Detailed information for compound 1201262

Basic information

Technical information
  • TDR Targets ID: 1201262
  • Name: 2-[(4-phenyl-1,2,4-triazol-3-yl)sulfanylmethy l]imidazo[1,2-a]pyrimidine
  • MW: 308.361 | Formula: C15H12N6S
  • H donors: 0 H acceptors: 4 LogP: 2.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)n1cnnc1SCc1cn2c(n1)nccc2
  • InChi: 1S/C15H12N6S/c1-2-5-13(6-3-1)21-11-17-19-15(21)22-10-12-9-20-8-4-7-16-14(20)18-12/h1-9,11H,10H2
  • InChiKey: LVENVUHBIDYWKR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[(4-phenyl-1,2,4-triazol-3-yl)thio]methyl]imidazo[1,2-a]pyrimidine
  • ZINC00180606
  • STOCK1S-69474
  • Oprea1_339408
  • 2-(4-Phenyl-4H-[1,2,4]triazol-3-ylsulfanylmethyl)-imidazo[1,2-a]pyrimidine
  • MLS000595219
  • SMR000149742

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Sus scrofa Trypsin Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis enteropeptidase Trypsin   231 aa 230 aa 27.8 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin   231 aa 237 aa 24.1 %
Drosophila melanogaster Jonah 99Ci Trypsin   231 aa 235 aa 31.9 %
Drosophila melanogaster CG13744 gene product from transcript CG13744-RA Trypsin   231 aa 249 aa 31.3 %
Drosophila melanogaster Jonah 66Ci Trypsin   231 aa 234 aa 32.9 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Drosophila melanogaster CG30287 gene product from transcript CG30287-RA Trypsin   231 aa 249 aa 27.7 %
Drosophila melanogaster CG31326 gene product from transcript CG31326-RA Trypsin   231 aa 249 aa 24.1 %
Schistosoma japonicum Cercarial protease precursor (EC 3.4.21.-) (Cercarial elastase), putative Trypsin   231 aa 204 aa 25.0 %
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) Trypsin   231 aa 286 aa 25.2 %
Schistosoma japonicum Enteropeptidase, putative Trypsin   231 aa 262 aa 25.6 %
Drosophila melanogaster CG11313 gene product from transcript CG11313-RC Trypsin   231 aa 255 aa 31.8 %
Echinococcus multilocularis transmembrane protease serine 3 Trypsin   231 aa 233 aa 33.0 %
Onchocerca volvulus Trypsin   231 aa 251 aa 22.7 %
Echinococcus granulosus enteropeptidase Trypsin   231 aa 230 aa 28.3 %
Schistosoma mansoni aminopeptidase PILS (M01 family) Trypsin   231 aa 300 aa 22.3 %
Drosophila melanogaster CG9997 gene product from transcript CG9997-RB Trypsin   231 aa 194 aa 23.2 %
Echinococcus granulosus transmembrane protease serine 3 Trypsin   231 aa 234 aa 33.8 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Trypsin   231 aa 302 aa 24.8 %
Drosophila melanogaster Jonah 65Aii Trypsin   231 aa 235 aa 35.3 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin   231 aa 235 aa 25.5 %
Drosophila melanogaster CG33465 gene product from transcript CG33465-RC Trypsin   231 aa 225 aa 21.8 %
Drosophila melanogaster CG4815 gene product from transcript CG4815-RA Trypsin   231 aa 212 aa 27.4 %
Trypanosoma cruzi hypothetical protein, conserved Trypsin   231 aa 188 aa 23.9 %
Drosophila melanogaster CG3505 gene product from transcript CG3505-RA Trypsin   231 aa 232 aa 30.6 %
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Trypsin   231 aa 247 aa 35.2 %
Schistosoma japonicum ko:K09637 transmembrane protease, serine 6, putative Trypsin   231 aa 242 aa 28.9 %
Drosophila melanogaster CG18420 gene product from transcript CG18420-RA Trypsin   231 aa 239 aa 28.4 %
Drosophila melanogaster CG6582 gene product from transcript CG6582-RA Trypsin   231 aa 187 aa 23.5 %
Onchocerca volvulus Trypsin   231 aa 212 aa 21.2 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin   231 aa 235 aa 25.5 %
Drosophila melanogaster CG4914 gene product from transcript CG4914-RA Trypsin   231 aa 245 aa 38.8 %
Neospora caninum ELMO/CED-12 family domain-containing protein, putative Trypsin   231 aa 193 aa 22.8 %
Drosophila melanogaster CG9673 gene product from transcript CG9673-RB Trypsin   231 aa 239 aa 27.6 %
Drosophila melanogaster CG9733 gene product from transcript CG9733-RB Trypsin   231 aa 262 aa 31.3 %
Drosophila melanogaster CG5909 gene product from transcript CG5909-RA Trypsin   231 aa 256 aa 28.9 %
Loa Loa (eye worm) hypothetical protein Trypsin   231 aa 238 aa 21.4 %
Drosophila melanogaster CG3916 gene product from transcript CG3916-RA Trypsin   231 aa 245 aa 31.4 %
Drosophila melanogaster CG30323 gene product from transcript CG30323-RB Trypsin   231 aa 210 aa 23.3 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Schistosoma mansoni cercarial elastase (S01 family) Trypsin   231 aa 201 aa 22.9 %
Drosophila melanogaster CG14990 gene product from transcript CG14990-RA Trypsin   231 aa 238 aa 29.4 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Echinococcus multilocularis Mastin Trypsin   231 aa 306 aa 24.2 %
Drosophila melanogaster CG33458 gene product from transcript CG33458-RA Trypsin   231 aa 254 aa 28.4 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Drosophila melanogaster CG31267 gene product from transcript CG31267-RA Trypsin   231 aa 233 aa 32.2 %
Schistosoma japonicum IPR001254,Peptidase S1 and S6, chymotrypsin/Hap;IPR009003,Peptidase, trypsin-like serine and cysteine,domain-containing Trypsin   231 aa 225 aa 23.1 %
Echinococcus multilocularis glycoprotein Antigen 5 Trypsin   231 aa 301 aa 22.3 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Drosophila melanogaster CG30288 gene product from transcript CG30288-RC Trypsin   231 aa 245 aa 29.0 %
Echinococcus granulosus Mastin Trypsin   231 aa 306 aa 23.9 %
Drosophila melanogaster CG17239 gene product from transcript CG17239-RB Trypsin   231 aa 227 aa 33.5 %
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family Trypsin   231 aa 286 aa 24.8 %
Drosophila melanogaster CG32277 gene product from transcript CG32277-RA Trypsin   231 aa 221 aa 33.5 %
Drosophila melanogaster CG30083 gene product from transcript CG30083-RB Trypsin   231 aa 209 aa 29.7 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Drosophila melanogaster CG31220 gene product from transcript CG31220-RB Trypsin   231 aa 263 aa 27.8 %
Schistosoma japonicum ko:K01346 pancreatic elastase II [EC3.4.21.71], putative Trypsin   231 aa 303 aa 24.1 %
Drosophila melanogaster CG10405 gene product from transcript CG10405-RB Trypsin   231 aa 242 aa 31.8 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Drosophila melanogaster CG34436 gene product from transcript CG34436-RA Trypsin   231 aa 214 aa 22.0 %
Drosophila melanogaster CG18180 gene product from transcript CG18180-RA Trypsin   231 aa 233 aa 27.9 %
Drosophila melanogaster Spatzle-Processing Enzyme Trypsin   231 aa 271 aa 29.1 %
Schistosoma japonicum Transmembrane protease, serine 9, putative Trypsin   231 aa 246 aa 21.1 %
Drosophila melanogaster Jonah 65Aiii Trypsin   231 aa 241 aa 34.0 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Echinococcus granulosus glycoprotein Antigen 5 Trypsin   231 aa 301 aa 23.9 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.1797 0.4934
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.1372 0.6638
Leishmania major DNA polymerase eta, putative 0.0107 0.1942 0.5409
Leishmania major DNA polymerase kappa, putative 0.0031 0.0399 0.0343
Brugia malayi Pip kinase protein 2 0.0322 0.6307 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.1687 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0026 0.0295 0.0468
Leishmania major DNA polymerase eta, putative 0.0176 0.3339 1
Echinococcus multilocularis expressed protein 0.0106 0.1917 0.3025
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0026 0.0295 0.0468
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0036 0.0499 0.2571
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1687 0.9209
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.1797 0.4934
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0431 0.2553
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0221 0.0329
Mycobacterium tuberculosis Conserved protein 0.0079 0.1372 0.0385
Trichomonas vaginalis rotamase, putative 0.0103 0.1866 0.9688
Giardia lamblia DNA damage repair protein 0.0031 0.0399 0.1134
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1687 0.9209
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.1372 0.0385
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0103 0.1866 0.5162
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0221 0.0329
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0014 0.0022
Schistosoma mansoni DNA helicase recq1 0.0022 0.0221 0.035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0891 0.1413
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0322 0.6307 1
Echinococcus granulosus flap endonuclease 1 0.0031 0.0409 0.0628
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.1372 0.6956
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0221 0.1137
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0014 0.0022
Trypanosoma cruzi DNA polymerase eta, putative 0.0176 0.3339 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0014 0.0022
Mycobacterium ulcerans beta-lactamase 0.0079 0.1372 0.6956
Brugia malayi ImpB/MucB/SamB family protein 0.01 0.1797 0.2834
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.1168 0.2868
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0353 0.0191
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0014 0.0022
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0014 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.1372 0.6638
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0409 0.0373
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0032 0.0423 0.2179
Loa Loa (eye worm) hypothetical protein 0.0079 0.1372 0.2158
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.1797 0.4934
Giardia lamblia Hypothetical protein 0.0026 0.0295 0.0472
Plasmodium vivax hypothetical protein, conserved 0.0079 0.1372 0.7737
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1687 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0107 0.1942 0.5409
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0014 0.0022
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.1026 0.4744
Trypanosoma brucei DNA polymerase IV, putative 0.01 0.1797 0.4934
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.01 0.1797 0.926
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0103 0.1866 0.5162
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0026 0.0295 0.152
Loa Loa (eye worm) hypothetical protein 0.0079 0.1372 0.2158
Brugia malayi Bloom's syndrome protein homolog 0.0054 0.0861 0.1347
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.01 0.1797 0.0859
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0026 0.0295 0.0447
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.1797 0.4934
Loa Loa (eye worm) hypothetical protein 0.0031 0.0399 0.0613
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.1797 0.4934
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0036 0.0508 0.153
Onchocerca volvulus 0.0106 0.1929 0.3044
Brugia malayi Trypsin family protein 0.0114 0.2079 0.3283
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.1797 0.4934
Trypanosoma cruzi DNA damage repair protein, putative 0.0031 0.0399 0.0343
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0322 0.6307 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.1026 0.1609
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.1372 0.6638
Loa Loa (eye worm) hypothetical protein 0.0163 0.3086 0.4883
Entamoeba histolytica phosphoinositide kinase, putative 0.0026 0.0295 0.1581
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0891 0.1395
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0423 0.0421
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0221 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.1797 0.4934
Plasmodium vivax DNA repair protein REV1, putative 0.0031 0.0399 0.075
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.1372 0.0385
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.1687 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0031 0.0399 0.1219
Loa Loa (eye worm) beta-lactamase 0.0079 0.1372 0.2158
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.1168 0.2868
Toxoplasma gondii peptidylprolyl isomerase 0.0103 0.1866 0.9613
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0399 0.0343
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0107 0.1942 1
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.1797 0.4934
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0047 0.0729 0.3466
Entamoeba histolytica recQ family helicase, putative 0.0029 0.0353 0.1892
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0026 0.0295 0.152
Loa Loa (eye worm) pip kinase 1 0.0026 0.0295 0.0447
Mycobacterium leprae Probable lipase LipE 0.0079 0.1372 0.7493
Trypanosoma cruzi DNA damage repair protein, putative 0.0031 0.0399 0.0343
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.1372 0.0385
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0409 0.2189
Schistosoma mansoni DNA polymerase eta 0.0176 0.3339 0.5295
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0106 0.1917 0.3025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0891 0.1395
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1687 1
Brugia malayi Flap endonuclease-1 0.0031 0.0409 0.0628
Brugia malayi Pip kinase protein 1 0.0026 0.0295 0.0447
Mycobacterium tuberculosis Conserved protein 0.0079 0.1372 0.0385
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0026 0.0295 0.0447
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.01 0.1797 0.2849
Mycobacterium tuberculosis Conserved protein 0.0079 0.1372 0.0385
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0026 0.0295 0.0447
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0322 0.6307 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0423 0.0421
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0026 0.0295 0.0468
Trichomonas vaginalis rotamase, putative 0.0106 0.1917 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.01 0.1797 0.2834
Toxoplasma gondii ABC1 family protein 0.0079 0.1372 0.7065
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.1797 0.4934
Echinococcus multilocularis bloom syndrome protein 0.0054 0.0861 0.1347
Trypanosoma brucei DNA polymerase eta, putative 0.0176 0.3339 1
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.1797 0.4934
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0026 0.0295 0.0447
Onchocerca volvulus 0.0079 0.1372 0.2158
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.1372 0.2158
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0026 0.0295 0.0447
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0026 0.0295 0.0447
Schistosoma mansoni coup transcription factor 0.0012 0.0014 0.0022
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0221 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.1917 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.1687 0.2674
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.01 0.1797 0.4934
Echinococcus multilocularis dna polymerase kappa 0.01 0.1797 0.2834
Giardia lamblia DINP protein human, muc B family 0.01 0.1797 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0014 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.1797 0.4934
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.1797 0.4934
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.01 0.1797 0.2834
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0423 0.0421
Echinococcus granulosus dna polymerase eta 0.0176 0.3339 0.5285
Loa Loa (eye worm) hypothetical protein 0.0079 0.1372 0.2158
Brugia malayi polk-prov protein 0.0031 0.0399 0.0613
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0221 0.0329
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0221 0.1137
Loa Loa (eye worm) hypothetical protein 0.0114 0.2079 0.3283
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.1797 0.4934
Trichomonas vaginalis DNA helicase recq1, putative 0.0054 0.0861 0.349
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.1372 0.0385
Loa Loa (eye worm) hypothetical protein 0.0114 0.2079 0.3283
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.1797 0.4934
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.1372 0.0385
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0103 0.1866 0.5162
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0399 0.2058
Mycobacterium ulcerans hypothetical protein 0.0079 0.1372 0.6956
Loa Loa (eye worm) RecQ helicase 0.0054 0.0861 0.1347
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0014 0.0022
Brugia malayi beta-lactamase family protein 0.0079 0.1372 0.2158
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.1372 0.6638
Loa Loa (eye worm) hypothetical protein 0.0176 0.3339 0.5285
Loa Loa (eye worm) hypothetical protein 0.0079 0.1372 0.2158
Echinococcus granulosus dna polymerase kappa 0.01 0.1797 0.2834
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0409 0.0628
Echinococcus granulosus bloom syndrome protein 0.0054 0.0861 0.1347
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0221 0.0329
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0103 0.1866 0.5162
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.1687 0.2658
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0353 0.0191
Trypanosoma brucei chrX additional, unordered contigs 0.0031 0.0399 0.0343
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.1372 0.6638
Onchocerca volvulus 0.0079 0.1372 0.2158
Trichomonas vaginalis esterase, putative 0.0079 0.1372 0.6638
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1687 0.8686
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0029 0.0353 0.0191
Schistosoma mansoni flap endonuclease-1 0.0028 0.0347 0.0551
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0014 0.0022
Schistosoma mansoni DNA helicase recq5 0.0022 0.0221 0.035
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.1372 0.2158
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0409 0.2104
Onchocerca volvulus 0.0114 0.2079 0.3283
Trypanosoma brucei unspecified product 0.01 0.1797 0.4934
Mycobacterium ulcerans DNA polymerase IV 0.01 0.1797 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1687 0.8686
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0103 0.1866 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.1372 0.6956
Leishmania major hypothetical protein, conserved 0.0079 0.1372 0.3537
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.1372 0.2158
Mycobacterium ulcerans DNA polymerase IV 0.01 0.1797 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0031 0.0399 0.2058
Trypanosoma cruzi DNA polymerase kappa, putative 0.01 0.1797 0.4934
Trichomonas vaginalis DNA helicase recq, putative 0.0054 0.0861 0.349
Onchocerca volvulus 0.0079 0.1372 0.2158
Echinococcus granulosus expressed protein 0.0106 0.1917 0.3025
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0409 0.0815
Schistosoma mansoni hypothetical protein 0.0205 0.3922 0.6219
Trypanosoma brucei unspecified product 0.0069 0.1168 0.2868
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.1168 0.2868
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.1797 0.4934
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0106 0.1917 0.3025
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.1372 0.0385
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0322 0.6307 1
Trichomonas vaginalis DNA polymerase eta, putative 0.01 0.1797 0.926
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0891 0.1395
Schistosoma mansoni DNA polymerase IV / kappa 0.0031 0.0399 0.0633
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0891 0.1395
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0026 0.0295 0.152
Trypanosoma brucei DNA damage repair protein, putative 0.0031 0.0399 0.0343
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0409 0.0373
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0026 0.0295 0.0507
Mycobacterium ulcerans lipase LipD 0.0079 0.1372 0.6956
Loa Loa (eye worm) hypothetical protein 0.0079 0.1372 0.2158
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0399 0.0343
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.1372 0.2175
Onchocerca volvulus 0.0322 0.6307 1
Brugia malayi Probable ClpP-like protease 0.0094 0.1687 0.2658
Loa Loa (eye worm) hypothetical protein 0.0079 0.1372 0.2158
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0114 0.2079 0.3297
Toxoplasma gondii hypothetical protein 0.0033 0.0431 0.2218
Echinococcus granulosus geminin 0.0205 0.3922 0.6211
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0399 0.0343
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0114 0.2079 0.3297
Trypanosoma brucei unspecified product 0.0069 0.1168 0.2868
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0409 0.1191
Trypanosoma brucei DNA damage repair protein, putative 0.0031 0.0399 0.0343
Plasmodium falciparum flap endonuclease 1 0.0031 0.0409 0.1281
Entamoeba histolytica deoxycytidyl transferase, putative 0.01 0.1797 0.9628
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.1372 0.0385
Schistosoma mansoni hypothetical protein 0.0205 0.3922 0.6219
Echinococcus multilocularis dna polymerase eta 0.0176 0.3339 0.5285
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0014 0.0022
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1687 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.01 0.1797 0.0859
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.1372 0.2158
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.1372 0.3537
Loa Loa (eye worm) hypothetical protein 0.0094 0.1687 0.2658
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0399 0.0343
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.1372 0.3537
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0322 0.6307 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.1687 0.2658
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0431 0.1432
Schistosoma mansoni rotamase 0.0106 0.1917 0.304
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.1687 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0891 0.1395
Leishmania major DNA damage repair protein, putative 0.0031 0.0399 0.0343
Loa Loa (eye worm) hypothetical protein 0.0022 0.0221 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0891 0.1413
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0014 0.0022
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0423 0.0421
Loa Loa (eye worm) FYVE zinc finger family protein 0.0026 0.0295 0.0447
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0026 0.0295 0.0468
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1687 1
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0026 0.0295 0.0472
Schistosoma mansoni terminal deoxycytidyl transferase 0.01 0.1797 0.2849
Loa Loa (eye worm) pip kinase 2 0.0322 0.6307 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0431 0.0974
Brugia malayi beta-lactamase family protein 0.0079 0.1372 0.2158
Schistosoma mansoni blooms syndrome DNA helicase 0.0042 0.0632 0.1002
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0409 0.0699
Echinococcus multilocularis geminin 0.0205 0.3922 0.6211
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0409 0.0373
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0221 0.0329
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0353 0.0358
Leishmania major DNA polymerase kappa, putative 0.01 0.1797 0.4934
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0399 0.0343
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0399 0.0343
Brugia malayi ImpB/MucB/SamB family protein 0.0176 0.3339 0.5285
Mycobacterium leprae conserved hypothetical protein 0.0079 0.1372 0.7493
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.1372 0.3537
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0409 0.0628
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0891 0.1413
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.1372 0.2175
Brugia malayi beta-lactamase 0.0079 0.1372 0.2158
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.01 0.1797 0.2834
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0891 0.1395
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.1026 0.1609
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0026 0.0295 0.1581

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 9.655 uM PUBCHEM_BIOASSAY: Trypsin Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] ChEMBL. No reference
Potency (functional) 0.4147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 5.1735 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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