Detailed information for compound 1196493

Basic information

Technical information
  • TDR Targets ID: 1196493
  • Name: tert-butyl N-(adamantane-1-carbonylamino)carb amate
  • MW: 294.389 | Formula: C16H26N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.02 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C12CC3CC(C2)CC(C1)C3)NNC(=O)OC(C)(C)C
  • InChi: 1S/C16H26N2O3/c1-15(2,3)21-14(20)18-17-13(19)16-7-10-4-11(8-16)6-12(5-10)9-16/h10-12H,4-9H2,1-3H3,(H,17,19)(H,18,20)
  • InChiKey: MZNAKNLNBSBMNL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1-adamantyl-oxomethyl)amino]carbamic acid tert-butyl ester
  • N-(adamantane-1-carbonylamino)carbamic acid tert-butyl ester
  • tert-butyl N-(1-adamantylcarbonylamino)carbamate
  • MLS000729876
  • SMR000308153
  • tert-butyl 2-(1-adamantylcarbonyl)hydrazinecarboxylate
  • STK140368
  • BIM-0033589.P001
  • CBMicro_033560
  • ZINC04576243

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0039 0.0189 0.0403
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0363 0.117
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.001 0.0017 0.0018
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0008 0.0032
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0009 0.0007 0.0106
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0008 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0016 0.0247
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.001 0.0017 0.0208
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0023 0.0413
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0039 0.0189 0.1587
Toxoplasma gondii aldehyde dehydrogenase 0.019 0.1107 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0047 0.024 0.0774
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.001 0.0017 0.0018
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0095 0.2058
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0629 0.1439
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0555 0.1688
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0047 0.024 0.0774
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0039 0.0189 0.1587
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0629 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0047 0.024 0.024
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0009 0.001 0.001
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0039 0.0189 0.0403
Entamoeba histolytica hypothetical protein 0.001 0.0016 0.028
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0132 0.0426
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.001 0.0017 0.0017
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0039 0.0189 0.1587
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.011 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0047 0.024 0.0774
Echinococcus granulosus nibrin 0.001 0.0016 0.0047
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.0505 0.8039
Loa Loa (eye worm) hypothetical protein 0.0091 0.0507 0.1637
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0056
Brugia malayi photoreceptor-specific nuclear receptor 0.052 0.3099 1
Echinococcus granulosus FTZ F1 alpha 0.0047 0.024 0.0729
Mycobacterium ulcerans aldehyde dehydrogenase 0.019 0.1107 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0014 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0331 0.1332
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0074 0.1183
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0039 0.0189 0.0403
Brugia malayi hypothetical protein 0.001 0.0016 0.005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0099 0.0764
Brugia malayi nuclear receptor NHR-88 0.0047 0.024 0.0774
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0189 0.3003
Brugia malayi MH2 domain containing protein 0.0144 0.0827 0.2667
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0008 0.0008
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.001 0.0017 0.0278
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0074 0.024
Echinococcus multilocularis expressed conserved protein 0.0093 0.0519 0.0519
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.001 0.0017 0.0278
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.001 0.0017 0.007
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.001 0.0017 0.0017
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0023 0.0207
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0039 0.0189 0.1706
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.001 0.0017 0.0018
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.001 0.0017 0.0278
Leishmania major cytochrome p450-like protein 0.0039 0.0189 0.1706
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0008 0.0024
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0009 0.0029
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.011 0.1752
Schistosoma mansoni hypothetical protein 0.0146 0.0837 0.3364
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0039 0.0189 0.1587
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.001 0.0017 0.0315
Loa Loa (eye worm) hypothetical protein 0.0008 0.0000003444 0.0000011112
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0047 0.024 0.0729
Brugia malayi RNA binding protein 0.0349 0.2069 0.6677
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0089 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0629 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.011 0.0991
Leishmania major aldehyde dehydrogenase, putative 0.001 0.0017 0.0158
Loa Loa (eye worm) hypothetical protein 0.0067 0.0363 0.117
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0016 0.0247
Mycobacterium leprae conserved hypothetical protein 0.0026 0.011 0.1536
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.001 0.0017 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.024 0.0774
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0011 0.0023 0.0365
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.0837 0.2699
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0016 0.005
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.011 0.0217
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0058 0.0308 0.2679
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Schistosoma mansoni cytochrome P450 0.0039 0.0189 0.0759
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.001 0.0017 0.0056
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0047 0.024 0.0965
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0047 0.024 0.0774
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0014 0.0014
Echinococcus granulosus histone acetyltransferase KAT2B 0.0301 0.1776 0.5397
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.001 0.0017 0.0018
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0099 0.178
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.0505 0.8039
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0247
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0172 0.0172
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0629 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0212 0.3375
Echinococcus granulosus bloom syndrome protein 0.0023 0.0095 0.0287
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.011 0.0991
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.001 0.0017 0.0017
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0095 0.1504
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.001 0.0017 0.0018
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0201
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0827 0.2667
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0095 0.0305
Mycobacterium tuberculosis Conserved protein 0.0111 0.0629 0.1439
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0629 0.2528
Mycobacterium ulcerans aldehyde dehydrogenase 0.019 0.1107 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0047 0.024 0.0774
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0105 0.0423
Brugia malayi steroid hormone receptor 0.0047 0.024 0.0774
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0047 0.024 0.024
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0039 0.0189 0.1587
Brugia malayi cytochrome P450 0.0039 0.0189 0.0609
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0016 0.0247
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.019 0.1107 1
Brugia malayi beta-lactamase family protein 0.0111 0.0629 0.2028
Giardia lamblia Replication factor C, subunit 1 0.001 0.0016 0.0338
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.2487 0.2487
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0083
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.011 0.1745
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0363 0.1101
Schistosoma mansoni hypothetical protein 0.0067 0.0363 0.1458
Schistosoma mansoni cpg binding protein 0.0031 0.0142 0.0571
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0062 0.0105
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0039 0.0189 0.1587
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0089 0.027
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0039 0.0189 0.1587
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0047 0.024 0.0965
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0095 0.0305
Entamoeba histolytica acetyltransferase, GNAT family 0.0083 0.0459 0.8271
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.011 0.2397
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0099 0.136
Schistosoma mansoni nuclear hormone receptor 0.0047 0.024 0.0965
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0349 0.2069 0.6677
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0074 0.0672
Loa Loa (eye worm) hypothetical protein 0.0043 0.0212 0.0685
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0039 0.0189 0.0403
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0363 0.117
Schistosoma mansoni cpg binding protein 0.0031 0.0142 0.0571
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0047 0.024 0.0729
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Echinococcus multilocularis nibrin 0.001 0.0016 0.0016
Brugia malayi DKFZp564C0469 protein 0.001 0.0016 0.005
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0039 0.0189 0.0403
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0629 0.1439
Brugia malayi RNA recognition motif domain containing protein 0.0349 0.2069 0.6677
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0095 0.0287
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.0505 0.8039
Schistosoma mansoni topbp1 0.001 0.0016 0.0062
Brugia malayi Calcitonin receptor-like protein seb-1 0.0213 0.1245 0.4017
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.001 0.0017 0.0018
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0054
Entamoeba histolytica hypothetical protein 0.0036 0.0172 0.3096
Brugia malayi BRM protein 0.0008 0.000000000057925 0.00000000018689
Brugia malayi hypothetical protein 0.001 0.0016 0.005
Mycobacterium leprae Conserved hypothetical protein 0.0039 0.0189 0.2825
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0089 0.027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0339
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0827 0.2667
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.024 0.024
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.001 0.0017 0.0017
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0095 0.2058
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.001 0.0017 0.0018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0047 0.024 0.0729
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0016 0.0338
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0074 0.1618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0047 0.024 0.0774
Giardia lamblia Histone acetyltransferase GCN5 0.0083 0.0459 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0047 0.024 0.024
Giardia lamblia Transcription regulatory protein SNF2 0.0008 0.000000000057925 0.0000000012607
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0039 0.0189 0.0403
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0025
Leishmania major aldehyde dehydrogenase, putative 0.001 0.0017 0.0158
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0074 0.024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0009 0.001 0.0031
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.001 0.0017 0.0018
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.0507 0.1541
Brugia malayi tailless protein 0.0022 0.0089 0.0287
Brugia malayi Aldehyde dehydrogenase protein 4 0.001 0.0017 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0099 0.0192
Loa Loa (eye worm) RecQ helicase 0.0023 0.0095 0.0305
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0089 0.0358
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.001 0.0017 0.007
Loa Loa (eye worm) aldehyde dehydrogenase 0.001 0.0017 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.024 0.0729
Schistosoma mansoni tar DNA-binding protein 0.0349 0.2069 0.8322
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0008 0.0032
Schistosoma mansoni retinoic acid receptor RXR 0.0047 0.024 0.0965
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0039 0.0189 0.1587
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0629 0.1439
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.0505 0.4567
Schistosoma mansoni nuclear receptor 0.0022 0.0089 0.0358
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0074 0.1183
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0089 0.0287
Brugia malayi CHE-14 protein 0.0043 0.0212 0.0685
Onchocerca volvulus 0.001 0.0016 0.0148
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0105 0.0339
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.001 0.0017 0.0158
Echinococcus multilocularis tar DNA binding protein 0.0349 0.2069 0.2069
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0014 0.0044
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0074 0.1183
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0039 0.0189 0.1587
Schistosoma mansoni zinc finger protein 0.0022 0.0089 0.0358
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0047 0.024 0.0774
Echinococcus granulosus zinc finger protein 0.0009 0.001 0.0031
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0089 0.0358
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0212 0.0645
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0089 0.0358
Onchocerca volvulus 0.0055 0.0289 0.2759
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0201
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0039 0.0189 0.3003
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0074 0.0134
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0097
Echinococcus multilocularis zinc finger protein 0.0009 0.001 0.001
Echinococcus granulosus cytochrome P450 2K1 0.0039 0.0189 0.0573
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0786 0.2538
Loa Loa (eye worm) BRM protein 0.0008 0.000000000057925 0.00000000018689
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.001 0.0017 0.0158
Echinococcus granulosus survival motor neuron protein 1 0.0271 0.1596 0.4849
Brugia malayi hypothetical protein 0.0271 0.1596 0.515
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0555 1
Mycobacterium tuberculosis Conserved protein 0.0111 0.0629 0.1439
Onchocerca volvulus 0.0047 0.024 0.2291
Onchocerca volvulus 0.0029 0.0132 0.1259
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0629 0.5619
Schistosoma mansoni hypothetical protein 0.0039 0.0189 0.0759
Entamoeba histolytica hypothetical protein 0.0026 0.011 0.1975
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0039 0.0189 0.0403
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.011 0.2397
Loa Loa (eye worm) acetyltransferase 0.031 0.1829 0.5901
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0039 0.0189 0.1587
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0008 0.000000000057925 0.00000000052339
Onchocerca volvulus 0.0091 0.0507 0.4844
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.001 0.0017 0.0053
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.001 0.0017 0.0278
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0565 0.2271
Loa Loa (eye worm) hypothetical protein 0.0047 0.024 0.0774
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0308 0.0993
Loa Loa (eye worm) hypothetical protein 0.0051 0.0262 0.0847
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0089 0.0358
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0786 0.3163
Onchocerca volvulus 0.0051 0.0262 0.2506
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0009
Brugia malayi nuclear receptor RXR 0.0025 0.0105 0.0339
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.0505 0.1535
Brugia malayi nuclear hormone receptor 0.0047 0.024 0.0774
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0095 0.0854
Mycobacterium ulcerans hypothetical protein 0.0024 0.0099 0.0764
Brugia malayi hypothetical protein 0.0009 0.0008 0.0025
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0047 0.024 0.0965
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.031 0.1829 0.1829
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.001 0.0017 0.0278
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0014 0.0041
Brugia malayi MH1 domain containing protein 0.001 0.0014 0.0044
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0039 0.0189 0.1587
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0099 0.0192
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0039 0.0189 0.1587
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.024 0.0774
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.0507 0.1637
Schistosoma mansoni helicase 0.0008 0.000000000057925 0.00000000023293
Schistosoma mansoni RAR-like nuclear receptor 0.0047 0.024 0.0965
Brugia malayi beta-lactamase 0.0111 0.0629 0.2028
Onchocerca volvulus 0.0111 0.0629 0.6002
Entamoeba histolytica hypothetical protein 0.0036 0.0172 0.3096
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.001 0.0017 0.0018
Brugia malayi nuclear receptor NHR-88 0.0022 0.0089 0.0287
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0039 0.0189 0.1587
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0089 0.0089
Echinococcus granulosus GPCR family 2 0.0067 0.0363 0.1101
Schistosoma mansoni hypothetical protein 0.0041 0.0203 0.0816
Echinococcus granulosus global transcription activator snf2l2 0.0008 0.000000000057925 0.00000000017598
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0262 0.1056
Schistosoma mansoni hypothetical protein 0.0067 0.0363 0.1458
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.001 0.0017 0.0315
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0074 0.1183
Brugia malayi hypothetical protein 0.0009 0.0008 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.005
Schistosoma mansoni hypothetical protein 0.001 0.0017 0.007
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0089 0.0849
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0308 0.4898
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0099 0.0764
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0212 0.0212
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0089 0.0358
Schistosoma mansoni dishevelled 0.0009 0.0008 0.0032
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0089 0.027
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0289 0.0932
Plasmodium falciparum histone acetyltransferase GCN5 0.0083 0.0459 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.024 0.0774
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0213 0.1245 0.4017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0339
Loa Loa (eye worm) hypothetical protein 0.0271 0.1596 0.515
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0095 0.0287
Echinococcus multilocularis cpg binding protein 0.0031 0.0142 0.0142
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0016 0.014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0074 0.0226
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0629 0.191
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Schistosoma mansoni patched 1 0.0043 0.0212 0.0853
Brugia malayi hypothetical protein 0.0022 0.0089 0.0287
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0062 0.1356
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.001 0.0017 0.0018
Trypanosoma brucei aldehyde dehydrogenase, putative 0.001 0.0017 0.0278
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.052 0.3099 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0026 0.0408
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0105 0.0319
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0008 0.0008
Onchocerca volvulus 0.0024 0.0099 0.0944
Brugia malayi acetyltransferase, GNAT family protein 0.031 0.1829 0.5901
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0039 0.0189 0.0403
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0008 0.0032
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0089 0.0089
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0017 0.007
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.019 0.1107 0.3362
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.001 0.0017 0.0158
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0056 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0056 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0056 0.0092
Brugia malayi Cytochrome P450 family protein 0.0058 0.0308 0.0993
Echinococcus multilocularis 0.0039 0.0189 0.0189
Brugia malayi hypothetical protein 0.0026 0.011 0.0355
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0016 0.0247
Loa Loa (eye worm) hypothetical protein 0.0181 0.1047 0.3379
Brugia malayi PHD-finger family protein 0.0009 0.001 0.0033
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.011 0.0995
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.001 0.0017 0.0278
Echinococcus multilocularis Smad4 0.001 0.0014 0.0014
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.011 0.2387
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0008 0.0024
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0008 0.0025
Schistosoma mansoni dishevelled 0.0009 0.0008 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.024 0.0774
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0099 0.0764
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0074 0.6247
Loa Loa (eye worm) cytochrome P450 family protein 0.0143 0.0817 0.2636
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0095 0.1504
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0008 0.0075
Schistosoma mansoni hypothetical protein 0.0354 0.21 0.8443
Brugia malayi MH2 domain containing protein 0.001 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0146 0.0837 0.2699
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0089 0.0287
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0074 0.1183
Loa Loa (eye worm) DR-78 0.0022 0.0089 0.0287
Schistosoma mansoni tar DNA-binding protein 0.0349 0.2069 0.8322
Brugia malayi nuclear hormone receptor 0.0022 0.0089 0.0287
Treponema pallidum ATP-dependent DNA helicase 0.0012 0.0026 0.1076
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0099 0.0319
Schistosoma mansoni cpg binding protein 0.0029 0.0132 0.053
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0363 0.117
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0047 0.024 0.0774
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0105 0.0339
Echinococcus multilocularis global transcription activator snf2l2 0.0008 0.000000000057925 0.000000000057925
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0047 0.024 0.0774
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.001 0.0017 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0017 0.007
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0014 0.0041
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0016 0.0062
Brugia malayi topoisomerase 0.001 0.0016 0.005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0319
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0308 0.4898
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0024 0.0073
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0062 0.4965
Echinococcus multilocularis ecdysone induced protein 78C 0.0047 0.024 0.024
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0014 0.0014
Loa Loa (eye worm) steroid hormone receptor 0.0047 0.024 0.0774
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0213 0.1245 0.4017
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0039 0.0189 0.1587
Schistosoma mansoni ap endonuclease 0.002 0.0074 0.0299
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.005
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0089 0.0287
Toxoplasma gondii hypothetical protein 0.0009 0.0008 0.0071
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.001 0.0017 0.0167
Leishmania major hypothetical protein, conserved 0.0111 0.0629 0.568
Echinococcus granulosus cpg binding protein 0.0031 0.0142 0.0432
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0099 0.178
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0039 0.0189 0.0403
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0074 0.1183
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.011 0.0863
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.011 0.1752
Loa Loa (eye worm) hypothetical protein 0.0213 0.1245 0.4017
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.011 0.1752
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0201
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0629 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0074 0.0539
Toxoplasma gondii cytochrome p450 superfamily protein 0.0039 0.0189 0.1706
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0089 0.0287
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.011 0.1752
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0008 0.0008
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0062 0.0428
Schistosoma mansoni thyroid hormone receptor 0.0047 0.024 0.0965
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0629 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0363 0.1101
Plasmodium vivax SET domain containing protein 0.0008 0.0004 0.0062
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0047 0.024 0.024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0099 0.178
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Brugia malayi Smad1 0.001 0.0014 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0047 0.024 0.0774
Schistosoma mansoni Smad4 0.001 0.0014 0.0054
Brugia malayi Cytochrome P450 family protein 0.0143 0.0817 0.2636
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.001 0.0017 0.0278
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0023 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0349 0.2069 0.8322
Schistosoma mansoni hypothetical protein 0.0354 0.21 0.8443
Schistosoma mansoni steroid hormone receptor ad4bp 0.0047 0.024 0.0965
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.011 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0025
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0089 0.0089
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.001 0.0017 0.0315
Echinococcus multilocularis GPCR, family 2 0.0067 0.0363 0.0363
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.001 0.0017 0.0056
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0099 0.0764
Schistosoma mansoni aldehyde dehydrogenase 0.019 0.1107 0.445
Giardia lamblia Alcohol dehydrogenase 0.001 0.0017 0.0381
Brugia malayi TAR-binding protein 0.0349 0.2069 0.6677
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0008 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0308 0.0993
Schistosoma mansoni ap endonuclease 0.002 0.0074 0.0299
Treponema pallidum gamma-glutamyl phosphate reductase 0.001 0.0017 0.0208
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0629 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.001 0.0017 0.0018
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0095 0.0854
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0363 0.0363
Echinococcus granulosus replication factor c subunit 1 0.001 0.0016 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.024 0.024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0786 0.2389
Echinococcus multilocularis FTZ F1 alpha 0.0047 0.024 0.024
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0172 0.0691
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.005
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0009 0.0007 0.0106
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.011 0.0863
Schistosoma mansoni dep domain containing protein 0.0009 0.0008 0.0032
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0039 0.0189 0.0403
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0008 0.0025
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0095 0.0095
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.001 0.0017 0.0053
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0212 0.0645
Mycobacterium leprae Probable lipase LipE 0.0111 0.0629 1
Schistosoma mansoni DNA ligase IV 0.001 0.0016 0.0062
Echinococcus multilocularis protein patched 0.0043 0.0212 0.0212
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0008 0.0024
Leishmania major cytochrome p450-like protein 0.0039 0.0189 0.1706
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.001 0.0017 0.0018
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0016 0.0247
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.011 0.0991
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0083
Loa Loa (eye worm) hypothetical protein 0.0099 0.0555 0.1792
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0047 0.024 0.0774
Trypanosoma brucei aldehyde dehydrogenase, putative 0.001 0.0017 0.0278
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0629 1
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.001 0.0017 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.024 0.0774
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0629 0.1439
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0008 0.0027
Brugia malayi Cytochrome P450 family protein 0.0039 0.0189 0.0609
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0095 0.2058
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.005
Mycobacterium ulcerans beta-lactamase 0.0111 0.0629 0.5619
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0033
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0201
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0629 0.2028
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0039 0.0189 0.0403
Loa Loa (eye worm) hypothetical protein 0.0018 0.0062 0.0201
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0247
Brugia malayi N-terminal motif family protein 0.0181 0.1047 0.3379
Schistosoma mansoni hypothetical protein 0.0055 0.0289 0.1162
Brugia malayi aldehyde dehydrogenase 0.001 0.0017 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0786 0.3163
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0105 0.0423
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0319
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0095 0.1504
Echinococcus granulosus geminin 0.0354 0.21 0.6379
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.001 0.0017 0.0158
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0016 0.028
Echinococcus granulosus ecdysone induced protein 78C 0.0047 0.024 0.0729
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0089 0.0089
Brugia malayi DIX domain containing protein 0.0009 0.0008 0.0025
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0016 0.014
Brugia malayi conserved hypotetical protein 0.0022 0.0089 0.0287
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0039 0.0189 0.0403
Brugia malayi Bromodomain containing protein 0.0009 0.001 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0039 0.0189 0.0403
Schistosoma mansoni thyroid hormone receptor 0.0047 0.024 0.0965
Brugia malayi MH2 domain containing protein 0.001 0.0014 0.0044
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.011 0.1745
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0008 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0099 0.0319
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0008 0.0000003444 0.0000010463
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.001 0.0017 0.0278
Brugia malayi hypothetical protein 0.0017 0.0055 0.0177
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0095 0.0095
Brugia malayi ecdysteroid receptor 0.0047 0.024 0.0774
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0026 0.0462
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0028
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0016 0.0247
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0099 0.0894
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0016 0.0247
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0039 0.0189 0.1587
Loa Loa (eye worm) TAR-binding protein 0.0349 0.2069 0.6677
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0017 0.007
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0629 0.1439
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.001 0.0017 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0056 0.0092
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0047 0.024 0.0774
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0786 0.3163
Loa Loa (eye worm) hypothetical protein 0.0023 0.0095 0.0305
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0039 0.0189 0.1587
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0105 0.0339
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0026 0.0408
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0026 0.0232
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.001 0.0017 0.0278
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0099 0.0764
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0095 0.0854
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0095 0.1504
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0025
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0551 0.3291 0.3291
Loa Loa (eye worm) hypothetical protein 0.0047 0.024 0.0774
Brugia malayi beta-lactamase family protein 0.0111 0.0629 0.2028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0089 0.027
Schistosoma mansoni aldehyde dehydrogenase 0.019 0.1107 0.445
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0786 0.2538
Brugia malayi hypothetical protein 0.0025 0.0105 0.0339
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.001 0.0017 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0247
Schistosoma mansoni tar DNA-binding protein 0.0349 0.2069 0.8322
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0339
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0016 0.0247
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0355
Loa Loa (eye worm) hypothetical protein 0.0111 0.0629 0.2028
Loa Loa (eye worm) hypothetical protein 0.0111 0.0629 0.2028
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0629 1
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0017 0.007
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.031 0.1829 0.7354
Brugia malayi nuclear receptor RXR 0.0022 0.0089 0.0287
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0089 0.027
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0039 0.0189 0.1587
Echinococcus granulosus smad 0.001 0.0014 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0047 0.024 0.0774
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.011 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0039 0.0189 0.0403
Trichomonas vaginalis lymphoid specific helicase, putative 0.0008 0.000000000057925 0.00000000092141
Loa Loa (eye worm) hypothetical protein 0.0047 0.024 0.0774
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0008 0.0025
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0039 0.0189 0.0403
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.0507 0.0507
Mycobacterium leprae putative cytochrome p450 0.0039 0.0189 0.2825
Schistosoma mansoni bromodomain containing protein 0.0009 0.001 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.024 0.0774
Brugia malayi hypothetical protein 0.0036 0.0172 0.0555
Brugia malayi MH1 domain containing protein 0.001 0.0014 0.0044
Onchocerca volvulus Protein ultraspiracle homolog 0.0047 0.024 0.2291
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0712 0.4264 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0047 0.024 0.0965
Onchocerca volvulus 0.0111 0.0629 0.6002
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0095 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0016 0.0247
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0039 0.0189 0.0403
Onchocerca volvulus Bile acid receptor homolog 0.0047 0.024 0.2291
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.024 0.0774
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0189 0.3003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.024 0.0729
Onchocerca volvulus 0.0022 0.0089 0.0849
Loa Loa (eye worm) hypothetical protein 0.0022 0.0089 0.0287
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0099 0.0894
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0212 0.0685
Echinococcus granulosus tumor protein p63 0.0348 0.2061 0.6262
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0016 0.005
Echinococcus granulosus betaine aldehyde dehydrogenase 0.001 0.0017 0.0053
Onchocerca volvulus 0.0111 0.0629 0.6002
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0008 0.0000003444 0.0000003444
Onchocerca volvulus 0.0022 0.0089 0.0849
Echinococcus multilocularis survival motor neuron protein 1 0.0271 0.1596 0.1596
Loa Loa (eye worm) hypothetical protein 0.0052 0.027 0.0872
Trichomonas vaginalis esterase, putative 0.0111 0.0629 1
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0016 0.0016
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0089 0.0287
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.0507 0.204
Echinococcus granulosus Smad4 0.001 0.0014 0.0041
Brugia malayi hypothetical protein 0.0025 0.0105 0.0339
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0099 0.0894
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0786 0.0786
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.001 0.0017 0.0158
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0047 0.024 0.024
Schistosoma mansoni DNA helicase recq1 0.0023 0.0095 0.038
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.001 0.0017 0.0278
Echinococcus granulosus expressed conserved protein 0.0093 0.0519 0.1577
Onchocerca volvulus 0.0009 0.0008 0.0075
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0814 0.2472
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0039 0.0189 0.3003
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0629 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0629 0.2028
Echinococcus multilocularis protein dispatched 1 0.0049 0.0249 0.0249
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0039 0.0189 0.1587
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0026 0.0103
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0099 0.0764
Schistosoma mansoni topbp1 0.001 0.0016 0.0062
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0099 0.136
Loa Loa (eye worm) hypothetical protein 0.0111 0.0629 0.2028
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0089 0.0287
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0236
Trypanosoma brucei cytochrome P450, putative 0.0058 0.0308 0.4898
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0172 0.0522
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0074 0.1339
Schistosoma mansoni survival motor neuron protein 0.0055 0.0289 0.1162
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0551 0.3291 1
Schistosoma mansoni tar DNA-binding protein 0.0349 0.2069 0.8322
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0337 0.3044
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0074 0.1618
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0089 0.0287
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0008 0.0008
Brugia malayi Cytochrome P450 family protein 0.0058 0.0308 0.0993
Loa Loa (eye worm) hypothetical protein 0.0111 0.0629 0.2028
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.001 0.0017 0.0032
Echinococcus multilocularis geminin 0.0354 0.21 0.21
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0089 0.0287
Schistosoma mansoni bromodomain containing protein 0.0009 0.001 0.0041
Echinococcus granulosus tar DNA binding protein 0.0349 0.2069 0.6287
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0047 0.024 0.0965
Toxoplasma gondii ABC1 family protein 0.0111 0.0629 0.568
Echinococcus granulosus dnaJ subfamily B 0.0418 0.2487 0.7555
Schistosoma mansoni coup transcription factor 0.0047 0.024 0.0965
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.1047 1
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0629 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0016 0.0247
Brugia malayi ecdysone receptor 0.0022 0.0089 0.0287
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0008 0.0025
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0089 0.0287
Loa Loa (eye worm) CYP4Cod1 0.0058 0.0308 0.0993
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.001 0.0017 0.0315
Schistosoma mansoni zinc finger protein 0.0009 0.001 0.0041
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.001 0.0017 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0099 0.0319
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.005
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0629 0.5619
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0039 0.0189 0.0403
Entamoeba histolytica hypothetical protein 0.0036 0.0172 0.3096
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0814 0.0814
Toxoplasma gondii exonuclease III APE 0.002 0.0074 0.0672
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0247
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0074 0.6247
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0629 0.0629
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0039 0.0189 0.1587
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0074 0.0074
Brugia malayi Steroid receptor seven-up type 2 0.0047 0.024 0.0774
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0095 0.1504
Brugia malayi ATPase, AAA family protein 0.0008 0.0000003444 0.0000011112
Schistosoma mansoni hypothetical protein 0.0067 0.0363 0.1458
Mycobacterium ulcerans lipase LipD 0.0111 0.0629 0.5619
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.024 0.0965
Schistosoma mansoni hypothetical protein 0.0041 0.0203 0.0816
Trypanosoma brucei AAA ATPase, putative 0.0008 0.0000003444 0.0000054785
Loa Loa (eye worm) hypothetical protein 0.0111 0.0629 0.2028
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.001 0.0017 0.0032
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0629 0.1439
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0039 0.0189 0.0403
Mycobacterium ulcerans aldehyde dehydrogenase 0.019 0.1107 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0105 0.0105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0786 0.2389
Schistosoma mansoni DNA helicase recq5 0.0023 0.0095 0.038
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0095 0.0305
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0047 0.024 0.0729
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.001 0.0017 0.0056
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0047 0.024 0.2291
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0039 0.0189 0.1587
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0629 0.2028
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0339
Entamoeba histolytica hypothetical protein 0.0036 0.0172 0.3096
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.001 0.0017 0.0278
Echinococcus multilocularis smad 0.001 0.0014 0.0014
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0555 0.1792
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0095 0.1702
Schistosoma mansoni hypothetical protein 0.0036 0.0172 0.0691
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0062 0.0991
Brugia malayi hypothetical protein 0.0022 0.0089 0.0287
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0016 0.0247
Schistosoma mansoni hypothetical protein 0.0041 0.0203 0.0816
Leishmania major hypothetical protein, conserved 0.0026 0.011 0.0995
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.001 0.0017 0.0018
Echinococcus multilocularis tumor protein p63 0.0348 0.2061 0.2061
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0016 0.0247
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.001 0.0017 0.0158
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.001 0.0017 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0047 0.024 0.0774
Schistosoma mansoni hypothetical protein 0.0041 0.0203 0.0816
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.019 0.1107 0.2565
Mycobacterium tuberculosis Conserved protein 0.0111 0.0629 0.1439
Loa Loa (eye worm) hypothetical protein 0.0047 0.024 0.0774
Schistosoma mansoni nuclear receptor 0.0022 0.0089 0.0358
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0629 0.2528
Schistosoma mansoni smad 0.001 0.0014 0.0054
Brugia malayi CXXC zinc finger family protein 0.0029 0.0132 0.0426
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.001 0.0017 0.0278
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0363 0.0363
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0099 0.0764
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.001 0.0017 0.0278
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0047 0.024 0.0729
Leishmania major aldehyde dehydrogenase, putative 0.001 0.0017 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0047 0.024 0.0774
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0026 0.0408
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0629 0.1439
Loa Loa (eye worm) cytochrome P450 0.0039 0.0189 0.0609
Loa Loa (eye worm) Smad1 0.001 0.0014 0.0044
Schistosoma mansoni aldehyde dehydrogenase 0.001 0.0017 0.007
Schistosoma mansoni hypothetical protein 0.0418 0.2487 1
Brugia malayi nuclear receptor NHR-67 0.0022 0.0089 0.0287
Loa Loa (eye worm) hypothetical protein 0.0047 0.024 0.0774
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.001 0.0017 0.0053
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.019 0.1107 0.1107
Schistosoma mansoni hypothetical protein 0.0067 0.0363 0.1458
Leishmania major cytochrome p450-like protein 0.0058 0.0308 0.2782
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0039 0.0189 0.0403
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0089 0.0849
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0339
Loa Loa (eye worm) RNA binding protein 0.0349 0.2069 0.6677
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0089 0.0089
Loa Loa (eye worm) beta-lactamase 0.0111 0.0629 0.2028
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.005
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.0505 0.4567
Loa Loa (eye worm) hypothetical protein 0.0047 0.024 0.0774
Mycobacterium ulcerans hypothetical protein 0.0111 0.0629 0.5619
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0095 0.0305
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0089 0.027
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0039 0.0189 0.0403

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3696 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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