Detailed information for compound 1193259

Basic information

Technical information
  • TDR Targets ID: 1193259
  • Name: 4-(4-methylpiperazin-1-yl)-2-phenylquinazolin e
  • MW: 304.389 | Formula: C19H20N4
  • H donors: 0 H acceptors: 2 LogP: 3.47 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)c1nc(nc2c1cccc2)c1ccccc1
  • InChi: 1S/C19H20N4/c1-22-11-13-23(14-12-22)19-16-9-5-6-10-17(16)20-18(21-19)15-7-3-2-4-8-15/h2-10H,11-14H2,1H3
  • InChiKey: ISTAMDOKBVHVBX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-methylpiperazin-1-yl)-2-phenyl-quinazoline
  • 4-(4-Methyl-1-piperazinyl)-2-phenylquinazoline
  • Oprea1_092773
  • Oprea1_307454
  • AIDS-005047
  • AIDS005047
  • Quinazoline 2Ph4(4MePiperaz)
  • ST5439669
  • EU-0077669
  • 4-(4-Methyl-piperazin-1-yl)-2-phenyl-quinazoline
  • BAS 03309832

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA binding protein 0.0455 0.4 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0201
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0958 0.4163
Trichomonas vaginalis penicillin-binding protein, putative 0.0061 0.0484 0.2105
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0076 0.0726
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0015 0.0076 0.0332
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.0484 0.2105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.2301 1
Schistosoma mansoni hypothetical protein 0.0205 0.1765 0.3487
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0399 0.039
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0129 0.1094 1
Schistosoma mansoni tar DNA-binding protein 0.0455 0.4 0.792
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0399 0.039
Echinococcus granulosus tar DNA binding protein 0.0455 0.4 0.3994
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0086 0.0201
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0774 0.1521
Onchocerca volvulus 0.0008 0.001 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.0484 0.2105
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0086 0.0157
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0048 0.0011
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0086 0.0077
Brugia malayi Intermediate filament tail domain containing protein 0.0043 0.0328 0.0806
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0012 0.0048 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0958 0.4163
Trichomonas vaginalis inositol monophosphatase, putative 0.0033 0.0239 0.1039
Schistosoma mansoni hypothetical protein 0.0171 0.1469 0.29
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0958 0.1885
Mycobacterium tuberculosis Probable hydrolase 0.0061 0.0484 0.1344
Trichomonas vaginalis 1-phosphatidylinositol phosphodiesterase, putative 0.0007 0.0007 0.0032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0086 0.0077
Onchocerca volvulus 0.0012 0.0048 0.0198
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0462 0.0453
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0213 0.0203
Echinococcus granulosus microtubule associated protein 2 0.0573 0.5048 0.5043
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0475 0.0466
Echinococcus granulosus dna polymerase kappa 0.0015 0.0076 0.0067
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0021 0.0132 0.0303
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0076 0.0131
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0061 0.0484 0.4179
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0076 0.0726
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0774 0.0765
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0086 0.0201
Trypanosoma brucei unspecified product 0.001 0.0034 0.0283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.2301 1
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0086 0.0201
Loa Loa (eye worm) inositol-1 0.0033 0.0239 0.0583
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0076 0.0726
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0076 0.0726
Loa Loa (eye worm) hypothetical protein 0.0058 0.0462 0.1142
Schistosoma mansoni inositol monophosphatase 0.0033 0.0239 0.046
Entamoeba histolytica acyl-coA synthetase, putative 0.0041 0.0306 0.1149
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0475 0.0466
Echinococcus multilocularis dna polymerase kappa 0.0015 0.0076 0.0067
Loa Loa (eye worm) hypothetical protein 0.0251 0.2177 0.5435
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0648 0.0639
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0047 0.0037
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0008 0.001 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0086 0.0201
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0048 0.0105
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0648 0.0639
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0129 0.1094 1
Brugia malayi jmjC domain containing protein 0.0016 0.0083 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0086 0.0201
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0008 0.001 0.0011
Mycobacterium leprae conserved hypothetical protein 0.0061 0.0484 0.4172
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0018 0.0029
Brugia malayi Pre-SET motif family protein 0.003 0.0213 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0086 0.0201
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0076 0.0067
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0265 0.2301 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0648 0.1608
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.049 0.0957
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0019 0.0108 0.1062
Onchocerca volvulus 0.0041 0.0306 0.1455
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0029
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.0306 0.2473
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.003 0.0208 0.0527
Loa Loa (eye worm) hypothetical protein 0.0061 0.0484 0.1197
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.003 0.0208 0.1529
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0444 0.1931
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0023 0.0148 0.0356
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0306 0.2473
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0021 0.0128 0.0118
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.0048 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0083 0.0193
Echinococcus multilocularis tumor protein p63 0.1128 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0504 0.0985
Schistosoma mansoni hypothetical protein 0.0044 0.033 0.0641
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0012 0.0048 0.0013
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0041 0.0306 0.2473
Schistosoma mansoni ferritin 0.0021 0.0132 0.0247
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0086 0.0077
Echinococcus multilocularis tar DNA binding protein 0.0455 0.4 0.3994
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0018 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0018 0.0029
Schistosoma mansoni inositol monophosphatase 0.0033 0.0239 0.046
Loa Loa (eye worm) hypothetical protein 0.0031 0.0214 0.0519
Mycobacterium ulcerans esterase/lipase LipP 0.0061 0.0484 0.4179
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.0484 0.5018
Echinococcus granulosus geminin 0.0205 0.1765 0.1757
Schistosoma mansoni nuclear hormone receptor 0.0008 0.001 0.0004
Schistosoma mansoni lamin 0.0043 0.0328 0.0636
Loa Loa (eye worm) beta-lactamase 0.0061 0.0484 0.1197
Brugia malayi hypothetical protein 0.0009 0.0018 0.0029
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0018 0.0029
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0774 0.1922
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0086 0.0201
Loa Loa (eye worm) TAR-binding protein 0.0455 0.4 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0076 0.0726
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0086 0.0157
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0083 0.0074
Loa Loa (eye worm) hypothetical protein 0.0031 0.0214 0.0519
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0083 0.0074
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0958 1
Brugia malayi intermediate filament protein 0.0043 0.0328 0.0806
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.2301 1
Brugia malayi tailless protein 0.0008 0.001 0.0008
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0108 0.0256
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0076 0.0324
Echinococcus multilocularis lamin 0.0043 0.0328 0.0319
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1802 0.4497
Brugia malayi jmjC domain containing protein 0.0062 0.049 0.1211
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0239 0.2438
Echinococcus granulosus intermediate filament protein 0.0043 0.0328 0.0319
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0048 0.0105
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.0484 0.2105
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0012 0.0047 0.0415
Loa Loa (eye worm) hypothetical protein 0.002 0.0121 0.0287
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0018 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0958 0.4163
Trypanosoma brucei polo-like protein kinase 0.0114 0.0958 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0012 0.0048 0.0011
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0462 0.0453
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0012 0.0048 0.0055
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.0788
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0012 0.0048 0.0011
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0083 0.0833
Loa Loa (eye worm) hypothetical protein 0.0165 0.1413 0.3523
Echinococcus granulosus survival motor neuron protein 1 0.0214 0.185 0.1843
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0086 0.0077
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0033 0.0239 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0774 0.0765
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Giardia lamblia Kinase, PLK 0.0114 0.0958 0.4044
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0033 0.0239 0.4395
Brugia malayi CXXC zinc finger family protein 0.0029 0.0202 0.0489
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0958 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0031 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0306 0.075
Loa Loa (eye worm) hypothetical protein 0.0043 0.0328 0.0806
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0086 0.0077
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0086 0.0386
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0021 0.0128 0.0118
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0086 0.0157
Loa Loa (eye worm) ABC transporter 0.001 0.0031 0.0061
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0061 0.0484 0.1197
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0011 0.0042 0.0068
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0021 0.0132 0.0303
Echinococcus granulosus phd:f box containing protein 0.0016 0.0083 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0105
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0239 0.2438
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0086 0.0157
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0013 0.0059 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0958 0.4163
Loa Loa (eye worm) DR-78 0.0008 0.001 0.0008
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0047 0.0037
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0083 0.0074
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0015 0.0076 0.0726
Schistosoma mansoni cellular tumor antigen P53 0.0165 0.1413 0.2789
Echinococcus multilocularis expressed protein 0.0021 0.0132 0.0123
Echinococcus multilocularis cpg binding protein 0.0031 0.0217 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0086 0.0201
Entamoeba histolytica acyl-CoA synthetase, putative 0.0041 0.0306 0.1149
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0076 0.0726
Trichomonas vaginalis DNA polymerase eta, putative 0.0015 0.0076 0.0332
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0774 0.1922
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0213 0.0407
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.003 0.006
Onchocerca volvulus 0.0051 0.0399 0.1908
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0958 0.4163
Mycobacterium tuberculosis Conserved protein 0.0061 0.0484 0.1344
Brugia malayi ecdysone receptor 0.0008 0.001 0.0008
Schistosoma mansoni ferritin light chain 0.0021 0.0132 0.0247
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0041 0.0306 0.2473
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0018 0.0008
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0958 0.2383
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0086 0.0201
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0008 0.001 0.0004
Entamoeba histolytica hypothetical protein 0.0039 0.0287 0.1066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0199 0.05
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0098 0.0089
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0007 0.0007 0.0003
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0012 0.0048 0.0428
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0239 0.2111
Schistosoma mansoni hypothetical protein 0.0039 0.0287 0.0555
Echinococcus granulosus TGF beta signal transducer SmadC 0.0013 0.0059 0.005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0099 0.0232
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0012 0.0048 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0086 0.0201
Loa Loa (eye worm) hypothetical protein 0.0019 0.0108 0.0256
Schistosoma mansoni lamin 0.0043 0.0328 0.0636
Schistosoma mansoni tar DNA-binding protein 0.0455 0.4 0.792
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0012 0.0048 0.007
Schistosoma mansoni tar DNA-binding protein 0.0455 0.4 0.792
Mycobacterium tuberculosis Probable lipase LipE 0.0061 0.0484 0.1344
Onchocerca volvulus 0.0008 0.001 0.0011
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0083 0.0151
Trichomonas vaginalis penicillin-binding protein, putative 0.0061 0.0484 0.2105
Brugia malayi TAR-binding protein 0.0455 0.4 1
Brugia malayi nuclear receptor RXR 0.0009 0.0018 0.0029
Schistosoma mansoni thyroid hormone receptor 0.022 0.19 0.3754
Loa Loa (eye worm) hypothetical protein 0.0016 0.0083 0.0193
Leishmania major acetyl-CoA synthetase, putative 0.0012 0.0048 0.0428
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0129 0.1095 0.2726
Schistosoma mansoni ABC transporter 0.001 0.0031 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0306 0.0817
Brugia malayi beta-lactamase family protein 0.0061 0.0484 0.1197
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0086 0.0077
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0048 0.0011
Schistosoma mansoni hypothetical protein 0.0079 0.0648 0.1271
Brugia malayi Nuclear hormone receptor E75 0.0008 0.001 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0076 0.0726
Echinococcus multilocularis smad 0.0013 0.0059 0.005
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0958 0.0949
Loa Loa (eye worm) MH2 domain-containing protein 0.0013 0.0059 0.0132
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0129 0.1094 0.3146
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0019 0.0108 0.1404
Schistosoma mansoni phospholipase C beta 0.0018 0.0099 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0076 0.0324
Plasmodium vivax SET domain protein, putative 0.003 0.0213 0.3791
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0061 0.0484 0.0946
Echinococcus multilocularis GPCR, family 2 0.0079 0.0648 0.0639
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0399 0.0983
Brugia malayi Smad1 0.0013 0.0059 0.0132
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.1469 0.3663
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0012 0.0048 0.0039
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0015 0.0006
Trichomonas vaginalis antibiotic synthetase, putative 0.0012 0.0048 0.0209
Echinococcus granulosus lamin 0.0043 0.0328 0.0319
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0086 0.0077
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0306 0.2473
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0086 0.0201
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0462 0.0453
Echinococcus multilocularis thyroid hormone receptor alpha 0.022 0.19 0.1892
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0012 0.0048 0.0027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0306 0.075
Leishmania major DNA polymerase kappa, putative 0.0015 0.0076 0.0726
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0076 0.0726
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0034 0.0283
Mycobacterium ulcerans bacterioferritin BfrA 0.0021 0.0132 0.0814
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0086 0.0201
Schistosoma mansoni ferritin 0.0021 0.0132 0.0247
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.049 0.0957
Onchocerca volvulus 0.0012 0.0048 0.0198
Onchocerca volvulus 0.0238 0.2058 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0076 0.0726
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0019 0.0108 0.0099
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0083 0.04
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0202 0.0489
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0086 0.0077
Schistosoma mansoni coup transcription factor 0.0016 0.0086 0.0157
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0012 0.0048 0.0039
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0012 0.0048 0.0055
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0083 0.0074
Brugia malayi MH2 domain containing protein 0.0013 0.0059 0.0132
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0086 0.0157
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0086 0.0201
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0076 0.0726
Echinococcus multilocularis musashi 0.0043 0.0328 0.0319
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0958 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0811 0.717 0.7167
Schistosoma mansoni nuclear receptor 0.0008 0.001 0.0004
Plasmodium vivax acetyl-CoA synthetase, putative 0.0012 0.0048 0.0027
Brugia malayi hypothetical protein 0.0163 0.1395 0.3478
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0086 0.0077
Brugia malayi Pre-SET motif family protein 0.0209 0.1802 0.4497
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0958 0.4634
Schistosoma mansoni nuclear receptor nhr-48 0.0008 0.001 0.0004
Loa Loa (eye worm) Plcb4 protein 0.0018 0.0099 0.0232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0086 0.0201
Schistosoma mansoni tar DNA-binding protein 0.0455 0.4 0.792
Echinococcus granulosus smad 0.0013 0.0059 0.005
Onchocerca volvulus 0.0012 0.0048 0.0198
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0083 0.0833
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0018 0.0099 0.0962
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0012 0.0048 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0199 0.05
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0012 0.0048 0.0005
Brugia malayi nuclear receptor NHR-88 0.0008 0.001 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0083 0.0193
Loa Loa (eye worm) MH1 domain-containing protein 0.0013 0.0059 0.0132
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.0306 0.2465
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0201
Loa Loa (eye worm) hypothetical protein 0.0051 0.0399 0.0983
Schistosoma mansoni Smad4 0.0013 0.0059 0.0102
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.049 0.1211
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.2301 1
Brugia malayi orphan nuclear receptor NR2E1 0.0008 0.001 0.0008
Brugia malayi nuclear receptor NHR-88 0.0016 0.0086 0.0201
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0213 0.0407
Brugia malayi Variant SH3 domain containing protein 0.0129 0.1095 0.2726
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0086 0.0201
Onchocerca volvulus 0.0163 0.1395 0.6766
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0012 0.0048 0.0013
Trypanosoma brucei ATP-binding cassette protein, putative 0.0012 0.0047 0.0415
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0455 0.4 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0086 0.0077
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0083 0.0151
Onchocerca volvulus 0.0044 0.033 0.1575
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0015 0.0006
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0399 0.0776
Plasmodium vivax acyl-CoA synthetase, putative 0.0031 0.0214 0.381
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0213 0.0203
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0086 0.0077
Brugia malayi nuclear hormone receptor family member nhr-6 0.0008 0.001 0.0008
Loa Loa (eye worm) intermediate filament protein 0.0043 0.0328 0.0806
Toxoplasma gondii propionate-CoA ligase 0.0012 0.0048 0.0027
Schistosoma mansoni hypothetical protein 0.0079 0.0648 0.1271
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0012 0.0048 0.0055
Echinococcus granulosus lamin dm0 0.0043 0.0328 0.0319
Schistosoma mansoni hypothetical protein 0.001 0.003 0.0044
Mycobacterium tuberculosis Probable esterase LipL 0.0061 0.0484 0.1344
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0958 0.4163
Brugia malayi nuclear receptor NHR-67 0.0008 0.001 0.0008
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0083 0.2185
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0031 0.0214 0.0544
Echinococcus granulosus GPCR family 2 0.0079 0.0648 0.0639
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0086 0.0157
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0958 0.2383
Loa Loa (eye worm) hypothetical protein 0.0031 0.0214 0.0519
Schistosoma mansoni smad1 5 8 and 0.0013 0.0059 0.0102
Brugia malayi beta-lactamase family protein 0.0061 0.0484 0.1197
Schistosoma mansoni smad 0.0013 0.0059 0.0102
Brugia malayi jmjC domain containing protein 0.006 0.0475 0.1173
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0203 0.1754 0.1746
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0015 0.0006
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0047 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0034 0.0283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.2301 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0399 0.039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0086 0.0201
Plasmodium vivax JmjC domain containing protein 0.0016 0.0083 0.0833
Loa Loa (eye worm) hypothetical protein 0.0041 0.0306 0.075
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0044 0.033 0.0812
Loa Loa (eye worm) hypothetical protein 0.0061 0.0484 0.1197
Entamoeba histolytica acyl-CoA synthetase, putative 0.0041 0.0306 0.1149
Schistosoma mansoni ferritin light chain 0.0021 0.0132 0.0247
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0086 0.0077
Mycobacterium ulcerans bacterioferritin BfrB 0.0021 0.0132 0.0814
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0012 0.0048 0.0105
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0031 0.0214 0.1592
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0086 0.0201
Trypanosoma brucei unspecified product 0.001 0.0034 0.0283
Onchocerca volvulus 0.0016 0.0086 0.0386
Echinococcus granulosus ferritin 0.0021 0.0132 0.0123
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0958 0.4041
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0648 0.0639
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0239 0.2111
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0061 0.0484 0.1344
Leishmania major phospholipase c-like protein 0.0019 0.0108 0.1062
Loa Loa (eye worm) hypothetical protein 0.0031 0.0214 0.0519
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0958 0.0949
Loa Loa (eye worm) hypothetical protein 0.002 0.0121 0.0287
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0041 0.0306 0.2473
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0648 0.1608
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.2177 0.5435
Mycobacterium tuberculosis Conserved protein 0.0061 0.0484 0.1344
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.2177 0.5435
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0012 0.0048 0.0105
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.049 0.0481
Echinococcus granulosus beta LACTamase domain containing family member 0.0061 0.0484 0.0475
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0213 0.3791
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.2301 1
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.0108 0.0256
Echinococcus granulosus cpg binding protein 0.0031 0.0217 0.0207
Schistosoma mansoni kinase 0.0058 0.0458 0.0893
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0061 0.0484 0.1197
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0399 0.0776
Echinococcus multilocularis beta LACTamase domain containing family member 0.0061 0.0484 0.0475
Loa Loa (eye worm) hypothetical protein 0.0016 0.0083 0.0193
Loa Loa (eye worm) hypothetical protein 0.0163 0.1395 0.3478
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0462 0.0902
Brugia malayi jmjC domain containing protein 0.0016 0.0083 0.0193
Trichomonas vaginalis 1-phosphatidylinositol phosphodiesterase, putative 0.0007 0.0007 0.0032
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0086 0.0077
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0445 0.9093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0076 0.0726
Schistosoma mansoni cpg binding protein 0.0029 0.0202 0.0385
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0199 0.05
Schistosoma mansoni jumonji domain containing protein 0.006 0.0475 0.0927
Echinococcus multilocularis Smad4 0.0013 0.0059 0.005
Brugia malayi ecdysteroid receptor 0.0016 0.0086 0.0201
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0086 0.0386
Entamoeba histolytica hypothetical protein 0.0039 0.0287 0.1066
Brugia malayi hypothetical protein 0.0008 0.001 0.0008
Onchocerca volvulus 0.0165 0.1413 0.6855
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0213 0.0407
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0048 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0076 0.0726
Brugia malayi mbt repeat family protein 0.0051 0.0399 0.0983
Schistosoma mansoni hypothetical protein 0.0312 0.2724 0.539
Trypanosoma brucei DNA polymerase kappa, putative 0.001 0.0034 0.0283
Brugia malayi nuclear hormone receptor family member odr-7 0.0008 0.001 0.0008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0086 0.0077
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0076 0.0282
Brugia malayi jmjC domain containing protein 0.0016 0.0083 0.0193
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0012 0.0048 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0086 0.0201
Onchocerca volvulus 0.0061 0.0484 0.2325
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0012 0.0048 0.0055
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0076 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0048 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0214 0.0519
Echinococcus multilocularis lamin dm0 0.0043 0.0328 0.0319
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0086 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0076 0.0726
Leishmania major hypothetical protein, conserved 0.0061 0.0484 0.5018
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0083 0.0151
Schistosoma mansoni hypothetical protein 0.0079 0.0648 0.1271
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0029
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0389 0.3413 1
Brugia malayi hypothetical protein 0.0008 0.001 0.0008
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0083 0.04
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0048 0.0055
Brugia malayi hypothetical protein 0.0039 0.0287 0.0703
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0048 0.0055
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0201
Trypanosoma brucei unspecified product 0.0015 0.0076 0.0726
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.2301 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0013 0.0059 0.0102
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0076 0.0324
Onchocerca volvulus 0.0012 0.0048 0.0198
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.1745 0.1737
Schistosoma mansoni DNA polymerase eta 0.0015 0.0076 0.0137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0128 0.0304
Loa Loa (eye worm) histone methyltransferase 0.001 0.0031 0.0063
Loa Loa (eye worm) nuclear receptor NHR-67 0.0008 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Mycobacterium ulcerans acetyl-CoA synthetase 0.0012 0.0048 0.0011
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0462 0.0453
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0041 0.0306 0.0817
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0086 0.0157
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0061 0.0484 0.1344
Schistosoma mansoni smad1 5 8 and 0.0013 0.0059 0.0102
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0048 0.0011
Mycobacterium ulcerans lipase LipD 0.0061 0.0484 0.4179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0086 0.0201
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0012 0.0048 0.0105
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0018 0.0099 0.0962
Brugia malayi Inositol-1 0.0033 0.0239 0.0583
Brugia malayi beta-lactamase 0.0061 0.0484 0.1197
Echinococcus granulosus Smad4 0.0013 0.0059 0.005
Echinococcus multilocularis mothers against decapentaplegic 5 0.0013 0.0059 0.005
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0048 0.0105
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0019 0.0108 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0048 0.0011
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0018 0.0099 0.0232
Schistosoma mansoni hypothetical protein 0.0203 0.1754 0.3465
Giardia lamblia DINP protein human, muc B family 0.0015 0.0076 0.0136
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0201
Entamoeba histolytica hypothetical protein 0.0039 0.0287 0.1066
Schistosoma mansoni tar DNA-binding protein 0.0455 0.4 0.792
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0007 0.0007 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0086 0.0201
Loa Loa (eye worm) hypothetical protein 0.0171 0.1469 0.3663
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0012 0.0048 0.0011
Loa Loa (eye worm) Smad1 0.0013 0.0059 0.0132
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0083 0.0151
Brugia malayi MH2 domain containing protein 0.0013 0.0059 0.0132
Schistosoma mansoni microtubule-associated protein tau 0.0573 0.5048 1
Brugia malayi ABC transporter family protein 0.001 0.0031 0.0061
Echinococcus multilocularis geminin 0.0205 0.1765 0.1757
Brugia malayi phospholipase C homolog 0.0007 0.0007 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0076 0.0176
Schistosoma mansoni cpg binding protein 0.0031 0.0217 0.0415
Treponema pallidum fructose-bisphosphate aldolase 0.0265 0.2301 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0083 0.0151
Echinococcus granulosus mothers against decapentaplegic 5 0.0013 0.0059 0.005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.0029
Brugia malayi conserved hypotetical protein 0.0008 0.001 0.0008
Leishmania major DNA polymerase eta, putative 0.0015 0.0076 0.0726
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0008 0.001 0.0004
Toxoplasma gondii ABC1 family protein 0.0061 0.0484 1
Loa Loa (eye worm) MBCTL1 0.0058 0.0462 0.1142
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0475 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0086 0.0201
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0076 0.0282
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0287 0.0278
Brugia malayi Nuclear hormone receptor E75 0.0008 0.001 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0076 0.0324
Brugia malayi nuclear receptor RXR 0.0008 0.001 0.0008
Brugia malayi steroid hormone receptor 0.0016 0.0086 0.0201
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0061 0.0484 0.0946
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.2177 0.5435
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0083 0.0798
Schistosoma mansoni thyroid hormone receptor 0.022 0.19 0.3754
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0287 0.0555
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0484 1
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0076 0.0726
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0287 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0086 0.0201
Schistosoma mansoni hypothetical protein 0.0079 0.0648 0.1271
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0076 0.0176
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Schistosoma mansoni ferritin 0.0021 0.0132 0.0247
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0086 0.0077
Echinococcus multilocularis ATP binding cassette sub family G 0.0012 0.0047 0.0037
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0099 0.0232
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0648 0.1608
Brugia malayi nuclear hormone receptor 0.0016 0.0086 0.0201
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0265 0.2301 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0399 0.1908
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0015 0.0016
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0203 0.1754 0.1746
Leishmania major acetyl-CoA synthetase, putative 0.0012 0.0048 0.0428
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0012 0.0048 0.0011
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0043 0.0328 0.0806
Plasmodium vivax phospholipase C-like, putative 0.0018 0.0099 0.1187
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0008 0.001 0.0011
Onchocerca volvulus 0.0061 0.0484 0.2325
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0033 0.0239 0.1837
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0076 0.0176
Mycobacterium ulcerans beta-lactamase 0.0061 0.0484 0.4179
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0019 0.0108 0.0674
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0265 0.2301 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0012 0.0048 0.0011
Brugia malayi mbt repeat family protein 0.0051 0.0399 0.0983
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0399 0.039
Brugia malayi hypothetical protein 0.0009 0.0018 0.0029
Onchocerca volvulus 0.0043 0.0328 0.1564
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0201
Trypanosoma brucei ABC transporter, putative 0.0012 0.0047 0.0415
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0197 0.0188
Schistosoma mansoni smad1 5 8 and 0.0013 0.0059 0.0102
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.001 0.0033 0.0011
Echinococcus multilocularis survival motor neuron protein 1 0.0214 0.185 0.1843
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0399 0.0776
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0484 0.4803
Echinococcus multilocularis microtubule associated protein 2 0.0573 0.5048 0.5043
Mycobacterium tuberculosis Probable lipase LipD 0.0061 0.0484 0.1344
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0015 0.0076 0.0138
Schistosoma mansoni acetyl-CoA synthetase 0.0012 0.0048 0.0081
Brugia malayi MH2 domain containing protein 0.0194 0.1675 0.4178
Echinococcus multilocularis inositol monophosphatase 1 0.0033 0.0239 0.023
Brugia malayi phospholipase C homolog 0.0011 0.0042 0.0089
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0031 0.0214 0.5
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0012 0.0048 0.0428
Schistosoma mansoni cpg binding protein 0.0031 0.0217 0.0415
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0012 0.0048 0.0011
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0047 0.0037
Loa Loa (eye worm) nuclear hormone receptor 0.0008 0.001 0.0008
Loa Loa (eye worm) oxidoreductase 0.0012 0.0048 0.0105
Schistosoma mansoni zinc finger protein 0.0008 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.003 0.0213 0.0517
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0201
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.1745 0.1737
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0213 0.0203
Loa Loa (eye worm) hypothetical protein 0.0041 0.0306 0.075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0774 0.0765
Brugia malayi cytoplasmic intermediate filament protein 0.0023 0.0148 0.0356
Onchocerca volvulus 0.0019 0.0108 0.0492
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.0306 0.314
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0086 0.0157
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0098 0.0089
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0048 0.0105
Schistosoma mansoni ferritin 0.0021 0.0132 0.0247
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0031 0.0022
Loa Loa (eye worm) hypothetical protein 0.0061 0.0484 0.1197
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0083 0.0074
Mycobacterium leprae Probable lipase LipE 0.0061 0.0484 0.4172
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0105
Echinococcus granulosus ATP binding cassette sub family G 0.0012 0.0047 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0048 0.0011
Mycobacterium ulcerans hypothetical protein 0.0061 0.0484 0.4179
Echinococcus multilocularis ferritin 0.0021 0.0132 0.0123
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0012 0.0047 0.0415
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0033 0.0239 0.0853
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0648 0.0639
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0086 0.0386
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0048 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0306 0.075
Schistosoma mansoni hypothetical protein 0.0205 0.1765 0.3487
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.0306 0.314
Loa Loa (eye worm) hypothetical protein 0.0061 0.0484 0.1197
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0086 0.0201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0176
Trichomonas vaginalis antibiotic synthetase, putative 0.0012 0.0048 0.0209
Schistosoma mansoni intermediate filament proteins 0.0043 0.0328 0.0636
Loa Loa (eye worm) MH2 domain-containing protein 0.0194 0.1675 0.4178
Schistosoma mansoni survival motor neuron protein 0.0044 0.033 0.0641
Echinococcus granulosus dna polymerase eta 0.0015 0.0076 0.0067
Loa Loa (eye worm) hypothetical protein 0.0061 0.0484 0.1197
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0012 0.0048 0.0055
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0444 0.1931
Leishmania major hypothetical protein, conserved 0.0016 0.0083 0.0798
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0199 0.05
Mycobacterium ulcerans acyl-CoA synthetase 0.0041 0.0306 0.2473
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0076 0.0137
Giardia lamblia Fructose-bisphosphate aldolase 0.0265 0.2301 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0041 0.0306 0.314
Brugia malayi jmjC domain containing protein 0.0016 0.0083 0.0193
Onchocerca volvulus 0.0019 0.0108 0.0492
Onchocerca volvulus 0.0043 0.0328 0.1564
Schistosoma mansoni apoferritin-2 0.0021 0.0132 0.0247
Echinococcus granulosus inositol monophosphatase 1 0.0033 0.0239 0.023
Onchocerca volvulus 0.0061 0.0484 0.2325
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0239 0.1039
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0008 0.001 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0086 0.0201
Mycobacterium tuberculosis Conserved protein 0.0061 0.0484 0.1344
Brugia malayi RNA binding protein 0.0455 0.4 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0648 0.1608
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0012 0.0048 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0012 0.0048 0.0105
Onchocerca volvulus 0.003 0.0213 0.1001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0076 0.0138
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0086 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0213 0.0407
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0012 0.0047 0.0078
Trichomonas vaginalis ferritin, putative 0.0021 0.0132 0.0574
Brugia malayi nuclear hormone receptor 0.0008 0.001 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0076 0.0324
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0015 0.0006
Trichomonas vaginalis set domain proteins, putative 0.0238 0.2058 0.8945
Brugia malayi AMP-binding enzyme family protein 0.0041 0.0306 0.075
Mycobacterium ulcerans hypothetical protein 0.0041 0.0306 0.2473
Loa Loa (eye worm) hypothetical protein 0.0016 0.0083 0.0193
Loa Loa (eye worm) hypothetical protein 0.0214 0.185 0.4618
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.0306 0.2465
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0958 0.4163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0774 0.0765
Brugia malayi hypothetical protein 0.0214 0.185 0.4618
Loa Loa (eye worm) hypothetical protein 0.0008 0.001 0.0008
Plasmodium falciparum acyl-CoA synthetase 0.0031 0.0214 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0239 0.1039
Echinococcus multilocularis dna polymerase eta 0.0015 0.0076 0.0067
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0021 0.0132 0.0803
Brugia malayi MH1 domain containing protein 0.0013 0.0059 0.0132
Schistosoma mansoni apoferritin-2 0.0021 0.0132 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0484 0.4803
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0061 0.0484 0.1344
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0048 0.0055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0108 0.0256
Brugia malayi RNA recognition motif domain containing protein 0.0455 0.4 1
Schistosoma mansoni nuclear receptor 0.0008 0.001 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0774 0.1521
Trichomonas vaginalis esterase, putative 0.0061 0.0484 0.2105
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0086 0.0077
Onchocerca volvulus 0.0029 0.0202 0.0947
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0462 0.1142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0774 0.1521
Echinococcus granulosus expressed protein 0.0021 0.0132 0.0123
Loa Loa (eye worm) hypothetical protein 0.0061 0.0484 0.1197
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0018 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0083 0.0193
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0012 0.0048 0.0055
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0018 0.0099 0.3116
Mycobacterium ulcerans acyl-CoA synthetase 0.0012 0.0048 0.0011
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0083 0.0074
Entamoeba histolytica hypothetical protein 0.0039 0.0287 0.1066
Schistosoma mansoni nuclear hormone receptor 0.0008 0.001 0.0004
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0083 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0086 0.0077
Loa Loa (eye worm) transcription factor SMAD2 0.0194 0.1675 0.4178
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0076 0.0067
Brugia malayi MH1 domain containing protein 0.0013 0.0059 0.0132
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0012 0.0048 0.0428

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 86.2 % Analgesic activity against heat induced nociception in Swiss albino mouse assessed as increase in latency at 100 mg/kg, po measured 60 mins post compound dose by hot plate method relative to pretreatment level ChEMBL. 20817329
IC50 (functional) = 22.37 ug ml-1 Cytotoxicity against human HCT15 cells by sulforhodamine B assay ChEMBL. 21684168
IC50 (functional) = 26.84 ug ml-1 Cytotoxicity against human SKOV3 cells by sulforhodamine B assay ChEMBL. 21684168
IC50 (functional) = 26.88 ug ml-1 Cytotoxicity against human A549 cells by sulforhodamine B assay ChEMBL. 21684168
IC50 (functional) = 37.04 ug ml-1 Cytotoxicity against human SK-MEL-2 cells by sulforhodamine B assay ChEMBL. 21684168
IC50 (functional) 80 uM PubChem BioAssay. SAR confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay, set 2. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 80 uM PubChem BioAssay. SAR confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay, set 2. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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