Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Serratia marcescens | Chitinase A | Starlite/ChEMBL | References |
Serratia marcescens | Chitinase B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0101 | 0 | 0.5 |
Loa Loa (eye worm) | chitinase I | 0.0182 | 0.0449 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.1436 | 0.1436 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.1901 | 1 | 1 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0134 | 0.0185 | 0.1288 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.1901 | 1 | 1 |
Trypanosoma brucei | Emopamil binding protein, putative | 0.0134 | 0.0185 | 0.1288 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0234 | 0.0737 | 0.0737 |
Brugia malayi | Endochitinase | 0.0182 | 0.0449 | 0.1046 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.03 | 0.03 |
Leishmania major | hypothetical protein, conserved | 0.0134 | 0.0185 | 0.1288 |
Onchocerca volvulus | Putative endochitinase | 0.0182 | 0.0449 | 1 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0134 | 0.0185 | 0.1288 |
Echinococcus multilocularis | geminin | 0.0167 | 0.0369 | 0.0369 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0101 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0101 | 0 | 0.5 |
Entamoeba histolytica | chitinase, putative | 0.0182 | 0.0449 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0182 | 0.0449 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0182 | 0.0449 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.0737 | 0.0737 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0155 | 0.03 | 1 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0134 | 0.0185 | 0.1288 |
Onchocerca volvulus | 0.0134 | 0.0185 | 0.4116 | |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0359 | 0.1436 | 0.3344 |
Brugia malayi | endochitinase | 0.0182 | 0.0449 | 0.1046 |
Leishmania major | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.0134 | 0.0185 | 0.1288 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0155 | 0.03 | 0.03 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0155 | 0.03 | 1 |
Brugia malayi | endochitinase | 0.0182 | 0.0449 | 0.1046 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0182 | 0.0449 | 0.0449 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0101 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0359 | 0.1436 | 1 |
Toxoplasma gondii | aminopeptidase N protein | 0.0101 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0167 | 0.0369 | 0.0369 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0101 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0874 | 0.4294 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0359 | 0.1436 | 1 |
Brugia malayi | hypothetical protein | 0.0234 | 0.0737 | 0.1717 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0101 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible chitinase | 0.0155 | 0.03 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.1901 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.046 | 0.046 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0359 | 0.1436 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0182 | 0.0449 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0234 | 0.0737 | 0.0737 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0369 | 0.0369 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.0369 | 0.0369 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.0134 | 0.0185 | 0.1288 |
Leishmania major | chitinase | 0.0182 | 0.0449 | 0.3129 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0101 | 0 | 0.5 |
Onchocerca volvulus | Putative endochitinase | 0.0182 | 0.0449 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.025 uM | Displacement of 4-methylumbelliferydiacetyl-chitobiose from Serratia marcescens ChiA | ChEMBL. | 19297173 |
IC50 (binding) | = 0.091 uM | Displacement of 4-methylumbelliferydiacetyl-chitobiose from Serratia marcescens ChiB | ChEMBL. | 19297173 |
IC50 (binding) | > 30 uM | Displacement of 4-methylumbelliferydiacetyl-chitobiose from Serratia marcescens ChiC | ChEMBL. | 19297173 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.