Detailed information for compound 1201763

Basic information

Technical information
  • TDR Targets ID: 1201763
  • Name: N-[2-(cyclopentylamino)-2-oxo-1-pyridin-4-yle thyl]-N-(thiophen-2-ylmethyl)thiadiazole-4-ca rboxamide
  • MW: 427.543 | Formula: C20H21N5O2S2
  • H donors: 1 H acceptors: 5 LogP: 2.68 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(N(C(=O)c1csnn1)Cc1cccs1)c1ccncc1)NC1CCCC1
  • InChi: 1S/C20H21N5O2S2/c26-19(22-15-4-1-2-5-15)18(14-7-9-21-10-8-14)25(12-16-6-3-11-28-16)20(27)17-13-29-24-23-17/h3,6-11,13,15,18H,1-2,4-5,12H2,(H,22,26)
  • InChiKey: DRGFPVYMKROMPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(cyclopentylamino)-2-oxo-1-(4-pyridyl)ethyl]-N-(2-thienylmethyl)thiadiazole-4-carboxamide
  • N-[2-(cyclopentylamino)-2-oxo-1-(4-pyridyl)ethyl]-N-(2-thienylmethyl)-4-thiadiazolecarboxamide
  • N-[2-(cyclopentylamino)-2-keto-1-(4-pyridyl)ethyl]-N-(2-thienylmethyl)thiadiazole-4-carboxamide
  • N-[2-(cyclopentylamino)-2-oxo-1-pyridin-4-yl-ethyl]-N-(thiophen-2-ylmethyl)-1,2,3-thiadiazole-4-carboxamide
  • MLS000074074
  • [1,2,3]Thiadiazole-4-carboxylic acid (cyclopentylcarbamoyl-pyridin-4-yl-methyl)-thiophen-2-ylmethyl-amide
  • BAS 06291940
  • TimTec1_007166
  • SMR000013683

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0005 0.0014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0169 0.0536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.0759 0.0754
Schistosoma mansoni hypothetical protein 0.0036 0.007 0.0065
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0094 0.0859 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0176 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0268 0.0849
Mycobacterium ulcerans beta-lactamase 0.0081 0.0681 0.3191
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0237 0.1234
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0081 0.0681 0.0862
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0081 0.0681 0.2379
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0104 0.0998 0.5402
Loa Loa (eye worm) hypothetical protein 0.006 0.0397 0.1446
Schistosoma mansoni methyl-cpg binding protein mbd 0.0054 0.0308 0.0303
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.007 0.0065
Echinococcus granulosus chromobox protein 1 0.0079 0.0648 0.0644
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.0681 0.792
Echinococcus multilocularis zinc finger protein 0.0065 0.0463 0.0459
Loa Loa (eye worm) inositol-1 0.0045 0.0182 0.0654
Brugia malayi Latrophilin receptor protein 2 0.0036 0.007 0.023
Onchocerca volvulus Huntingtin homolog 0.0148 0.1592 0.4976
Loa Loa (eye worm) RNA binding protein 0.007 0.0524 0.1914
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0075 0.0597 0.6934
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.007 0.0241
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0322 0.141
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0113 0.0109
Mycobacterium tuberculosis Probable esterase LipL 0.0081 0.0681 0.0862
Loa Loa (eye worm) hypothetical protein 0.0148 0.1592 0.5849
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0054 0.0308 0.0303
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0681 0.3813
Schistosoma mansoni methyl-cpg binding protein mbd 0.0054 0.0308 0.0303
Brugia malayi Bromodomain containing protein 0.0124 0.1269 0.4445
Mycobacterium ulcerans lipase LipD 0.0081 0.0681 0.3191
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0015 0.0035
Entamoeba histolytica hypothetical protein 0.004 0.0113 0.0323
Echinococcus multilocularis chromobox protein 1 0.0079 0.0648 0.0644
Onchocerca volvulus 0.0114 0.1126 0.3476
Onchocerca volvulus 0.006 0.0397 0.113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.0759 0.0754
Trypanosoma cruzi ISWI complex protein 0.0048 0.0232 0.2662
Echinococcus granulosus zinc finger protein 0.0065 0.0463 0.0459
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0159 0.1746 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0268 0.0849
Loa Loa (eye worm) beta-lactamase 0.0081 0.0681 0.2494
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.053 0.168
Echinococcus granulosus tar DNA binding protein 0.007 0.0524 0.052
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0159 0.1746 1
Schistosoma mansoni zinc finger protein 0.0048 0.0232 0.0228
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0182 0.0914
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0182 0.0577
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0574 0.2504
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0182 0.1214
Echinococcus granulosus peptidase Clp S14 family 0.0104 0.0998 0.0994
Echinococcus granulosus chromobox protein 1 0.0079 0.0648 0.0644
Mycobacterium tuberculosis Conserved protein 0.0081 0.0681 0.0862
Loa Loa (eye worm) intermediate filament protein 0.006 0.0397 0.1446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0596 0.189
Schistosoma mansoni hypothetical protein 0.0065 0.0462 0.0457
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1585 0.1582
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2257 0.2254
Onchocerca volvulus 0.0262 0.3152 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.1884 0.188
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0397 0.1446
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0113 0.0109
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0113 0.112 0.1116
Loa Loa (eye worm) hypothetical protein 0.0081 0.0681 0.2494
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0094 0.0859 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0237 0.1234
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0169 0.0536
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0075 0.0597 0.6934
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1585 0.1582
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0169 0.0536
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0574 0.0697
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0192 0.219 0.2186
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0169 0.0536
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0045 0.0181 0.207
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0182 0.2076
Loa Loa (eye worm) hypothetical protein 0.0138 0.1456 0.5349
Schistosoma mansoni bromodomain containing protein 0.0203 0.2344 0.2341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0342 0.1083
Loa Loa (eye worm) acetyltransferase 0.0147 0.1585 0.5826
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0943 0.0939
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0094 0.0859 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0081 0.0681 0.3191
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0322 0.1728
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0237 0.0233
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0169 0.0839
Entamoeba histolytica hypothetical protein 0.004 0.0113 0.0323
Brugia malayi TAR-binding protein 0.007 0.0524 0.1826
Schistosoma mansoni tar DNA-binding protein 0.007 0.0524 0.052
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0169 0.0536
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0648 0.2056
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0015 0.0037
Loa Loa (eye worm) hypothetical protein 0.0079 0.0646 0.2365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0596 0.189
Brugia malayi Pre-SET motif family protein 0.0231 0.2718 0.9542
Echinococcus multilocularis beta LACTamase domain containing family member 0.0081 0.0681 0.0677
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.007 0.023
Brugia malayi intermediate filament protein 0.006 0.0397 0.138
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0222 0.0703
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0681 0.0677
Echinococcus granulosus histone lysine methyltransferase setb 0.0087 0.0759 0.0754
Schistosoma mansoni alpha glucosidase 0.0044 0.0169 0.0165
Mycobacterium ulcerans esterase/lipase LipP 0.0081 0.0681 0.3191
Echinococcus multilocularis musashi 0.006 0.0397 0.0393
Leishmania major hypothetical protein, conserved 0.0081 0.0681 0.792
Loa Loa (eye worm) hypothetical protein 0.0081 0.0681 0.2494
Loa Loa (eye worm) bromodomain containing protein 0.0059 0.0381 0.1386
Echinococcus granulosus GPCR family 2 0.0036 0.007 0.0065
Mycobacterium tuberculosis Conserved protein 0.0081 0.0681 0.0862
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0071 0.0544 0.0539
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0104 0.0998 0.1347
Loa Loa (eye worm) hypothetical protein 0.0115 0.1143 0.4194
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0094 0.0859 0.0855
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0169 0.0165
Onchocerca volvulus 0.0081 0.0681 0.2045
Echinococcus multilocularis microtubule associated protein 2 0.0764 1 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0104 0.0998 0.0994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0334 0.1059
Echinococcus granulosus lamin dm0 0.006 0.0397 0.0393
Brugia malayi PHD-finger family protein 0.0082 0.0693 0.2419
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0192 0.219 0.2186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0267 0.0845
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0094 0.0859 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0113 0.0109
Onchocerca volvulus 0.006 0.0397 0.113
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0648 0.2056
Schistosoma mansoni tar DNA-binding protein 0.007 0.0524 0.052
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0943 0.0939
Loa Loa (eye worm) hypothetical protein 0.0132 0.1374 0.5046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0005 0.0014
Toxoplasma gondii hypothetical protein 0.0055 0.0322 0.1728
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0182 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0596 0.189
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.02 0.0196
Entamoeba histolytica hypothetical protein 0.004 0.0113 0.0323
Echinococcus multilocularis lamin 0.006 0.0397 0.0393
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0159 0.1746 0.5
Echinococcus granulosus methyl CpG binding domain protein 2 0.0054 0.0308 0.0303
Schistosoma mansoni hypothetical protein 0.0036 0.007 0.0065
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0094 0.0859 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.1592 0.4976
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0169 0.0536
Brugia malayi chromobox protein homolog 3 0.0044 0.0176 0.0602
Mycobacterium ulcerans hypothetical protein 0.0081 0.0681 0.3191
Mycobacterium leprae Probable lipase LipE 0.0081 0.0681 0.3458
Loa Loa (eye worm) hypothetical protein 0.0044 0.0176 0.0631
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0159 0.1746 0.5
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0081 0.0681 0.0862
Loa Loa (eye worm) PHD-finger family protein 0.0065 0.0462 0.1684
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2257 0.2254
Mycobacterium tuberculosis Probable hydrolase 0.0081 0.0681 0.0862
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.053 0.168
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0159 0.1746 1
Brugia malayi Inositol-1 0.0045 0.0182 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0342 0.1083
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0039 0.0107 0.1204
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0159 0.1746 0.1743
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0524 0.1826
Onchocerca volvulus 0.0046 0.02 0.0498
Loa Loa (eye worm) TAR-binding protein 0.007 0.0524 0.1914
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0081 0.0681 0.0862
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0094 0.0859 0.0855
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0943 0.33
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0169 0.1925
Schistosoma mansoni hypothetical protein 0.0048 0.0232 0.0228
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0681 0.2161
Schistosoma mansoni hypothetical protein 0.004 0.0113 0.0109
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0574 0.2504
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0397 0.138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0268 0.0849
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0169 0.0536
Brugia malayi beta-lactamase family protein 0.0081 0.0681 0.2379
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0159 0.1746 0.1743
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0681 0.2161
Brugia malayi beta-lactamase 0.0081 0.0681 0.2379
Schistosoma mansoni tar DNA-binding protein 0.007 0.0524 0.052
Schistosoma mansoni peptidase Clp (S14 family) 0.0159 0.1746 0.1743
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0169 0.1925
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0681 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0408 0.1294
Schistosoma mansoni microtubule-associated protein tau 0.0764 1 1
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0222 0.0703
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0237 0.1234
Brugia malayi Pre-SET motif family protein 0.0033 0.0025 0.007
Schistosoma mansoni hypothetical protein 0.0036 0.007 0.0065
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0237 0.0752
Schistosoma mansoni alpha-glucosidase 0.0169 0.1884 0.188
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0169 0.1047
Mycobacterium tuberculosis Probable lipase LipE 0.0081 0.0681 0.0862
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.053 0.168
Loa Loa (eye worm) hypothetical protein 0.0036 0.007 0.0241
Trichomonas vaginalis esterase, putative 0.0081 0.0681 0.2161
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0237 0.0752
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0169 0.1925
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0671 0.2128
Schistosoma mansoni hypothetical protein 0.0036 0.007 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.053 0.168
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.007 0.0065
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2257 0.7922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0436 0.1382
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.1143 0.4002
Schistosoma mansoni tar DNA-binding protein 0.007 0.0524 0.052
Brugia malayi Heterochromatin protein 1 0.0079 0.0648 0.2263
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0859 0.3148
Brugia malayi Bromodomain containing protein 0.024 0.2848 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0334 0.1059
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0159 0.1746 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0075 0.0597 0.6934
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.0322 0.1253
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2257 0.2254
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0159 0.1746 1
Echinococcus multilocularis tar DNA binding protein 0.007 0.0524 0.052
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0094 0.0859 0.0855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0596 0.189
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0182 0.2076
Schistosoma mansoni hypothetical protein 0.0079 0.0646 0.0642
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0574 0.2504
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.007 0.0065
Mycobacterium tuberculosis Probable lipase LipD 0.0081 0.0681 0.0862
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0681 0.2161
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0081 0.0681 0.2494
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0169 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0859 0.2724
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0182 0.2076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0859 0.2724
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0943 0.0939
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0169 0.0606
Mycobacterium tuberculosis Conserved protein 0.0081 0.0681 0.0862
Onchocerca volvulus 0.0081 0.0681 0.2045
Onchocerca volvulus 0.0081 0.0681 0.2045
Brugia malayi hypothetical protein 0.004 0.0113 0.0382
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0159 0.1746 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0267 0.0845
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0681 0.2161
Loa Loa (eye worm) hypothetical protein 0.0059 0.0382 0.139
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0681 0.792
Loa Loa (eye worm) hypothetical protein 0.0159 0.1746 0.6419
Loa Loa (eye worm) hypothetical protein 0.0148 0.1592 0.5849
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0176 0.0419
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0859 0.2724
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.0081 0.0681 0.2494
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0519 0.665 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0071 0.0544 0.0539
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0681 0.3458
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0025 0.002
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0574 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.053 0.168
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0094 0.0859 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0524 0.052
Toxoplasma gondii target of rapamycin (TOR), putative 0.007 0.053 0.2933
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0176 0.0558
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0574 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.053 0.168
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0087 0.0759 0.0754
Entamoeba histolytica hypothetical protein 0.004 0.0113 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0268 0.0849
Trichomonas vaginalis set domain proteins, putative 0.0262 0.3152 1
Schistosoma mansoni lamin 0.006 0.0397 0.0393
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0094 0.0859 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0182 0.0177
Loa Loa (eye worm) hypothetical protein 0.01 0.0943 0.3459
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1585 0.5559
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0182 0.0177
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0681 0.2161
Schistosoma mansoni inositol monophosphatase 0.0045 0.0182 0.0177
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0159 0.1746 1
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0681 0.792
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0025 0.002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.1143 0.4194
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.007 0.0065
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0169 0.0536
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0222 0.0566
Trypanosoma brucei glucosidase, putative 0.0044 0.0169 0.1925
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0574 0.319
Echinococcus granulosus fetal alzheimer antigen falz 0.0071 0.0544 0.0539
Onchocerca volvulus 0.01 0.0943 0.2888
Echinococcus multilocularis GPCR, family 2 0.0036 0.007 0.0065
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0524 0.1914
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0859 0.3004
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.0646 0.2256
Loa Loa (eye worm) hypothetical protein 0.0081 0.0681 0.2494
Loa Loa (eye worm) hypothetical protein 0.0087 0.0759 0.2779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0005 0.0014
Schistosoma mansoni chromobox protein 0.0079 0.0648 0.0644
Trypanosoma cruzi ISWI complex protein 0.0048 0.0232 0.2662
Schistosoma mansoni zinc finger protein 0.0065 0.0463 0.0459
Brugia malayi hypothetical protein 0.0148 0.1592 0.5581
Trypanosoma brucei ISWI complex protein 0.0048 0.0232 0.2662
Echinococcus multilocularis chromobox protein 1 0.0079 0.0648 0.0644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0342 0.1083
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0159 0.1746 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0681 0.2494
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0169 0.0578
Echinococcus granulosus intermediate filament protein 0.006 0.0397 0.0393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0005 0.0014
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0169 0.0536
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0574 0.0569
Schistosoma mansoni chromobox protein 0.0079 0.0648 0.0644
Loa Loa (eye worm) hypothetical protein 0.0121 0.1225 0.4498
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0113 0.112 0.1116
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0182 0.0177
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.2718 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0159 0.1746 1
Schistosoma mansoni lamin 0.006 0.0397 0.0393
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0574 0.0569
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0169 0.0165
Echinococcus granulosus beta LACTamase domain containing family member 0.0081 0.0681 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0267 0.0845
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0648 0.2372
Brugia malayi beta-lactamase family protein 0.0081 0.0681 0.2379
Brugia malayi RNA binding protein 0.007 0.0524 0.1826
Loa Loa (eye worm) hypothetical protein 0.0081 0.0681 0.2494
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2257 0.8302
Echinococcus multilocularis lamin dm0 0.006 0.0397 0.0393
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.1143 0.4002
Echinococcus granulosus lamin 0.006 0.0397 0.0393
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.143 0.1426
Toxoplasma gondii ABC1 family protein 0.0081 0.0681 0.3813
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0182 0.0577
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0574 0.6662
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0182 0.2076
Brugia malayi Probable ClpP-like protease 0.0159 0.1746 0.6125
Schistosoma mansoni intermediate filament proteins 0.006 0.0397 0.0393
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0104 0.0998 0.1347
Loa Loa (eye worm) hypothetical protein 0.0223 0.2617 0.9629
Giardia lamblia GTOR 0.0094 0.0859 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.053 0.168
Leishmania major hypothetical protein, conserved 0.0048 0.0232 0.2662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0005 0.0014
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0094 0.0859 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0596 0.189

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 19.8003 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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