Detailed information for compound 1192165

Basic information

Technical information
  • TDR Targets ID: 1192165
  • Name: 5-chloro-N-(3-methylphenyl)-2-methylsulfonylp yrimidine-4-carboxamide
  • MW: 325.771 | Formula: C13H12ClN3O3S
  • H donors: 1 H acceptors: 5 LogP: 1.93 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)NC(=O)c1nc(ncc1Cl)S(=O)(=O)C
  • InChi: 1S/C13H12ClN3O3S/c1-8-4-3-5-9(6-8)16-12(18)11-10(14)7-15-13(17-11)21(2,19)20/h3-7H,1-2H3,(H,16,18)
  • InChiKey: VOSYOZRKGURHJY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-N-(3-methylphenyl)-2-methylsulfonyl-pyrimidine-4-carboxamide
  • 5-chloro-N-(3-methylphenyl)-2-methylsulfonyl-4-pyrimidinecarboxamide
  • 5-chloro-2-mesyl-N-(3-methylphenyl)pyrimidine-4-carboxamide
  • ZINC04840662
  • D053-0002
  • NCGC00141441-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum thioredoxin reductase 0.0036 0.0654 0.1025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0709 0.0672
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.125 0.4264
Brugia malayi MH2 domain containing protein 0.0144 0.4119 0.5439
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0654 0.2059
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.125 0.1613
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.125 0.4397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.125 0.1347
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.2106 0.2075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0895 0.0932
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.125 0.1657
Plasmodium falciparum thioredoxin reductase 0.0103 0.2798 1
Echinococcus granulosus GPCR family 2 0.0016 0.004 0.0073
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.004 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0451 0.0413
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0337 0.0883
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0557 0.0739
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0709 0.0715
Onchocerca volvulus 0.0037 0.0709 0.0188
Mycobacterium tuberculosis Probable reductase 0.0234 0.7001 0.8837
Echinococcus granulosus tar DNA binding protein 0.0076 0.1959 0.6932
Brugia malayi beta-lactamase family protein 0.0037 0.0709 0.0893
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0654 0.082
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.125 0.4264
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.2106 0.2285
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1959 0.1927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0451 0.0413
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0654 0.2059
Onchocerca volvulus 0.0286 0.8648 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.004 0.0073
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0709 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0453 0.0415
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1959 0.2598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0552 0.0531
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0709 0.1256
Loa Loa (eye worm) hypothetical protein 0.0032 0.0538 0.0713
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0654 0.227
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0654 0.2059
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1168 0.1549
Brugia malayi Probable ClpP-like protease 0.0081 0.2106 0.2755
Trypanosoma brucei trypanothione reductase 0.0103 0.2798 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0709 0.0077
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0668 0.2319
Treponema pallidum NADH oxidase 0.0036 0.0654 0.1444
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0098 0.0059
Schistosoma mansoni hypothetical protein 0.0037 0.0708 0.0672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0542 0.0519
Loa Loa (eye worm) RNA binding protein 0.0076 0.1959 0.2598
Schistosoma mansoni lamin 0.0033 0.0557 0.0519
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0654 0.2059
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.2798 0.2985
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.2106 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0709 0.0077
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0654 0.2059
Plasmodium falciparum glutathione reductase 0.0036 0.0654 0.1025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0709 0.0941
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0709 0.0672
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.1214 0.4271
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1959 0.2598
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0668 0.0631
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0074 0.0098
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0668 0.2319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0451 0.0413
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0654 0.2059
Plasmodium vivax glutathione reductase, putative 0.0103 0.2798 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0806 0.0827
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0709 0.0077
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0654 0.1025
Brugia malayi Pre-SET motif family protein 0.0251 0.754 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.125 0.4264
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.2798 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.125 0.4264
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0654 0.2059
Brugia malayi glutathione reductase 0.0103 0.2798 0.3678
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.125 0.4264
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0654 0.2059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0542 0.0519
Brugia malayi RNA binding protein 0.0076 0.1959 0.2559
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0806 0.0827
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0654 0.2059
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.2106 0.7458
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0098 0.013
Leishmania major trypanothione reductase 0.0103 0.2798 1
Giardia lamblia GTOR 0.0054 0.125 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.1214 0.078
Mycobacterium tuberculosis Conserved protein 0.0037 0.0709 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0996 0.105
Loa Loa (eye worm) hypothetical protein 0.0037 0.0709 0.0941
Echinococcus multilocularis musashi 0.0033 0.0557 0.1922
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1959 0.1927
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0654 0.2059
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0806 0.0827
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0654 0.2059
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0806 0.0827
Echinococcus multilocularis lamin dm0 0.0033 0.0557 0.1922
Brugia malayi hypothetical protein 0.0037 0.0708 0.0892
Loa Loa (eye worm) hypothetical protein 0.0037 0.0709 0.0941
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.2106 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.7001 0.8837
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0709 0.2263
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.004 0.0073
Echinococcus multilocularis lamin 0.0033 0.0557 0.1922
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.7837 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0708 0.0672
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0098 0.0283
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0025
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.2106 0.7103
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0897 0.2957
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0709 0.0893
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0642 0.0636
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0708 0.2463
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.2106 0.7103
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0654 0.2059
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1959 0.1927
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0074 0.0046
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0654 0.2059
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.1214 0.4271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0453 0.0415
Loa Loa (eye worm) glutathione reductase 0.0103 0.2798 0.3711
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.7001 0.8837
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0352 0.0417
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.754 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1168 0.1504
Schistosoma mansoni intermediate filament proteins 0.0033 0.0557 0.0519
Brugia malayi Thioredoxin reductase 0.0103 0.2798 0.3678
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.125 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0806 0.0827
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0352 0.0417
Toxoplasma gondii ABC1 family protein 0.0037 0.0709 0.1256
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1959 0.1927
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0654 0.1025
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0709 0.0077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0709 0.0941
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0668 0.0631
Mycobacterium ulcerans beta-lactamase 0.0037 0.0709 0.0379
Mycobacterium tuberculosis Conserved protein 0.0037 0.0709 0.0077
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0709 0.0077
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4119 0.5463
Schistosoma mansoni hypothetical protein 0.0035 0.0646 0.0608
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.125 0.4397
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0654 0.1025
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.004 0.0073
Schistosoma mansoni lamin 0.0033 0.0557 0.0519
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0557 0.0739
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.7001 0.8837
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0646 0.0808
Loa Loa (eye worm) hypothetical protein 0.0037 0.0709 0.0941
Onchocerca volvulus 0.0036 0.0668 0.0137
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.7837 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0654 0.2059
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.2106 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.1214 0.078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0453 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0453 0.0415
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0237 0.0513
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0654 0.2059
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0709 0.0077
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.004 0.0073
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0654 0.1025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0895 0.0932
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.2798 0.3711
Mycobacterium leprae Probable lipase LipE 0.0037 0.0709 0.0404
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0654 0.2059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0895 0.0932
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0709 0.0379
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.7837 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0897 0.2957
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0654 0.0617
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0709 0.0715
Loa Loa (eye worm) hypothetical protein 0.0037 0.0709 0.0941
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1959 0.1927
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1168 0.1504
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.7001 0.8837
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.7133 0.902
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0709 0.0379
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1959 0.6932
Loa Loa (eye worm) hypothetical protein 0.0033 0.0557 0.0739
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0654 0.1025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0626 0.2168
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0709 0.0404
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.2818 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0668 0.0631
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.7001 0.8876
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.2798 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0654 0.2059
Trichomonas vaginalis set domain proteins, putative 0.0286 0.8648 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0806 0.166
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0897 0.2957
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0895 0.0932
Leishmania major hypothetical protein, conserved 0.0037 0.0709 0.2263
Loa Loa (eye worm) hypothetical protein 0.0035 0.0646 0.0856
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0709 0.2263
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0557 0.069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0552 0.0531
Onchocerca volvulus 0.0037 0.0709 0.0188
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0668 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0552 0.0531
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0654 0.227
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.125 0.4264
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0709 0.2263
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.7837 1
Trichomonas vaginalis esterase, putative 0.0037 0.0709 0.0715
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.2106 0.7103
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.125 1
Brugia malayi beta-lactamase family protein 0.0037 0.0709 0.0893
Loa Loa (eye worm) hypothetical protein 0.0081 0.2106 0.2793
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0709 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0679 0.068
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.7001 0.8837
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0709 0.0715
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0654 0.065
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0668 0.1083
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.125 0.1215
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.2106 0.7458
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0806 0.0827
Mycobacterium ulcerans hypothetical protein 0.0037 0.0709 0.0379
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0709 0.0715
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.1214 0.1084
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.2106 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.2106 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1959 0.2559
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.2818 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0708 0.2463
Plasmodium vivax SET domain protein, putative 0.0036 0.0668 0.1083
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0098 0.0283
Echinococcus granulosus lamin 0.0033 0.0557 0.1922
Echinococcus granulosus intermediate filament protein 0.0033 0.0557 0.1922
Loa Loa (eye worm) hypothetical protein 0.0052 0.1168 0.1549
Loa Loa (eye worm) hypothetical protein 0.0037 0.0709 0.0941
Mycobacterium ulcerans lipase LipD 0.0037 0.0709 0.0379
Mycobacterium tuberculosis Conserved protein 0.0037 0.0709 0.0077
Brugia malayi intermediate filament protein 0.0033 0.0557 0.069
Echinococcus granulosus lamin dm0 0.0033 0.0557 0.1922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0895 0.0932
Loa Loa (eye worm) hypothetical protein 0.0036 0.0668 0.0886
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0098 0.0078
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.2106 0.7103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0668 0.2319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.125 0.1347
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0709 0.2466
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0806 0.0827
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4119 0.5463
Brugia malayi Pre-SET motif family protein 0.0036 0.0668 0.0838
Brugia malayi beta-lactamase 0.0037 0.0709 0.0893
Onchocerca volvulus 0.0037 0.0709 0.0188
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0654 0.065
Brugia malayi TAR-binding protein 0.0076 0.1959 0.2559
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.2106 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0709 0.0941
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0654 0.1025
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0709 0.2466
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.125 0.1347
Plasmodium falciparum glutathione reductase 0.0103 0.2798 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.004 0.0073
Toxoplasma gondii thioredoxin reductase 0.0103 0.2798 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.004 0.0052

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.6482 uM PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in WT MEF Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0749 uM PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6122 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 3.2885 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 5.2119 uM PubChem BioAssay. InCell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in WT MEF Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2119 uM PubChem BioAssay. InCell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 70.7946 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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