Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.02164 | 0 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.02164 | 0 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.02164 | 0 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.02164 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.02164 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.02164 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.02164 | 0 | 0.5 |
Brugia malayi | Peroxidasin | 0.02164 | 0 | 0.5 |
Mycobacterium ulcerans | proteasome PrcA | 0.120021 | 1 | 0.5 |
Onchocerca volvulus | 0.02164 | 0 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.02164 | 0 | 0.5 |
Onchocerca volvulus | 0.02164 | 0 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.02164 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.02164 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.02164 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.02164 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.02164 | 0 | 0.5 |
Mycobacterium leprae | probable proteasome (alpha subunit) PrcA | 0.120021 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.02164 | 0 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.02164 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.02164 | 0 | 0.5 |
Onchocerca volvulus | 0.02164 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02164 | 0 | 0.5 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.120021 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.013 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction in parasitaemia after 48 hrs by FACS | ChEMBL. | 20945914 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20945914 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.