Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.4775 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.4775 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.4775 | 0.4775 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.