Detailed information for compound 1195635

Basic information

Technical information
  • TDR Targets ID: 1195635
  • Name: ethyl 4-[2-(furan-2-carbonylamino)propanoyl]p iperazine-1-carboxylate
  • MW: 323.344 | Formula: C15H21N3O5
  • H donors: 1 H acceptors: 3 LogP: 0.57 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)N1CCN(CC1)C(=O)C(NC(=O)c1ccco1)C
  • InChi: 1S/C15H21N3O5/c1-3-22-15(21)18-8-6-17(7-9-18)14(20)11(2)16-13(19)12-5-4-10-23-12/h4-5,10-11H,3,6-9H2,1-2H3,(H,16,19)
  • InChiKey: RASGOKZZIQLSRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-[(2-furyl-oxomethyl)amino]-1-oxopropyl]-1-piperazinecarboxylic acid ethyl ester
  • 4-[2-(furan-2-carbonylamino)propanoyl]piperazine-1-carboxylic acid ethyl ester
  • ethyl 4-[2-(furan-2-ylcarbonylamino)propanoyl]piperazine-1-carboxylate
  • MLS001163100
  • SMR000499418
  • ethyl 4-(N-2-furoylalanyl)-1-piperazinecarboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0887 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1548 0.2031
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.006 0.1512
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.7613 0.7613
Leishmania major hypothetical protein, conserved 0.0043 0.0395 0.4454
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0395 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0887 1
Echinococcus granulosus FTZ F1 alpha 0.0428 0.885 1
Onchocerca volvulus 0.024 0.4712 0.4657
Loa Loa (eye worm) beta-lactamase 0.0043 0.0395 0.0395
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0949 0.1244
Schistosoma mansoni hypothetical protein 0.0037 0.0251 0.0327
Loa Loa (eye worm) hypothetical protein 0.0043 0.0395 0.0395
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0887 0.0955
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0395 0.0833
Brugia malayi beta-lactamase family protein 0.0043 0.0395 0.0395
Plasmodium vivax importin-beta 2, putative 0.0035 0.0205 0.5179
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0628 0.0628
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0887 0.1162
Brugia malayi Importin beta-1 subunit 0.0035 0.0205 0.0205
Brugia malayi beta-lactamase family protein 0.0043 0.0395 0.0395
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0949 0.0949
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0251 0.0251
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0395 0.0444
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0002 0.006
Echinococcus granulosus tar DNA binding protein 0.0069 0.0949 0.107
Mycobacterium leprae Probable lipase LipE 0.0043 0.0395 0.5
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0395 0.0516
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0103 0.0133
Plasmodium falciparum importin beta, putative 0.0035 0.0205 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0395 0.0833
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0205 0.2307
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.006 0.0122
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0395 0.0516
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0395 1
Schistosoma mansoni hypothetical protein 0.0205 0.3938 0.5172
Schistosoma mansoni hypothetical protein 0.0205 0.3938 0.5172
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0205 0.5179
Loa Loa (eye worm) hypothetical protein 0.0043 0.0395 0.0395
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0887 0.1162
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0887 0.0999
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0395 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.048 1 1
Echinococcus granulosus snurportin 1 0.0372 0.7613 0.8602
Brugia malayi RNA, U transporter 1 0.0099 0.1616 0.1616
Echinococcus multilocularis Protein lozenge 0.006 0.0764 0.1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.5547 1
Onchocerca volvulus 0.0043 0.0395 0.0295
Loa Loa (eye worm) hypothetical protein 0.0043 0.0395 0.0395
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0628 0.0628
Loa Loa (eye worm) RNA binding protein 0.0069 0.0949 0.0949
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.4072 0.4072
Echinococcus granulosus importin subunit beta 1 0.0035 0.0205 0.0228
Trichomonas vaginalis importin beta-1, putative 0.0028 0.006 0.0122
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0395 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1548 0.2031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0887 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0103 0.1166
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0887 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1548 0.1747
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1548 0.1548
Loa Loa (eye worm) hypothetical protein 0.0043 0.0395 0.0395
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0395 0.0833
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0395 0.0833
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0002 0.0027
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0002 0.006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0103 0.0133
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0103 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0949 0.1244
Loa Loa (eye worm) hypothetical protein 0.003 0.0103 0.0103
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1548 0.2031
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0205 0.0266
Onchocerca volvulus 0.0043 0.0395 0.0295
Loa Loa (eye worm) hypothetical protein 0.0043 0.0395 0.0395
Brugia malayi RNA binding protein 0.0069 0.0949 0.0949
Brugia malayi hypothetical protein 0.0153 0.2803 0.2803
Onchocerca volvulus 0.048 1 1
Plasmodium vivax SET domain protein, putative 0.003 0.0103 0.2619
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.006 0.0122
Brugia malayi Pre-SET motif family protein 0.003 0.0103 0.0103
Leishmania major GTP-binding protein, putative 0.0026 0.0002 0.0027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0079 0.0087
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0103 0.0133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0887 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.2803 0.2803
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0949 0.1244
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0002 0.0002
Brugia malayi TAR-binding protein 0.0069 0.0949 0.0949
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0103 0.0114
Entamoeba histolytica hypothetical protein 0.0028 0.006 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0949 0.1244
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0395 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0103 0.0133
Loa Loa (eye worm) hypothetical protein 0.0035 0.0205 0.0205
Schistosoma mansoni lozenge 0.006 0.0764 0.1
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0887 0.1162
Trichomonas vaginalis esterase, putative 0.0043 0.0395 0.0833
Echinococcus multilocularis snurportin 1 0.0372 0.7613 1
Toxoplasma gondii ABC1 family protein 0.0043 0.0395 0.4454
Echinococcus granulosus geminin 0.0205 0.3938 0.4449
Trichomonas vaginalis set domain proteins, putative 0.024 0.4712 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1548 0.1548
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0395 0.0395
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0205 0.5179
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1548 0.1747
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1548 0.2031
Loa Loa (eye worm) hypothetical protein 0.048 1 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0002 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0395 0.0395
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0395 0.0833
Loa Loa (eye worm) runx1 0.006 0.0764 0.0764
Schistosoma mansoni importin beta-1 0.0035 0.0205 0.0266
Loa Loa (eye worm) hypothetical protein 0.0037 0.0251 0.0251
Echinococcus multilocularis geminin 0.0205 0.3938 0.5172
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0949 0.0949
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0002 0.0002
Leishmania major importin beta-1 subunit, putative 0.0028 0.006 0.0673
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0002 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1548 0.2031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0395 0.0516
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0395 0.0395
Onchocerca volvulus 0.0043 0.0395 0.0295
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0002 0.0116
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0628 0.0628
Brugia malayi beta-lactamase 0.0043 0.0395 0.0395
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0103 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0949 0.1244
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0002 0.006
Brugia malayi Pre-SET motif family protein 0.0211 0.4072 0.4072
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0949 0.0949
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0949 0.1244
Onchocerca volvulus 0.0153 0.2803 0.2728
Schistosoma mansoni hypothetical protein 0.0372 0.7613 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1095 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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