Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | trypanothione reductase | 0.0055 | 0.0173 | 0.0096 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.044 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0055 | 0.0173 | 0.0429 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0118 | 0.0485 | 0.0485 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0126 | 0.0521 | 0.0814 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0126 | 0.0521 | 0.0814 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0103 | 0.041 | 0.0555 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.0382 | 0.0956 |
Brugia malayi | hypothetical protein | 0.0109 | 0.044 | 0.1007 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0118 | 0.0485 | 0.1313 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0054 | 0.0054 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0782 | 0.3752 | 0.3752 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0054 | 0.0054 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0108 | 0.0108 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0144 | 0.0612 | 0.1809 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0571 | 0.271 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0144 | 0.0612 | 0.1029 |
Plasmodium vivax | hypothetical protein, conserved | 0.0144 | 0.0612 | 0.1809 |
Brugia malayi | glutathione reductase | 0.0055 | 0.0173 | 0.0327 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0059 | 0.0194 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0612 | 0.1536 |
Schistosoma mansoni | microtubule-associated protein tau | 0.2052 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.0587 | 0.1472 |
Trypanosoma brucei | protein kinase, putative | 0.0059 | 0.0194 | 0.0178 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0144 | 0.0612 | 0.1029 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0022 | 0.0013 | 0.0013 |
Onchocerca volvulus | 0.0217 | 0.0969 | 0.1198 | |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0126 | 0.0521 | 0.0814 |
Brugia malayi | hypothetical protein | 0.0103 | 0.041 | 0.0931 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0059 | 0.0194 | 0.0178 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0059 | 0.0194 | 0.0194 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0109 | 0.044 | 0.044 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0054 | 0.0054 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0144 | 0.0612 | 0.0964 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0059 | 0.0194 | 0.0482 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0612 | 0.1536 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0118 | 0.0485 | 0.0485 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0138 | 0.0583 | 0.0583 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0055 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0054 | 0.0128 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0014 | 0.0014 |
Onchocerca volvulus | 0.0144 | 0.0612 | 0.0314 | |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0022 | 0.0013 | 0.0013 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0144 | 0.0612 | 0.0964 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0054 | 0.0054 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0059 | 0.0194 | 0.0178 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0061 | 0.0042 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0782 | 0.3752 | 0.9461 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.0382 | 0.086 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0144 | 0.0612 | 0.1029 |
Plasmodium falciparum | glutathione reductase | 0.0055 | 0.0173 | 0.0096 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0059 | 0.0194 | 0.0178 |
Mycobacterium ulcerans | thymidylate synthase | 0.0217 | 0.0969 | 0.1138 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0144 | 0.0612 | 0.0612 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0054 | 0.0023 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0571 | 0.271 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0055 | 0.0173 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0122 | 0.03 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.023 | 0.0473 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0217 | 0.0969 | 0.1867 |
Plasmodium vivax | SET domain protein, putative | 0.0118 | 0.0485 | 0.1313 |
Schistosoma mansoni | bromodomain containing protein | 0.0074 | 0.0265 | 0.0265 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0144 | 0.0612 | 0.1029 |
Onchocerca volvulus | 0.0144 | 0.0612 | 0.0314 | |
Mycobacterium tuberculosis | Probable hydrolase | 0.0144 | 0.0612 | 0.1029 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0144 | 0.0612 | 0.0612 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0059 | 0.0194 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0059 | 0.0194 | 0.0178 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0055 | 0.0173 | 0.0173 |
Brugia malayi | Bromodomain containing protein | 0.0087 | 0.0332 | 0.0732 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0126 | 0.0521 | 0.0814 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0059 | 0.0194 | 0.0194 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0782 | 0.3752 | 0.8392 |
Echinococcus multilocularis | thymidylate synthase | 0.0217 | 0.0969 | 0.0969 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0059 | 0.0194 | 0.0178 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.014 | 0.059 | 0.0214 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.014 | 0.059 | 0.0976 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0054 | 0.0054 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.044 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0144 | 0.0612 | 0.0612 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0144 | 0.0612 | 0.0964 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0114 | 0.0464 | 0.0464 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0109 | 0.044 | 0.044 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0144 | 0.0612 | 0.1809 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0583 | 0.1462 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0021 | 0.0021 |
Brugia malayi | beta-lactamase family protein | 0.0144 | 0.0612 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0612 | 0.1536 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0059 | 0.0194 | 0.0178 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.044 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0118 | 0.0485 | 0.0485 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0014 | 0.0014 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.2052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0054 | 0.0128 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0031 | 0.0031 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | thymidylate synthase | 0.0217 | 0.0969 | 0.2438 |
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.0122 | 0.0196 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0059 | 0.0194 | 0.0178 |
Echinococcus granulosus | thymidylate synthase | 0.0217 | 0.0969 | 0.0969 |
Leishmania major | hypothetical protein, conserved | 0.0144 | 0.0612 | 0.1809 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0054 | 0.0054 |
Toxoplasma gondii | thioredoxin reductase | 0.0055 | 0.0173 | 0.0096 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0109 | 0.044 | 0.044 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.0587 | 0.1472 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0014 | 0.0014 |
Mycobacterium tuberculosis | Conserved protein | 0.0144 | 0.0612 | 0.1029 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.041 | 0.0498 |
Brugia malayi | MAP kinase sur-1 | 0.0059 | 0.0194 | 0.0381 |
Brugia malayi | Thioredoxin reductase | 0.0055 | 0.0173 | 0.0327 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0571 | 0.271 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.007 | 0.0244 | 0.0244 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.007 | 0.0244 | 0.0244 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0571 | 0.271 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0144 | 0.0612 | 0.1809 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0147 | 0.0361 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0054 | 0.0023 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.0587 | 0.1382 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0126 | 0.0521 | 0.0814 |
Brugia malayi | beta-lactamase family protein | 0.0144 | 0.0612 | 0.1446 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0021 | 0.0043 |
Plasmodium falciparum | thioredoxin reductase | 0.0055 | 0.0173 | 0.0096 |
Echinococcus granulosus | dihydrofolate reductase | 0.0782 | 0.3752 | 0.3752 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.014 | 0.059 | 0.0976 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0144 | 0.0612 | 0.1029 |
Entamoeba histolytica | hypothetical protein | 0.0109 | 0.044 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0031 | 0.0031 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0059 | 0.0194 | 0.0194 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0059 | 0.0194 | 0.0194 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0571 | 0.271 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.044 | 0.044 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0103 | 0.041 | 0.102 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0144 | 0.0612 | 0.1029 |
Brugia malayi | Pre-SET motif family protein | 0.0118 | 0.0485 | 0.1122 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0782 | 0.3752 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.094 | 0.4527 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0826 | 0.3965 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0826 | 0.3965 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0782 | 0.3752 | 1 |
Brugia malayi | hypothetical protein | 0.005 | 0.0149 | 0.0265 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0055 | 0.0173 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0149 | 0.0367 |
Mycobacterium tuberculosis | Conserved protein | 0.0144 | 0.0612 | 0.1029 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0108 | 0.0108 |
Mycobacterium tuberculosis | Probable reductase | 0.0126 | 0.0521 | 0.0814 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0144 | 0.0612 | 0.1446 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0059 | 0.0194 | 0.0178 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0612 | 0.1536 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0054 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0013 | 0.0013 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0138 | 0.0583 | 0.0583 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0031 | 0.0031 |
Brugia malayi | beta-lactamase | 0.0144 | 0.0612 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0612 | 0.1536 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0612 | 0.1536 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.0382 | 0.086 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.014 | 0.059 | 0.0976 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0144 | 0.0612 | 0.0964 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0571 | 0.271 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0054 | 0.0054 |
Brugia malayi | thymidylate synthase | 0.0217 | 0.0969 | 0.2358 |
Onchocerca volvulus | 0.0144 | 0.0612 | 0.0314 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0217 | 0.0969 | 0.0969 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0054 | 0.0054 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0144 | 0.0612 | 0.1809 |
Plasmodium vivax | glutathione reductase, putative | 0.0055 | 0.0173 | 0.0096 |
Brugia malayi | dihydrofolate reductase family protein | 0.0782 | 0.3752 | 0.9455 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.023 | 0.0573 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0382 | 0.0956 |
Schistosoma mansoni | dihydrofolate reductase | 0.0782 | 0.3752 | 0.3752 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0055 | 0.0173 | 0.0096 |
Brugia malayi | Dihydrofolate reductase | 0.0782 | 0.3752 | 0.9455 |
Mycobacterium tuberculosis | Conserved protein | 0.0144 | 0.0612 | 0.1029 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.023 | 0.023 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0144 | 0.0612 | 0.0612 |
Mycobacterium leprae | conserved hypothetical protein | 0.0144 | 0.0612 | 0.0283 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0138 | 0.0583 | 0.0583 |
Onchocerca volvulus | 0.094 | 0.4527 | 1 | |
Loa Loa (eye worm) | glutathione reductase | 0.0055 | 0.0173 | 0.0429 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0138 | 0.0583 | 0.0583 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0217 | 0.0969 | 0.1389 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0782 | 0.3752 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0144 | 0.0612 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0308 | 0.0768 |
Trichomonas vaginalis | esterase, putative | 0.0144 | 0.0612 | 0.0964 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0922 | 0.4437 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0136 | 0.0334 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0144 | 0.0612 | 0.0964 |
Loa Loa (eye worm) | beta-lactamase | 0.0144 | 0.0612 | 0.1536 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0144 | 0.0612 | 0.1536 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kb (binding) | = 366 nM | Antimuscarinic activity against muscarinic acetylcholine receptor M3 from the ileum of guinea pig | ChEMBL. | 1447741 |
Kb (binding) | > 10000 nM | Antimuscarinic activity test against muscarinic acetylcholine receptor M1 from rabbit vas deferens | ChEMBL. | 1447741 |
Kb (binding) | > 10000 nM | Antimuscarinic activity to muscarinic acetylcholine receptor M2 from atria of guinea pig. | ChEMBL. | 1447741 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.