Detailed information for compound 1200323

Basic information

Technical information
  • TDR Targets ID: 1200323
  • Name: 5-(4-ethoxyphenyl)-7-(2-methylphenyl)-1,5,6,7 -tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidin-2 -amine
  • MW: 349.43 | Formula: C20H23N5O
  • H donors: 2 H acceptors: 2 LogP: 3.97 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C1Nc2nc(nn2C(C1)c1ccccc1C)N
  • InChi: 1S/C20H23N5O/c1-3-26-15-10-8-14(9-11-15)17-12-18(16-7-5-4-6-13(16)2)25-20(22-17)23-19(21)24-25/h4-11,17-18H,3,12H2,1-2H3,(H3,21,22,23,24)
  • InChiKey: LPZPNYHQOPXYFG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [5-(4-ethoxyphenyl)-7-(2-methylphenyl)-1,5,6,7-tetrahydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]amine
  • MLS000114939
  • SMR000092211
  • STK116209

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0306 0.4152 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0896 0.19
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0776 0.0776
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0095 0.1104 0.2419
Leishmania major cytochrome p450-like protein 0.0095 0.1104 0.249
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.4086 0.9839
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0259 0.3466 0.8295
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0028 0.0132 0.0096
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0095 0.1104 0.2419
Trypanosoma cruzi metacaspase 5, putative 0.0306 0.4152 1
Loa Loa (eye worm) acetyltransferase 0.0153 0.1933 0.1933
Leishmania major short chain dehydrogenase-like protein 0.0028 0.0132 0.0096
Loa Loa (eye worm) cytochrome P450 family protein 0.0113 0.1354 0.1354
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0341 0.035
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0132 0.0135
Echinococcus multilocularis musashi 0.0028 0.0123 0.0126
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.032 0.0564
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Schistosoma mansoni caspase-3 (C14 family) 0.069 0.9697 0.9949
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0259 0.3466 0.3556
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0024 0.0024
Onchocerca volvulus 0.0036 0.0246 0.0228
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.1622 0.1664
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.1622 0.3707
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0024 0.0024
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0028 0.0132 0.0096
Onchocerca volvulus 0.0028 0.0132 0.0111
Treponema pallidum exodeoxyribonuclease (exoA) 0.0081 0.0896 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0024 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.2586 0.6144
Echinococcus granulosus dual specificity protein kinase clk2 0.0259 0.3466 0.3556
Brugia malayi Bromodomain containing protein 0.0039 0.0288 0.0288
Loa Loa (eye worm) oxidoreductase 0.0028 0.0132 0.0132
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0028 0.0132 0.0135
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0028 0.0132 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.4152 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0028 0.0132 0.0132
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0028 0.0132 0.0135
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0132 0.0096
Leishmania major hypothetical protein, conserved 0.0028 0.0132 0.0096
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0093 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0095 0.1104 0.2419
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0306 0.415 0.4258
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0132 0.0096
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0028 0.0132 0.0096
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0374 0.0692
Echinococcus multilocularis 0.0095 0.1104 0.1132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0095 0.1104 0.2419
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.1933 0.1983
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Loa Loa (eye worm) CYP4Cod1 0.0113 0.1354 0.1354
Loa Loa (eye worm) oxidoreductase 0.0028 0.0132 0.0132
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0095 0.1104 0.2419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0246 0.0252
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0896 0.1978
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.1622 0.1664
Mycobacterium ulcerans putative regulatory protein 0.0073 0.0773 0.1597
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0095 0.1104 0.249
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0132 0.0135
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.4152 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Plasmodium falciparum phd finger protein, putative 0.0035 0.0234 0.0253
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0369 0.1837
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0024 0.0024
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0132 0.0135
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0306 0.415 1
Echinococcus granulosus peregrin 0.0039 0.0288 0.0295
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0132 0.0096
Onchocerca volvulus Glucosylceramidase homolog 0.0198 0.2586 0.2635
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.069 0.9697 0.9949
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0374 0.0602
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0024 0.0024
Echinococcus granulosus hypothetical protein 0.0028 0.0132 0.0135
Echinococcus multilocularis lamin dm0 0.0028 0.0123 0.0126
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0028 0.0132 0.0096
Echinococcus multilocularis 0.0255 0.3411 0.3499
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0246 0.0252
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0095 0.1104 0.2419
Echinococcus multilocularis dual specificity protein kinase clk2 0.0259 0.3466 0.3556
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0024 0.0024
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0374 0.0384
Brugia malayi jmjC domain containing protein 0.0043 0.0341 0.0341
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.2586 0.6144
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0028 0.0132 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.2586 0.6144
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0024 0.0024
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.032 0.1453
Onchocerca volvulus 0.0025 0.0093 0.0071
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0095 0.1104 0.2419
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0148 0.0136
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0081 0.0896 0.19
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0132 0.0135
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0024
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0024 0.0024
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.032 0.032
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0024 0.0024
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0118 0.1425 1
Leishmania major cytochrome p450-like protein 0.0095 0.1104 0.249
Trichomonas vaginalis CMGC family protein kinase 0.0207 0.2724 0.6483
Onchocerca volvulus 0.0028 0.0132 0.0111
Giardia lamblia Kinase, CMGC MAPK 0.0207 0.2724 0.7775
Echinococcus granulosus cytochrome P450 2K1 0.0095 0.1104 0.1132
Trypanosoma brucei Metacaspase-4 0.0306 0.4152 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0024 0.0024
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0148 0.0136
Plasmodium vivax hypothetical protein, conserved 0.0306 0.4152 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0028 0.0132 0.0135
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0095 0.1104 0.2419
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.1622 0.3708
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0255 0.3411 0.3411
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0148 0.0136
Onchocerca volvulus 0.0028 0.0132 0.0111
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.4152 1
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0095 0.1104 0.2419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0306 0.4152 0.4152
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0024 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0095 0.1104 0.2419
Schistosoma mansoni aryl hydrocarbon receptor 0.0098 0.1142 0.1171
Leishmania major dehydrogenase-like protein 0.0028 0.0132 0.0096
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0118 0.1425 0.1462
Schistosoma mansoni ap endonuclease 0.0081 0.0896 0.0919
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0234 0.024
Brugia malayi nuclear hormone receptor 0.0021 0.0024 0.0024
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0132 0.0135
Trichomonas vaginalis CMGC family protein kinase 0.0207 0.2724 0.6483
Trypanosoma brucei metacaspase MCA2 0.0306 0.4152 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0896 0.19
Echinococcus granulosus oxidoreductase 0.0028 0.0132 0.0135
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0369 0.0591
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0095 0.1104 0.2419
Brugia malayi dehydrogenases, short chain protein 2 0.0028 0.0132 0.0132
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0118 0.1425 0.3283
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0306 0.415 0.4258
Toxoplasma gondii cytochrome p450 superfamily protein 0.0095 0.1104 0.2418
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0024 0.0024
Onchocerca volvulus Cell death protein 3 homolog 0.0693 0.9747 1
Schistosoma mansoni lamin 0.0028 0.0123 0.0126
Brugia malayi Inositol-1 0.0045 0.0369 0.0369
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0024 0.0024
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0028 0.0132 0.0096
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0306 0.4152 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0595 0.0595
Brugia malayi intermediate filament protein 0.0028 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0025 0.0093 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0024 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0595 0.0595
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0028 0.0132 0.0135
Echinococcus granulosus caspase 2 0.0693 0.9747 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0024 0.0024
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0132 0.0096
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0024 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0024 0.0024
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0433 0.0444
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.4152 1
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0028 0.0132 0.0135
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0306 0.4152 0.4259
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0118 0.1425 0.1462
Echinococcus multilocularis lamin 0.0028 0.0123 0.0126
Onchocerca volvulus 0.0028 0.0132 0.0111
Leishmania major short chain dehydrogenase/reductase, putative 0.0028 0.0132 0.0096
Loa Loa (eye worm) hypothetical protein 0.0118 0.1425 0.1425
Loa Loa (eye worm) oxidoreductase 0.0028 0.0132 0.0132
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0081 0.0896 0.0896
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.1933 0.1933
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0024 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1392 0.1428
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0081 0.0896 0.5905
Onchocerca volvulus 0.0028 0.0132 0.0111
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0132 0.0096
Leishmania major 3-keto-dihydrosphingosine reductase 0.0028 0.0132 0.0096
Leishmania major protein kinase, putative 0.0259 0.3466 0.8311
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Brugia malayi Pre-SET motif family protein 0.0036 0.0246 0.0246
Trypanosoma cruzi metacaspase 5, putative 0.0306 0.4152 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.1933 0.1983
Echinococcus granulosus caspase 8 0.0306 0.4152 0.4259
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0095 0.1104 0.2419
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0132 0.0096
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0246 0.0252
Brugia malayi Dehydrogenases, short chain protein 30 0.0028 0.0132 0.0132
Echinococcus granulosus caspase 3 0.0384 0.527 0.5407
Trichomonas vaginalis steroid dehydrogenase, putative 0.0028 0.0132 0.0096
Loa Loa (eye worm) oxidoreductase 0.0028 0.0132 0.0132
Leishmania major hypothetical protein, conserved 0.0028 0.0132 0.0096
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0132 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.4152 1
Mycobacterium leprae Probable oxidoreductase 0.0028 0.0132 0.0386
Echinococcus granulosus lamin dm0 0.0028 0.0123 0.0126
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0132 0.0135
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0132 0.0135
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0028 0.0132 0.0132
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0118 0.1425 0.3283
Brugia malayi Retinol dehydrogenase 12 0.0028 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0113 0.1354 0.3042
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0024 0.0024
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.1622 0.1664
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0095 0.1104 0.2419
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0132 0.0096
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0234 0.0253
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.0093 0.5
Plasmodium vivax metacaspase 1, putative 0.0306 0.4152 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0024 0.0024
Echinococcus multilocularis retinol dehydrogenase 13 0.0028 0.0132 0.0135
Leishmania major protein kinase, putative 0.0029 0.0148 0.0136
Echinococcus granulosus single minded 2 0.0073 0.0773 0.0794
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.1425 0.3217
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0132 0.0135
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Echinococcus multilocularis caspase 0.069 0.9697 0.9949
Leishmania major metacaspase, putative 0.0306 0.4152 1
Leishmania major short chain dehydrogenase, putative 0.0028 0.0132 0.0096
Brugia malayi oxidoreductase 0.0028 0.0132 0.0132
Brugia malayi hypothetical protein 0.0028 0.0132 0.0132
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0095 0.1104 0.2419
Echinococcus multilocularis steroid dehydrogenase 0.0028 0.0132 0.0135
Brugia malayi Cytochrome P450 family protein 0.0113 0.1354 0.1354
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0028 0.0132 0.0386
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0341 0.0341
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0306 0.415 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0369 0.0681
Echinococcus granulosus retinol dehydrogenase 11 0.0028 0.0132 0.0135
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Echinococcus multilocularis oxidoreductase 0.0028 0.0132 0.0135
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0374 0.0692
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0028 0.0132 0.0096
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0118 0.1425 0.1462
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0081 0.0896 0.229
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0132 0.0096
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0433 0.0444
Schistosoma mansoni hypothetical protein 0.0095 0.1104 0.1132
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0132 0.0135
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0024 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0028 0.0132 0.0096
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0095 0.1104 0.2419
Echinococcus multilocularis caspase 3 0.0384 0.527 0.5407
Brugia malayi ecdysteroid receptor 0.0021 0.0024 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Echinococcus granulosus mitogen activated protein kinase 0.0207 0.2724 0.2795
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0132 0.0135
Loa Loa (eye worm) hypothetical protein 0.0387 0.532 0.532
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0024 0.0024
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0028 0.0132 0.0132
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0081 0.0896 0.0919
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0028 0.0132 0.0096
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0028 0.0132 0.0386
Echinococcus multilocularis conserved hypothetical protein 0.0028 0.0132 0.0135
Echinococcus granulosus hypothetical protein 0.0255 0.3411 0.3499
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0207 0.2724 0.6483
Echinococcus multilocularis retinol dehydrogenase 11 0.0028 0.0132 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.2586 0.6144
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0095 0.1104 0.2419
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0095 0.1104 0.2419
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0024
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.032 0.0467
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0341 0.035
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0095 0.1104 0.2419
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0024 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0024 0.0024
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.4152 1
Leishmania major short chain dehydrogenase, putative 0.0028 0.0132 0.0096
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0095 0.1104 0.2419
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0081 0.0896 0.1978
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1622 0.3708
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0024 0.0024
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0028 0.0132 0.0096
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0369 0.0379
Onchocerca volvulus 0.0028 0.0132 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.2741 0.6523
Trichomonas vaginalis CMGC family protein kinase 0.0259 0.3466 0.8311
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0302 0.0423
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0369 0.0681
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.4152 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0234 0.024
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0207 0.2724 0.6483
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0093 0.0095
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0207 0.2724 0.6483
Onchocerca volvulus 0.0073 0.0773 0.0771
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.4086 0.9839
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0246 0.0252
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0234 0.024
Brugia malayi bHLH-PAS transcription factor 0.0073 0.0773 0.0773
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0306 0.415 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0207 0.2724 0.2724
Trypanosoma cruzi metacaspase, putative 0.0306 0.4152 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0095 0.1104 0.2418
Brugia malayi Pre-SET motif family protein 0.0251 0.3358 0.3358
Trypanosoma cruzi short chain dehydrogenase, putative 0.0028 0.0132 0.0096
Brugia malayi jmjC domain containing protein 0.0115 0.1392 0.1392
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.4152 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0207 0.2724 0.6483
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0028 0.0132 0.0096
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0132 0.0096
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.1425 0.3283
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1392 0.1428
Loa Loa (eye worm) cytochrome P450 family protein 0.0113 0.1354 0.1354
Echinococcus granulosus caspase 0.069 0.9697 0.9949
Loa Loa (eye worm) oxidoreductase 0.0028 0.0132 0.0132
Loa Loa (eye worm) oxidoreductase 0.0028 0.0132 0.0132
Loa Loa (eye worm) oxidoreductase 0.0028 0.0132 0.0132
Schistosoma mansoni carbonyl reductase 0.0028 0.0132 0.0135
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0028 0.0132 0.0096
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.4152 1
Schistosoma mansoni single-minded 0.0098 0.1142 0.1171
Loa Loa (eye worm) hypothetical protein 0.006 0.0595 0.0595
Onchocerca volvulus 0.0028 0.0132 0.0111
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0369 0.0379
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0095 0.1104 0.2419
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0132 0.0135
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.006 0.0597 0.0597
Leishmania major short chain dehydrogenase/reductase, putative 0.0028 0.0132 0.0096
Brugia malayi Protein kinase domain containing protein 0.0259 0.3466 0.3466
Brugia malayi MAP kinase sur-1 0.0207 0.2724 0.2724
Brugia malayi nuclear receptor NHR-88 0.0021 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0095 0.1104 0.2419
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0024 0.0024
Echinococcus multilocularis mitogen activated protein kinase 3 0.0207 0.2724 0.2795
Leishmania major protein kinase, putative 0.0259 0.3466 0.8311
Echinococcus granulosus steroid dehydrogenase 0.0028 0.0132 0.0135
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0095 0.1104 0.2419
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.4152 1
Brugia malayi steroid hormone receptor 0.0021 0.0024 0.0024
Echinococcus multilocularis ubiquitin specific protease 41 0.0118 0.1425 0.1462
Trichomonas vaginalis CMGC family protein kinase 0.0207 0.2724 0.6483
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0132 0.0096
Onchocerca volvulus 0.0028 0.0132 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.4086 0.9839
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0132 0.0096
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0369 0.0681
Echinococcus granulosus hypothetical protein 0.0028 0.0132 0.0135
Schistosoma mansoni serine/threonine protein kinase 0.0259 0.3466 0.3556
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0095 0.1104 0.2419
Echinococcus multilocularis caspase 2 0.0693 0.9747 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0028 0.0132 0.0111
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0132 0.0096
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0132 0.0096
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0028 0.0132 0.0135
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0028 0.0132 0.0096
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Schistosoma mansoni coup transcription factor 0.0021 0.0024 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.4086 0.9839
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0024 0.0024
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0234 0.0253
Brugia malayi hypothetical protein 0.0387 0.532 0.532
Trypanosoma cruzi short chain dehydrogenase, putative 0.0028 0.0132 0.0096
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0093 0.0095
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.4152 1
Trypanosoma brucei metacaspase 0.0306 0.4152 1
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0024 0.0024
Schistosoma mansoni inositol monophosphatase 0.0045 0.0369 0.0379
Brugia malayi cytochrome P450 0.0095 0.1104 0.1104
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0028 0.0123 0.0123
Loa Loa (eye worm) oxidoreductase 0.0028 0.0132 0.0132
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0227 0.0232
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Echinococcus granulosus lamin 0.0028 0.0123 0.0126
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0132 0.0135
Onchocerca volvulus 0.0028 0.0132 0.0111
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0369 0.0681
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.4152 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0095 0.1104 0.249
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0207 0.2724 0.6483
Loa Loa (eye worm) hypothetical protein 0.0329 0.4479 0.4479
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0028 0.0132 0.0135
Loa Loa (eye worm) inositol-1 0.0045 0.0369 0.0369
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0148 0.0136
Echinococcus multilocularis transient receptor potential cation channel 0.0028 0.0132 0.0135
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Brugia malayi PHD-finger family protein 0.0035 0.0234 0.0234
Giardia lamblia Kinase, CMGC CLK 0.0259 0.3466 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0123 0.0126
Brugia malayi hypoxia-induced factor 1 0.0303 0.4111 0.4111
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0095 0.1104 0.2419
Loa Loa (eye worm) hypothetical protein 0.0027 0.0116 0.0116
Plasmodium falciparum metacaspase 1 0.0306 0.4152 1
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0132 0.0135
Mycobacterium leprae putative cytochrome p450 0.0095 0.1104 1
Loa Loa (eye worm) oxidoreductase 0.0028 0.0132 0.0132
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0028 0.0132 0.0096
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0095 0.1104 0.2419
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.1622 0.3767
Trichomonas vaginalis CMGC family protein kinase 0.0207 0.2724 0.6483
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0132 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0024 0.0024
Schistosoma mansoni lamin 0.0028 0.0123 0.0126
Leishmania major oxidoreductase-like protein 0.0028 0.0132 0.0096
Loa Loa (eye worm) hypothetical protein 0.0041 0.032 0.032
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0095 0.1104 0.2419
Trypanosoma cruzi cytochrome P450, putative 0.0113 0.1354 0.3108
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0306 0.415 0.415
Onchocerca volvulus Alhambra homolog 0.0035 0.0234 0.0216
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0132 0.0096
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0028 0.0132 0.0096
Trypanosoma cruzi metacaspase, putative 0.0306 0.4152 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0369 0.0681
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0246 0.0252
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0207 0.2724 0.6449
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0024 0.0024
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1049 0.1076
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0259 0.3466 0.8311
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0234 0.0234
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0369 0.311
Loa Loa (eye worm) hypothetical protein 0.0036 0.0246 0.0246
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0095 0.1104 0.2419
Leishmania major protein kinase, putative 0.0029 0.0148 0.0136
Loa Loa (eye worm) dehydrogenase 0.0028 0.0132 0.0132
Schistosoma mansoni carbonyl reductase 0.0028 0.0132 0.0135
Echinococcus granulosus carbonyl reductase 1 0.0028 0.0132 0.0135
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0081 0.0896 0.1978
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0896 0.1978
Leishmania major hypothetical protein, conserved 0.0028 0.0132 0.0096
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.1871 0.1919
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0024 0.0024
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0234 0.0253
Onchocerca volvulus 0.0028 0.0123 0.0102
Schistosoma mansoni caspase-7 (C14 family) 0.069 0.9697 0.9949
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Echinococcus multilocularis apoptotic protease activating factor 1 0.0387 0.532 0.5458
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0095 0.1104 0.249
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0095 0.1104 0.2419
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0118 0.1425 0.3879
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.4152 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0132 0.0096
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0132 0.0096
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0024 0.0024
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0259 0.3466 0.8295
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0024 0.0024
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0118 0.1425 0.1425
Onchocerca volvulus 0.0387 0.532 0.5447
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0028 0.0132 0.0132
Echinococcus multilocularis caspase 8 0.0306 0.4152 0.4259
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0095 0.1104 0.2419
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0341 0.035
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0259 0.3466 0.8311
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0024 0.0024
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0095 0.1104 0.249
Leishmania major hypothetical protein, conserved 0.0028 0.0132 0.0096
Leishmania major pteridine reductase 1 0.0028 0.0132 0.0096
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0081 0.0896 0.0919
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0259 0.3466 0.3466
Trypanosoma brucei metacaspase MCA3 0.0306 0.4152 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0028 0.0132 0.0096
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0306 0.415 0.4258
Brugia malayi Cytochrome P450 family protein 0.0274 0.3688 0.3688
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0081 0.0896 1
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Brugia malayi exodeoxyribonuclease III family protein 0.0081 0.0896 0.0896
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0024
Onchocerca volvulus 0.0028 0.0132 0.0111
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0302 0.2067
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0028 0.0132 0.0096
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0246 0.0283
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0024 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0024 0.0024
Echinococcus multilocularis mitogen activated protein kinase 0.0207 0.2724 0.2795
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0306 0.4152 1
Echinococcus multilocularis peregrin 0.0039 0.0288 0.0295
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0028 0.0132 0.0386
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0595 0.0595
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0028 0.0132 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.4086 0.9839
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0095 0.1104 0.2419
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1622 0.3708
Loa Loa (eye worm) cytochrome P450 family protein 0.0274 0.3688 0.3688
Schistosoma mansoni inositol monophosphatase 0.0045 0.0369 0.0379
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0259 0.3466 0.8295
Echinococcus granulosus retinol dehydrogenase 11 0.0028 0.0132 0.0135
Onchocerca volvulus Sepiapterin reductase homolog 0.0028 0.0132 0.0111
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0095 0.1104 0.2419
Schistosoma mansoni retinal dehydrogenase 0.0028 0.0132 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0024 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1622 0.3708
Trichomonas vaginalis conserved hypothetical protein 0.0306 0.4152 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0369 0.0681
Echinococcus granulosus ubiquitin specific protease 41 0.0118 0.1425 0.1462
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0024 0.0024
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0095 0.1104 0.2419
Loa Loa (eye worm) hypothetical protein 0.0693 0.9747 0.9747
Onchocerca volvulus 0.0028 0.0132 0.0111
Schistosoma mansoni ap endonuclease 0.0081 0.0896 0.0919
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0024 0.0024
Onchocerca volvulus 0.0028 0.0123 0.0102
Echinococcus multilocularis transfer RNA-Lys 0.0073 0.0773 0.0794
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0259 0.3466 0.8311
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0095 0.1104 0.2419
Echinococcus granulosus apoptotic protease activating factor 1 0.0387 0.532 0.5458
Plasmodium falciparum protein serine/threonine kinase-1 0.0259 0.3466 0.8295
Leishmania major quinonoid dihydropteridine reductase 0.0028 0.0132 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.2586 0.6144
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0132 0.0096
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0028 0.0132 0.0386
Echinococcus granulosus mitogen activated protein kinase 3 0.0207 0.2724 0.2795
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0306 0.4152 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0081 0.0896 0.1978
Echinococcus multilocularis retinol dehydrogenase 11 0.0028 0.0132 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0095 0.1104 0.2419
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0095 0.1104 0.2419
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0093 0.0095
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0306 0.415 0.9996
Schistosoma mansoni hypothetical protein 0.0035 0.0234 0.024
Brugia malayi Cytochrome P450 family protein 0.0113 0.1354 0.1354
Brugia malayi hypothetical protein 0.0028 0.0132 0.0132
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0302 0.4086 0.4086
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0024 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0095 0.1104 0.2419
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.1622 0.1664
Echinococcus granulosus intermediate filament protein 0.0028 0.0123 0.0126
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0024 0.0024
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0278 0.3743 0.3743
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0246 0.0252
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0118 0.1425 0.1462
Trypanosoma cruzi metacaspase, putative 0.0306 0.4152 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0028 0.0132 0.0135
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Trypanosoma brucei protein kinase, putative 0.0207 0.2724 0.6449
Trypanosoma brucei cytochrome P450, putative 0.0113 0.1354 0.3041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0081 0.0896 0.1901
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0132
Trypanosoma cruzi metacaspase, putative 0.0306 0.4152 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0123 0.0123
Echinococcus multilocularis steroid dehydrogenase 0.0028 0.0132 0.0135
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0081 0.0896 0.1901
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0095 0.1104 0.2419
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0132 0.0096
Loa Loa (eye worm) hypoxia-induced factor 1 0.0303 0.4111 0.4111
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0123 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.2586 0.6144
Leishmania major hypothetical protein, conserved 0.0028 0.0132 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.0209 0.2741 0.6523
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0024
Giardia lamblia PHD finger protein 15 0.0035 0.0234 0.0305
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0024 0.0024
Brugia malayi Cytochrome P450 family protein 0.0095 0.1104 0.1104
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0374 0.0602
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.3358 0.3358
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0024 0.0024
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0207 0.2724 0.6449
Echinococcus multilocularis carbonyl reductase 1 0.0028 0.0132 0.0135
Onchocerca volvulus 0.0028 0.0132 0.0111
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0306 0.4152 0.4152
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0093 0.0095
Schistosoma mansoni hypothetical protein 0.0041 0.032 0.0328
Schistosoma mansoni cytochrome P450 0.0095 0.1104 0.1132
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0711 1 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0207 0.2724 0.6483
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0095 0.1104 0.2419
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0246 0.0252
Mycobacterium leprae Conserved hypothetical protein 0.0095 0.1104 1
Brugia malayi dehydrogenases, short chain protein 9 0.0028 0.0132 0.0132
Loa Loa (eye worm) dehydrogenase 0.0028 0.0132 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0198 0.2586 0.6144
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0095 0.1104 0.2419
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0369 0.0591
Trypanosoma cruzi cytochrome P450, putative 0.0113 0.1354 0.3108
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0341 0.035
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0374 0.0602
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0095 0.1104 0.2419
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0302 0.4086 0.4086
Schistosoma mansoni caspase-7 (C14 family) 0.0693 0.9747 1
Trypanosoma brucei metacaspase 5, putative 0.0306 0.4152 1
Schistosoma mansoni hypothetical protein 0.0387 0.532 0.5458
Brugia malayi PAS domain containing protein 0.0098 0.1142 0.1142
Trichomonas vaginalis glucosylceramidase, putative 0.0302 0.4086 0.9839
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0118 0.1425 0.1462
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0132 0.0096
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.069 0.9697 0.9949
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.1425 0.3283
Brugia malayi hypothetical protein 0.0329 0.4479 0.4479
Schistosoma mansoni carbonyl reductase 0.0028 0.0132 0.0135
Schistosoma mansoni steroid dehydrogenase 0.0028 0.0132 0.0135
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0118 0.1425 0.3283
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0028 0.0132 0.0096
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0024
Onchocerca volvulus 0.0028 0.0132 0.0111
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0259 0.3466 0.8311
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0024 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.2724 0.2795
Trichomonas vaginalis set domain proteins, putative 0.0286 0.386 0.9282
Onchocerca volvulus 0.0286 0.386 0.3945
Toxoplasma gondii exonuclease III APE 0.0081 0.0896 0.19
Plasmodium falciparum metacaspase-like protein 0.0306 0.4152 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0024 0.0024
Echinococcus granulosus WW domain containing oxidoreductase 0.0028 0.0132 0.0135
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0028 0.0132 0.0111
Loa Loa (eye worm) cytochrome P450 0.0095 0.1104 0.1104
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0028 0.0132 0.0386
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0118 0.1425 0.3283
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0028 0.0132 0.0096
Brugia malayi Cell death protein 3 precursor 0.0693 0.9747 0.9747
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0118 0.1425 0.1462
Plasmodium vivax SET domain protein, putative 0.0036 0.0246 0.0283
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0028 0.0132 0.0096
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0024 0.0024
Plasmodium vivax serine/threonine kinase-1, putative 0.0259 0.3466 0.8295
Schistosoma mansoni short chain dehydrogenase 0.0028 0.0132 0.0135
Leishmania major cytochrome p450-like protein 0.0113 0.1354 0.3108
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0369 0.0591
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0132 0.0132

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0126 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2079 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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