Detailed information for compound 1199724

Basic information

Technical information
  • TDR Targets ID: 1199724
  • Name: [1-(2-fluorophenyl)-2-(2-methoxyethylamino)-2 -oxoethyl] furan-2-carboxylate
  • MW: 321.3 | Formula: C16H16FNO5
  • H donors: 1 H acceptors: 2 LogP: 2.17 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=O)C(c1ccccc1F)OC(=O)c1ccco1
  • InChi: 1S/C16H16FNO5/c1-21-10-8-18-15(19)14(11-5-2-3-6-12(11)17)23-16(20)13-7-4-9-22-13/h2-7,9,14H,8,10H2,1H3,(H,18,19)
  • InChiKey: SJHNJKAMURSKPR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-(2-fluorophenyl)-2-(2-methoxyethylamino)-2-oxo-ethyl] furan-2-carboxylate
  • 2-furancarboxylic acid [1-(2-fluorophenyl)-2-(2-methoxyethylamino)-2-oxoethyl] ester
  • furan-2-carboxylic acid [1-(2-fluorophenyl)-2-keto-2-(2-methoxyethylamino)ethyl] ester
  • ASN 06396679

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0041 0.0282 0.0708
Loa Loa (eye worm) hypothetical protein 0.0041 0.0282 0.0895
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0178 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.1642 0.7286
Loa Loa (eye worm) transcription factor SMAD2 0.0256 0.3052 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0052 0.0052
Brugia malayi Cathepsin L-like precursor 0.0026 0.008 0.0252
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0053 0.0145
Echinococcus granulosus cathepsin l1 0.0026 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0232
Echinococcus granulosus cathepsin L 0.002 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0052 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0244 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0071 0.0667 0.295
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0282 0.0282
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.1642 0.7286
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0194 0.2253 0.683
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0052 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0052 0.0141
Trypanosoma brucei phosphoglycerate kinase 0.0071 0.0667 0.295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0052 0.0161
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0071 0.0667 0.295
Plasmodium vivax vivapain-2 0.0038 0.0244 0.1072
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0052 0.0141
Loa Loa (eye worm) hypothetical protein 0.0041 0.0282 0.0895
Brugia malayi Phosphoglycerate kinase 0.0194 0.2253 0.738
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0244 0.0732
Brugia malayi Phosphoglycerate kinase 0.0071 0.0667 0.2177
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0052 0.0052
Brugia malayi steroid hormone receptor 0.0024 0.0052 0.0161
Brugia malayi ecdysteroid receptor 0.0024 0.0052 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.1642 0.7286
Brugia malayi Heterochromatin protein 1 0.0081 0.0791 0.2585
Schistosoma mansoni chromobox protein 0.0081 0.0791 0.0791
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0377 0.1134
Schistosoma mansoni phosphoglycerate kinase 0.0194 0.2253 0.2253
Chlamydia trachomatis phosphoglycerate kinase 0.0194 0.2253 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Leishmania major phosphoglycerate kinase B, cytosolic 0.0194 0.2253 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0141
Brugia malayi hypothetical protein 0.0042 0.0286 0.0928
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0244 0.0244
Echinococcus multilocularis cathepsin L 0.002 0.0003 0.0003
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0082 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Trypanosoma cruzi cruzipain precursor, putative 0.0147 0.1642 0.7286
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0244 0.1072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0244 0.0732
Onchocerca volvulus 0.0038 0.0244 0.0592
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0232
Echinococcus multilocularis phosphoglycerate kinase 1 0.0194 0.2253 0.2253
Loa Loa (eye worm) hypothetical protein 0.0045 0.0332 0.1062
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0003 0.0003
Schistosoma mansoni coup transcription factor 0.0024 0.0052 0.0052
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0634 0.0634
Toxoplasma gondii ABC1 family protein 0.0041 0.0282 0.0425
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0244 0.1072
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0134 0.1478 0.6555
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0052 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.1642 0.7286
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0052 0.0052
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0082 0.0082
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0052 0.0052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0282 0.0282
Echinococcus multilocularis microtubule associated protein 2 0.0793 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0052 0.0161
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0052 0.0052
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0082 0.0082
Trichomonas vaginalis esterase, putative 0.0041 0.0282 0.0846
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0194 0.2253 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0038 0.0244 0.0244
Onchocerca volvulus 0.0041 0.0282 0.0708
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0003 0.0003
Brugia malayi Cathepsin L-like precursor 0.0038 0.0244 0.0791
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0052 0.0052
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0282 0.0282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.008 0.0233
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0038 0.0244 0.1072
Brugia malayi PHD-finger family protein 0.0029 0.0117 0.0373
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0634 0.0634
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Plasmodium falciparum phosphoglycerate kinase 0.0194 0.2253 1
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0141
Brugia malayi Bromodomain containing protein 0.0086 0.0861 0.2814
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0332 0.0999
Echinococcus multilocularis cysteine protease 0.0038 0.0244 0.0244
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0052 0.0141
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0244 0.0592
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0052 0.0161
Brugia malayi chromobox protein homolog 3 0.0045 0.0332 0.108
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0244 0.0732
Echinococcus multilocularis chromobox protein 1 0.0081 0.0791 0.0791
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0052 0.0161
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0071 0.0667 0.295
Echinococcus granulosus phosphoglycerate kinase 1 0.0194 0.2253 0.2253
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0448 0.0448
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0041 0.0282 0.0895
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0194 0.0194
Brugia malayi MH2 domain containing protein 0.0256 0.3052 1
Plasmodium vivax SET domain protein, putative 0.0035 0.0194 0.085
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0052 0.0161
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0052 0.0052
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0282 0.1238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.1642 0.7286
Brugia malayi nuclear receptor NHR-88 0.0024 0.0052 0.0161
Entamoeba histolytica hypothetical protein 0.0042 0.0286 0.1258
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0194 0.2253 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0194 0.2253 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0244 0.0244
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0791 0.2392
Echinococcus multilocularis cysteine protease 0.0038 0.0244 0.0244
Echinococcus granulosus chromobox protein 1 0.0081 0.0791 0.0791
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0003 0.0003
Onchocerca volvulus 0.0038 0.0244 0.0592
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0294 0.3549 0.3549
Loa Loa (eye worm) ctsf protein 0.0038 0.0244 0.0773
Schistosoma mansoni bromodomain containing protein 0.0073 0.0687 0.0687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.008 0.0233
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.1642 0.7286
Schistosoma mansoni hypothetical protein 0.0024 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0161 0.048
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.1642 0.7286
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0332 0.0999
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0194 0.2253 1
Brugia malayi Pre-SET motif family protein 0.0241 0.2867 0.9392
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0052 0.0161
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0141
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0141
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.1642 0.7286
Onchocerca volvulus 0.0038 0.0244 0.0592
Onchocerca volvulus 0.0038 0.0244 0.0592
Trypanosoma brucei phosphoglycerate kinase, putative 0.0071 0.0667 0.295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0052 0.0141
Brugia malayi cathepsin L-like precursor 0.0026 0.008 0.0252
Brugia malayi Bromodomain containing protein 0.0044 0.0316 0.1026
Echinococcus multilocularis chromobox protein 1 0.0081 0.0791 0.0791
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.008 0.0341
Loa Loa (eye worm) hypothetical protein 0.0054 0.0448 0.1441
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0294 0.3549 0.3549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Loa Loa (eye worm) hypothetical protein 0.0194 0.2253 0.7375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0052 0.0161
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0052 0.0052
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0052 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0052 0.0161
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0052 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0052 0.0052
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0038 0.0244 0.1072
Loa Loa (eye worm) hypothetical protein 0.0041 0.0282 0.0895
Schistosoma mansoni hypothetical protein 0.0294 0.3549 0.3549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Onchocerca volvulus 0.0041 0.0282 0.0708
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0052 0.0052
Trypanosoma brucei phosphoglycerate kinase 0.0194 0.2253 1
Leishmania major cathepsin L-like protease 0.0147 0.1642 0.696
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0041 0.0282 0.0895
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0377 0.1134
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0052 0.0052
Leishmania major cathepsin L-like protease 0.0147 0.1642 0.696
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0071 0.0667 0.2103
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0052 0.0161
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0232
Brugia malayi Cathepsin L-like precursor 0.0026 0.008 0.0252
Echinococcus granulosus cathepsin l cysteine peptidase 0.0038 0.0244 0.0244
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0244 0.0244
Entamoeba histolytica hypothetical protein 0.0042 0.0286 0.1258
Onchocerca volvulus 0.0038 0.0244 0.0592
Echinococcus multilocularis thyroid hormone receptor alpha 0.0318 0.3854 0.3854
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0052 0.0161
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0052 0.0052
Brugia malayi Cathepsin L-like precursor 0.0038 0.0244 0.0791
Onchocerca volvulus 0.0048 0.0365 0.0965
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Schistosoma mansoni phosphoglycerate kinase 0.0194 0.2253 0.2253
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.008 0.008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0052 0.0052
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0244 0.0244
Echinococcus multilocularis zinc finger protein 0.0022 0.0037 0.0037
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0244 0.0592
Loa Loa (eye worm) hypothetical protein 0.0041 0.0282 0.0895
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0286 0.0286
Onchocerca volvulus 0.0026 0.008 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0052 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0244 0.0732
Schistosoma mansoni zinc finger protein 0.0022 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0244 0.0732
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.1642 0.7286
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0194 0.2253 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0797 0.2591
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0038 0.0244 0.0773
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0244 0.0732
Brugia malayi Pre-SET motif family protein 0.0035 0.0194 0.0627
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0244 0.1072
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0052 0.0161
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0003 0.0003
Onchocerca volvulus 0.0275 0.3298 1
Onchocerca volvulus 0.0038 0.0244 0.0592
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0282 0.1238
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0244 0.0244
Entamoeba histolytica hypothetical protein 0.0042 0.0286 0.1258
Entamoeba histolytica phosphoglycerate kinase, putative 0.0194 0.2253 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0256 0.3052 1
Brugia malayi Cathepsin L-like precursor 0.0038 0.0244 0.0791
Plasmodium falciparum cysteine proteinase falcipain 3 0.0038 0.0244 0.1072
Entamoeba histolytica cysteine protease, putative 0.0038 0.0244 0.1072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0244 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Loa Loa (eye worm) hypothetical protein 0.0047 0.0352 0.1127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0282 0.0914
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0161 0.048
Leishmania major hypothetical protein, conserved 0.0041 0.0282 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0244 0.0773
Mycobacterium ulcerans phosphoglycerate kinase 0.0194 0.2253 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0052 0.0052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0286 0.0286
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0448 0.0448
Schistosoma mansoni microtubule-associated protein tau 0.0793 1 1
Loa Loa (eye worm) beta-lactamase 0.0041 0.0282 0.0895
Schistosoma mansoni thyroid hormone receptor 0.0318 0.3854 0.3854
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0377 0.1
Brugia malayi Cathepsin L-like precursor 0.0038 0.0244 0.0791
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0282 0.0846
Onchocerca volvulus 0.0038 0.0244 0.0592
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0365 0.0365
Schistosoma mansoni hypothetical protein 0.0042 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.1642 0.7286
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0282 0.0846
Trypanosoma cruzi major cysteine proteinase, putative 0.0115 0.1237 0.5483
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0448 0.0448
Brugia malayi nuclear hormone receptor 0.0024 0.0052 0.0161
Trichomonas vaginalis set domain proteins, putative 0.0275 0.3298 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.2867 0.9391
Trypanosoma cruzi cysteine peptidase, putative 0.0147 0.1642 0.7286
Echinococcus granulosus cysteine protease 0.002 0.0003 0.0003
Giardia lamblia Phosphoglycerate kinase 0.0194 0.2253 0.5
Loa Loa (eye worm) hypothetical protein 0.0044 0.0317 0.1011
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0282 0.1238
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0071 0.0667 0.295
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0282 0.0846
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0194 0.2253 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.1642 0.7286
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0052 0.0161
Brugia malayi beta-lactamase 0.0041 0.0282 0.0914
Echinococcus granulosus cathepsin l1 0.0038 0.0244 0.0244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0052 0.0141
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0052 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0282 0.0846
Loa Loa (eye worm) hypothetical protein 0.0024 0.0052 0.0141
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0194 0.2253 0.6839
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0052 0.0052
Loa Loa (eye worm) fibroinase 0.0038 0.0244 0.0773
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0244 0.0791
Brugia malayi Cathepsin L-like cysteine proteinase 0.0026 0.008 0.0252
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0244 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0244 0.0732
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.0791 0.257
Schistosoma mansoni thyroid hormone receptor 0.0318 0.3854 0.3854
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0052 0.0052
Onchocerca volvulus Cathepsin F homolog 0.0038 0.0244 0.0592
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0791 0.2392
Brugia malayi Cathepsin L-like precursor 0.0038 0.0244 0.0791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.1642 0.7286
Schistosoma mansoni chromobox protein 0.0081 0.0791 0.0791
Echinococcus granulosus zinc finger protein 0.0022 0.0037 0.0037
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0281 0.0281
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.3164 1
Plasmodium vivax vivapain-2 0.0038 0.0244 0.1072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0244 0.0732
Trypanosoma brucei phosphoglycerate kinase 0.0194 0.2253 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0282 0.1238
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0052 0.0052
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0282 0.0895
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0244 0.0732
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0282 0.0282
Toxoplasma gondii cathepsin CPL 0.0038 0.0244 0.0243
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0071 0.0667 0.295
Brugia malayi beta-lactamase family protein 0.0041 0.0282 0.0914
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0332 0.0863
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0194 0.2253 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0052 0.0141
Treponema pallidum phosphoglycerate kinase 0.0194 0.2253 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0052 0.0161
Leishmania major phosphoglycerate kinase C, glycosomal 0.0194 0.2253 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0281 0.0281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0147 0.1642 0.7286
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0194 0.2253 0.683
Brugia malayi beta-lactamase family protein 0.0041 0.0282 0.0914
Loa Loa (eye worm) cysteine protease 0.0038 0.0244 0.0773
Echinococcus granulosus chromobox protein 1 0.0081 0.0791 0.0791
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0448 0.0448
Loa Loa (eye worm) hypothetical protein 0.0035 0.0206 0.0646
Onchocerca volvulus 0.0035 0.0206 0.0474
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0194 0.0194
Brugia malayi Cathepsin L-like precursor 0.0038 0.0244 0.0791
Loa Loa (eye worm) hypothetical protein 0.0049 0.038 0.122
Leishmania major cathepsin L-like protease 0.0147 0.1642 0.696
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0052 0.0161
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0038 0.0244 0.0773
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0286 0.0286
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0282 0.0846
Entamoeba histolytica hypothetical protein 0.0042 0.0286 0.1258

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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