Detailed information for compound 1199025

Basic information

Technical information
  • TDR Targets ID: 1199025
  • Name: [2-(3,5-dimethylpiperidin-1-yl)-2-oxoethyl] 5 -methoxy-3-methyl-1-benzofuran-2-carboxylate
  • MW: 359.416 | Formula: C20H25NO5
  • H donors: 0 H acceptors: 2 LogP: 4.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(C)c(o2)C(=O)OCC(=O)N1CC(C)CC(C1)C
  • InChi: 1S/C20H25NO5/c1-12-7-13(2)10-21(9-12)18(22)11-25-20(23)19-14(3)16-8-15(24-4)5-6-17(16)26-19/h5-6,8,12-13H,7,9-11H2,1-4H3
  • InChiKey: AFQDDUHBILLKAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-(3,5-dimethyl-1-piperidyl)-2-oxo-ethyl] 5-methoxy-3-methyl-benzofuran-2-carboxylate
  • 5-methoxy-3-methyl-2-benzofurancarboxylic acid [2-(3,5-dimethyl-1-piperidinyl)-2-oxoethyl] ester
  • 5-methoxy-3-methyl-benzofuran-2-carboxylic acid [2-(3,5-dimethyl-1-piperidyl)-2-keto-ethyl] ester
  • [2-(3,5-dimethylpiperidin-1-yl)-2-oxo-ethyl] 5-methoxy-3-methyl-1-benzofuran-2-carboxylate
  • T5476252

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0043 0.0065 0.5
Leishmania major carbonic anhydrase-like protein 0.0189 0.0652 0.0591
Schistosoma mansoni carbonic anhydrase 0.0089 0.0248 0.0248
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0065 0.0009
Echinococcus granulosus sterol regulatory element binding protein 0.1034 0.4052 0.4052
Echinococcus multilocularis protein dispatched 1 0.1034 0.4052 0.4052
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.1178 0.4633 0.5
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0271 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0133 0.0121
Onchocerca volvulus 0.0043 0.0065 0.5
Echinococcus granulosus carbonic anhydrase 0.0089 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0094 0.0271 0.0216
Loa Loa (eye worm) carbonic anhydrase 3 0.0189 0.0652 0.0599
Loa Loa (eye worm) hypothetical protein 0.251 1 1
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.251 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0089 0.0248 0.0237
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0089 0.0248 0.0193
Echinococcus multilocularis carbonic anhydrase 0.0089 0.0248 0.0248
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0065 0.0065
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0065 0.1768
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1178 0.4633 1
Trypanosoma brucei carbonic anhydrase-like protein 0.0189 0.0652 0.0591
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0189 0.0652 0.0641
Echinococcus multilocularis Niemann Pick C1 protein 0.1034 0.4052 0.4052
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.251 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0189 0.0652 0.0591
Echinococcus granulosus Protein patched homolog 1 0.1034 0.4052 0.4052
Schistosoma mansoni carbonic anhydrase-related 0.0089 0.0248 0.0248
Brugia malayi CHE-14 protein 0.1034 0.4052 0.4046
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0089 0.0248 0.0237
Loa Loa (eye worm) hypothetical protein 0.0089 0.0248 0.0193
Toxoplasma gondii hypothetical protein 0.0089 0.0248 0.9101
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0056 0.0045
Brugia malayi Probable ClpP-like protease 0.0094 0.0271 0.0259
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0271 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0065 0.1768
Schistosoma mansoni hypothetical protein 0.0205 0.0714 0.0714
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0271 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0089 0.0248 0.0193
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0009
Loa Loa (eye worm) hypothetical protein 0.0052 0.0098 0.0042
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0271 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.1034 0.4052 0.4052
Brugia malayi Bromodomain containing protein 0.0046 0.0077 0.0065
Loa Loa (eye worm) hypothetical protein 0.1034 0.4052 0.4019
Echinococcus granulosus geminin 0.0205 0.0714 0.0714
Echinococcus granulosus carbonic anhydrase 0.0089 0.0248 0.0248
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.014 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.1034 0.4052 0.8729
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0271 0.5
Echinococcus multilocularis protein patched 0.1034 0.4052 0.4052
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1178 0.4633 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1009 1
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.251 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0089 0.0248 0.0248
Echinococcus granulosus Niemann Pick C1 protein 0.1034 0.4052 0.4052
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0065 0.0065
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0271 0.0271
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.251 1 1
Echinococcus multilocularis sterol regulatory element binding protein 0.1034 0.4052 0.4052
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0271 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0271 0.0271
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0089 0.0248 0.0237
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.251 1 1
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.014 0.014
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0271 0.0207
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0181 0.0181
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0089 0.0248 0.0237
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0065 0.0054
Schistosoma mansoni hypothetical protein 0.0041 0.0056 0.0056
Echinococcus granulosus carbonic anhydrase II 0.0189 0.0652 0.0652
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0271 0.0271
Echinococcus multilocularis carbonic anhydrase II 0.0189 0.0652 0.0652
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0009
Loa Loa (eye worm) hypothetical protein 0.006 0.0133 0.0077
Onchocerca volvulus 0.0043 0.0065 0.5
Schistosoma mansoni bromodomain containing protein 0.0076 0.0198 0.0198
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.251 1 1
Toxoplasma gondii ABC1 family protein 0.0043 0.0065 0.1768
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0009
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0271 0.0207
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0189 0.0652 0.0652
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0271 1
Schistosoma mansoni patched 1 0.1034 0.4052 0.4052
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0189 0.0652 0.0591
Brugia malayi beta-lactamase 0.0043 0.0065 0.0054
Schistosoma mansoni hypothetical protein 0.0205 0.0714 0.0714
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0065 0.0065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0065 0.0065
Brugia malayi beta-lactamase family protein 0.0043 0.0065 0.0054
Brugia malayi beta-lactamase family protein 0.0043 0.0065 0.0054
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.1034 0.4052 0.4019
Schistosoma mansoni hypothetical protein 0.0089 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0009
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0181 0.0181
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0089 0.0248 0.0237
Echinococcus multilocularis geminin 0.0205 0.0714 0.0714
Mycobacterium leprae Probable lipase LipE 0.0043 0.0065 0.1768
Loa Loa (eye worm) beta-lactamase 0.0043 0.0065 0.0009
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.251 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0133 0.0121
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0271 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0065 0.0009
Schistosoma mansoni carbonic anhydrase-related 0.0089 0.0248 0.0248
Brugia malayi Bromodomain containing protein 0.0091 0.0255 0.0244
Loa Loa (eye worm) hypothetical protein 0.0089 0.0248 0.0193
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.014 0.4744
Echinococcus multilocularis carbonic anhydrase 0.0089 0.0248 0.0248
Plasmodium falciparum carbonic anhydrase 0.0089 0.0248 0.9101
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0189 0.0652 0.0599
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.0179
Echinococcus granulosus carbonic anhydrase 0.0089 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0049 0.0088 0.0033
Echinococcus multilocularis carbonic anhydrase 0.0089 0.0248 0.0248
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3834 0.3834
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0189 0.0652 0.0641
Loa Loa (eye worm) hypothetical protein 0.0046 0.0077 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0133 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0065 0.0065
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.014 0.0786
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0189 0.0652 0.0652
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.251 1 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0271 1
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.1178 0.4633 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 44.878 uM PubChem BioAssay. Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4611 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.