 6-phosphofructokinase 0.0126 0.1523 0.2238
Echinococcus granulosus survival motor neuron protein 1 0.0522 0.6804 0.6804
Brugia malayi MH2 domain containing protein 0.0012 0.0006 0.0008
Echinococcus granulosus cpg binding protein 0.0033 0.029 0.029
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0373 0.0227
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.004
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0297 0.5
Loa Loa (eye worm) phosphofructokinase 0.0126 0.1523 0.2238
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0372 0.0372
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0216 0.2725 0.4005
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.1523 0.4027
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0285 0.3644 0.5356
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0372 0.0372
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0739 0.0739
Brugia malayi ecdysteroid receptor 0.0022 0.014 0.0206
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0167 0.2074 0.3048
Brugia malayi MH1 domain containing protein 0.0027 0.0207 0.0304
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.014 0.014
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.014 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2471 0.6496
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.014 0.0206
Brugia malayi MH1 domain containing protein 0.0027 0.0207 0.0304
Toxoplasma gondii isocitrate dehydrogenase 0.0053 0.055 0.3756
Plasmodium falciparum ataxin-2 like protein, putative 0.0085 0.0971 1
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.014 0.0206
Brugia malayi beta-lactamase family protein 0.004 0.0373 0.0548
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.1523 0.2238
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.014 0.0206
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.1523 0.3663
Loa Loa (eye worm) pax transcription factor protein 2 0.0265 0.3385 0.4975
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0644 0.5146
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.014 0.014
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0038 0.0349 0.0349
Brugia malayi hypothetical protein 0.0085 0.0971 0.1427
Brugia malayi beta-lactamase 0.004 0.0373 0.0548
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.1523 0.1523
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2337 0.6095
Loa Loa (eye worm) hypothetical protein 0.0022 0.014 0.0206
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0053 0.055 0.055
Loa Loa (eye worm) hypothetical protein 0.004 0.0373 0.0548
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0055 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.014 0.0206
Loa Loa (eye worm) Smad1 0.0027 0.0207 0.0304
Schistosoma mansoni hypothetical protein 0.0451 0.5863 0.5863

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) < 50 % Displacement of [3H]NECA from human adenosine A3 receptor expressed in HeLa cells at 10 uM after 180 mins ChEMBL. 20937560
Inhibition (binding) < 50 % Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells at 10 uM after 30 mins ChEMBL. 20937560
Inhibition (binding) < 50 % Displacement of [3H]ZM241385 from human adenosine A2a receptor expressed in HeLa cells at 10 uM after 30 mins ChEMBL. 20937560
Inhibition (binding) < 50 % Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO-A1 cells at 10 uM after 60 mins ChEMBL. 20937560

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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