Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2887 | 0.6022 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.4794 | 0.4794 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.4794 | 0.4794 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.4794 | 0.4794 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0925 | 0.0925 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2887 | 0.2887 |
Echinococcus multilocularis | geminin | 0.0168 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.4794 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2887 | 0.6022 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.4794 | 0.4794 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.4794 | 0.4794 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2887 | 0.2887 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2887 | 0.6022 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2887 | 0.2887 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.4794 | 0.4794 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1982 | 0.4135 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.4794 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2887 | 0.2887 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2887 | 0.2887 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2887 | 0.6022 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1982 | 0.4135 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2887 | 0.2887 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0925 | 0.1929 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1982 | 0.4135 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2887 | 0.6022 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.4794 | 0.4794 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0925 | 0.1929 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2887 | 0.6022 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1982 | 0.4135 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2887 | 0.2887 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | < 10 mm | Antibacterial activity against Escherichia coli after 16 to 18 hrs by serial dilution method | ChEMBL. | 20728250 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Escherichia coli after 16 to 18 hrs by serial dilution method | ChEMBL. | 20728250 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.