Detailed information for compound 1199040

Basic information

Technical information
  • TDR Targets ID: 1199040
  • Name: N,N'-di(phenyl)piperazine-1,4-dicarboxamide
  • MW: 324.377 | Formula: C18H20N4O2
  • H donors: 2 H acceptors: 2 LogP: 1.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)C(=O)Nc1ccccc1)Nc1ccccc1
  • InChi: 1S/C18H20N4O2/c23-17(19-15-7-3-1-4-8-15)21-11-13-22(14-12-21)18(24)20-16-9-5-2-6-10-16/h1-10H,11-14H2,(H,19,23)(H,20,24)
  • InChiKey: ONUDVYZRNCZADU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6511-89-3
  • ARONIS021441
  • BIM-0031191.P001
  • MLS000711549
  • ST056052
  • SMR000281316
  • CBMicro_031290
  • MixCom6_001594
  • 1,4-Piperazinedicarboxanilide
  • NSC35929
  • BAS 02283643
  • Piperazine-1,4-dicarboxylic acid bis-phenylamide
  • Oprea1_265307
  • Oprea1_324797
  • AN-329/40215233

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0313 0.0241
Brugia malayi Animal haem peroxidase family protein 0.0675 0.8043 1
Brugia malayi Delta serrate ligand family protein 0.0069 0.0538 0.0669
Schistosoma mansoni hypothetical protein 0.0069 0.0538 0.0483
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Toxoplasma gondii EGF family domain-containing protein 0.0069 0.0538 1
Echinococcus multilocularis protein jagged 1 0.0069 0.0538 0.0421
Loa Loa (eye worm) animal heme peroxidase 0.0675 0.8043 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.052 0.0461
Brugia malayi hypothetical protein 0.0162 0.1687 0.2097
Onchocerca volvulus 0.0069 0.0538 0.0525
Brugia malayi EGF-like domain containing protein 0.0069 0.0538 0.0669
Echinococcus multilocularis tar DNA binding protein 0.0068 0.052 0.0403
Onchocerca volvulus 0.0069 0.0538 0.0525
Brugia malayi Animal haem peroxidase family protein 0.0675 0.8043 1
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0098 0.089 0.0778
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0 0.5
Echinococcus multilocularis neurogenic locus notch protein 0.0069 0.0538 0.0421
Loa Loa (eye worm) TAR-binding protein 0.0068 0.052 0.0647
Schistosoma mansoni hypothetical protein 0.0069 0.0538 0.0483
Loa Loa (eye worm) animal heme peroxidase 0.0675 0.8043 1
Brugia malayi Blistered cuticle protein 3 0.0675 0.8043 1
Echinococcus multilocularis geminin 0.0174 0.1836 0.1735
Onchocerca volvulus Chorion peroxidase homolog 0.0675 0.8043 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0069 0.0538 0.0669
Brugia malayi hypothetical protein 0.0675 0.8043 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Echinococcus granulosus neurogenic locus notch protein 0.0069 0.0538 0.0525
Onchocerca volvulus 0.0675 0.8043 1
Brugia malayi EGF-like domain containing protein 0.0069 0.0538 0.0669
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.052 0.0647
Schistosoma mansoni notch 0.0069 0.0538 0.0483
Echinococcus granulosus neuropeptide s receptor 0.0463 0.5416 0.6683
Loa Loa (eye worm) MBCTL1 0.0058 0.04 0.0498
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0122 0.5
Echinococcus multilocularis notch 0.0069 0.0538 0.0421
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.5416 0.5359
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Brugia malayi Calcium binding EGF domain containing protein 0.0069 0.0538 0.0669
Echinococcus multilocularis neural cadherin 0.0069 0.0538 0.0421
Brugia malayi Muscle positioning protein 4 0.0069 0.0538 0.0669
Echinococcus granulosus peroxidasin 0.0675 0.8043 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.04 0.0282
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0098 0.089 0.1107
Schistosoma mansoni hypothetical protein 0.0174 0.1836 0.2129
Schistosoma mansoni tar DNA-binding protein 0.0068 0.052 0.0461
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Brugia malayi EGF-like domain containing protein 0.0069 0.0538 0.0669
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.2176 0.2079
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Schistosoma mansoni cell polarity protein 0.0069 0.0538 0.0483
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.5416 0.5359
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Schistosoma mansoni laminin gamma-3 chain 0.0069 0.0538 0.0483
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Echinococcus granulosus notch 0.0069 0.0538 0.0525
Trichomonas vaginalis AGC family protein kinase 0.0098 0.089 0.5
Onchocerca volvulus 0.0069 0.0538 0.0525
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Schistosoma mansoni peroxidasin 0.0675 0.8043 1
Schistosoma mansoni hypothetical protein 0.0069 0.0538 0.0483
Loa Loa (eye worm) notch protein 0.0069 0.0538 0.0669
Echinococcus granulosus geminin 0.0174 0.1836 0.2164
Brugia malayi EGF-like domain containing protein 0.0069 0.0538 0.0669
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0313 0.0197
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.04 0.0309
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Brugia malayi Animal haem peroxidase family protein 0.0675 0.8043 1
Schistosoma mansoni notch 0.0069 0.0538 0.0483
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Loa Loa (eye worm) animal heme peroxidase 0.0675 0.8043 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.052 0.0461
Onchocerca volvulus Slit protein homolog 0.0069 0.0538 0.0525
Echinococcus multilocularis neurogenic locus notch protein 4 0.0069 0.0538 0.0421
Giardia lamblia High cysteine protein 0.0069 0.0538 0.5
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Echinococcus granulosus neurogenic locus notch protein 0.0069 0.0538 0.0525
Echinococcus granulosus protein jagged 1 0.0069 0.0538 0.0525
Brugia malayi mbt repeat family protein 0.0051 0.0313 0.0389
Onchocerca volvulus 0.0051 0.0313 0.0241
Brugia malayi Peroxidasin 0.0675 0.8043 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.04 0.0351
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.2176 0.2593
Schistosoma mansoni hypothetical protein 0.0311 0.353 0.4277
Loa Loa (eye worm) hypothetical protein 0.0051 0.0313 0.0389
Echinococcus granulosus protein jagged 2 0.0069 0.0538 0.0525
Brugia malayi Protein kinase domain containing protein 0.0098 0.089 0.1107
Onchocerca volvulus Peroxidasin homolog 0.0675 0.8043 1
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0313 0.0193
Loa Loa (eye worm) animal heme peroxidase 0.0675 0.8043 1
Echinococcus granulosus neurogenic locus protein delta 0.0069 0.0538 0.0525
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Brugia malayi Calcium binding EGF domain containing protein 0.0069 0.0538 0.0669
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.052 0.0647
Trichomonas vaginalis AGC family protein kinase 0.0098 0.089 0.5
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.1531 0.1904
Echinococcus granulosus protein jagged 2 0.0069 0.0538 0.0525
Brugia malayi GCC2 and GCC3 family protein 0.0069 0.0538 0.0669
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.5416 0.6683
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0313 0.0197
Brugia malayi hypothetical protein 0.0039 0.0157 0.0195
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Echinococcus multilocularis fat cadherin tumor suppressor 0.0069 0.0538 0.0421
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0278 0.0153
Onchocerca volvulus 0.0675 0.8043 1
Onchocerca volvulus 0.0675 0.8043 1
Echinococcus granulosus slit 2 protein 0.0069 0.0538 0.0525
Brugia malayi hypoxia-induced factor 1 0.0149 0.1531 0.1904
Brugia malayi RNA binding protein 0.0068 0.052 0.0647
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0157 0.0035
Leishmania major hypothetical protein, conserved 0.0026 0 0.5
Brugia malayi EGF-like domain containing protein 0.0069 0.0538 0.0669
Onchocerca volvulus Peroxidase homolog 0.0675 0.8043 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0 0.5
Brugia malayi Cadherin domain containing protein 0.0069 0.0538 0.0669
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.04 0.0282
Schistosoma mansoni hypothetical protein 0.0069 0.0538 0.0483
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0098 0.089 0.1107
Echinococcus multilocularis peroxidasin 0.0675 0.8043 0.8019
Echinococcus multilocularis neurogenic locus protein delta 0.0069 0.0538 0.0421
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0313 0.0193
Echinococcus multilocularis neurogenic locus notch protein 0.0069 0.0538 0.0421
Brugia malayi EGF-like domain containing protein 0.0069 0.0538 0.0669
Onchocerca volvulus 0.0069 0.0538 0.0525
Brugia malayi Animal haem peroxidase family protein 0.0675 0.8043 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.052 0.0461
Schistosoma mansoni hypothetical protein 0.0069 0.0538 0.0483
Brugia malayi Cadherin domain containing protein 0.0069 0.0538 0.0669
Loa Loa (eye worm) blistered cuticle protein 3 0.0675 0.8043 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0069 0.0538 0.0483
Loa Loa (eye worm) hypothetical protein 0.0162 0.1687 0.2097
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Schistosoma mansoni single-minded 0.0048 0.0278 0.0153
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Schistosoma mansoni septate junction protein 0.0069 0.0538 0.0483
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Loa Loa (eye worm) RNA binding protein 0.0068 0.052 0.0647
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0313 0.0241
Schistosoma mansoni notch 0.0069 0.0538 0.0483
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0157 0.0044
Entamoeba histolytica protein kinase, putative 0.0098 0.089 1
Brugia malayi EGF-like domain containing protein 0.0069 0.0538 0.0669
Echinococcus multilocularis fibropellin Ia 0.0069 0.0538 0.0421
Schistosoma mansoni peroxidasin 0.0675 0.8043 1
Echinococcus multilocularis neurogenic locus protein delta 0.0069 0.0538 0.0421
Onchocerca volvulus Dual oxidase homolog 0.0675 0.8043 1
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Brugia malayi Animal haem peroxidase family protein 0.0675 0.8043 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0313 0.0241
Schistosoma mansoni hypothetical protein 0.0069 0.0538 0.0483
Schistosoma mansoni hypothetical protein 0.0069 0.0538 0.0483
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.089 0.093
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Schistosoma mansoni hypothetical protein 0.0174 0.1836 0.2129
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Schistosoma mansoni notch 0.0069 0.0538 0.0483
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.2586 0.3216
Schistosoma mansoni notch 0.0069 0.0538 0.0483
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.052 0.0461
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0122 0.0152
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Echinococcus granulosus tar DNA binding protein 0.0068 0.052 0.0503
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.04 0.0498
Echinococcus granulosus neurogenic locus notch protein 4 0.0069 0.0538 0.0525
Onchocerca volvulus Peroxidase homolog 0.0675 0.8043 1
Echinococcus multilocularis slit 2 protein 0.0069 0.0538 0.0421
Brugia malayi PAS domain containing protein 0.0048 0.0278 0.0345
Loa Loa (eye worm) hypothetical protein 0.0058 0.04 0.0498
Echinococcus granulosus fibropellin Ia 0.0069 0.0538 0.0525
Brugia malayi notch-like transmembrane receptor 0.0069 0.0538 0.0669
Brugia malayi TAR-binding protein 0.0068 0.052 0.0647
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Onchocerca volvulus Peroxidasin homolog 0.0675 0.8043 1
Brugia malayi phosphoinositide-dependent protein kinase I 0.0098 0.089 0.1107
Loa Loa (eye worm) Notch2 0.0069 0.0538 0.0669
Onchocerca volvulus 0.0069 0.0538 0.0525
Schistosoma mansoni notch 0.0069 0.0538 0.0483
Echinococcus multilocularis protein jagged 2 0.0069 0.0538 0.0421
Echinococcus granulosus protein jagged 1 0.0069 0.0538 0.0525
Brugia malayi Calcium binding EGF domain containing protein 0.0069 0.0538 0.0669
Onchocerca volvulus Neurogenic locus notch homolog 0.0069 0.0538 0.0525
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0098 0.089 0.097
Echinococcus granulosus neural cadherin 0.0069 0.0538 0.0525
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.04 0.0351
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0313 0.0389
Brugia malayi Cytochrome P450 family protein 0.0026 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Brugia malayi mbt repeat family protein 0.0051 0.0313 0.0389
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0069 0.0538 0.0525
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0 0.5
Echinococcus multilocularis protein jagged 1 0.0069 0.0538 0.0421
Onchocerca volvulus Putative cubilin 0.0069 0.0538 0.0525
Loa Loa (eye worm) hypothetical protein 0.0069 0.0538 0.0669
Loa Loa (eye worm) hypothetical protein 0.0675 0.8043 1
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0313 0.0197
Schistosoma mansoni slit 0.0069 0.0538 0.0483
Echinococcus granulosus delta-like protein 1 0.0069 0.0538 0.0525
Trichomonas vaginalis AGC family protein kinase 0.0098 0.089 0.5
Brugia malayi follicle stimulating hormone receptor 0.0234 0.2586 0.3216

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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