Detailed information for compound 1200536

Basic information

Technical information
  • TDR Targets ID: 1200536
  • Name: 5-(4-chlorophenyl)-1-methylimidazol-2-amine
  • MW: 207.659 | Formula: C10H10ClN3
  • H donors: 1 H acceptors: 1 LogP: 1.96 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1cnc(n1C)N
  • InChi: 1S/C10H10ClN3/c1-14-9(6-13-10(14)12)7-2-4-8(11)5-3-7/h2-6H,1H3,(H2,12,13)
  • InChiKey: BAOMGQNIXYVJKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-chlorophenyl)-1-methyl-imidazol-2-amine
  • 5-(4-chlorophenyl)-1-methyl-2-imidazolamine
  • [5-(4-chlorophenyl)-1-methyl-imidazol-2-yl]amine
  • ZINC00873780
  • ST073619
  • BAS 10113342
  • 5-(4-Chloro-phenyl)-1-methyl-1H-imidazol-2-ylamine
  • MLS000027859
  • SMR000015278

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA recognition motif domain containing protein 0.0075 0.1337 0.9595
Echinococcus multilocularis ubiquitin specific protease 41 0.0048 0.0773 0.3046
Brugia malayi beta-lactamase family protein 0.0078 0.1393 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.2333 1
Brugia malayi hypothetical protein 0.0042 0.0652 0.4679
Loa Loa (eye worm) hypothetical protein 0.0078 0.1393 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.1059 0.461
Echinococcus granulosus ubiquitin specific protease 41 0.0048 0.0773 0.3312
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.1393 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1393 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0773 0.3312
Schistosoma mansoni tar DNA-binding protein 0.0075 0.1337 0.527
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0075 0.1337 0.9595
Echinococcus granulosus tar DNA binding protein 0.0075 0.1337 0.573
Trypanosoma brucei protein kinase, putative 0.0062 0.1059 0.461
Brugia malayi RNA binding protein 0.0075 0.1337 0.9595
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.1393 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1059 0.461
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0773 0.3312
Onchocerca volvulus 0.0078 0.1393 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1393 0.5492
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.1059 0.76
Brugia malayi MAP kinase sur-1 0.0062 0.1059 0.76
Loa Loa (eye worm) hypothetical protein 0.0078 0.1393 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.2333 0.9197
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.1059 0.4538
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.1059 0.4174
Trichomonas vaginalis esterase, putative 0.0078 0.1393 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.1059 1
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1393 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1059 0.461
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.1059 0.4174
Brugia malayi beta-lactamase 0.0078 0.1393 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0048 0.0773 0.5547
Mycobacterium ulcerans beta-lactamase 0.0078 0.1393 0.5
Toxoplasma gondii ABC1 family protein 0.0078 0.1393 1
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1393 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1059 0.461
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1393 1
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.1059 0.4174
Brugia malayi TAR-binding protein 0.0075 0.1337 0.9595
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.1059 0.461
Schistosoma mansoni tar DNA-binding protein 0.0075 0.1337 0.527
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1393 1
Loa Loa (eye worm) RNA binding protein 0.0075 0.1337 0.9595
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1059 0.461
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.1059 0.461
Schistosoma mansoni tar DNA-binding protein 0.0075 0.1337 0.527
Loa Loa (eye worm) hypothetical protein 0.0078 0.1393 1
Onchocerca volvulus 0.0078 0.1393 1
Schistosoma mansoni tar DNA-binding protein 0.0075 0.1337 0.527
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0048 0.0773 0.3046
Schistosoma mansoni tar DNA-binding protein 0.0075 0.1337 0.527
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0048 0.0773 0.3046
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1393 1
Plasmodium vivax hypothetical protein, conserved 0.0078 0.1393 0.5
Loa Loa (eye worm) beta-lactamase 0.0078 0.1393 1
Mycobacterium leprae Probable lipase LipE 0.0078 0.1393 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.1393 1
Mycobacterium ulcerans lipase LipD 0.0078 0.1393 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.1393 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.1059 0.4538
Schistosoma mansoni thyroid hormone receptor 0.0134 0.2537 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1059 0.461
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0652 0.257
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.1393 1
Mycobacterium ulcerans hypothetical protein 0.0078 0.1393 0.5
Loa Loa (eye worm) TAR-binding protein 0.0075 0.1337 0.9595
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0652 0.257
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.1393 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.1393 0.5972
Loa Loa (eye worm) hypothetical protein 0.0048 0.0773 0.5547
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.1393 0.5
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.1393 0.5492
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.1059 0.461
Schistosoma mansoni hypothetical protein 0.0124 0.2333 0.9197
Schistosoma mansoni thyroid hormone receptor 0.0134 0.2537 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.2537 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0048 0.0773 1
Echinococcus multilocularis tar DNA binding protein 0.0075 0.1337 0.527
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1393 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1393 1
Schistosoma mansoni hypothetical protein 0.0042 0.0652 0.257
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0048 0.0773 0.3046
Brugia malayi beta-lactamase family protein 0.0078 0.1393 1
Leishmania major hypothetical protein, conserved 0.0078 0.1393 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.1059 0.461
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0048 0.0773 0.3046
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1059 0.461
Mycobacterium leprae conserved hypothetical protein 0.0078 0.1393 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1393 0.5492
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0652 0.2795
Onchocerca volvulus 0.0078 0.1393 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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