Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.1169 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.1169 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0897 | 0.0897 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.017 | 1 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0038 | 0.1169 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1978 | 0.1438 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.1169 | 0.0299 |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0.1169 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0719 | 0.0719 |
Schistosoma mansoni | alpha-glucosidase | 0.0146 | 0.8419 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.1169 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.1169 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1978 | 0.1188 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1169 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3259 | 0.314 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.017 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.575 | 0.575 |
Onchocerca volvulus | 0.0098 | 0.5215 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.3259 | 0.2595 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.575 | 0.575 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.3504 | 0.3465 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0038 | 0.1169 | 0.5 |
Brugia malayi | RNA binding protein | 0.0069 | 0.3259 | 0.3259 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.1169 | 0.1169 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.3504 | 0.3504 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0897 | 0.0897 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3259 | 0.314 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.1169 | 0.1169 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.3259 | 0.3259 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1169 | 0.5 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0.1169 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1978 | 0.1188 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.3259 | 0.3259 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1169 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1169 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3259 | 0.314 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.575 | 0.575 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.1978 | 0.1978 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1978 | 0.1438 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1169 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1169 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1169 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.7337 | 0.7337 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.7337 | 0.7337 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.7337 | 0.7337 |
Schistosoma mansoni | alpha-glucosidase | 0.0146 | 0.8419 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.017 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.3259 | 0.3259 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.1978 | 0.1438 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.1169 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0897 | 0.0897 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.575 | 0.575 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.1169 | 0.0362 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.1978 | 0.1188 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.1978 | 0.1188 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.3259 | 0.2595 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.1169 | 0.0299 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.1978 | 0.1978 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.017 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.3504 | 0.3504 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0897 | 0.0897 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3259 | 0.314 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.3259 | 0.3259 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0719 | 0.0719 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3259 | 0.314 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.3259 | 0.3259 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 17.2 ug ml-1 | Antiproliferative activity against human HCT116 cells after 24 hrs by MTS assay | ChEMBL. | 20813435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.