Detailed information for compound 1191996

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 622.619 | Formula: C32H34N2O11
  • H donors: 5 H acceptors: 6 LogP: 3.51 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO[C@@H]1[C@@H](OC(=O)c2ccc([nH]2)C)[C@@H](O)[C@@H](OC1(C)C)Oc1ccc2c(c1)oc(=O)c(c2O)NC(=O)c1cc(C)c(c(c1)C)O
  • InChi: 1S/C32H34N2O11/c1-14-11-17(12-15(2)23(14)35)28(38)34-22-24(36)19-9-8-18(13-21(19)43-30(22)40)42-31-25(37)26(27(41-6)32(4,5)45-31)44-29(39)20-10-7-16(3)33-20/h7-13,25-27,31,33,35-37H,1-6H3,(H,34,38)/t25-,26+,27-,31-/m1/s1
  • InChiKey: HCJJVFGHYYFOIL-KUYWTNKVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli DNA gyrase, subunit B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium falciparum DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium yoelii DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma congolense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Treponema pallidum DNA gyrase, subunit B (gyrB) Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania braziliensis mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_128755 All targets in OG5_128755
Babesia bovis DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Theileria parva DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma brucei gambiense DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania mexicana mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Neospora caninum hypothetical protein Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma brucei DNA topoisomerase ii Get druggable targets OG5_128755 All targets in OG5_128755
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein Get druggable targets OG5_128755 All targets in OG5_128755
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania infantum mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium berghei DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB Get druggable targets OG5_128755 All targets in OG5_128755
Mycobacterium ulcerans DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania major mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Leishmania donovani mitochondrial DNA topoisomerase II Get druggable targets OG5_128755 All targets in OG5_128755
Plasmodium knowlesi DNA gyrase subunit B, putative Get druggable targets OG5_128755 All targets in OG5_128755
Chlamydia trachomatis DNA gyrase subunit B Get druggable targets OG5_128755 All targets in OG5_128755
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ferrodoxin reductase-like protein 0.0037 0.0204 0.0644
Trichomonas vaginalis ran, putative 0.0022 0.0088 0.0188
Mycobacterium ulcerans NADH dehydrogenase 0.0037 0.0204 0.0318
Schistosoma mansoni serine/threonine protein kinase 0.0295 0.2218 0.2218
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0103 0.0717 0.1639
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0068 0.0068
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0037 0.0204 0.0174
Trypanosoma cruzi polo-like protein kinase, putative 0.0295 0.2218 0.7157
Loa Loa (eye worm) thioredoxin reductase 0.0405 0.3072 0.7022
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0037 0.0204 0.0174
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0068 0.0156
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0037 0.0204 0.0452
Leishmania major GTP-binding protein, putative 0.0022 0.0088 0.0071
Schistosoma mansoni kinase 0.015 0.1084 0.1084
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0923 0.7119 0.8958
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0037 0.0204 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0061 0.0125
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0037 0.0204 0.0465
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0061 0.0139
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1741 0.397
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.0531
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0061 0.0198
Schistosoma mansoni ran 0.0022 0.0088 0.0088
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0037 0.0204 0.0644
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.014 0.1008 0.2184
Entamoeba histolytica hypothetical protein 0.0038 0.0207 0.0908
Loa Loa (eye worm) TOPoisomerase family member 0.0036 0.0192 0.0439
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.2218 0.5062
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0256 0.1156
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0037 0.0204 0.0465
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0088 0.0133
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0061 0.0092
Plasmodium vivax thioredoxin reductase, putative 0.0405 0.3072 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0923 0.7119 0.8976
Onchocerca volvulus 0.0012 0.0006 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.2218 0.5062
Mycobacterium ulcerans monoxygenase 0.0037 0.0204 0.0318
Brugia malayi hypothetical protein 0.0019 0.0061 0.0139
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.014 0.1008 0.8902
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0037 0.0204 0.0174
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0014
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0061 0.0061
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0037 0.0204 0.0452
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0037 0.0204 0.0308
Echinococcus multilocularis chromobox protein 1 0.0073 0.0482 0.0731
Brugia malayi glutaminase DH11.1 0.0571 0.4375 1
Schistosoma mansoni chromobox protein 0.0012 0.0006 0.0006
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0037 0.0204 0.066
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.014 0.1008 0.2184
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0037 0.0204 0.0455
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0061 0.0139
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0256 0.0573
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0037 0.0204 0.0452
Trypanosoma cruzi DNA topoisomerase II, putative 0.0025 0.0107 0.0133
Schistosoma mansoni hypothetical protein 0.0187 0.1371 0.1371
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0037 0.0204 0.0318
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0036 0.0192 0.0439
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0061 0.0139
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0207 0.0314
Toxoplasma gondii NADPH-glutathione reductase 0.014 0.1008 0.3267
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0061 0.0092
Schistosoma mansoni chromobox protein 0.0073 0.0482 0.0482
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0037 0.0204 0.0452
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0006 0.0014
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0037 0.0204 0.0892
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0037 0.0204 0.0644
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0088 0.0201
Leishmania major dihydrolipoamide dehydrogenase, putative 0.014 0.1008 0.3131
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.014 0.1008 0.3267
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0061 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0237 0.0237
Echinococcus granulosus expressed protein 0.0369 0.2793 0.9056
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0061 0.0061
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0037 0.0204 0.0455
Giardia lamblia NADH oxidase lateral transfer candidate 0.014 0.1008 0.4375
Echinococcus granulosus importin subunit beta 1 0.003 0.0151 0.0489
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0061 0.0061
Brugia malayi Heterochromatin protein 1 0.0073 0.0482 0.1103
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0295 0.2218 0.3358
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0037 0.0204 0.0318
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0037 0.0204 0.1316
Treponema pallidum NADH oxidase 0.014 0.1008 0.9046
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0061 0.0061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0143 0.0217
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0037 0.0204 0.1316
Mycobacterium tuberculosis Probable oxidoreductase 0.1026 0.7923 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0061 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0061 0.0125
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0295 0.2218 0.719
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0187 0.1371 0.1371
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.014 0.1008 0.3131
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0037 0.0204 0.0318
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0037 0.0204 0.0174
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.014 0.1008 0.1008
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0006 0.0006
Echinococcus multilocularis glutamate synthase 0.0037 0.0204 0.0308
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.2218 0.5062
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0106 0.0228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0139
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0036 0.0192 0.0291
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0643 0.1471
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0139
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0405 0.3072 0.3825
Leishmania major DNA topoisomerase ii 0.0025 0.0107 0.0133
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0067 0.0153
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0088 0.0603 0.1947
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0643 0.2086
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0088 0.0071
Brugia malayi glutathione reductase 0.0405 0.3072 0.7022
Loa Loa (eye worm) hypothetical protein 0.003 0.0151 0.0345
Brugia malayi Pre-SET motif family protein 0.0206 0.1519 0.3472
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0037 0.0204 0.0308
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.014 0.1008 0.9046
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.014 0.1008 0.3267
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0643 0.0974
Plasmodium falciparum DNA topoisomerase 2 0.0036 0.0192 0.0606
Brugia malayi Probable DNA topoisomerase II 0.0036 0.0192 0.0439
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0088 0.0267
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0088 0.0267
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.014 0.1008 0.1526
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.014 0.1008 0.9046
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0037 0.0204 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0061 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0204 0.0455
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0325 0.2453 0.5607
Plasmodium falciparum glutathione reductase 0.0405 0.3072 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0643 0.0643
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0244
Leishmania major mitochondrial DNA topoisomerase II 0.0088 0.0603 0.1785
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1026 0.7923 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0037 0.0204 0.0318
Schistosoma mansoni disulfide oxidoreductase 0.0037 0.0204 0.0204
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0153 0.1107 1
Brugia malayi PXA domain containing protein 0.0019 0.0061 0.0139
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0037 0.0204 0.0452
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.014 0.1008 0.3131
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0014
Brugia malayi Protein cec-1. 0.0012 0.0006 0.0014
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0061 0.0125
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0061 0.0198
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0037 0.0204 0.0452
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0036 0.0192 0.0623
Trichomonas vaginalis glutamate synthase, putative 0.0037 0.0204 0.0452
Entamoeba histolytica hypothetical protein 0.0038 0.0207 0.0908
Treponema pallidum thioredoxin reductase (trxB) 0.0037 0.0204 0.1316
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.2218 0.5062
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0037 0.0204 0.0892
Mycobacterium tuberculosis Probable reductase 0.0923 0.7119 0.8976
Trypanosoma brucei NADH dehydrogenase 0.0037 0.0204 0.0455
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0153 0.1107 0.1324
Echinococcus multilocularis chromobox protein 1 0.0073 0.0482 0.0731
Loa Loa (eye worm) programmed cell death 8 0.0037 0.0204 0.0465
Treponema pallidum oxidoreductase 0.0037 0.0204 0.1316
Entamoeba histolytica hypothetical protein 0.0019 0.0061 0.0247
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0143 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0139 0.0304
Loa Loa (eye worm) glutaminase 0.0571 0.4375 1
Plasmodium falciparum thioredoxin reductase 0.0405 0.3072 1
Echinococcus multilocularis chromobox protein 2 0.0012 0.0006 0.0009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0923 0.7119 0.8976
Entamoeba histolytica hypothetical protein 0.0038 0.0207 0.0908
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0037 0.0204 0.0636
Trichomonas vaginalis CAMK family protein kinase 0.0146 0.1054 0.2398
Entamoeba histolytica hypothetical protein 0.0019 0.0061 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0204 0.0455
Plasmodium vivax glutathione reductase, putative 0.0405 0.3072 1
Schistosoma mansoni hypothetical protein 0.0038 0.0207 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0061 0.0125
Entamoeba histolytica hypothetical protein 0.0038 0.0207 0.0908
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0006 0.0014
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0232 0.1047
Schistosoma mansoni sulfide quinone reductase 0.0037 0.0204 0.0204
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0006 0.002
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0036 0.0192 0.0439
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0006 0.0006
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0006 0.0014
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0025 0.0107 0.0133
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.014 0.1008 0.3131
Mycobacterium ulcerans flavoprotein disulfide reductase 0.014 0.1008 0.2184
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.014 0.1008 0.3267
Plasmodium vivax DNA topoisomerase II, putative 0.0036 0.0192 0.0606
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0088 0.01
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0037 0.0204 0.0455
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0037 0.0204 0.0455
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0037 0.0204 0.066
Echinococcus multilocularis thioredoxin glutathione reductase 0.0406 0.3084 0.467
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0014
Entamoeba histolytica hypothetical protein 0.0019 0.0061 0.0247
Plasmodium falciparum importin beta, putative 0.003 0.0151 0.0472
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0088 0.0603 0.1785
Brugia malayi Thioredoxin reductase 0.0405 0.3072 0.7022
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0006 0.0014
Chlamydia trachomatis DNA gyrase subunit B 0.01 0.0696 0.545
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.014 0.1008 0.3131
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0037 0.0204 0.0644
Trypanosoma cruzi DNA topoisomerase II, putative 0.0025 0.0107 0.0133
Echinococcus granulosus thioredoxin glutathione reductase 0.0406 0.3084 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0061 0.0139
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0061 0.0139
Trypanosoma cruzi NADH dehydrogenase, putative 0.0037 0.0204 0.0455
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0025 0.0107 0.0133
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1026 0.7923 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.014 0.1008 0.3131
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0037 0.0204 0.0318
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0037 0.0204 0.0892
Giardia lamblia DNA topoisomerase II 0.0031 0.0155 0.0408
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0014
Mycobacterium ulcerans dehydrogenase 0.0037 0.0204 0.0318
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0482 0.109
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0014
Entamoeba histolytica DNA topoisomerase II, putative 0.0036 0.0192 0.084
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0088 0.0603 0.1785
Trypanosoma cruzi trypanothione reductase, putative 0.014 0.1008 0.3131
Brugia malayi Pre-SET motif family protein 0.0029 0.0143 0.0328
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0037 0.0204 0.066
Echinococcus multilocularis expressed protein 0.0369 0.2793 0.4229
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0037 0.0204 0.0452
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.014 0.1008 0.3131
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0037 0.0204 0.0892
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0061 0.0139
Schistosoma mansoni sulfide quinone reductase 0.0037 0.0204 0.0204
Trypanosoma brucei trypanothione reductase 0.0405 0.3072 1
Brugia malayi CHD4 protein 0.0012 0.0006 0.0014
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0037 0.0204 0.0465
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0037 0.0204 0.1316
Plasmodium vivax ferrodoxin reductase, putative 0.0037 0.0204 0.0644
Plasmodium vivax SET domain protein, putative 0.0029 0.0143 0.0447
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0061 0.0061
Plasmodium falciparum DNA gyrase subunit B 0.0153 0.1107 0.359
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0151 0.028
Echinococcus granulosus geminin 0.0187 0.1371 0.4447
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0061 0.0061
Brugia malayi RNA, U transporter 1 0.0087 0.059 0.1348
Schistosoma mansoni glutamate synthase 0.0037 0.0204 0.0204
Brugia malayi Importin beta-1 subunit 0.003 0.0151 0.0345
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0006 0.0006
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0006 0.0006
Schistosoma mansoni chromobox protein 0.0012 0.0006 0.0006
Giardia lamblia Glutamate synthase 0.0037 0.0204 0.0636
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.014 0.1008 0.3131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0143 0.0328
Brugia malayi glutamate synthase 0.0037 0.0204 0.0465
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0139
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0061 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0232 0.0517
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0037 0.0204 0.0174
Schistosoma mansoni glutamate synthase 0.0037 0.0204 0.0204
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0088 0.0267
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0037 0.0204 0.0455
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0061 0.0198
Leishmania major trypanothione reductase 0.0405 0.3072 1
Schistosoma mansoni ap endonuclease 0.002 0.0067 0.0067
Onchocerca volvulus 0.0037 0.0204 0.0918
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0088 0.0071
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0061 0.0092
Echinococcus multilocularis importin subunit beta 1 0.003 0.0151 0.0229
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0151 0.0472
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0139
Plasmodium vivax DNA gyrase subunit B, putative 0.0153 0.1107 0.359
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0106 0.0228
Echinococcus granulosus snurportin 1 0.0325 0.2453 0.7954
Loa Loa (eye worm) glutaminase 2 0.0571 0.4375 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0037 0.0204 0.0892
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0061 0.0061
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0482 0.109
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.014 0.1008 0.3131
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0006 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0405 0.3072 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0643 0.2086
Loa Loa (eye worm) hypothetical protein 0.0032 0.0163 0.0373
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.014 0.1008 0.3131
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0204 0.0455
Toxoplasma gondii selenide, water dikinase 0.0037 0.0204 0.0644
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1026 0.7923 1
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.2218 0.5062
Brugia malayi SET domain containing protein 0.0013 0.0015 0.0034
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0006 0.002
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0061 0.0139
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0061 0.0092
Echinococcus granulosus chromobox protein 2 0.0012 0.0006 0.002
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0068 0.0104
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0068 0.0068
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.014 0.1008 0.1198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0143 0.0143
Schistosoma mansoni glutaminase 0.0571 0.4375 0.4375
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0067 0.0274
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0037 0.0204 0.0455
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0037 0.0204 0.0452
Leishmania major NADH dehydrogenase, putative 0.0037 0.0204 0.0455
Schistosoma mansoni chromobox protein 0.0073 0.0482 0.0482
Giardia lamblia Kinase, PLK 0.0295 0.2218 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0139
Echinococcus multilocularis geminin 0.0187 0.1371 0.2077
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0061 0.0092
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.014 0.1008 0.3267
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0068 0.0222
Onchocerca volvulus 0.0012 0.0006 0.0028
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0036 0.0192 0.0866
Mycobacterium ulcerans hypothetical protein 0.0037 0.0204 0.0318
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0006 0.0014
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.014 0.1008 0.3267
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0244
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0037 0.0204 0.0308
Plasmodium falciparum glutathione reductase 0.014 0.1008 0.3267
Echinococcus granulosus chromobox protein 1 0.0073 0.0482 0.1564
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0037 0.0204 0.0308
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0061 0.0092
Plasmodium falciparum thioredoxin reductase 0.014 0.1008 0.3267
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0643 0.0974
Entamoeba histolytica serine/threonine protein kinase, putative 0.0295 0.2218 1
Loa Loa (eye worm) helicase 0.0012 0.0006 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0037 0.0204 0.0452
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.2218 0.5062
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.014 0.1008 0.3267
Trichomonas vaginalis DNA topoisomerase II, putative 0.0036 0.0192 0.0425
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0006 0.0009
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0061 0.0139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0643 0.0643
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0923 0.7119 0.8976
Trichomonas vaginalis CAMK family protein kinase 0.0295 0.2218 0.5062
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0037 0.0204 0.0318
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0061 0.0198
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0037 0.0204 0.0174
Leishmania major hypothetical protein, conserved 0.0037 0.0204 0.0455
Brugia malayi PXA domain containing protein 0.0019 0.0061 0.0139
Mycobacterium ulcerans ferredoxin reductase 0.0037 0.0204 0.0318
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0037 0.0204 0.0455
Mycobacterium ulcerans DNA gyrase subunit B 0.0153 0.1107 0.2414
Brugia malayi serine/threonine-protein kinase plk-2 0.0295 0.2218 0.5069
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0067 0.0101
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0068 0.0156
Trichomonas vaginalis glutathione reductase, putative 0.014 0.1008 0.2292
Trichomonas vaginalis CAMK family protein kinase 0.0146 0.1054 0.2398
Echinococcus granulosus chromobox protein 1 0.0073 0.0482 0.1564
Toxoplasma gondii DNA topoisomerase 2, putative 0.0036 0.0192 0.0606
Entamoeba histolytica disulphide oxidoreductase, putative 0.0037 0.0204 0.0892
Onchocerca volvulus 0.0032 0.0163 0.0736
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0143 0.0143
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0037 0.0204 0.066
Echinococcus granulosus Chromo domain 0.0012 0.0006 0.002
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0061 0.0198
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0143 0.0447
Brugia malayi hypothetical protein 0.0012 0.0006 0.0014
Mycobacterium ulcerans glutamate synthase subunit beta 0.0037 0.0204 0.0318
Brugia malayi chromobox protein homolog 3 0.0041 0.0232 0.0531
Onchocerca volvulus 0.0041 0.0237 0.1067
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0106 0.0228
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.014 0.1008 0.3131
Entamoeba histolytica Ran family GTPase 0.0022 0.0088 0.037
Mycobacterium tuberculosis Probable dehydrogenase 0.0923 0.7119 0.8976
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0643 0.1471
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0053 0.0324 0.0156
Schistosoma mansoni hypothetical protein 0.0012 0.0006 0.0006
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0037 0.0204 0.0644
Onchocerca volvulus 0.0234 0.1741 0.785
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0061 0.0092
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0006 0.0009
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0037 0.0204 0.0644
Schistosoma mansoni importin beta-1 0.003 0.0151 0.0151
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0067 0.0216
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0037 0.0204 0.0465
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0923 0.7119 0.8976
Trichomonas vaginalis glutaminase, putative 0.0571 0.4375 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0857 0.6605 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0295 0.2218 1
Brugia malayi hypothetical protein 0.0038 0.0207 0.0473
Entamoeba histolytica thioredoxin reductase, putative 0.0037 0.0204 0.0892
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0153 0.1107 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0207 0.0207
Plasmodium vivax importin-beta 2, putative 0.003 0.0151 0.0472
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0037 0.0204 0.0644
Leishmania major dihydrolipoamide dehydrogenase, putative 0.014 0.1008 0.3131
Trypanosoma brucei polo-like protein kinase 0.0295 0.2218 0.7157
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0068 0.0156
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0061 0.0198
Mycobacterium ulcerans glutaminase 0.0571 0.4375 1
Schistosoma mansoni DNA topoisomerase II 0.0036 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0037 0.0204 0.0465
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0036 0.0192 0.0866
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0295 0.2218 0.7157
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0061 0.0198
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0037 0.0204 0.0644
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0295 0.2218 0.5069
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0139
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.014 0.1008 0.2303
Schistosoma mansoni ap endonuclease 0.002 0.0067 0.0067
Schistosoma mansoni glutamate synthase 0.0037 0.0204 0.0204
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0143 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0232 0.0517
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0067 0.0153
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0067 0.0197
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0037 0.0204 0.0455
Leishmania major acetoin dehydrogenase e3 component-like protein 0.014 0.1008 0.3131
Leishmania major importin beta-1 subunit, putative 0.0025 0.0106 0.0131
Giardia lamblia Thioredoxin reductase 0.0037 0.0204 0.0636
Loa Loa (eye worm) glutathione reductase 0.0405 0.3072 0.7022
Echinococcus granulosus Chromobox protein 3 0.0012 0.0006 0.002
Toxoplasma gondii thioredoxin reductase 0.0405 0.3072 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0037 0.0204 0.066
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0067 0.0197
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0037 0.0204 0.0452
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0037 0.0204 0.0318
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0037 0.0204 0.0308
Trichomonas vaginalis apoptosis inducing factor, putative 0.0037 0.0204 0.0452
Schistosoma mansoni hypothetical protein 0.0037 0.0204 0.0204
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0088 0.0071
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0135 0.0437
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0037 0.0204 0.0644
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0207 0.0671
Trichomonas vaginalis glutamate synthase, putative 0.0037 0.0204 0.0452
Echinococcus multilocularis snurportin 1 0.0325 0.2453 0.3714
Leishmania major hypothetical protein, conserved 0.0037 0.0204 0.0455
Entamoeba histolytica hypothetical protein 0.0025 0.0106 0.0451
Schistosoma mansoni hypothetical protein 0.0325 0.2453 0.2453
Leishmania major hypothetical protein, conserved 0.0037 0.0204 0.0455
Toxoplasma gondii exonuclease III APE 0.002 0.0067 0.0197
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0067 0.0139
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0143 0.0465
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0643 0.0643
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.014 0.1008 0.3131
Brugia malayi hypothetical protein 0.0019 0.0061 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0061 0.0125
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0088 0.0201
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0103 0.0717 0.1639
Trypanosoma cruzi polo-like protein kinase, putative 0.0295 0.2218 0.7157
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0037 0.0204 0.0455
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0088 0.0286
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0067 0.0139
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0151 0.028
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0036 0.0192 0.0866
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.014 0.1008 0.3131
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0037 0.0204 0.0455
Chlamydia trachomatis DNA gyrase subunit B 0.0153 0.1107 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0139 0.0304
Trichomonas vaginalis mercuric reductase, putative 0.014 0.1008 0.2292
Schistosoma mansoni ran 0.0022 0.0088 0.0088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1519 0.3472
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0037 0.0204 0.0308
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0014
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0482 0.1103
Echinococcus multilocularis Chromo domain 0.0012 0.0006 0.0009
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0061 0.0092
Trypanosoma brucei DNA topoisomerase ii 0.0088 0.0603 0.1785
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0037 0.0204 0.0455
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.014 0.1008 0.3131
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0256 0.0573
Echinococcus granulosus glutamate synthase 0.0037 0.0204 0.066
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0068 0.0068
Trypanosoma cruzi NADH dehydrogenase, putative 0.0037 0.0204 0.0455
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0061 0.0092
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0106 0.0131

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of Escherichia coli K-12 DNA sulA expressed in Escherichia coli DC2 assessed as compound concentration required for => 4-fold induction of luxCDABE operon by reported gene assay ChEMBL. 18347114
Activity (binding) > 100 uM Inhibition of Escherichia coli K-12 DNA gyrase A expressed in Escherichia coli DC2 assessed as compound concentration required for => 4-fold induction of luxCDABE operon by reported gene assay ChEMBL. 18347114
IC50 (binding) = 120 nM Inhibition of Escherichia coli JM109 DNA gyrase subunit B assessed as DNA triple helix formation by supercoiling assay ChEMBL. 18347114
IC50 (binding) = 229 nM Inhibition of Escherichia coli JM109 DNA gyrase subunit B assessed as ATP hydrolysis by ATPase assay ChEMBL. 18347114
MIC (functional) > 32 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method ChEMBL. 18347114
MIC (functional) > 32 ug ml-1 Antibacterial activity against Escherichia coli UB1005 by broth microdilution method ChEMBL. 18347114
MIC (functional) > 32 ug ml-1 Antibacterial activity against Escherichia coli DC2 by broth microdilution method ChEMBL. 18347114
Ratio IC50 (binding) = 1.9 Ratio of IC50 for Escherichia coli JM109 DNA gyrase subunit B by ATPase assay to IC50 for Escherichia coli JM109 DNA gyrase subunit B by supercoiling assay ChEMBL. 18347114

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.