Detailed information for compound 1201424

Basic information

Technical information
  • TDR Targets ID: 1201424
  • Name: 2-(2,4-dibromophenoxy)-N-(3,4-dihydro-2H-quin oline-1-carbothioyl)acetamide
  • MW: 484.205 | Formula: C18H16Br2N2O2S
  • H donors: 1 H acceptors: 1 LogP: 4.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(=S)N1CCCc2c1cccc2)COc1ccc(cc1Br)Br
  • InChi: 1S/C18H16Br2N2O2S/c19-13-7-8-16(14(20)10-13)24-11-17(23)21-18(25)22-9-3-5-12-4-1-2-6-15(12)22/h1-2,4,6-8,10H,3,5,9,11H2,(H,21,23,25)
  • InChiKey: OKKBFUNZYZSYRB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(2,4-dibromophenoxy)-N-(3,4-dihydro-2H-quinolin-1-yl-thioxomethyl)acetamide
  • 2-(2,4-dibromophenoxy)-N-(3,4-dihydro-2H-quinolin-1-ylcarbothioyl)ethanamide
  • ST059071
  • ZINC00676387
  • AN-329/41574330
  • ARONIS004530
  • 2-(2,4-dibromophenoxy)-N-(3,4-dihydro-1(2H)-quinolinylcarbothioyl)acetamide
  • MLS000537462
  • SMR000160644

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0081 0.0798 0.2198
Echinococcus granulosus histone lysine methyltransferase setb 0.0073 0.0701 0.0701
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0487 0.0478
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.001 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0162 0.1524
Onchocerca volvulus 0.0048 0.0401 0.108
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.002 0.0058 0.0058
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0076 0.0739 0.2832
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0208 0.0569
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0059 0.0002
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0251 0.0251
Brugia malayi glutamate synthase 0.002 0.0058 0.0155
Echinococcus multilocularis geminin 0.0196 0.2204 0.2204
Trypanosoma brucei ISWI complex protein 0.0032 0.0206 0.0608
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.1136 0.3131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Brugia malayi intermediate filament protein 0.003 0.018 0.0493
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0305 0.1054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0048 0.0125
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0073 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0058 0.004
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0076 0.0739 1
Brugia malayi MH2 domain containing protein 0.0016 0.001 0.0022
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0208 0.0208
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0208 0.0208
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0208 0.0489
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0162 0.4415
Plasmodium falciparum phd finger protein, putative 0.0029 0.0168 0.0493
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0162 0.1524
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0076 0.0739 0.2803
Loa Loa (eye worm) hypothetical protein 0.0032 0.0208 0.0569
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0317 0.0307
Brugia malayi Smad1 0.0016 0.001 0.0022
Echinococcus multilocularis GPCR, family 2 0.005 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0081 0.08 0.2203
Leishmania major basic transcription factor 3a, putative 0.004 0.0305 0.1054
Schistosoma mansoni hypothetical protein 0.0196 0.2204 0.2197
Onchocerca volvulus 0.003 0.018 0.0404
Brugia malayi glutathione reductase 0.0219 0.2488 0.6863
Entamoeba histolytica hypothetical protein 0.004 0.0298 0.9716
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0076 0.0739 1
Brugia malayi Latrophilin receptor protein 2 0.005 0.0424 0.1167
Brugia malayi hypothetical protein 0.0017 0.0021 0.0053
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0162 0.0442
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0048 0.0048
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0128 0.1373 0.1373
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0047 0.0123
Echinococcus granulosus tar DNA binding protein 0.0069 0.065 0.065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0208 0.0569
Loa Loa (eye worm) hypothetical protein 0.0086 0.0861 0.2372
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0708 0.0699
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Echinococcus granulosus fetal alzheimer antigen falz 0.0049 0.0416 0.0416
Loa Loa (eye worm) fibroinase 0.0019 0.0048 0.0128
Schistosoma mansoni glutamate synthase 0.002 0.0058 0.0048
Schistosoma mansoni hypothetical protein 0.005 0.0424 0.0415
Giardia lamblia NADH oxidase lateral transfer candidate 0.0076 0.0739 1
Plasmodium vivax glutathione reductase, putative 0.0219 0.2488 1
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0298 0.0289
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0208 0.0198
Schistosoma mansoni thyroid hormone receptor 0.0291 0.3365 0.3359
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0424 0.1167
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0262 0.0875
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0058 0.004
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0076 0.0739 0.0739
Onchocerca volvulus Alhambra homolog 0.0029 0.0168 0.0368
Echinococcus multilocularis lamin 0.003 0.018 0.018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0059 0.0002
Leishmania major cathepsin L-like protease 0.0074 0.0712 0.2723
Schistosoma mansoni hypothetical protein 0.0494 0.585 0.5847
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0076 0.0739 0.2803
Schistosoma mansoni sulfide quinone reductase 0.002 0.0058 0.0048
Loa Loa (eye worm) hypothetical protein 0.005 0.0423 0.1163
Schistosoma mansoni cpg binding protein 0.0035 0.0236 0.0226
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0708 0.0994
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0708 0.0708
Plasmodium vivax thioredoxin reductase, putative 0.0219 0.2488 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0289 0.0792
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0198
Mycobacterium tuberculosis Probable dehydrogenase 0.0499 0.5917 0.8958
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0162 0.4415
Brugia malayi PHD-finger family protein 0.0054 0.0477 0.1313
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0739 0.2832
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0208 0.0208
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0317 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0305 0.0836
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0208 0.0569
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0236 0.0236
Loa Loa (eye worm) TAR-binding protein 0.0069 0.065 0.1791
Loa Loa (eye worm) hypothetical protein 0.0032 0.0208 0.0569
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0305 0.1054
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0208 0.0569
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0712 0.2694
Echinococcus multilocularis cpg binding protein 0.0041 0.0309 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0208 0.0569
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0058 0.0152
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0073 0.0023
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0258 0.2969 0.2969
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0076 0.0739 0.2832
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0739 0.2832
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0208 0.0569
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0712 0.2723
Loa Loa (eye worm) hypothetical protein 0.0149 0.1633 0.4503
Schistosoma mansoni hypothetical protein 0.0029 0.0168 0.0159
Onchocerca volvulus 0.0031 0.0186 0.0422
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0053
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0076 0.0739 0.2832
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0058 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0047 0.0123
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0076 0.0739 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.065 0.0641
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0059 0.0002
Brugia malayi Pre-SET motif family protein 0.0252 0.2894 0.7983
Schistosoma mansoni hypothetical protein 0.004 0.0298 0.0289
Schistosoma mansoni zinc finger protein 0.0043 0.034 0.0331
Entamoeba histolytica hypothetical protein 0.004 0.0298 0.9716
Echinococcus multilocularis thyroid hormone receptor alpha 0.0291 0.3365 0.3365
Schistosoma mansoni lamin 0.003 0.018 0.0171
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0058 0.0058
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.0058 0.004
Loa Loa (eye worm) RNA binding protein 0.0069 0.065 0.1791
Trichomonas vaginalis mercuric reductase, putative 0.0076 0.0739 0.2033
Giardia lamblia PHD finger protein 15 0.0029 0.0168 0.1621
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.001 0.0022
Trichomonas vaginalis chromobox protein, putative 0.007 0.0664 0.1826
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0555 0.6598 1
Onchocerca volvulus 0.0032 0.0208 0.0489
Onchocerca volvulus 0.002 0.0058 0.003
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.002 0.0058 0.0152
Echinococcus multilocularis chromobox protein 1 0.007 0.0664 0.0664
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0058 0.0152
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0168 0.0493
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0048 0.0048
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.065 0.1791
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0092 0.0934 0.2574
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0289 0.0792
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2313 0.638
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.098 0.098
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0076 0.0739 0.2832
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0162 0.1524
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0416 0.0407
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0048 0.0125
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0053
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.002 0.0058 0.004
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0708 0.0708
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0076 0.0739 0.1042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0198
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0548 0.1508
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.585 0.585
Brugia malayi Thioredoxin reductase 0.0219 0.2488 0.6863
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0487 0.0487
Schistosoma mansoni bromodomain containing protein 0.0135 0.1465 0.1457
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0555 0.6598 1
Entamoeba histolytica thioredoxin reductase, putative 0.002 0.0058 0.0378
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3624 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0708 0.9545
Leishmania major hypothetical protein, conserved 0.002 0.0058 0.004
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0499 0.5917 0.8958
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0058 0.0155
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0128 0.1373 0.1373
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0708 0.2705
Brugia malayi Heterochromatin protein 1 0.007 0.0664 0.1828
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2448 0.6752
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.002 0.0058 0.004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0236 0.0646
Schistosoma mansoni hypothetical protein 0.0108 0.1136 0.1127
Echinococcus granulosus sulfide:quinone oxidoreductase 0.002 0.0058 0.0058
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0076 0.0739 0.2832
Entamoeba histolytica disulphide oxidoreductase, putative 0.002 0.0058 0.0378
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0739 0.2832
Trichomonas vaginalis glutathione reductase, putative 0.0076 0.0739 0.2033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0262 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.015 0.0406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Toxoplasma gondii NADPH-glutathione reductase 0.0076 0.0739 0.2832
Schistosoma mansoni hypothetical protein 0.005 0.0424 0.0415
Echinococcus multilocularis smad 0.0016 0.001 0.001
Schistosoma mansoni jumonji domain containing protein 0.0076 0.074 0.0731
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0049 0.0416 0.0416
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0024 0.0024
Brugia malayi Bromodomain containing protein 0.0034 0.0229 0.0628
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0198
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.052 0.1933
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0251 0.0241
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0058 0.0155
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0424 0.1167
Onchocerca volvulus 0.0029 0.0162 0.0347
Mycobacterium tuberculosis Probable reductase 0.0499 0.5917 0.8958
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0048 0.0125
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0208 0.0208
Brugia malayi Bromodomain containing protein 0.016 0.1767 0.4874
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0048 0.0128
Schistosoma mansoni intermediate filament proteins 0.003 0.018 0.0171
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.1749 0.4822
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0162 0.0442
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0208 0.0569
Brugia malayi Cathepsin L-like precursor 0.0019 0.0048 0.0128
Plasmodium falciparum glutathione reductase 0.0076 0.0739 0.2832
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3624 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0487 0.0487
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0162 0.0442
Brugia malayi Cathepsin L-like precursor 0.0019 0.0048 0.0128
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0326 0.0849
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0162 0.0465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0208 0.0569
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0024 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0047 0.0123
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.002 0.0058 0.0378
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.0442
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0048 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0208 0.0569
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0208 0.0569
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3624 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.098 0.098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0208 0.0569
Schistosoma mansoni hypothetical protein 0.0196 0.2204 0.2197
Loa Loa (eye worm) hypothetical protein 0.003 0.0173 0.0474
Trypanosoma brucei trypanothione reductase 0.0219 0.2488 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.005 0.004
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0058 0.004
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0076 0.0739 0.2832
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0424 0.0424
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0021 0.0053
Brugia malayi PHD-finger family protein 0.0029 0.0168 0.046
Echinococcus multilocularis cysteine protease 0.0019 0.0048 0.0048
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0048 0.0048
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0208 0.0569
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.0123 0.0335
Loa Loa (eye worm) hypothetical protein 0.0029 0.0168 0.046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0208 0.0198
Brugia malayi MH2 domain containing protein 0.0238 0.2718 0.7497
Loa Loa (eye worm) hypothetical protein 0.0032 0.0208 0.0569
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0208 0.0208
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0058 0.0152
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0739 0.2832
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Schistosoma mansoni lamin 0.003 0.018 0.0171
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0208 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0208 0.0569
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0058 0.0152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0059 0.0002
Loa Loa (eye worm) Smad1 0.0016 0.001 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0069 0.065 0.0641
Echinococcus multilocularis thioredoxin glutathione reductase 0.0221 0.2515 0.2515
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0021 0.0053
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0343 0.0942
Schistosoma mansoni glutamate synthase 0.002 0.0058 0.0048
Echinococcus multilocularis lamin dm0 0.003 0.018 0.018
Toxoplasma gondii NAC domain-containing protein 0.004 0.0305 0.1054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0048 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2313 0.638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0048 0.0125
Echinococcus granulosus GPCR family 2 0.005 0.0424 0.0424
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0058 0.0378
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0712 0.2723
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0076 0.0739 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0487 0.0478
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.002 0.0058 0.0058
Schistosoma mansoni zinc finger protein 0.0032 0.0206 0.0196
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0208 0.0569
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0076 0.0739 0.2803
Loa Loa (eye worm) hypothetical protein 0.0158 0.1749 0.4822
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.002 0.0058 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0208 0.0208
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0058 0.0152
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0162 0.1524
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0053
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0076 0.0739 0.2832
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.002 0.0058 0.0058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.1749 0.4822
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.001 0.001
Schistosoma mansoni transcription factor btf3 0.004 0.0305 0.0296
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0708 0.9545
Trypanosoma cruzi trypanothione reductase, putative 0.0219 0.2488 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0128
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.0442
Trichomonas vaginalis chromobox protein, putative 0.007 0.0664 0.1826
Echinococcus granulosus dnaJ subfamily B 0.0494 0.585 0.585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0712 0.2694
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0058 0.004
Schistosoma mansoni hypothetical protein 0.005 0.0424 0.0415
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0499 0.5917 0.8958
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.3624 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0048 0.0125
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0073 0.0225
Loa Loa (eye worm) hypothetical protein 0.0032 0.0208 0.0569
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0048 0.0128
Brugia malayi nuclear hormone receptor 0.0032 0.0208 0.0569
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0048 0.0125
Echinococcus granulosus transcription factor btf3 0.004 0.0305 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0298 0.0298
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0208 0.0208
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0208 0.0198
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0298 0.0298
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0076 0.0739 0.2803
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0168 0.0159
Loa Loa (eye worm) hypothetical protein 0.0032 0.0208 0.0569
Echinococcus granulosus cpg binding protein 0.0041 0.0309 0.0309
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.0058 0.004
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0076 0.0739 0.2036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0208 0.0569
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0162 0.0159
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.002 0.0058 0.004
Echinococcus multilocularis transcription factor btf3 0.004 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0198
Echinococcus multilocularis musashi 0.003 0.018 0.018
Leishmania major cathepsin L-like protease 0.0074 0.0712 0.2723
Brugia malayi beta-NAC-like protein 0.004 0.0305 0.0839
Plasmodium falciparum glutathione reductase 0.0219 0.2488 1
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.2718 0.7497
Entamoeba histolytica hypothetical protein 0.004 0.0298 0.9716
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0058 0.004
Echinococcus granulosus intermediate filament protein 0.003 0.018 0.018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0072 0.0692 0.2639
Schistosoma mansoni chromobox protein 0.007 0.0664 0.0655
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.0058 0.004
Loa Loa (eye worm) programmed cell death 8 0.002 0.0058 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0069 0.065 0.0641
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.0058 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0712 0.2694
Echinococcus multilocularis cysteine protease 0.0019 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0258 0.2969 0.2963
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0168 0.0493
Leishmania major trypanothione reductase 0.0219 0.2488 1
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.002 0.0058 0.004
Onchocerca volvulus 0.0035 0.0236 0.0574
Echinococcus granulosus Smad4 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.018 0.0493
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0048 0.0048
Mycobacterium tuberculosis Probable oxidoreductase 0.0555 0.6598 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0024 0.0024
Echinococcus multilocularis glutamate synthase 0.002 0.0058 0.0058
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0162 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2313 0.638
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0499 0.5917 0.8958
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0305 0.1054
Leishmania major NADH dehydrogenase, putative 0.002 0.0058 0.004
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0032 0.0208 0.0569
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0053
Loa Loa (eye worm) thioredoxin reductase 0.0219 0.2488 0.6863
Echinococcus granulosus cathepsin l1 0.0019 0.0048 0.0048
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0208 0.0208
Echinococcus granulosus chromobox protein 1 0.007 0.0664 0.0664
Echinococcus granulosus glutamate synthase 0.002 0.0058 0.0058
Brugia malayi Cathepsin L-like precursor 0.0019 0.0048 0.0128
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0208 0.0569
Brugia malayi chromobox protein homolog 3 0.0039 0.0289 0.0794
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0664 0.1828
Loa Loa (eye worm) hypothetical protein 0.0029 0.0162 0.0442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.0058 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0047 0.0123
Schistosoma mansoni cpg binding protein 0.0041 0.0309 0.03
Onchocerca volvulus 0.003 0.018 0.0404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0712 0.2694
Brugia malayi MH1 domain containing protein 0.0016 0.001 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0009 0.0021
Brugia malayi TAR-binding protein 0.0069 0.065 0.1791
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0208 0.0208
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.002 0.0058 0.0058
Leishmania major hypothetical protein, conserved 0.002 0.0058 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2313 0.638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0058 0.0152
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0168 0.046
Brugia malayi Cathepsin L-like precursor 0.0019 0.0048 0.0128
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0058 0.0152
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.3624 1
Loa Loa (eye worm) intermediate filament protein 0.003 0.018 0.0493
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0305 0.0836
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3624 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0712 0.2694
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.002 0.0058 0.0058
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0737 0.0737
Schistosoma mansoni disulfide oxidoreductase 0.002 0.0058 0.0048
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0058 0.0152
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0424 0.0424
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0251 0.0251
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0712 0.2723
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0047 0.0123
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.002 0.0058 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0487 0.0478
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3624 1
Brugia malayi CHD4 protein 0.0017 0.0024 0.0063
Mycobacterium ulcerans hypothetical protein 0.0029 0.0162 0.1524
Leishmania major hypothetical protein, conserved 0.002 0.0058 0.004
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0168 0.0493
Toxoplasma gondii selenide, water dikinase 0.002 0.0058 0.004
Brugia malayi Cathepsin L-like precursor 0.0019 0.0048 0.0128
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0058 0.0058
Echinococcus granulosus geminin 0.0196 0.2204 0.2204
Trypanosoma cruzi ISWI complex protein 0.0032 0.0206 0.0646
Brugia malayi hypothetical protein 0.004 0.0298 0.0818
Schistosoma mansoni sulfide quinone reductase 0.002 0.0058 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0208 0.0569
Echinococcus granulosus chromobox protein 1 0.007 0.0664 0.0664
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.002 0.0058 0.0378
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0058 0.004
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0208 0.0198
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.002 0.0058 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0069 0.065 0.0641
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0155
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.002 0.0058 0.004
Schistosoma mansoni hypothetical protein 0.002 0.0058 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0712 0.2694
Loa Loa (eye worm) hypothetical protein 0.0031 0.0186 0.051
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.065 0.1791
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.1749 0.4822
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0067 0.0634 0.2403
Echinococcus multilocularis tar DNA binding protein 0.0069 0.065 0.065
Echinococcus multilocularis chromobox protein 1 0.007 0.0664 0.0664
Plasmodium vivax SET domain protein, putative 0.0037 0.0262 0.0875
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0047 0.0123
Treponema pallidum NADH oxidase 0.0076 0.0739 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0727 0.0718
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3318 0.9154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0208 0.0569
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0208 0.0208
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0308 0.0308
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0739 0.2832
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0076 0.0739 0.2832
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.2894 0.7983
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.2718 0.7497
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0208 0.0208
Brugia malayi Pre-SET motif family protein 0.0037 0.0262 0.0718
Brugia malayi jmjC domain containing protein 0.0096 0.098 0.27
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0208 0.0198
Entamoeba histolytica hypothetical protein 0.004 0.0298 0.9716
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0073 0.0701 0.0701
Brugia malayi steroid hormone receptor 0.0032 0.0208 0.0569
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0076 0.0739 0.2832
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0737 0.0737
Brugia malayi CXXC zinc finger family protein 0.0035 0.0236 0.0646
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0073 0.0225
Echinococcus multilocularis Smad4 0.0016 0.001 0.001
Schistosoma mansoni glutamate synthase 0.002 0.0058 0.0048
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0162 0.4415
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0208 0.0208
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0208 0.0569
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0021 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0487 0.134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0712 0.2694
Echinococcus granulosus zinc finger protein 0.0043 0.034 0.034
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0168 0.0168
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0162 0.1524
Echinococcus multilocularis zinc finger protein 0.0043 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0053
Echinococcus granulosus smad 0.0016 0.001 0.001
Onchocerca volvulus 0.0287 0.3318 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0487 0.0487
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.002 0.0058 0.0378
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.002 0.0058 0.0152
Brugia malayi Cathepsin L-like precursor 0.0019 0.0048 0.0128
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0162 0.1524
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2313 0.638
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0162 0.1524
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.015 0.0406
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0305 0.1054
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0024 0.0063
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0208 0.0198
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.018 0.0493
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0076 0.0739 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0208 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0712 0.2694
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0162 0.0465
Schistosoma mansoni tar DNA-binding protein 0.0069 0.065 0.0641
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0208 0.0569
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0712 0.2694
Leishmania major hypothetical protein, conserved 0.0032 0.0206 0.0646
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0073 0.0701 0.0692
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0708 0.2705
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0499 0.5917 0.8958
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0048 0.0125
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0208 0.0208
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0076 0.0739 0.2832
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0058 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0208 0.0569
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0058 0.004
Loa Loa (eye worm) bromodomain containing protein 0.0037 0.0266 0.0732
Loa Loa (eye worm) ICD-1 protein 0.004 0.0305 0.0839
Plasmodium falciparum thioredoxin reductase 0.0219 0.2488 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0208 0.0569
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0219 0.2488 0.3716
Schistosoma mansoni hypothetical protein 0.0043 0.0343 0.0334
Loa Loa (eye worm) hypothetical protein 0.0108 0.1136 0.3131
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0076 0.0739 0.2832
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0326 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0305 0.0836
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0208 0.0569
Echinococcus granulosus thioredoxin glutathione reductase 0.0221 0.2515 0.2515
Plasmodium falciparum ferrodoxin reductase-like protein 0.002 0.0058 0.004
Schistosoma mansoni hypothetical protein 0.0032 0.0206 0.0196
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0021 0.0011
Plasmodium falciparum thioredoxin reductase 0.0076 0.0739 0.2832
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0048 0.0038
Echinococcus multilocularis peregrin 0.0034 0.0229 0.0229
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0009 0.0021
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.002 0.0058 0.0058
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.002 0.0058 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0712 0.2694
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0162 0.0159
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0499 0.5917 0.8958
Brugia malayi nuclear receptor NHR-88 0.0032 0.0208 0.0569
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0305 0.1019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0289 0.0794
Loa Loa (eye worm) hypothetical protein 0.0073 0.0701 0.193
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0424 0.0424
Echinococcus granulosus lamin dm0 0.003 0.018 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0208 0.0569
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0058 0.0378
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3624 1
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0317 0.0317
Schistosoma mansoni cpg binding protein 0.0041 0.0309 0.03
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0208 0.0208
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.002 0.0058 0.004
Leishmania major cathepsin L-like protease 0.0074 0.0712 0.2723
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0424 0.0424
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Brugia malayi RNA binding protein 0.0069 0.065 0.1791
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0162 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2313 0.638
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0401 0.0392
Loa Loa (eye worm) ctsf protein 0.0019 0.0048 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0208 0.0569
Trichomonas vaginalis apoptosis inducing factor, putative 0.002 0.0058 0.0152
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0076 0.0739 0.0739
Brugia malayi jmjC domain containing protein 0.0041 0.0317 0.087
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0021 0.0053
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0326 0.0892
Toxoplasma gondii thioredoxin reductase 0.0219 0.2488 1
Trypanosoma cruzi trypanothione reductase, putative 0.0076 0.0739 0.2832
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0162 0.0465
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0048 0.0048
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0289 0.0738
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0021 0.0021
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0708 0.0699
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0208 0.0489
Brugia malayi hypothetical protein 0.0017 0.0021 0.0053
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0021 0.0021
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.001 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0712 0.2723
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0073 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0712 0.2694
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.018 0.0493
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0308 0.0308
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0208 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0048 0.0125
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0208 0.0489
Brugia malayi ecdysteroid receptor 0.0032 0.0208 0.0569
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0208 0.0198
Echinococcus granulosus peregrin 0.0034 0.0229 0.0229
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0317 0.087
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0076 0.0739 1
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0208 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2313 0.638
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0208 0.0198
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0048 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0262 0.0252
Brugia malayi MH1 domain containing protein 0.0016 0.001 0.0022
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0047 0.0123
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0251 0.0241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0048 0.0125
Loa Loa (eye worm) cysteine protease 0.0019 0.0048 0.0128
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.2313 0.6927
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0305 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0076 0.0739 0.2832
Brugia malayi nuclear receptor RXR 0.0017 0.0021 0.0053
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0058 0.0152
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.002 0.0058 0.0155
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0487 0.0487
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.001 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0708 0.9545
Loa Loa (eye worm) glutathione reductase 0.0219 0.2488 0.6863
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0555 0.6598 1
Schistosoma mansoni hypothetical protein 0.005 0.0424 0.0415
Echinococcus granulosus lamin 0.003 0.018 0.018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0048 0.0125
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0208 0.0198
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0056 0.0493 0.1356
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0056 0.0493 0.1356
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0258 0.2969 0.2969
Brugia malayi MH2 domain containing protein 0.0016 0.001 0.0022
Schistosoma mansoni coup transcription factor 0.0032 0.0208 0.0198
Entamoeba histolytica hypothetical protein 0.004 0.0305 1
Plasmodium vivax ferrodoxin reductase, putative 0.002 0.0058 0.004
Schistosoma mansoni chromobox protein 0.007 0.0664 0.0655
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0073 0.0701 0.0692
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2448 0.6752
Loa Loa (eye worm) hypothetical protein 0.005 0.0424 0.1167
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0048 0.0048
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0047 0.0123
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0208 0.0569
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0198
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0487 0.134
Schistosoma mansoni thyroid hormone receptor 0.0291 0.3365 0.3359
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0048 0.0125
Trypanosoma cruzi ISWI complex protein 0.0032 0.0206 0.0646
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0076 0.0739 0.073

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.092 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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