Detailed information for compound 1198266

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 377.436 | Formula: C22H23N3O3
  • H donors: 2 H acceptors: 3 LogP: 2.77 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc2c(c1)N=C1CC(C)(C)CC(=C1C(N2)c1ccncc1)O
  • InChi: 1S/C22H23N3O3/c1-22(2)11-17-19(18(26)12-22)20(13-6-8-23-9-7-13)25-15-5-4-14(21(27)28-3)10-16(15)24-17/h4-10,20,25-26H,11-12H2,1-3H3
  • InChiKey: VAUPIUQHWUZONE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0037 0.0303 0.0966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0519 0.0519
Schistosoma mansoni coup transcription factor 0.0078 0.0837 0.0885
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0066 0.0869
Loa Loa (eye worm) hypothetical protein 0.0022 0.0115 0.0115
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0303 0.0966
Brugia malayi Cathepsin L-like precursor 0.0019 0.0071 0.0071
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0185 0.2133
Plasmodium vivax glutathione reductase, putative 0.0053 0.0519 0.5971
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0071 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0078 0.0837 0.0837
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0167 0.1993 0.2105
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.1232 0.1232
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0066 0.085
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.1406 0.8844
Plasmodium vivax vivapain-2 0.0019 0.0071 0.0821
Onchocerca volvulus 0.0037 0.0303 0.0966
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0837 0.0837
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0204 0.247 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.0303 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0078 0.0837 0.0837
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0837 0.0837
Brugia malayi N-terminal motif family protein 0.0204 0.247 0.247
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0271 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.076 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0066 0.0869
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0303 0.0303
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0271 0.0271
Schistosoma mansoni loxhd1 0.0022 0.0115 0.0121
Brugia malayi tailless protein 0.0037 0.0303 0.0303
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0002 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0303 0.032
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0066 0.085
Trypanosoma brucei trypanothione reductase 0.0053 0.0519 0.682
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.076 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0078 0.0837 0.0837
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0868 0.0917
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0115 0.0115
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0058 0.0662
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0074 0.0787 0.0787
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0868 1
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0071 1
Brugia malayi nuclear hormone receptor 0.0037 0.0303 0.0303
Plasmodium falciparum thioredoxin reductase 0.0019 0.0066 0.0761
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0777 0.0777
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0078 0.0837 0.0837
Schistosoma mansoni hypothetical protein 0.0034 0.0271 0.0286
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0635 0.0635
Schistosoma mansoni retinoic acid receptor RXR 0.0078 0.0837 0.0885
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0837 0.0837
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.1406 0.8738
Brugia malayi isocitrate dehydrogenase 0.0018 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0078 0.0837 0.0837
Schistosoma mansoni hypothetical protein 0.0034 0.0271 0.0286
Echinococcus multilocularis RUN 0.0022 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0041 0.036 0.036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0078 0.0837 0.0837
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0353 0.0353
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0058 0.0757
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.0837 0.0837
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0868 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0071 0.0075
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0078 0.0837 0.3194
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0271 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.076 1
Toxoplasma gondii cathepsin CPL 0.0019 0.0071 0.0821
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0034 0.0271 0.0286
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0167 0.1993 0.2105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0837 0.0837
Schistosoma mansoni hypothetical protein 0.0191 0.2308 0.2438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0066 0.0869
Loa Loa (eye worm) hypothetical protein 0.0041 0.036 0.036
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0679 0.8934
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0041 0.0353 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0837 0.0837
Toxoplasma gondii thioredoxin reductase 0.0053 0.0519 0.5971
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.1406 0.8844
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0837 0.0837
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0058 0.0058
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0066 0.0869
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.1574 0.1574
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0058 0.0662
Plasmodium falciparum thioredoxin reductase 0.0053 0.0519 0.5971
Echinococcus multilocularis thyroid hormone receptor alpha 0.0078 0.0837 0.0837
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0115 0.0115
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0078 0.0837 0.0837
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0058 0.0662
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0066 0.0761
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0071 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0303 0.032
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0868 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0115 0.0115
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0058 0.0061
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0303 0.0966
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0078 0.0837 0.0837
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0509 0.0509
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0071 0.0071
Brugia malayi nuclear receptor NHR-67 0.0037 0.0303 0.0303
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0066 0.0869
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0078 0.0837 0.0837
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0066 0.0761
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0303 0.0303
Entamoeba histolytica hypothetical protein 0.0041 0.0353 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.076 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0868 1
Schistosoma mansoni lipoxygenase 0.0022 0.0115 0.0121
Loa Loa (eye worm) fibroinase 0.0019 0.0071 0.0071
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.1406 0.8844
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0066 0.085
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0303 0.0303
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0353 0.0373
Loa Loa (eye worm) steroid hormone receptor 0.0078 0.0837 0.0837
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0002 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0078 0.0837 0.0837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.076 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0837 0.0837
Leishmania major cathepsin L-like protease 0.0019 0.0071 0.0918
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.1582 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0509 0.2964
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.036 0.036
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0037 0.0303 0.0303
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0837 0.0837
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0271 0.0271
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0066 0.085
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0785 1 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0185 0.2133
Brugia malayi Doublecortin family protein 0.0022 0.0115 0.0115
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.076 1
Leishmania major cathepsin L-like protease 0.0019 0.0071 0.0918
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Brugia malayi Cathepsin L-like precursor 0.0019 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0078 0.0837 0.0837
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0066 0.0869
Brugia malayi hypothetical protein 0.0022 0.0115 0.0115
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0115 0.0115
Brugia malayi Probable ClpP-like protease 0.008 0.0868 0.0868
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0078 0.0837 0.0885
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0519 0.682
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.036 0.0381
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Schistosoma mansoni nuclear receptor 0.0037 0.0303 0.032
Schistosoma mansoni rab6-interacting 0.0022 0.0115 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.076 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0303 0.0303
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0066 0.0869
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0777 1
Brugia malayi hypothetical protein 0.0041 0.036 0.036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0066 0.0869
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0058 0.0058
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0071 0.0821
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.1574 0.1574
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0071 0.0071
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Brugia malayi hypothetical protein 0.0037 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0071 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0066 0.0869
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0868 1
Loa Loa (eye worm) pip kinase 2 0.0167 0.1993 0.1993
Onchocerca volvulus 0.0078 0.0837 0.3194
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0071 1
Brugia malayi nuclear receptor NHR-88 0.0078 0.0837 0.0837
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0115 0.1322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0078 0.0837 0.0837
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.1232 0.1232
Brugia malayi hypothetical protein 0.0022 0.0115 0.0115
Plasmodium falciparum glutathione reductase 0.0053 0.0519 0.5971
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0078 0.0837 0.0837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0071 1
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.076 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0115 0.1322
Loa Loa (eye worm) cysteine protease 0.0019 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0041 0.036 0.036
Brugia malayi Cathepsin L-like precursor 0.0019 0.0071 0.0071
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0066 0.007
Schistosoma mansoni zinc finger protein 0.0037 0.0303 0.032
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0167 0.1993 0.1993
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.036 0.036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0078 0.0837 0.0837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.076 1
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0071 0.202
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0066 0.0869
Schistosoma mansoni rab6-interacting 0.0022 0.0115 0.0121
Brugia malayi hypothetical protein 0.0041 0.0353 0.0353
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0271 0.0271
Schistosoma mansoni thyroid hormone receptor 0.0078 0.0837 0.0885
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0058 0.0757
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0078 0.0837 0.0885
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0066 0.9264
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.1406 0.8844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0078 0.0837 0.0837
Schistosoma mansoni steroid hormone receptor ad4bp 0.0078 0.0837 0.0885
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0071 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0868 0.4892
Loa Loa (eye worm) hypothetical protein 0.0078 0.0837 0.0837
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0034 0.0271 0.0286
Leishmania major cathepsin L-like protease 0.0019 0.0071 0.0918
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0115 0.0115
Onchocerca volvulus 0.0167 0.1993 0.8011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0837 0.0837
Leishmania major cathepsin L-like protease 0.0072 0.076 0.9787
Echinococcus granulosus FTZ F1 alpha 0.0078 0.0837 0.0837
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0071 0.0071
Entamoeba histolytica hypothetical protein 0.0041 0.0353 1
Onchocerca volvulus Bile acid receptor homolog 0.0078 0.0837 0.3194
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0071 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.076 1
Echinococcus multilocularis GPCR, family 2 0.0034 0.0271 0.0271
Leishmania major trypanothione reductase 0.0053 0.0519 0.6675
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.1406 0.8844
Loa Loa (eye worm) hypothetical protein 0.0078 0.0837 0.0837
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0787 0.0787
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0519 0.3024
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0777 0.0821
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0868 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0868 1
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0303 0.0303
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.1582 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Brugia malayi conserved hypotetical protein 0.0037 0.0303 0.0303
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0066 0.0869
Entamoeba histolytica cysteine protease, putative 0.0019 0.0071 0.202
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0303 0.0303
Schistosoma mansoni RAR-like nuclear receptor 0.0078 0.0837 0.0885
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0837 0.0837
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0777 0.0821
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0078 0.0837 0.0837
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0066 0.9264
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0066 0.0761
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0058 0.0741
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.036 0.036
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0868 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0509 0.2321
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0303 0.0303
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0078 0.0837 0.0837
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0868 0.0868
Schistosoma mansoni hypothetical protein 0.0074 0.0787 0.0831
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0078 0.0837 0.0885
Loa Loa (eye worm) hypothetical protein 0.008 0.0868 0.0868
Leishmania major cathepsin L-like protease 0.0019 0.0071 0.0918
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0058 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0777 0.8859
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0078 0.0837 0.0837
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.1582 1
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0071 0.0918
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0868 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0071 1
Schistosoma mansoni hypothetical protein 0.0022 0.0115 0.0121
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0115 0.0115
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0071 0.0071
Leishmania major cathepsin L-like protease 0.0072 0.076 0.9787
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.036 0.036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0058 0.0058
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0271 0.0271
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0058 0.0058
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0066 1
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0071 0.0938
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0303 0.0303
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0185 0.1485
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0743 0.9466 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0509 0.2964
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0837 0.0837
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0353 0.0353
Brugia malayi nuclear receptor RXR 0.0041 0.036 0.036
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0635 0.0635
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0303 0.032
Loa Loa (eye worm) hypothetical protein 0.0108 0.1232 0.1232
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0066 0.0761
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0066 0.0066
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0777 0.8859
Schistosoma mansoni polycystin 1-related 0.0022 0.0115 0.0121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0777 0.8859
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.076 1
Echinococcus multilocularis geminin 0.0191 0.2308 0.2308
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.036 0.0381
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.1232 0.1232
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0058 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.076 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0071 0.0821
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0078 0.0837 0.0837
Brugia malayi Cathepsin L-like precursor 0.0019 0.0071 0.0071
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0868 0.0868
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0071
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0519 0.0519
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0078 0.0837 0.0837
Onchocerca volvulus 0.0022 0.0115 0.0181
Schistosoma mansoni hypothetical protein 0.0041 0.0353 0.0373
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0071 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.076 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0303 0.0303
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0167 0.1993 0.1993
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0303 0.0303
Plasmodium falciparum glutathione reductase 0.0019 0.0066 0.0761
Brugia malayi MH2 domain containing protein 0.0135 0.1574 0.1574
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Brugia malayi ecdysteroid receptor 0.0078 0.0837 0.0837
Loa Loa (eye worm) hypothetical protein 0.0078 0.0837 0.0837
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0785 1 1
Brugia malayi Thioredoxin reductase 0.0053 0.0519 0.0519
Echinococcus granulosus GPCR family 2 0.0034 0.0271 0.0271
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.1582 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.076 1
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.076 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0303 0.0303
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0078 0.0837 0.0885
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0078 0.0837 0.0885
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0519 0.5971
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0066 0.0761
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0777 0.8945
Schistosoma mansoni nuclear hormone receptor 0.0078 0.0837 0.0885
Loa Loa (eye worm) hypothetical protein 0.0041 0.036 0.036
Brugia malayi photoreceptor-specific nuclear receptor 0.0078 0.0837 0.0837
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0785 1 1
Leishmania major cathepsin L-like protease 0.0019 0.0071 0.0918
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0271 0.0271
Echinococcus granulosus geminin 0.0191 0.2308 0.2308
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0058 0.0757
Brugia malayi Pip kinase protein 2 0.0167 0.1993 0.1993
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0078 0.0837 0.0885
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0837 0.0837
Echinococcus multilocularis cysteine protease 0.0019 0.0071 0.0071
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0777 0.4719
Brugia malayi Cathepsin L-like precursor 0.0019 0.0071 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0078 0.0837 0.0837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0066 0.0869
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0078 0.0837 0.0837
Brugia malayi glutathione reductase 0.0053 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0204 0.247 0.247
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0509 0.0509
Brugia malayi nuclear hormone receptor 0.0078 0.0837 0.0837
Brugia malayi nuclear receptor NHR-88 0.0037 0.0303 0.0303
Loa Loa (eye worm) DR-78 0.0037 0.0303 0.0303
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0066 0.0056
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0066 0.0869
Echinococcus multilocularis cysteine protease 0.0019 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Schistosoma mansoni thyroid hormone receptor 0.0078 0.0837 0.0885
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0868 1
Toxoplasma gondii hypothetical protein 0.0028 0.0185 0.2133
Schistosoma mansoni lipoxygenase 0.0062 0.0635 0.067
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0271 0.0271
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0058 0.0662
Loa Loa (eye worm) hypothetical protein 0.0041 0.036 0.036
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0303 0.032
Plasmodium vivax vivapain-2 0.0019 0.0071 0.0821
Loa Loa (eye worm) ctsf protein 0.0019 0.0071 0.0071
Mycobacterium tuberculosis Probable reductase 0.0122 0.1406 0.8844
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0058 0.0757
Echinococcus granulosus ecdysone induced protein 78C 0.0078 0.0837 0.0837
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.056 0.737
Echinococcus granulosus cathepsin l1 0.0019 0.0071 0.0071
Echinococcus granulosus RUN 0.0022 0.0115 0.0115
Brugia malayi hypothetical protein 0.0041 0.036 0.036
Brugia malayi hypothetical protein 0.0037 0.0303 0.0303
Loa Loa (eye worm) glutathione reductase 0.0053 0.0519 0.0519
Brugia malayi Steroid receptor seven-up type 2 0.0078 0.0837 0.0837
Brugia malayi Cathepsin L-like precursor 0.0019 0.0071 0.0071
Leishmania major cathepsin L-like protease 0.0072 0.076 0.9787
Onchocerca volvulus 0.0022 0.0115 0.0181
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0066 0.0761
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0071 0.0821
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0071 0.0075
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0071 0.202
Loa Loa (eye worm) hypothetical protein 0.0037 0.0303 0.0303
Echinococcus multilocularis FTZ F1 alpha 0.0078 0.0837 0.0837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0071 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0058 0.0058
Onchocerca volvulus Protein ultraspiracle homolog 0.0078 0.0837 0.3194
Echinococcus multilocularis ecdysone induced protein 78C 0.0078 0.0837 0.0837
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0519 0.0519
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.036 0.036
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0777 0.0777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0071 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0191 0.2308 0.2438
Brugia malayi nuclear receptor RXR 0.0037 0.0303 0.0303
Schistosoma mansoni nuclear receptor 0.0037 0.0303 0.032
Brugia malayi ecdysone receptor 0.0037 0.0303 0.0303
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0071 0.0071
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0303 0.0303
Entamoeba histolytica hypothetical protein 0.0041 0.0353 1
Brugia malayi steroid hormone receptor 0.0078 0.0837 0.0837
Loa Loa (eye worm) hypothetical protein 0.0167 0.1993 0.1993
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0071 0.0071

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0026 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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