Detailed information for compound 1200949

Basic information

Technical information
  • TDR Targets ID: 1200949
  • Name: 2-methyl-3-(4-phenylphenyl)quinazolin-4-one
  • MW: 312.365 | Formula: C21H16N2O
  • H donors: 0 H acceptors: 1 LogP: 4.06 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc2ccccc2c(=O)n1c1ccc(cc1)c1ccccc1
  • InChi: 1S/C21H16N2O/c1-15-22-20-10-6-5-9-19(20)21(24)23(15)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-14H,1H3
  • InChiKey: NPMQVCODDMQMCL-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-methyl-3-(4-phenylphenyl)-4-quinazolinone
  • STOCK3S-36101
  • ZINC00448592
  • BIM-0042942.P001
  • Oprea1_568384
  • CBMicro_043171

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.1712 0.4029
Schistosoma mansoni cpg binding protein 0.003 0.0673 0.066
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0092
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.001 0.01 0.0083
Mycobacterium tuberculosis Conserved protein 0.0043 0.1034 0.0867
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0008 0.0054 0.0036
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0024 0.0006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0411 0.0859
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.1904 0.3295
Schistosoma mansoni hypothetical protein 0.0008 0.0054 0.004
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.229 0.2276
Loa Loa (eye worm) hypothetical protein 0.001 0.01 0.0173
Echinococcus granulosus dna polymerase eta 0.0155 0.4213 0.4203
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0209 0.073
Mycobacterium tuberculosis Conserved protein 0.0043 0.1034 0.0867
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.013 0.0112
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.1712 0.1811
Brugia malayi hypothetical protein 0.004 0.0957 0.1635
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0355 0.0338
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.1712 0.4029
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0209 0.073
Schistosoma mansoni polybromo-1 0.0008 0.0054 0.004
Loa Loa (eye worm) acetyltransferase 0.0008 0.0054 0.0092
Schistosoma mansoni ap endonuclease 0.0021 0.0411 0.0398
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.1438 0.1429
Echinococcus granulosus Protein son of sevenless 0.0007 0.0024 0.0006
Trypanosoma cruzi bloodstream- specific protein 2 precursor 0.0009 0.0059 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Echinococcus multilocularis protein disulfide isomerase 0.0009 0.0059 0.0042
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Echinococcus multilocularis GPCR, family 2 0.0019 0.0355 0.0338
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0405 0.0843
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0108 0.009
Schistosoma mansoni hypothetical protein 0.0019 0.0355 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Brugia malayi hypothetical protein 0.0016 0.0275 0.044
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0405 0.0843
Schistosoma mansoni hypothetical protein 0.036 1 1
Echinococcus granulosus son of sevenless 1 0.0007 0.0024 0.0006
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.152 0.2621
Echinococcus granulosus bloom syndrome protein 0.0027 0.0576 0.0559
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0014 0.0209 0.0192
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0024 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0209 0.0441
Onchocerca volvulus Brd8 homolog 0.0008 0.0054 0.0052
Schistosoma mansoni helicase 0.0008 0.0054 0.004
Giardia lamblia Protein disulfide isomerase PDI2 0.0009 0.0059 0.0032
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0108 0.009
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0209 0.0195
Entamoeba histolytica bromodomain-containing protein 0.0049 0.1195 0.6225
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0411 0.0394
Mycobacterium ulcerans hypothetical protein 0.0043 0.1034 0.3336
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Echinococcus granulosus zinc finger protein 0.001 0.01 0.0083
Loa Loa (eye worm) protein disulfide isomerase 0.0009 0.0059 0.0102
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0008 0.0054 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.1712 0.3986
Onchocerca volvulus 0.0049 0.1195 0.2051
Entamoeba histolytica bromodomain-containing protein 0.0008 0.0054 0.0159
Echinococcus multilocularis cpg binding protein 0.003 0.0673 0.0656
Echinococcus multilocularis son of sevenless 1 0.0007 0.0024 0.0006
Mycobacterium tuberculosis Conserved protein 0.0043 0.1034 0.0867
Trichomonas vaginalis bromodomain containing protein, putative 0.0008 0.0054 0.0188
Echinococcus multilocularis bromodomain containing 2 0.0108 0.2863 0.285
Loa Loa (eye worm) RecQ helicase 0.0027 0.0576 0.1003
Onchocerca volvulus 0.0043 0.1034 0.1769
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Loa Loa (eye worm) BRM protein 0.0008 0.0054 0.0092
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0067 0.1712 0.1697
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0092
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0014 0.0209 0.0935
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.1034 0.0867
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0064 0.007
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0024 0.0006
Trichomonas vaginalis esterase, putative 0.0043 0.1034 0.3611
Brugia malayi bromodomain containing protein 0.0008 0.0054 0.0052
Trichomonas vaginalis protein disulfide isomerase, putative 0.0009 0.0059 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0405 0.0843
Trichomonas vaginalis dullard protein, putative 0.0014 0.0209 0.073
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1085 0.1891
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.229 0.784
Toxoplasma gondii ABC1 family protein 0.0043 0.1034 0.3435
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0008 0.0054 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Schistosoma mansoni CREB-binding protein 2 0.0083 0.2157 0.2146
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis lymphoid specific helicase, putative 0.0008 0.0054 0.0188
Schistosoma mansoni terminal deoxycytidyl transferase 0.0067 0.1712 0.17
Echinococcus multilocularis zinc finger protein 0.001 0.01 0.0083
Echinococcus granulosus protein disulfide isomerase A3 0.0009 0.0059 0.0042
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.152 0.265
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0024 0.001
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0108 0.009
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Onchocerca volvulus 0.0146 0.3947 0.6873
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1123 0.2571
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0209 0.0693
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.1034 0.1018
Entamoeba histolytica bromodomain-containing protein 0.0008 0.0054 0.0159
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.1034 0.3336
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0108 0.009
Loa Loa (eye worm) hypothetical protein 0.0043 0.1034 0.1802
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.003 0.0669 0.137
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1034 0.3611
Onchocerca volvulus 0.001 0.0108 0.0146
Schistosoma mansoni hypothetical protein 0.0011 0.0135 0.0122
Trypanosoma cruzi DNA damage repair protein, putative 0.0021 0.0405 0.0909
Trichomonas vaginalis DNA polymerase eta, putative 0.0067 0.1712 0.5979
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0092
Loa Loa (eye worm) Pdia4 protein 0.0009 0.0059 0.0102
Loa Loa (eye worm) hypothetical protein 0.0209 0.5731 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0222 0.0473
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0355 0.0581
Brugia malayi hypothetical protein 0.001 0.0108 0.0146
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.1722 0.6016
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0108 0.009
Plasmodium falciparum protein disulfide isomerase 0.0009 0.0059 0.0024
Trypanosoma brucei unspecified product 0.0067 0.1712 0.3986
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.1712 0.6932
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0024 0.0006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trichomonas vaginalis protein disulfide isomerase, putative 0.0009 0.0059 0.0207
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.1712 0.3986
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.152 0.2621
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0008 0.0054 0.0188
Brugia malayi acetyltransferase, GNAT family protein 0.0008 0.0054 0.0052
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0067 0.1712 0.3986
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0014 0.0209 0.0693
Leishmania major hypothetical protein, conserved 0.0014 0.0209 0.0373
Loa Loa (eye worm) hypothetical protein 0.0087 0.229 0.3994
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0222 0.0404
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0067 0.1712 0.1697
Mycobacterium leprae conserved hypothetical protein 0.0043 0.1034 0.2251
Echinococcus granulosus PH interacting protein 0.0008 0.0054 0.0036
Schistosoma mansoni protein disulfide-isomerase 0.0009 0.0059 0.0046
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0411 0.0925
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0411 0.0716
Loa Loa (eye worm) hypothetical protein 0.0011 0.013 0.0225
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0049 0.1195 0.4173
Echinococcus multilocularis Bromodomain containing protein 0.0049 0.1195 0.1179
Echinococcus multilocularis CREB binding protein 0.0059 0.1484 0.1469
Schistosoma mansoni bromodomain containing protein 0.001 0.01 0.0086
Trichomonas vaginalis bromodomain containing protein, putative 0.0067 0.1722 0.6016
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0411 0.0859
Loa Loa (eye worm) hypothetical protein 0.0135 0.3638 0.6348
Schistosoma mansoni DNA helicase recq1 0.0011 0.013 0.0116
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0108 0.2863 0.2853
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0355 0.0618
Trypanosoma cruzi Bromodomain, putative 0.0008 0.0054 0.0071
Loa Loa (eye worm) bromodomain containing protein 0.0049 0.1195 0.2083
Schistosoma mansoni Probable protein disulfide-isomerase ER-60 precursor (ERP60) 0.0009 0.0059 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1085 0.1072
Echinococcus granulosus transcription factor Dp 1 0.0043 0.1025 0.1009
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1034 0.3611
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0024 0.0006
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0067 0.1712 0.5979
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0411 0.1437
Brugia malayi Probable ClpP-like protease 0.0087 0.229 0.397
Brugia malayi Bromodomain containing protein 0.0008 0.0054 0.0052
Trichomonas vaginalis bromodomain containing protein, putative 0.0049 0.1195 0.4173
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0324 0.0946
Echinococcus granulosus Bromodomain containing protein 0.0008 0.0054 0.0036
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.013 0.034
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0108 0.009
Brugia malayi PHD-finger family protein 0.001 0.01 0.0133
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0669 0.2749
Echinococcus granulosus global transcription activator snf2l2 0.0008 0.0054 0.0036
Entamoeba histolytica deoxycytidyl transferase, putative 0.0067 0.1712 0.8975
Mycobacterium leprae Probable lipase LipE 0.0043 0.1034 0.2251
Brugia malayi beta-lactamase family protein 0.0043 0.1034 0.1769
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.1034 0.3336
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1034 0.241
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.013 0.0112
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0222 0.1054
Toxoplasma gondii hypothetical protein 0.003 0.0669 0.2155
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0411 0.2156
Echinococcus granulosus Bromodomain containing protein 0.0008 0.0054 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0527 0.1201
Echinococcus multilocularis PH interacting protein 0.0008 0.0054 0.0036
Brugia malayi Bromodomain containing protein 0.0108 0.2863 0.4974
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Loa Loa (eye worm) hypothetical protein 0.001 0.0108 0.0186
Echinococcus granulosus cpg binding protein 0.003 0.0673 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Trypanosoma cruzi DNA damage repair protein, putative 0.0021 0.0405 0.0909
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Giardia lamblia DINP protein human, muc B family 0.0067 0.1712 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.1712 0.3986
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1123 0.2571
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.1712 0.3986
Entamoeba histolytica bromodomain-containing protein 0.0008 0.0054 0.0159
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1034 0.3611
Loa Loa (eye worm) hypothetical protein 0.0036 0.0821 0.1431
Trypanosoma cruzi Bromodomain, putative 0.0008 0.0054 0.0071
Echinococcus granulosus GPCR family 2 0.0019 0.0355 0.0338
Echinococcus multilocularis dna polymerase kappa 0.0067 0.1712 0.1697
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0109 0.2906 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Brugia malayi Bromodomain containing protein 0.0008 0.0054 0.0052
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0209 0.073
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0108 0.0146
Mycobacterium ulcerans beta-lactamase 0.0043 0.1034 0.3336
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0024 0.0006
Schistosoma mansoni hypothetical protein 0.0008 0.0054 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1085 0.1069
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.1712 0.3986
Echinococcus granulosus protein disulfide isomerase 0.0009 0.0059 0.0042
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Schistosoma mansoni hypothetical protein 0.0041 0.0981 0.0968
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Trichomonas vaginalis bromodomain-containing protein, putative 0.0108 0.2863 1
Brugia malayi Bromodomain containing protein 0.0108 0.2863 0.4974
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0014 0.0209 0.0192
Plasmodium vivax DNA repair protein REV1, putative 0.0021 0.0405 0.1569
Loa Loa (eye worm) hypothetical protein 0.0108 0.2863 0.4994
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.013 0.0458
Echinococcus multilocularis Bromodomain containing protein 0.0008 0.0054 0.0036
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0014 0.0209 0.0983
Brugia malayi Bromodomain containing protein 0.0008 0.0054 0.0052
Brugia malayi beta-lactamase family protein 0.0043 0.1034 0.1769
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0108 0.0186
Schistosoma mansoni DNA polymerase eta 0.0155 0.4213 0.4205
Loa Loa (eye worm) hypothetical protein 0.001 0.0108 0.0186
Brugia malayi Bromodomain containing protein 0.0008 0.0054 0.0052
Toxoplasma gondii bromodomain-containing protein 0.0049 0.1195 0.3999
Trichomonas vaginalis hypothetical protein 0.0008 0.0054 0.0188
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.013 0.0266
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.1438 0.1423
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Echinococcus granulosus CREB binding protein 0.0083 0.2157 0.2143
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1904 0.4489
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.1904 0.4449
Echinococcus granulosus histone acetyltransferase KAT2B 0.0008 0.0054 0.0036
Brugia malayi hypothetical protein 0.0146 0.3947 0.6873
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.001 0.01 0.0083
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.229 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1034 0.241
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Onchocerca volvulus 0.0043 0.1034 0.1769
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0626 0.1091
Toxoplasma gondii exonuclease III APE 0.0021 0.0411 0.1253
Leishmania major DNA polymerase kappa, putative 0.0067 0.1712 0.3986
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0108 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.1195 0.4173
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0411 0.1598
Leishmania major hypothetical protein, conserved 0.0043 0.1034 0.2355
Plasmodium vivax SET domain containing protein 0.0009 0.0072 0.0079
Schistosoma mansoni protein disulfide-isomerase er-60 precursor (erp60) 0.0009 0.0059 0.0046
Trypanosoma cruzi Bromodomain factor 1 0.0008 0.0054 0.0071
Brugia malayi beta-lactamase 0.0043 0.1034 0.1769
Brugia malayi Bromodomain containing protein 0.0008 0.0054 0.0052
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.229 0.5
Echinococcus granulosus CREB binding protein 0.0012 0.0167 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Brugia malayi hypothetical protein 0.0025 0.0527 0.0882
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0355 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0083 0.2157 0.2146
Echinococcus granulosus CREB binding protein 0.0012 0.0167 0.015
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0416 0.0403
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0527 0.2117
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0024 0.0084
Trypanosoma cruzi Bromodomain, putative 0.0008 0.0054 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1085 0.1072
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.229 1
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0008 0.0054 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0355 0.0338
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1534 0.1523
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1085 0.1859
Echinococcus multilocularis dna polymerase eta 0.0155 0.4213 0.4203
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0108 0.0146
Loa Loa (eye worm) hypothetical protein 0.001 0.0108 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.1712 0.3986
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.0024 0.0084
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0014 0.0209 0.0543
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0008 0.0054 0.0188
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0108 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1123 0.2571
Loa Loa (eye worm) hypothetical protein 0.0043 0.1034 0.1802
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0008 0.0054 0.0188
Brugia malayi polybromodomain protein 0.0008 0.0054 0.0052
Trichomonas vaginalis bromodomain containing protein, putative 0.0008 0.0054 0.0188
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.1034 0.0867
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0527 0.2117
Giardia lamblia DNA damage repair protein 0.0021 0.0405 0.2116
Schistosoma mansoni bromodomain containing 0.0008 0.0054 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.1712 0.3986
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0092
Schistosoma mansoni phd finger protein 0.0008 0.0054 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1034 0.1021
Brugia malayi DIX domain containing protein 0.001 0.0108 0.0146
Schistosoma mansoni bromodomain containing protein 0.0008 0.0054 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.1712 0.4029
Loa Loa (eye worm) hypothetical protein 0.0043 0.1034 0.1802
Toxoplasma gondii hypothetical protein 0.001 0.0108 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Brugia malayi TAZ zinc finger family protein 0.0083 0.2157 0.3737
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.229 0.784
Leishmania major DNA damage repair protein, putative 0.0021 0.0405 0.0843
Loa Loa (eye worm) hypothetical protein 0.0043 0.1034 0.1802
Trypanosoma cruzi bromodomain factor 2 protein 0.0008 0.0054 0.0071
Echinococcus multilocularis polybromo 1 0.0008 0.0054 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Brugia malayi ATPase, AAA family protein 0.0008 0.0054 0.0052
Onchocerca volvulus 0.0043 0.1034 0.1769
Brugia malayi transglutaminase 0.0009 0.0059 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0008 0.0054 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.1034 0.2355
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.1904 1
Echinococcus multilocularis 0.0014 0.0209 0.0192
Loa Loa (eye worm) hypothetical protein 0.0043 0.1034 0.1802
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.229 0.2279
Loa Loa (eye worm) hypothetical protein 0.0041 0.0981 0.171
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0576 0.0559
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0981 0.1676
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis bromodomain containing protein, putative 0.0008 0.0054 0.0188
Schistosoma mansoni hypothetical protein 0.0008 0.0054 0.004
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0405 0.0909
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.1034 0.0867
Brugia malayi Bromodomain containing protein 0.001 0.01 0.0133
Entamoeba histolytica hypothetical protein 0.0008 0.0054 0.0159
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.1904 0.3321
Echinococcus granulosus bromodomain containing protein 8 0.0008 0.0054 0.0036
Brugia malayi ImpB/MucB/SamB family protein 0.0155 0.4213 0.734
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Loa Loa (eye worm) hypothetical protein 0.0019 0.0355 0.0618
Loa Loa (eye worm) hypothetical protein 0.0007 0.0024 0.004
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Schistosoma mansoni bromodomain containing protein 0.001 0.01 0.0086
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.033 0.1234
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.1712 0.3986
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0008 0.0054 0.0188
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.1034 0.1802
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Echinococcus multilocularis CREB binding protein 0.0012 0.0167 0.015
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0024 0.004
Echinococcus multilocularis peregrin 0.0008 0.0054 0.0036
Mycobacterium ulcerans lipase LipD 0.0043 0.1034 0.3336
Brugia malayi CXXC zinc finger family protein 0.0029 0.0626 0.1055
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.0008 0.0054 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Trypanosoma brucei unspecified product 0.0046 0.1123 0.2571
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0092
Trypanosoma brucei DNA polymerase eta, putative 0.0155 0.4213 1
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0014 0.0209 0.0324
Trypanosoma brucei unspecified product 0.0046 0.1123 0.2571
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0355 0.0581
Echinococcus multilocularis protein disulfide isomerase A3 0.0009 0.0059 0.0042
Leishmania major DNA polymerase eta, putative 0.0155 0.4213 1
Echinococcus multilocularis bromodomain containing protein 8 0.0008 0.0054 0.0036
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.1034 0.0867
Trichomonas vaginalis hypothetical protein 0.0008 0.0054 0.0188
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0411 0.1437
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0007 0.0024 0.004
Echinococcus multilocularis CREB binding protein 0.0012 0.0167 0.015
Loa Loa (eye worm) hypothetical protein 0.001 0.01 0.0173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1085 0.1069
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Brugia malayi BRM protein 0.0008 0.0054 0.0052
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0067 0.0115
Loa Loa (eye worm) beta-lactamase 0.0043 0.1034 0.1802
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1085 0.1069
Leishmania major hypothetical protein, conserved 0.0025 0.0527 0.1138
Brugia malayi protein disulphide isomerase 0.0009 0.0059 0.0062
Schistosoma mansoni transcription initiation factor tfiid 0.0008 0.0054 0.004
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0008 0.0054 0.00000000045312
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.1712 0.3986
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Loa Loa (eye worm) hypothetical protein 0.006 0.152 0.265
Loa Loa (eye worm) hypothetical protein 0.0146 0.3947 0.6886
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Plasmodium falciparum DNA repair protein REV1, putative 0.0021 0.0405 0.1569
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.013 0.0225
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trichomonas vaginalis bromodomain-containing protein, putative 0.0108 0.2863 1
Brugia malayi N-terminal motif family protein 0.0209 0.5731 1
Schistosoma mansoni hypothetical protein 0.0014 0.0204 0.019
Trypanosoma cruzi DNA polymerase eta, putative 0.0155 0.4213 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1034 0.1021
Leishmania major DNA polymerase eta, putative 0.0109 0.2906 0.6858
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trypanosoma cruzi DNA polymerase eta, putative 0.0109 0.2906 0.688
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0024 0.0006
Echinococcus granulosus CREB binding protein 0.0054 0.1337 0.1321
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Schistosoma mansoni hypothetical protein 0.036 1 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.1438 0.1429
Onchocerca volvulus 0.0029 0.0626 0.1055
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0024 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1085 0.1072
Trichomonas vaginalis protein disulfide isomerase, putative 0.0009 0.0059 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Echinococcus multilocularis protein kinase C binding protein 1 0.0008 0.0054 0.0036
Schistosoma mansoni zinc finger protein 0.001 0.01 0.0086
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.229 1
Leishmania major protein disulfide isomerase 0.0009 0.0059 0.0013
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.229 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.1904 0.1893
Echinococcus multilocularis geminin 0.036 1 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.013 0.0186
Loa Loa (eye worm) hypothetical protein 0.0008 0.0031 0.0052
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0067 0.1712 0.1811
Echinococcus granulosus peregrin 0.0008 0.0054 0.0036
Entamoeba histolytica bromodomain-containing protein 0.0049 0.1195 0.6225
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1904 0.4449
Entamoeba histolytica bromodomain-containing protein 0.0049 0.1195 0.6225
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0405 0.0843
Toxoplasma gondii protein disulfide isomerase 0.0009 0.0059 0.0019
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.229 0.5
Schistosoma mansoni ap endonuclease 0.0021 0.0411 0.0398
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.0363
Brugia malayi ImpB/MucB/SamB family protein 0.0067 0.1712 0.2957
Loa Loa (eye worm) transglutaminase 0.0009 0.0059 0.0102
Loa Loa (eye worm) hypothetical protein 0.0155 0.4213 0.735
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0024 0.0006
Brugia malayi probable protein disulfide-isomerase 0.0009 0.0059 0.0062
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.0024 0.0084
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0108 0.0186
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.013 0.0266
Loa Loa (eye worm) hypothetical protein 0.0021 0.0405 0.0704
Echinococcus multilocularis CREB binding protein 0.0012 0.0167 0.015
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0067 0.1712 0.17
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Brugia malayi Bromodomain containing protein 0.0008 0.0054 0.0052
Leishmania major DNA polymerase kappa, putative 0.0021 0.0405 0.0843
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.1025 0.1009
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0135 0.0118
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0067 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.1712 0.3986
Loa Loa (eye worm) hypothetical protein 0.0025 0.0527 0.0918
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0018 0.0004
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0576 0.2011
Brugia malayi polk-prov protein 0.0021 0.0405 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0576 0.2011
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0209 0.0195
Brugia malayi polybromodomain protein 0.0008 0.0054 0.0052
Loa Loa (eye worm) CBP-B 0.006 0.1503 0.2621
Trypanosoma cruzi Bromodomain, putative 0.0008 0.0054 0.0071
Trypanosoma brucei DNA damage repair protein, putative 0.0021 0.0405 0.0843
Trichomonas vaginalis bromodomain containing protein, putative 0.0008 0.0054 0.0188
Schistosoma mansoni cpg binding protein 0.003 0.0673 0.066
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.1712 0.3986
Schistosoma mansoni DNA polymerase IV / kappa 0.0021 0.0405 0.0391
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Schistosoma mansoni hypothetical protein 0.0008 0.0054 0.004
Schistosoma mansoni regulator of G protein signaling 0.001 0.0108 0.0094
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0355 0.0338
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.013 0.0112
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0024 0.0084
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0092
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.013 0.0112
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.013 0.0186
Brugia malayi Bromodomain containing protein 0.0008 0.0054 0.0052
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.1034 0.0867
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1034 0.3611
Onchocerca volvulus 0.0008 0.0054 0.0052
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.1712 0.6932
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0411 0.0394
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0067 0.1712 0.2985
Schistosoma mansoni hypothetical protein 0.0019 0.0355 0.0342
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0209 0.073
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0008 0.0054 0.0188
Onchocerca volvulus 0.0008 0.0054 0.0052
Schistosoma mansoni dishevelled 0.001 0.0108 0.0094
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1034 0.3611
Schistosoma mansoni dishevelled 0.001 0.0108 0.0094
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis bromodomain-containing protein, putative 0.0067 0.1722 0.6016
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.1712 0.3986
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0209 0.5731 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.1034 0.0867
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1904 0.4489
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.229 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.1712 0.4029
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0405 0.0909
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1588 0.538
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0008 0.0054 0.0188
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0054 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0222 0.0776
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0527 0.166
Trichomonas vaginalis dullard protein, putative 0.0014 0.0209 0.073
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Entamoeba histolytica ankyrin repeat protein, putative 0.0008 0.0054 0.0159
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0484 0.1921
Loa Loa (eye worm) hypothetical protein 0.0008 0.0054 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Schistosoma mansoni hypothetical protein 0.0019 0.0355 0.0342
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Loa Loa (eye worm) hypothetical protein 0.0043 0.1034 0.1802
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis dullard protein, putative 0.0014 0.0209 0.073
Echinococcus granulosus dna polymerase kappa 0.0067 0.1712 0.1697
Echinococcus granulosus bromodomain containing 2 0.0108 0.2863 0.285
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0209 0.0693
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0108 0.0146
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0014 0.0209 0.0373
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0024 0.001
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0411 0.0679
Echinococcus granulosus CTD small phosphatase protein like 0.0014 0.0209 0.0192
Trichomonas vaginalis bromodomain-containing protein, putative 0.0067 0.1722 0.6016
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0527 0.1138
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.1034 0.1769
Giardia lamblia Transcription regulatory protein SNF2 0.0008 0.0054 0.00000000077966
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0411 0.0925
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0021 0.0405 0.123
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Giardia lamblia Kinase, putative 0.0049 0.1195 0.6881
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0527 0.2117
Entamoeba histolytica thioredoxin, putative 0.0009 0.0059 0.0188
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0108 0.009
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0021 0.0405 0.123
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0411 0.1598
Schistosoma mansoni hypothetical protein 0.0019 0.0355 0.0342
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.1904 0.189
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.1438 0.1423
Loa Loa (eye worm) hypothetical protein 0.0014 0.0204 0.0354
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0275 0.7592 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.229 0.2276
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0067 0.0049
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0108 0.0094
Trypanosoma brucei protein disulfide isomerase 0.0009 0.0059 0.0013
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.1712 0.3986
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0222 0.0404
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0411 0.206
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0049 0.1195 0.4173
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0576 0.0967
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0411 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.1485 0.5186
Echinococcus multilocularis global transcription activator snf2l2 0.0008 0.0054 0.0036
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0024 0.001
Trypanosoma cruzi Bromodomain, putative 0.0008 0.0054 0.0071
Echinococcus multilocularis 0.0008 0.0054 0.0036
Trichomonas vaginalis protein disulfide isomerase, putative 0.0009 0.0059 0.0207
Schistosoma mansoni DNA helicase recq5 0.0011 0.013 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0108 0.009
Schistosoma mansoni cpg binding protein 0.0029 0.0626 0.0613
Brugia malayi hypothetical protein 0.001 0.0108 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0024 0.001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0067 0.1722 0.6016
Echinococcus granulosus protein kinase C binding protein 1 0.0008 0.0054 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1085 0.1069
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0669 0.2749
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Trypanosoma brucei DNA damage repair protein, putative 0.0021 0.0405 0.0843
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.1438 0.4744
Echinococcus granulosus polybromo 1 0.0008 0.0054 0.0036
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0135 0.0118
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.1034 0.0867
Plasmodium vivax protein disulfide isomerase, putative 0.0009 0.0059 0.0024
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0527 0.1201
Trichomonas vaginalis bromodomain-containing protein, putative 0.0008 0.0054 0.0188
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.229 1
Schistosoma mansoni dep domain containing protein 0.001 0.0108 0.0094
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.1034 0.1018
Plasmodium vivax hypothetical protein, conserved 0.0043 0.1034 0.4381
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.229 1
Trypanosoma brucei chrX additional, unordered contigs 0.0021 0.0405 0.0843
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1195 0.4173
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0108 0.0146
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.1904 0.189
Loa Loa (eye worm) bromodomain containing protein 0.0008 0.0054 0.0092
Trypanosoma cruzi bromodomain-containing protein 3 0.0008 0.0054 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0054 0.0188
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0108 0.009

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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