Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.6848 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.6848 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.6848 | 0.6848 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.6848 | 0.6848 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.6848 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.4916 | 0.4916 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.6848 | 1 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.6848 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.6848 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.6848 | 0.6848 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.6848 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.6848 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.6848 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.6848 | 0.6848 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.6848 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.6848 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.6848 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.6848 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.6848 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.6848 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.6848 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 1 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.6848 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.6848 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.6848 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.6848 | 0.6848 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Leishmania major | cytochrome p450-like protein | 0.0013 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.6848 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.6848 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.6848 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.6848 | 1 |
Onchocerca volvulus | 0.0011 | 0.6848 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.6848 | 0.6848 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.6848 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.6848 | 0.6848 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.6848 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.6848 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.6848 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.6848 | 0.6848 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.6848 | 0.6848 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.6848 | 0.6848 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.6848 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 1 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.6848 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.6848 | 0.6848 |
Trypanosoma brucei | cytochrome P450, putative | 0.0013 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 16 mm | Antimicrobial activity against Escherichia coli NCTC 10416 at 5 mg/ml after 24 hrs by agar well diffusion assay | ChEMBL. | 20828885 |
IZ (functional) | = 21 mm | Antimicrobial activity against Candida albicans ATCC 10145 at 5 mg/ml after 48 hrs by agar well diffusion assay | ChEMBL. | 20828885 |
MIC (functional) | = 1.25 mg/ml | Antimicrobial activity against Candida albicans ATCC 10145 by twofold serial dilution method | ChEMBL. | 20828885 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.