Detailed information for compound 1198205

Basic information

Technical information
  • TDR Targets ID: 1198205
  • Name: 3-[2-(2-methylpiperidin-1-yl)-2-oxoethyl]-1,3 -benzoxazol-2-one
  • MW: 274.315 | Formula: C15H18N2O3
  • H donors: 0 H acceptors: 2 LogP: 2.13 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCCN1C(=O)Cn1c(=O)oc2c1cccc2
  • InChi: 1S/C15H18N2O3/c1-11-6-4-5-9-16(11)14(18)10-17-12-7-2-3-8-13(12)20-15(17)19/h2-3,7-8,11H,4-6,9-10H2,1H3
  • InChiKey: QOIUNKJVWYJXAD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[2-(2-methyl-1-piperidyl)-2-oxo-ethyl]-1,3-benzoxazol-2-one
  • 3-[2-(2-methyl-1-piperidinyl)-2-oxoethyl]-1,3-benzoxazol-2-one
  • 3-[2-keto-2-(2-methyl-1-piperidyl)ethyl]-1,3-benzoxazol-2-one
  • 3-[2-(2-methylpiperidin-1-yl)-2-oxo-ethyl]-1,3-benzoxazol-2-one
  • T5228395
  • MLS000058164
  • SMR000063259

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Loa Loa (eye worm) hypothetical protein 0.0027 0.0147 0.0342
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0271 0.3014 0.377
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0094 0.0935 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0687 0.7901 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.008 0.024
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0057 0.0134
Echinococcus multilocularis tar DNA binding protein 0.0264 0.2936 0.3656
Echinococcus multilocularis lamin 0.0027 0.0147 0.0174
Schistosoma mansoni smad1 5 8 and 0.0026 0.0136 0.0128
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0057 0.0062
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0069 0.0642 0.1494
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.025 0.2608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0115 0.116
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.005 0.014
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0125 0.0388
Echinococcus granulosus glutamate synthase 0.0025 0.0125 0.0146
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0016 0.0038
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0125 0.0146
Entamoeba histolytica hypothetical protein 0.0039 0.0285 0.7609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0223 0.2315
Schistosoma mansoni glutamate synthase 0.0025 0.0125 0.0117
Schistosoma mansoni Smad4 0.0026 0.0136 0.0128
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0094 0.0935 0.3082
Echinococcus granulosus Smad4 0.0026 0.0136 0.016
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0554 0.5893
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0094 0.0935 1
Toxoplasma gondii NADPH-glutathione reductase 0.0094 0.0935 0.2803
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0125 0.0117
Echinococcus granulosus GPCR family 2 0.0016 0.0016 0.001
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0125 0.0146
Echinococcus multilocularis Smad4 0.0026 0.0136 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0125 0.0388
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0125 0.0388
Schistosoma mansoni lamin 0.0027 0.0147 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0143 0.1453
Schistosoma mansoni intermediate filament proteins 0.0027 0.0147 0.0139
Entamoeba histolytica thioredoxin reductase, putative 0.0025 0.0125 0.224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0146 0.1486
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0554 0.0547
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0935 0.3082
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0554 0.1817
Leishmania major NADH dehydrogenase, putative 0.0025 0.0125 0.0388
Echinococcus granulosus dna polymerase eta 0.0019 0.0057 0.0062
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0094 0.0935 0.3082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0115 0.1155
Plasmodium falciparum thioredoxin reductase 0.0271 0.3014 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0935 0.3082
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0025 0.0125 0.0765
Mycobacterium tuberculosis Probable dehydrogenase 0.0618 0.7091 0.8967
Loa Loa (eye worm) MH2 domain-containing protein 0.038 0.4296 1
Brugia malayi glutathione reductase 0.0271 0.3014 0.7017
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0285 0.0278
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0554 0.1486
Entamoeba histolytica hypothetical protein 0.0039 0.0285 0.7609
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0025 0.0125 0.0086
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0554 0.5893
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0094 0.0935 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0264 0.2936 0.6835
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0935 0.3082
Loa Loa (eye worm) transcription factor SMAD2 0.038 0.4296 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0008 0.0019
Loa Loa (eye worm) hypothetical protein 0.0102 0.103 0.2397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0146 0.1486
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0357 0.1161
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0125 0.0388
Loa Loa (eye worm) thioredoxin reductase 0.0271 0.3014 0.7017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0146 0.1486
Trypanosoma brucei trypanothione reductase 0.0271 0.3014 1
Giardia lamblia Glutamate synthase 0.0025 0.0125 0.0765
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0357 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0094 0.0935 0.2176
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0094 0.0935 0.3082
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0935 0.3082
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0094 0.0935 0.2803
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0125 0.0388
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0554 0.1817
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0125 0.0765
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0008
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0025 0.0125 0.0388
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0025 0.0125 0.0146
Echinococcus granulosus lamin 0.0027 0.0147 0.0174
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0415 0.0965
Echinococcus multilocularis musashi 0.0027 0.0147 0.0174
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0618 0.7091 0.8967
Loa Loa (eye worm) Smad1 0.0026 0.0136 0.0316
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.001
Schistosoma mansoni smad 0.0026 0.0136 0.0128
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0125 0.029
Brugia malayi glutamate synthase 0.0025 0.0125 0.029
Brugia malayi intermediate filament protein 0.0027 0.0147 0.0342
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0025 0.0125 0.0086
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0094 0.0935 0.0927
Onchocerca volvulus 0.0027 0.0147 0.0249
Echinococcus multilocularis glutamate synthase 0.0025 0.0125 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.028 0.2939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0223 0.2315
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0125 0.0388
Schistosoma mansoni disulfide oxidoreductase 0.0025 0.0125 0.0117
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0025 0.0125 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0223 0.2315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0115 0.116
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0125 0.1258
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0415 0.0965
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0357 0.3768
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0025 0.0125 0.0388
Brugia malayi TAR-binding protein 0.0264 0.2936 0.6835
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0025 0.0125 0.0765
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0285 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0223 0.2315
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0554 0.1817
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0057 0.0062
Echinococcus multilocularis tumor protein p63 0.0697 0.8017 1
Trichomonas vaginalis glutathione reductase, putative 0.0094 0.0935 1
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0264 0.2936 0.293
Leishmania major hypothetical protein, conserved 0.0025 0.0125 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0115 0.116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0143 0.1453
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0025 0.0125 0.0765
Leishmania major hypothetical protein, conserved 0.0025 0.0125 0.0388
Plasmodium falciparum glutathione reductase 0.0271 0.3014 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0554 0.5893
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0618 0.7091 0.8958
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0008 0.0019
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0001 0.0002
Leishmania major DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0115 0.1155
Trypanosoma cruzi trypanothione reductase, putative 0.0271 0.3014 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0094 0.0935 0.1118
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0025 0.0125 0.1258
Echinococcus multilocularis lamin dm0 0.0027 0.0147 0.0174
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0136 0.016
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0025 0.0125 0.029
Loa Loa (eye worm) programmed cell death 8 0.0025 0.0125 0.029
Schistosoma mansoni lamin 0.0027 0.0147 0.0139
Mycobacterium ulcerans dehydrogenase 0.0025 0.0125 0.0765
Trichomonas vaginalis apoptosis inducing factor, putative 0.0025 0.0125 0.1258
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0554 0.5662
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0935 0.3082
Leishmania major DNA polymerase eta, putative 0.0019 0.0057 0.0164
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0554 0.0682
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0038
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0025 0.0125 0.224
Loa Loa (eye worm) hypothetical protein 0.0026 0.0141 0.0329
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0094 0.0935 1
Brugia malayi RNA recognition motif domain containing protein 0.0264 0.2936 0.6835
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.025 0.0805
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0025 0.0125 0.0146
Brugia malayi Thioredoxin reductase 0.0271 0.3014 0.7017
Brugia malayi hypothetical protein 0.0039 0.0285 0.0665
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0554 0.129
Trypanosoma brucei NADH dehydrogenase 0.0025 0.0125 0.0388
Echinococcus multilocularis smad 0.0026 0.0136 0.016
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0125 0.0388
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0057 0.0164
Brugia malayi MH2 domain containing protein 0.0026 0.0136 0.0316
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.103 0.1023
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0057 0.0049
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.025 0.0805
Entamoeba histolytica disulphide oxidoreductase, putative 0.0025 0.0125 0.224
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0125 0.1258
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0025 0.0125 0.0765
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0125 0.224
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0147 0.0342
Schistosoma mansoni hypothetical protein 0.0025 0.0125 0.0117
Entamoeba histolytica hypothetical protein 0.0039 0.0285 0.7609
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0025 0.0125 0.0146
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0016 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Brugia malayi MH2 domain containing protein 0.038 0.4296 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0136 0.0128
Trichomonas vaginalis mercuric reductase, putative 0.0094 0.0935 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0094 0.0935 0.3082
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0357 0.0436
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0357 0.0436
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0057 0.0049
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0094 0.0935 0.3082
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0094 0.0935 0.2803
Leishmania major hypothetical protein, conserved 0.0025 0.0125 0.0388
Mycobacterium ulcerans ferredoxin reductase 0.0025 0.0125 0.0765
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0057 0.0062
Loa Loa (eye worm) TAR-binding protein 0.0264 0.2936 0.6835
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0025 0.0125 0.0388
Echinococcus granulosus thioredoxin glutathione reductase 0.0273 0.3033 0.3777
Schistosoma mansoni DNA polymerase eta 0.0019 0.0057 0.0049
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0554 0.1817
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0057 0.0164
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0094 0.0935 0.3082
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0357 0.0349
Schistosoma mansoni smad1 5 8 and 0.0026 0.0136 0.0128
Trypanosoma brucei unspecified product 0.0019 0.0057 0.0164
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0025 0.0125 0.0146
Onchocerca volvulus 0.0102 0.103 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0357 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0025 0.0125 0.224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0173 0.1779
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0025 0.0125 0.0146
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.023 0.0536
Mycobacterium ulcerans glutamate synthase subunit beta 0.0025 0.0125 0.0765
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0057 0.0164
Loa Loa (eye worm) RNA binding protein 0.0264 0.2936 0.6835
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0094 0.0935 0.2803
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0687 0.7901 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0025 0.0125 0.0146
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0025 0.0125 0.224
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.001
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0125 0.1258
Schistosoma mansoni tar DNA-binding protein 0.0264 0.2936 0.293
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0057 0.0533
Echinococcus multilocularis thioredoxin glutathione reductase 0.0273 0.3033 0.3777
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0618 0.7091 0.8967
Mycobacterium ulcerans NADH dehydrogenase 0.0025 0.0125 0.0765
Mycobacterium ulcerans hypothetical protein 0.0025 0.0125 0.0765
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0147 0.0342
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0357 0.1161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0223 0.2315
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0094 0.0935 0.3082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0223 0.2315
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0125 0.1258
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0184 0.1902
Brugia malayi MH1 domain containing protein 0.0026 0.0136 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0223 0.2315
Loa Loa (eye worm) hypothetical protein 0.0025 0.0125 0.029
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0136 0.016
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0094 0.0935 0.3082
Loa Loa (eye worm) glutathione reductase 0.0271 0.3014 0.7017
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0094 0.0935 0.2803
Echinococcus granulosus smad 0.0026 0.0136 0.016
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0554 0.1817
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0025 0.0125 0.0086
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0025 0.0125 0.0388
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0125 0.1258
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0357 0.0831
Brugia malayi MAP kinase sur-1 0.0062 0.0554 0.129
Giardia lamblia GTOR 0.0045 0.0357 0.3417
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0618 0.7091 0.8967
Echinococcus granulosus dna polymerase kappa 0.0019 0.0057 0.0062
Plasmodium vivax glutathione reductase, putative 0.0271 0.3014 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0687 0.7901 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0136 0.0316
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0025 0.0125 0.1258
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0357 0.1161
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0057 0.0164
Mycobacterium ulcerans monoxygenase 0.0025 0.0125 0.0765
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.001
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0125 0.0388
Schistosoma mansoni hypothetical protein 0.0039 0.0285 0.0278
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0025 0.0125 0.0388
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0025 0.0125 0.0388
Brugia malayi RNA binding protein 0.0264 0.2936 0.6835
Schistosoma mansoni glutamate synthase 0.0025 0.0125 0.0117
Echinococcus multilocularis dna polymerase eta 0.0019 0.0057 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0115 0.1155
Giardia lamblia Thioredoxin reductase 0.0025 0.0125 0.0765
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.025 0.0805
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0285 0.0346
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0094 0.0935 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0147 0.0174
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0094 0.0935 0.3082
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0687 0.7901 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0554 0.5893
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0094 0.0935 0.1157
Echinococcus granulosus tumor protein p63 0.0697 0.8017 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0136 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0357 0.3768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.025 0.2608
Toxoplasma gondii thioredoxin reductase 0.0271 0.3014 1
Schistosoma mansoni tar DNA-binding protein 0.0264 0.2936 0.293
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0057 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0115 0.116
Onchocerca volvulus 0.0027 0.0147 0.0249
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0125 0.1258
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0025 0.0125 0.029
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0554 0.0682
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0136 0.0316
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0025 0.0125 0.0765
Trichomonas vaginalis glutamate synthase, putative 0.0025 0.0125 0.1258
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.0935 0.3082
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0057 0.0164
Plasmodium falciparum glutathione reductase 0.0094 0.0935 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0001 0.0002
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0069 0.0642 0.1494
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0554 0.1817
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0357 0.0831
Trypanosoma brucei protein kinase, putative 0.0062 0.0554 0.1817
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0025 0.0125 0.0146
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0025 0.0125 0.1258
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0618 0.7091 0.8967
Plasmodium vivax thioredoxin reductase, putative 0.0271 0.3014 1
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0125 0.0388
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0125 0.1258
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0057 0.0533
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0136 0.016
Trypanosoma cruzi NADH dehydrogenase, putative 0.0025 0.0125 0.0388
Brugia malayi MH1 domain containing protein 0.0026 0.0136 0.0316
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0094 0.0935 0.3082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Entamoeba histolytica hypothetical protein 0.0039 0.0285 0.7609
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0094 0.0935 0.3082
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0357 0.1161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.025 0.2608
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0025 0.0125 0.0086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0057 0.0134
Brugia malayi Smad1 0.0026 0.0136 0.0316
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0025 0.0125 0.0086
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0025 0.0125 0.0146
Loa Loa (eye worm) hypothetical protein 0.0034 0.023 0.0536
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0057 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0264 0.2936 0.293
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0057 0.0134
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0357 0.1161
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0025 0.0125 0.0146
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0147 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.025 0.2608
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0554 0.0682
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0025 0.0125 0.0765
Mycobacterium tuberculosis Probable reductase 0.0618 0.7091 0.8967
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0025 0.0125 0.029
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0223 0.0339
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0357 0.1161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.025 0.2608
Schistosoma mansoni sulfide quinone reductase 0.0025 0.0125 0.0117
Plasmodium falciparum thioredoxin reductase 0.0094 0.0935 0.2803
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0025 0.0125 0.224
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0025 0.0125 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0357 0.3768
Schistosoma mansoni hypothetical protein 0.0034 0.023 0.0222
Loa Loa (eye worm) hypothetical protein 0.005 0.0415 0.0965
Echinococcus granulosus tar DNA binding protein 0.0264 0.2936 0.3656
Schistosoma mansoni glutamate synthase 0.0025 0.0125 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Schistosoma mansoni smad1 5 8 and 0.0026 0.0136 0.0128
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0008
Leishmania major trypanothione reductase 0.0271 0.3014 1
Schistosoma mansoni tar DNA-binding protein 0.0264 0.2936 0.293
Echinococcus granulosus lamin dm0 0.0027 0.0147 0.0174
Giardia lamblia NADH oxidase lateral transfer candidate 0.0094 0.0935 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0094 0.0935 1
Brugia malayi MH2 domain containing protein 0.0026 0.0136 0.0316
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0094 0.0935 0.1157
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0554 0.1817
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0415 0.0965
Echinococcus multilocularis GPCR, family 2 0.0016 0.0016 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0025 0.0125 0.0765
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0164
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0094 0.0935 0.2803
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0016 0.0038
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0025 0.0125 0.1258
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0554 0.0682
Treponema pallidum NADH oxidase 0.0094 0.0935 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.01 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.