Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0057 | 0.1623 | 0.692 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0653 | 0.0748 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8732 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0057 | 0.1623 | 0.742 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0229 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0229 | 0.5 |
Trypanosoma brucei | ISWI complex protein | 0.0018 | 0.0229 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0464 | 0.0532 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1243 | 0.1424 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0464 | 0.198 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0057 | 0.1623 | 0.742 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0871 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1435 | 0.1643 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2345 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2187 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2187 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0306 | 0.1306 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.2862 | 0.3277 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1623 | 0.1858 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8732 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0229 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2673 | 0.3061 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0871 | 0.3981 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0021 | 0.0306 | 0.1401 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0333 | 0.0382 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0871 | 0.3713 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0229 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0548 | 0.2508 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0548 | 0.2339 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0057 | 0.1623 | 0.692 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0871 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0418 | 0.1909 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1351 | 0.1547 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0229 | 0.0976 |
Onchocerca volvulus | 0.0036 | 0.0871 | 0.0871 | |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0021 | 0.0306 | 0.1401 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0822 | 0.376 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0418 | 0.1909 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0306 | 0.1306 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0548 | 0.2508 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1139 | 0.5207 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0418 | 0.1781 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1139 | 0.5207 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0871 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1246 | 0.1427 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0871 | 0.3713 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.1689 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.