TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 314.331 | Formula: C17H11FO3S
H donors: 2 H acceptors: 3 LogP: 4.33 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cccc(c1)C(=O)c1ccc(s1)c1ccc(c(c1)O)F
InChi: 1S/C17H11FO3S/c18-13-5-4-10(9-14(13)20)15-6-7-16(22-15)17(21)11-2-1-3-12(19)8-11/h1-9,19-20H
InChiKey: KRNODWSUZPVKGS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	hydroxysteroid (17-beta) dehydrogenase 1	Starlite/ChEMBL	References
Homo sapiens	hydroxysteroid (17-beta) dehydrogenase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	hydroxysteroid (17-beta) dehydrogenase 2	387 aa	359 aa	24.8 %
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	hydroxysteroid (17-beta) dehydrogenase 1	328 aa	265 aa	27.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0009	0.1215	0.5
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0005	0.0179	0.0179
Schistosoma mansoni	ap endonuclease	0.002	0.3733	0.3619
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.3733	1
Loa Loa (eye worm)	oxidoreductase	0.0009	0.1215	0.1215
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0009	0.1215	0.5
Echinococcus multilocularis	lamin	0.0027	0.5493	0.5411
Echinococcus multilocularis	lamin dm0	0.0027	0.5493	0.5411
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0005	0.0179	0.0179
Loa Loa (eye worm)	oxidoreductase	0.0009	0.1215	0.1215
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.3733	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.2143	0.2143
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.1215	0.3254
Entamoeba histolytica	hypothetical protein	0.0037	0.7656	1
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Onchocerca volvulus		0.0009	0.1215	0.1949
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0027	0.5375	0.5375
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1215	0.1215
Loa Loa (eye worm)	oxidoreductase	0.0009	0.1215	0.1215
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0009	0.1215	0.1215
Entamoeba histolytica	hypothetical protein	0.0037	0.7656	1
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0009	0.1215	0.1055
Schistosoma mansoni	carbonyl reductase	0.0009	0.1215	0.1055
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.1215	0.1055
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	1	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.2143	0.2
Brugia malayi	Low-density lipoprotein receptor-related protein, putative	0.0005	0.0179	0.0179
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.3733	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.1215	0.1055
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.1215	0.1055
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.3733	1
Echinococcus multilocularis	musashi	0.0027	0.5493	0.5411
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	1	1
Entamoeba histolytica	hypothetical protein	0.0037	0.7656	1
Brugia malayi	Retinol dehydrogenase 12	0.0009	0.1215	0.1215
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0005	0.0179	0.0179
Loa Loa (eye worm)	oxidoreductase	0.0009	0.1215	0.1215
Echinococcus multilocularis	transient receptor potential cation channel	0.0009	0.1215	0.1055
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.1215	0.1055
Schistosoma mansoni	carbonyl reductase	0.0009	0.1215	0.1055
Brugia malayi	Calcium binding EGF domain containing protein	0.0005	0.0179	0.0179
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0009	0.1215	0.1215
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.3733	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0009	0.1215	0.3254
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.1215	0.1055
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.7656	0.7613
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.1215	0.1055
Onchocerca volvulus		0.0009	0.1215	0.1949
Loa Loa (eye worm)	oxidoreductase	0.0009	0.1215	0.1215
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Onchocerca volvulus		0.0009	0.1215	0.1949
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Loa Loa (eye worm)	dehydrogenase	0.0009	0.1215	0.1215
Brugia malayi	oxidoreductase	0.0009	0.1215	0.1215
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0009	0.1215	0.1949
Echinococcus granulosus	retinol dehydrogenase 11	0.0009	0.1215	0.1055
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0009	0.1215	0.1055
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.1215	0.3254
Onchocerca volvulus		0.0009	0.1215	0.1949
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0005	0.0179	0.0179
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.1215	0.1055
Onchocerca volvulus		0.0009	0.1215	0.1949
Onchocerca volvulus		0.0009	0.1215	0.1949
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.2487	0.2487
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Schistosoma mansoni	carbonyl reductase	0.0009	0.1215	0.1055
Toxoplasma gondii	exonuclease III APE	0.002	0.3733	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.1215	0.3254
Echinococcus multilocularis	steroid dehydrogenase	0.0009	0.1215	0.1055
Schistosoma mansoni	retinal dehydrogenase	0.0009	0.1215	0.1055
Schistosoma mansoni	ap endonuclease	0.002	0.3733	0.3619
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.3733	1
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0005	0.0179	0.0179
Onchocerca volvulus		0.0009	0.1215	0.1949
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0009	0.1215	0.1055
Brugia malayi	hypothetical protein	0.0037	0.7656	0.7656
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.3733	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	1	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.3733	0.3619
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0005	0.0179	0.0179
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0009	0.1215	0.1215
Onchocerca volvulus		0.0009	0.1215	0.1949
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0009	0.1215	0.3254
Onchocerca volvulus	Sepiapterin reductase homolog	0.0009	0.1215	0.1949
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.3733	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0009	0.1215	0.3254
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0009	0.1215	0.1949
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.1215	0.1055
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0009	0.1215	0.1055
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.1215	0.1055
Brugia malayi	hypothetical protein	0.0009	0.1215	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0027	0.5493	0.5493
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.1215	0.1055
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	1	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.3733	0.3619
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0013	0.2025	0.2025
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.1215	0.3254
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1215	0.1215
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.2143	0.2
Echinococcus multilocularis	retinol dehydrogenase 11	0.0009	0.1215	0.1055
Echinococcus multilocularis	retinol dehydrogenase 13	0.0009	0.1215	0.1055
Echinococcus multilocularis	retinol dehydrogenase 11	0.0009	0.1215	0.1055
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.1215	0.1055
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0009	0.1215	0.1055
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.5493	0.5493
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1215	0.1215
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0005	0.0179	0.0179
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.3733	0.3733
Schistosoma mansoni	intermediate filament proteins	0.0027	0.5493	0.5411
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	1	1
Brugia malayi	Dehydrogenases, short chain protein 2	0.0009	0.1215	0.1215
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.7656	0.7613
Onchocerca volvulus		0.0027	0.5493	1
Echinococcus multilocularis	conserved hypothetical protein	0.0009	0.1215	0.1055
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.3733	0.391
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Brugia malayi	enteropeptidase precursor	0.0005	0.0179	0.0179
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.1215	0.3254
Echinococcus multilocularis	carbonyl reductase 1	0.0009	0.1215	0.1055
Onchocerca volvulus		0.0009	0.1215	0.1949
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.2487	0.2487
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0009	0.1215	0.3254
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	1	1
Brugia malayi	dehydrogenases, short chain protein 2	0.0009	0.1215	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1215	0.1215
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0009	0.1215	0.1055
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.1215	0.3254
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0009	0.1215	0.5
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.3733	0.3733
Echinococcus granulosus	hypothetical protein	0.0009	0.1215	0.1055
Schistosoma mansoni	hypothetical protein	0.0037	0.7656	0.7613
Echinococcus granulosus	WW domain containing oxidoreductase	0.0009	0.1215	0.1055
Mycobacterium leprae	Probable oxidoreductase	0.0009	0.1215	0.5
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0009	0.1215	0.1055
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0009	0.1215	0.1215
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.1215	0.1055
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.7656	0.7613
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0009	0.1215	0.1055
Brugia malayi	CUB domain containing protein	0.0005	0.0179	0.0179
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.3733	1
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.1215	0.1055
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.3733	1
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0005	0.0179	0.0179
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	1	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.1215	0.3254
Onchocerca volvulus		0.0009	0.1215	0.1949
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Echinococcus granulosus	steroid dehydrogenase	0.0009	0.1215	0.1055
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0009	0.1215	0.1055
Onchocerca volvulus		0.0027	0.5493	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Brugia malayi	intermediate filament protein	0.0027	0.5493	0.5493
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.5493	0.5493
Entamoeba histolytica	hypothetical protein	0.0037	0.7656	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Onchocerca volvulus		0.0009	0.1215	0.1949
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.1215	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1215	0.1215
Echinococcus granulosus	oxidoreductase	0.0009	0.1215	0.1055
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Brugia malayi	hypothetical protein	0.0009	0.1215	0.1215
Echinococcus granulosus	hypothetical protein	0.0009	0.1215	0.1055
Echinococcus granulosus	lamin	0.0027	0.5493	0.5411
Onchocerca volvulus		0.0009	0.1215	0.1949
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0009	0.1215	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1215	0.1215
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0009	0.1215	0.5
Brugia malayi	basement membrane proteoglycan precursor	0.0005	0.0179	0.0179
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.1215	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1215	0.1215
Brugia malayi	dehydrogenases, short chain protein 9	0.0009	0.1215	0.1215
Echinococcus granulosus	lamin dm0	0.0027	0.5493	0.5411
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.3733	1
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Loa Loa (eye worm)	dehydrogenase	0.0009	0.1215	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Echinococcus multilocularis	steroid dehydrogenase	0.0009	0.1215	0.1055
Schistosoma mansoni	lamin	0.0027	0.5493	0.5411
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0009	0.1215	0.1055
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0005	0.0179	0.0179
Echinococcus multilocularis	oxidoreductase	0.0009	0.1215	0.1055
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	1	1
Loa Loa (eye worm)	oxidoreductase	0.0009	0.1215	0.1215
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.3733	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0005	0.0179	0.0179
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.5493	0.5493
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0009	0.1215	0.5
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1215	0.1215
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.3733	1
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0009	0.1215	0.1055
Echinococcus granulosus	carbonyl reductase 1	0.0009	0.1215	0.1055
Loa Loa (eye worm)	calcium binding EGF domain-containing protein	0.0005	0.0179	0.0179
Loa Loa (eye worm)	oxidoreductase	0.0009	0.1215	0.1215
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0005	0.0179	0.0179
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1215	0.1215
Echinococcus granulosus	intermediate filament protein	0.0027	0.5493	0.5411
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0009	0.1215	0.1055
Loa Loa (eye worm)	oxidoreductase	0.0009	0.1215	0.1215
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0005	0.0179	0.0179
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0009	0.1215	0.1949
Echinococcus granulosus	retinol dehydrogenase 11	0.0009	0.1215	0.1055
Schistosoma mansoni	lamin	0.0027	0.5493	0.5411
Onchocerca volvulus		0.0009	0.1215	0.1949
Schistosoma mansoni	steroid dehydrogenase	0.0009	0.1215	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0013	0.2025	0.2025
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0009	0.1215	0.3254
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0009	0.1215	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1215	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0179	0.0179
Loa Loa (eye worm)	oxidoreductase	0.0009	0.1215	0.1215
Brugia malayi	Dehydrogenases, short chain protein 30	0.0009	0.1215	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0009	0.1215	0.1215
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055
Schistosoma mansoni	short chain dehydrogenase	0.0009	0.1215	0.1055

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Displacement of [2,4,6,7-3H]-17beta-estradiol from ERbeta after 1 hr relative to estradiol	ChEMBL.	20977238
Activity (binding)		Displacement of [2,4,6,7-3H]-17beta-estradiol from ERalpha after 1 hr relative to estradiol	ChEMBL.	20977238
IC50 (binding)	= 30 nM	Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 mins	ChEMBL.	20977238
IC50 (binding)	= 57 nM	Inhibition of human placenta 17beta-HSD2 using [2,4,6,7-3H]-17beta-estradiol as substrate after 10 mins	ChEMBL.	20977238

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1277616

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1193226