TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 305.799 | Formula: C17H20ClNO2
H donors: 0 H acceptors: 1 LogP: 3.52 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C=CCN1CCC2(CC1)OC=C(C2=O)c1ccccc1.Cl
InChi: 1S/C17H19NO2.ClH/c1-2-10-18-11-8-17(9-12-18)16(19)15(13-20-17)14-6-4-3-5-7-14;/h2-7,13H,1,8-12H2;1H
InChiKey: LVJZZOZFAFOKHS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	sigma non-opioid intracellular receptor 1	Starlite/ChEMBL	No references
Homo sapiens	dopamine receptor D2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma cruzi	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma brucei gambiense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania mexicana	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania donovani	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania braziliensis	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Leishmania infantum	C-8 sterol isomerase-like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131051	All targets in OG5_131051
Candida albicans	sterol C8-C7 isomerase	Get druggable targets OG5_131051	All targets in OG5_131051
Brugia malayi	ERG2 and Sigma1 receptor like protein	Get druggable targets OG5_131051	All targets in OG5_131051
Trypanosoma congolense	C-8 sterol isomerase, putative	Get druggable targets OG5_131051	All targets in OG5_131051

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.006	0.1005	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0342	0.0342
Schistosoma mansoni	importin beta-1	0.0033	0.0381	0.048
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0025	0.0175	0.0175
Echinococcus multilocularis	lamin dm0	0.0027	0.022	0.0277
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.084	0.1057
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.006	0.1005	0.1264
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0032	0.0342	0.043
Schistosoma mansoni	intermediate filament proteins	0.0027	0.022	0.0277
Onchocerca volvulus		0.0028	0.0262	0.2344
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0581	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.006	0.1005	0.1005
Schistosoma mansoni	retinoic acid receptor RXR	0.006	0.1005	0.1264
Onchocerca volvulus		0.006	0.1005	0.8986
Onchocerca volvulus		0.0017	0.0001	0.0006
Schistosoma mansoni	nuclear hormone receptor	0.0028	0.0262	0.033
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0141	0.2889	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0028	0.0262	0.033
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.084	0.1057
Brugia malayi	RNA, U transporter 1	0.0095	0.1824	0.1824
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0445	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.006	0.1005	0.1005
Brugia malayi	orphan nuclear receptor NR2E1	0.0028	0.0262	0.0262
Echinococcus granulosus	lamin	0.0027	0.022	0.0277
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.006	0.1005	0.1005
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.006	0.1005	0.1264
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0083	0.1534	0.1929
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.006	0.1005	0.1005
Brugia malayi	intermediate filament protein	0.0027	0.022	0.022
Echinococcus multilocularis	musashi	0.0027	0.022	0.0277
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0025	0.0175	0.0276
Brugia malayi	hypothetical protein	0.0065	0.1118	0.1118
Loa Loa (eye worm)	acetyltransferase	0.0143	0.2939	0.2939
Trichomonas vaginalis	ral, putative	0.0055	0.0886	0.1399
Loa Loa (eye worm)	hypothetical protein	0.008	0.1481	0.1481
Echinococcus multilocularis	ecdysone induced protein 78C	0.006	0.1005	0.1264
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0233	0.0233
Loa Loa (eye worm)	nuclear hormone receptor	0.0028	0.0262	0.0262
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0062	0.106	0.1332
Schistosoma mansoni	nuclear receptor	0.0028	0.0262	0.033
Schistosoma mansoni	lamin	0.0027	0.022	0.0277
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0184	0.3906	0.4912
Plasmodium falciparum	importin beta, putative	0.0033	0.0381	0.764
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0342	0.0342
Treponema pallidum	fructose-bisphosphate aldolase	0.0288	0.6334	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.006	0.1005	0.1264
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.006	0.1005	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Onchocerca volvulus	Matrilysin homolog	0.0038	0.049	0.4381
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.006	0.1005	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0581	0.0731
Onchocerca volvulus		0.0065	0.1118	1
Trichomonas vaginalis	ran, putative	0.0025	0.0175	0.0276
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0381	0.048
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Echinococcus granulosus	snurportin 1	0.0357	0.7953	1
Loa Loa (eye worm)	hypothetical protein	0.0227	0.4915	0.4915
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.022	0.022
Loa Loa (eye worm)	hypothetical protein	0.006	0.1005	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0209	0.0209
Brugia malayi	ecdysteroid receptor	0.006	0.1005	0.1005
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0028	0.0262	0.2344
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0381	0.5085
Giardia lamblia	Fructose-bisphosphate aldolase	0.0288	0.6334	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.006	0.1005	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0342	0.0342
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.084	0.1057
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0581	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0028	0.0262	0.0262
Schistosoma mansoni	ran	0.0025	0.0175	0.022
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0028	0.0262	0.2344
Brugia malayi	hypothetical protein	0.0028	0.0262	0.0262
Brugia malayi	hypothetical protein	0.0019	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0283	0.0283
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.6334	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.006	0.1005	0.1005
Onchocerca volvulus	Protein ultraspiracle homolog	0.006	0.1005	0.8986
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0143	0.2939	0.3695
Loa Loa (eye worm)	Ras protein let-60	0.0055	0.0886	0.0886
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.6334	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0445	1	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0028	0.0262	0.033
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Brugia malayi	Steroid receptor seven-up type 2	0.006	0.1005	0.1005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0028	0.0262	0.033
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.084	0.084
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0028	0.0262	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0088	0.0088
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0283	0.2662
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.006	0.1005	0.1005
Schistosoma mansoni	ran	0.0025	0.0175	0.022
Entamoeba histolytica	Ras family GTPase	0.0055	0.0886	0.1399
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0342	0.0342
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0141	0.2889	1
Onchocerca volvulus	Bile acid receptor homolog	0.006	0.1005	0.8986
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0032	0.0342	0.043
Schistosoma mansoni	thyroid hormone receptor	0.0184	0.3906	0.4912
Echinococcus multilocularis	lamin	0.0027	0.022	0.0277
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.0342	0.043
Echinococcus granulosus	lamin dm0	0.0027	0.022	0.0277
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0028	0.0262	0.033
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.006	0.1005	0.1264
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0021	0.0088	0.0088
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.006	0.1005	0.1264
Entamoeba histolytica	Ras family GTPase	0.0055	0.0886	0.1399
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0017	0.0001	0.0001
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0032	0.0342	0.0342
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.006	0.1005	0.1005
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0233	0.0369
Brugia malayi	Matrixin family protein	0.0017	0.0001	0.0001
Brugia malayi	acetyltransferase, GNAT family protein	0.0143	0.2939	0.2939
Echinococcus granulosus	ras gtpase	0.0055	0.0886	0.1114
Trichomonas vaginalis	rap1 and, putative	0.0055	0.0886	0.1399
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0886	0.0886
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0025	0.0175	0.3502
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.006	0.1005	0.1005
Loa Loa (eye worm)	hypothetical protein	0.006	0.1005	0.1005
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.006	0.1005	0.1264
Onchocerca volvulus		0.0027	0.022	0.197
Schistosoma mansoni	coup transcription factor	0.006	0.1005	0.1264
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.0175	0.0175
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0141	0.2889	1
Trichomonas vaginalis	rheb, putative	0.0055	0.0886	0.1399
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0139	0.2845	0.3578
Brugia malayi	tailless protein	0.0028	0.0262	0.0262
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0028	0.0262	0.033
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.006	0.1005	0.1264
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0381	0.5085
Loa Loa (eye worm)	steroid hormone receptor	0.006	0.1005	0.1005
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0032	0.0342	0.043
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0342	0.0342
Leishmania major	C-8 sterol isomerase-like protein	0.0445	1	1
Brugia malayi	Ras protein let-60	0.0055	0.0886	0.0886
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.006	0.1005	0.1264
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0025	0.0175	0.022
Brugia malayi	nuclear receptor RXR	0.0032	0.0342	0.0342
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0381	0.0381
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0342	0.0342
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0283	0.0283
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0283	0.2662
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.084	0.084
Schistosoma mansoni	hypothetical protein	0.0357	0.7953	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.006	0.1005	0.1264
Brugia malayi	Nuclear hormone receptor E75	0.0028	0.0262	0.0262
Echinococcus multilocularis	nuclear receptor nhr 48	0.0028	0.0262	0.033
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0062	0.106	0.1332
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.6334	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0283	0.0283
Brugia malayi	hypothetical protein	0.0029	0.0283	0.0283
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.006	0.1005	0.1264
Brugia malayi	Importin beta-1 subunit	0.0033	0.0381	0.0381
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.6334	1
Schistosoma mansoni	thyroid hormone receptor	0.0184	0.3906	0.4912
Schistosoma mansoni	hypothetical protein	0.0197	0.4198	0.5278
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0499	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0028	0.0262	0.033
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0233	0.0369
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0381	0.0381
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0581	0.0917
Entamoeba histolytica	Ran family GTPase	0.0025	0.0175	0.0276
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.006	0.1005	0.1005
Echinococcus multilocularis	FTZ F1 alpha	0.006	0.1005	0.1264
Brugia malayi	Nuclear hormone receptor-like 1	0.006	0.1005	0.1005
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.0175	0.0175
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.006	0.1005	0.1264
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.006	0.1005	0.8986
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.084	0.1057
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.006	0.1005	0.1005
Brugia malayi	nuclear hormone receptor family member odr-7	0.0028	0.0262	0.0262
Trichomonas vaginalis	GTP-binding protein rit, putative	0.0055	0.0886	0.1399
Brugia malayi	photoreceptor-specific nuclear receptor	0.006	0.1005	0.1005
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0028	0.0262	0.033
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.006	0.1005	0.1005
Brugia malayi	hypothetical protein	0.0032	0.0342	0.0342
Loa Loa (eye worm)	hypothetical protein	0.006	0.1005	0.1005
Brugia malayi	Ras-related protein R-Ras2	0.0055	0.0886	0.0886
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0025	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.006	0.1005	0.1005
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0083	0.1534	0.1929
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0288	0.6334	1
Onchocerca volvulus		0.0027	0.022	0.197
Loa Loa (eye worm)	hypothetical protein	0.0027	0.022	0.022
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Brugia malayi	nuclear receptor NHR-88	0.0028	0.0262	0.0262
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.006	0.1005	0.1264
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.006	0.1005	0.1005
Schistosoma mansoni	nuclear hormone receptor	0.006	0.1005	0.1264
Schistosoma mansoni	zinc finger protein	0.0028	0.0262	0.033
Brugia malayi	bZIP transcription factor family protein	0.0083	0.1534	0.1534
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0283	0.0283
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0025	0.0175	0.022
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.084	0.1057
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0342	0.0342
Brugia malayi	Hemopexin family protein	0.0024	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Echinococcus multilocularis	snurportin 1	0.0357	0.7953	1
Brugia malayi	steroid hormone receptor	0.006	0.1005	0.1005
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0581	0.0917
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0499	0.0788
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0028	0.0262	0.0262
Loa Loa (eye worm)	matrix metalloproteinase	0.0017	0.0001	0.0001
Schistosoma mansoni	nuclear receptor nhr-48	0.0028	0.0262	0.033
Entamoeba histolytica	hypothetical protein	0.0027	0.0233	0.0369
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0041	0.0553	0.0695
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0233	0.0369
Brugia malayi	Nuclear hormone receptor E75	0.0028	0.0262	0.0262
Schistosoma mansoni	hypothetical protein	0.0197	0.4198	0.5278
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0001	0.0001
Brugia malayi	Matrixin family protein	0.0017	0.0001	0.0001
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0124	0.25	0.3143
Loa Loa (eye worm)	hypothetical protein	0.006	0.1005	0.1005
Entamoeba histolytica	ras-1, putative	0.0055	0.0886	0.1399
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.6334	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0169	0.0212
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.006	0.1005	0.1264
Echinococcus multilocularis	geminin	0.0197	0.4198	0.5278
Brugia malayi	nuclear receptor NHR-88	0.006	0.1005	0.1005
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.006	0.1005	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0445	1	1
Schistosoma mansoni	nuclear hormone receptor	0.0028	0.0262	0.033
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.006	0.1005	0.1005
Brugia malayi	Matrixin family protein	0.0017	0.0001	0.0001
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.006	0.1005	0.1264
Brugia malayi	ecdysone receptor	0.0028	0.0262	0.0262
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.6334	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.006	0.1005	0.1264
Schistosoma mansoni	hypothetical protein	0.0067	0.1172	0.1473
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.084	0.1057
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Leishmania major	hypothetical protein, conserved	0.0029	0.0283	0.0283
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.022	0.022
Echinococcus granulosus	nuclear receptor nhr 48	0.0028	0.0262	0.033
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0124	0.25	0.3143
Brugia malayi	hypothetical protein	0.0032	0.0342	0.0342
Loa Loa (eye worm)	matrixin family protein	0.0038	0.049	0.049
Brugia malayi	nuclear receptor RXR	0.0028	0.0262	0.0262
Schistosoma mansoni	hypothetical protein	0.0124	0.25	0.3143
Echinococcus multilocularis	ras gtpase	0.0055	0.0886	0.1114
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.006	0.1005	0.1005
Brugia malayi	nuclear receptor NHR-67	0.0028	0.0262	0.0262
Schistosoma mansoni	jun-related protein	0.0067	0.1172	0.1473
Echinococcus granulosus	FTZ F1 alpha	0.006	0.1005	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0001	0.0001
Brugia malayi	conserved hypotetical protein	0.0028	0.0262	0.0262
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.006	0.1005	0.1264
Onchocerca volvulus		0.0024	0.0169	0.1507
Schistosoma mansoni	RAR-like nuclear receptor	0.006	0.1005	0.1264
Loa Loa (eye worm)	hypothetical protein	0.006	0.1005	0.1005
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0028	0.0262	0.033
Loa Loa (eye worm)	hypothetical protein	0.006	0.1005	0.1005
Schistosoma mansoni	nuclear receptor	0.0028	0.0262	0.033
Trichomonas vaginalis	ras-dva small GTPase, putative	0.0055	0.0886	0.1399
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.084	0.1057
Onchocerca volvulus		0.0028	0.0262	0.2344
Loa Loa (eye worm)	matrixin family protein	0.0042	0.057	0.057
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.006	0.1005	0.1005
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0028	0.0262	0.0262
Trichomonas vaginalis	dexras1, putative	0.0055	0.0886	0.1399
Brugia malayi	Matrixin family protein	0.0042	0.057	0.057
Loa Loa (eye worm)	hypothetical protein	0.006	0.1005	0.1005
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0233	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0001	0.0001
Brugia malayi	nuclear hormone receptor	0.0028	0.0262	0.0262
Loa Loa (eye worm)	DR-78	0.0028	0.0262	0.0262
Echinococcus granulosus	jun protein	0.0083	0.1534	0.1929
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0288	0.6334	1
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0038	0.049	0.4381
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0357	0.7953	0.7953
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.6334	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0262	0.0262
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0028	0.0262	0.033
Onchocerca volvulus	Matrilysin homolog	0.0017	0.0001	0.0006
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0499	0.0788
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.006	0.1005	0.1005
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.006	0.1005	0.1264
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.006	0.1005	0.1005
Leishmania major	GTP-binding protein, putative	0.0025	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0381	0.0381
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0025	0.0175	0.0175
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.6334	1
Echinococcus multilocularis	jun protein	0.0083	0.1534	0.1929
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0028	0.0262	0.033
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.006	0.1005	0.1264
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.006	0.1005	0.1005
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0028	0.0262	0.033
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0581	1
Brugia malayi	Matrixin family protein	0.0017	0.0001	0.0001
Brugia malayi	hypothetical protein	0.0028	0.0262	0.0262
Brugia malayi	nuclear hormone receptor	0.006	0.1005	0.1005
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0028	0.0262	0.033
Echinococcus granulosus	geminin	0.0197	0.4198	0.5278
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0143	0.2939	0.3695
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0283	0.5668
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0283	0.5668
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0381	0.048
Echinococcus granulosus	intermediate filament protein	0.0027	0.022	0.0277
Schistosoma mansoni	lamin	0.0027	0.022	0.0277
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.022	0.022

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 163 nM	Binding affinity for sigma receptor in guinea pig brain membrane using radiolabeled ligand [3H]-(+)-SKF- 10,047 was determined	ChEMBL.	No reference
Ki (binding)	= 4870 nM	Binding affinity for dopamine receptor D2 in guinea pig striatal membrane using radiolabeled ligand [3H]-spiperone	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL555614

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1197028