Detailed information for compound 1202228

Basic information

Technical information
  • TDR Targets ID: 1202228
  • Name: 4-(methylsulfanylmethyl)-6-morpholin-4-yl-2-p henylpyrimidine
  • MW: 301.407 | Formula: C16H19N3OS
  • H donors: 0 H acceptors: 2 LogP: 2.43 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCc1cc(nc(n1)c1ccccc1)N1CCOCC1
  • InChi: 1S/C16H19N3OS/c1-21-12-14-11-15(19-7-9-20-10-8-19)18-16(17-14)13-5-3-2-4-6-13/h2-6,11H,7-10,12H2,1H3
  • InChiKey: MLNZIJKKSLNUDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(methylsulfanylmethyl)-6-morpholino-2-phenyl-pyrimidine
  • 4-[(methylthio)methyl]-6-morpholino-2-phenylpyrimidine
  • 4-[(methylthio)methyl]-6-morpholino-2-phenyl-pyrimidine
  • 4-(methylsulfanylmethyl)-6-morpholin-4-yl-2-phenyl-pyrimidine
  • Oprea1_574812
  • MLS000707143
  • SMR000334520
  • methyl (6-morpholino-2-phenyl-4-pyrimidinyl)methyl sulfide
  • 2L-575S
  • ZINC01382558

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0083 0.009
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.011 0.0681
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0042 0.0045
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0048 0.0158
Schistosoma mansoni hypothetical protein 0.0033 0.0157 0.0169
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0071 0.0077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0069 0.0454
Onchocerca volvulus 0.0033 0.0154 0.0877
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0024 0.0158
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0345 0.2303
Brugia malayi nuclear receptor NHR-88 0.0021 0.0071 0.0217
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0052 0.0342
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0026 0.0113
Echinococcus granulosus tar DNA binding protein 0.0469 0.3279 0.3545
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.022 0.1498 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0024 0.0102
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0024 0.0074
Brugia malayi Importin beta-1 subunit 0.0059 0.0345 0.1053
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0242 0.1651 0.3702
Schistosoma mansoni ferritin 0.0018 0.0048 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0275 0.17
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.016
Onchocerca volvulus 0.022 0.1498 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0069 0.0454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0071 0.016
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0024 0.0158
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0071 0.0077
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0233 0.0523
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0275 0.17
Brugia malayi MH1 domain containing protein 0.0017 0.0042 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0242 0.1651 0.1785
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0054 0.0058
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0026 0.0252
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0048 0.0158
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0345 0.2303
Brugia malayi MH2 domain containing protein 0.0249 0.1706 0.5204
Mycobacterium tuberculosis Conserved protein 0.022 0.1498 0.149
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0375 0.0406
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0024 0.0687
Schistosoma mansoni intermediate filament proteins 0.0033 0.0154 0.0166
Echinococcus granulosus lamin dm0 0.0033 0.0154 0.0166
Entamoeba histolytica hypothetical protein 0.0152 0.1008 1
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0001 0.0001
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0026 0.0113
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0211 0.1404
Echinococcus granulosus importin 5 0.0011 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0275 0.0838
Schistosoma mansoni smad1 5 8 and 0.0017 0.0042 0.0045
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0059 0.0345 0.0774
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0071 0.0077
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0052 0.0342
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0233 0.1553
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0024 0.0074
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0266 0.0811
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0024 0.0158
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0071 0.0077
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0204 0.0221
Loa Loa (eye worm) hypothetical protein 0.0019 0.0054 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0204 0.1311
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0014
Echinococcus multilocularis GPCR, family 2 0.0015 0.003 0.0032
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.1201 0.1298
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0071 0.0217
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0134 0.0407
Trichomonas vaginalis ran, putative 0.0044 0.0233 0.1553
Echinococcus multilocularis expressed protein 0.0018 0.0048 0.0051
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0071 0.0077
Schistosoma mansoni ferritin 0.0018 0.0048 0.0051
Loa Loa (eye worm) hypothetical protein 0.0049 0.0275 0.0616
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.003 0.0032
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0071 0.0319
Loa Loa (eye worm) RecQ helicase 0.0023 0.0087 0.0194
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0154 0.0344
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0024 0.0102
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0024 0.0158
Onchocerca volvulus 0.0091 0.0575 0.3738
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0185 0.0415
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0071 0.016
Brugia malayi MH2 domain containing protein 0.0017 0.0042 0.0128
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.011 0.3187
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0033 0.0035
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0024 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0266 0.0596
Schistosoma mansoni importin beta-1 0.0059 0.0345 0.0373
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0211 0.0228
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0071 0.0077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0069 0.0454
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0052 0.1486
Trichomonas vaginalis ferritin, putative 0.0018 0.0048 0.0314
Echinococcus granulosus intermediate filament protein 0.0033 0.0154 0.0166
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0211 0.0643
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0204 0.136
Mycobacterium tuberculosis Probable esterase LipL 0.022 0.1498 0.149
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0071 0.0217
Loa Loa (eye worm) hypothetical protein 0.0048 0.0266 0.0596
Loa Loa (eye worm) hypothetical protein 0.022 0.1498 0.3358
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0115 0.0125
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0071 0.0077
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0275 0.1831
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0071 0.0217
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0054 0.0058
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0024 0.0074
Loa Loa (eye worm) hypothetical protein 0.0037 0.0185 0.0415
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0052 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.003 0.0032
Onchocerca volvulus 0.0103 0.0661 0.4319
Toxoplasma gondii exonuclease III APE 0.0018 0.0052 0.0342
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0071 0.0077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0071 0.0077
Leishmania major hypothetical protein, conserved 0.0015 0.0027 0.0178
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0031 0.0206
Schistosoma mansoni hypothetical protein 0.1302 0.9249 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.004 0.0043
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0233 0.1505
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0032
Echinococcus multilocularis tar DNA binding protein 0.0469 0.3279 0.3545
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0024 0.0102
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0204 0.0458
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0204 0.136
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0204 0.136
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0024 0.0158
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0054
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0024 0.0014
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0211 0.1404
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0204 0.136
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0024 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0469 0.3279 0.3545
Brugia malayi nuclear hormone receptor 0.0021 0.0071 0.0217
Echinococcus granulosus lamin 0.0033 0.0154 0.0166
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0052 0.0287
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.1201 0.2692
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.004 0.0043
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.016
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0048 0.0038
Entamoeba histolytica Ran family GTPase 0.0044 0.0233 0.2308
Schistosoma mansoni hypothetical protein 0.002 0.0065 0.007
Echinococcus granulosus importin subunit beta 1 0.0059 0.0345 0.0373
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0211 0.1354
Loa Loa (eye worm) hypothetical protein 0.0069 0.0415 0.0931
Echinococcus multilocularis dnaJ subfamily B 0.1302 0.9249 1
Brugia malayi beta-lactamase 0.022 0.1498 0.4568
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.003 0.009
Schistosoma mansoni cpg binding protein 0.0098 0.0626 0.0677
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0071 0.016
Brugia malayi hypothetical protein 0.0017 0.0043 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0069 0.0454
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0123 0.0133
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0024 0.0158
Schistosoma mansoni tar DNA-binding protein 0.0469 0.3279 0.3545
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0071 0.0077
Brugia malayi MH1 domain containing protein 0.0017 0.0042 0.0128
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0009 0.0057
Loa Loa (eye worm) hypothetical protein 0.0049 0.0275 0.0616
Loa Loa (eye worm) Smad1 0.0017 0.0042 0.0094
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.003 0.0066
Loa Loa (eye worm) hypothetical protein 0.0049 0.0275 0.0616
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0052 0.0287
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.011 0.3187
Trypanosoma cruzi hypothetical protein, conserved 0.022 0.1498 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0052 0.0342
Entamoeba histolytica hypothetical protein 0.0152 0.1008 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.0042 0.0045
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0024 0.0158
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0071 0.0077
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0026 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0171 0.0161
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.022 0.1498 0.3358
Mycobacterium tuberculosis Probable hydrolase 0.022 0.1498 0.149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0071 0.0077
Echinococcus multilocularis snurportin 1 0.0634 0.446 0.4822
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0211 0.0228
Loa Loa (eye worm) hypothetical protein 0.0016 0.0033 0.0073
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0042 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0211 0.1404
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0071 0.0217
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0233 0.0711
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0052 0.0508
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0071 0.0217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0242 0.1651 0.1785
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0024 0.0054
Schistosoma mansoni ferritin light chain 0.0018 0.0048 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0024 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0171 0.0161
Onchocerca volvulus 0.0148 0.0978 0.6473
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.022 0.1498 0.149
Loa Loa (eye worm) hypothetical protein 0.0037 0.0185 0.0415
Trichomonas vaginalis helicase, putative 0.0021 0.0069 0.0454
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.016
Schistosoma mansoni lamin 0.0033 0.0154 0.0166
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0071 0.0217
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0233 0.1505
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.011 0.0734
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0026 0.017
Brugia malayi TAR-binding protein 0.0469 0.3279 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0242 0.1651 0.1785
Echinococcus multilocularis translational activator gcn1 0.0011 0.0001 0.0001
Onchocerca volvulus 0.022 0.1498 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0052 0.0056
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0375 0.0406
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0204 0.136
Schistosoma mansoni hypothetical protein 0.0634 0.446 0.4822
Trypanosoma brucei glucosidase, putative 0.004 0.0204 0.136
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0069 0.0454
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0275 0.17
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0024 0.0158
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0083 0.009
Echinococcus multilocularis lamin dm0 0.0033 0.0154 0.0166
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0052 0.0042
Onchocerca volvulus 0.0033 0.0154 0.0877
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0275 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0071 0.016
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0087 0.0575
Schistosoma mansoni ferritin 0.0018 0.0048 0.0051
Schistosoma mansoni ran 0.0044 0.0233 0.0252
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0185 0.0175
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0069 0.0454
Brugia malayi Smad1 0.0017 0.0042 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0026 0.017
Brugia malayi Bromodomain containing protein 0.0037 0.0188 0.0574
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0026 0.017
Brugia malayi RNA recognition motif domain containing protein 0.0469 0.3279 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0071 0.0077
Schistosoma mansoni bromodomain containing protein 0.0067 0.0401 0.0433
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0071 0.0077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0242 0.1651 0.1785
Schistosoma mansoni alpha-glucosidase 0.0154 0.1022 0.1105
Loa Loa (eye worm) oxidoreductase 0.0015 0.0024 0.0054
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.022 0.1498 0.4568
Echinococcus multilocularis beta LACTamase domain containing family member 0.022 0.1498 0.1619
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0009 0.0057
Schistosoma mansoni zinc finger protein 0.0015 0.0027 0.0029
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0123 0.0275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0071 0.016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0083 0.009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0064
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0233 1
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0275 0.0838
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0069 0.0454
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0071 0.0217
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0024 0.0014
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0087 0.0094
Schistosoma mansoni myst-related protein 0.0013 0.0011 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0123 0.0133
Echinococcus granulosus transportin 1 0.0011 0.0001 0.0001
Schistosoma mansoni Smad4 0.0017 0.0042 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.022 0.1498 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0211 0.1404
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0024 0.0074
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.011 0.0734
Leishmania major hypothetical protein, conserved 0.022 0.1498 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0275 0.1831
Schistosoma mansoni tar DNA-binding protein 0.0469 0.3279 0.3545
Leishmania major importin beta-1 subunit, putative 0.0048 0.0265 0.1766
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0024 0.0014
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0233 0.0252
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0204 0.136
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0071 0.0077
Loa Loa (eye worm) hypothetical protein 0.0148 0.0978 0.2193
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0211 0.0228
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0211 0.0228
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0275 0.17
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0087 0.0575
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.016
Schistosoma mansoni zinc finger protein 0.0024 0.0095 0.0102
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0026 0.017
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0024 0.0235
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0194 0.131 0.1416
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0265 0.1719
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0211 0.0228
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0024 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0071 0.0217
Echinococcus granulosus bloom syndrome protein 0.0023 0.0087 0.0094
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0275 0.272
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0069 0.0454
Plasmodium vivax importin-beta 2, putative 0.0059 0.0345 0.2303
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0211 0.1354
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0071 0.016
Loa Loa (eye worm) TAR-binding protein 0.0469 0.3279 0.7352
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0032
Schistosoma mansoni smad1 5 8 and 0.0017 0.0042 0.0045
Brugia malayi Bromodomain containing protein 0.0078 0.0483 0.1472
Echinococcus granulosus dnaJ subfamily B 0.1302 0.9249 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0071 0.0077
Brugia malayi MH2 domain containing protein 0.0017 0.0042 0.0128
Loa Loa (eye worm) hypothetical protein 0.0037 0.0185 0.0415
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0033 0.0215
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0052 0.0342
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0071 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0069 0.0454
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0275 0.17
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0211 0.0228
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0071 0.0077
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0048 0.0158
Schistosoma mansoni apoferritin-2 0.0018 0.0048 0.0051
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.011 0.0681
Trichomonas vaginalis penicillin-binding protein, putative 0.022 0.1498 1
Mycobacterium leprae conserved hypothetical protein 0.022 0.1498 1
Loa Loa (eye worm) hypothetical protein 0.022 0.1498 0.3358
Schistosoma mansoni myst-related protein 0.0013 0.0011 0.0012
Entamoeba histolytica hypothetical protein 0.0152 0.1008 1
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0345 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0071 0.0217
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0026 0.017
Schistosoma mansoni hypothetical protein 0.0523 0.3668 0.3965
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0211 0.0228
Mycobacterium ulcerans hypothetical protein 0.0049 0.0275 0.17
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.0064
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0071 0.0319
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0026 0.017
Mycobacterium ulcerans esterase/lipase LipP 0.022 0.1498 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.011 0.0734
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0266 0.0811
Trypanosoma brucei hypothetical protein, conserved 0.022 0.1498 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0211 0.1404
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0854 0.6043 0.6534
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0265 0.1766
Mycobacterium tuberculosis Conserved protein 0.022 0.1498 0.149
Loa Loa (eye worm) hypothetical protein 0.0037 0.0185 0.0415
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0211 0.8766
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0069 0.0454
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0045 0.0138
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0009 0.0057
Echinococcus granulosus Smad4 0.0017 0.0042 0.0045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0083 0.009
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0047 0.0256 0.0574
Trypanosoma cruzi ISWI complex protein 0.0015 0.0027 0.0122
Plasmodium falciparum importin beta, putative 0.0059 0.0345 1
Brugia malayi beta-lactamase family protein 0.022 0.1498 0.4568
Mycobacterium ulcerans hypothetical protein 0.022 0.1498 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.1706 0.3826
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0026 0.017
Loa Loa (eye worm) RNA binding protein 0.0469 0.3279 0.7352
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0275 0.272
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0026 0.017
Trichomonas vaginalis D-aminoacylase, putative 0.022 0.1498 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0052 0.0158
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0024 0.0158
Echinococcus multilocularis importin 5 0.0011 0.0001 0.0001
Schistosoma mansoni importin-beta 2 0.0011 0.0001 0.0001
Brugia malayi CXXC zinc finger family protein 0.0091 0.0575 0.1754
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.016
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0154 0.0468
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0265 0.1766
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0014
Echinococcus granulosus cpg binding protein 0.0098 0.0626 0.0677
Echinococcus multilocularis cpg binding protein 0.0098 0.0626 0.0677
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0071 0.016
Mycobacterium ulcerans beta-lactamase 0.022 0.1498 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0172 0.0186
Brugia malayi RNA, U transporter 1 0.0169 0.1129 0.3445
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0204 0.0221
Loa Loa (eye worm) hypothetical protein 0.004 0.0205 0.046
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0054
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.003 0.0032
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0026 0.017
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0275 0.0265
Echinococcus multilocularis transportin 1 0.0011 0.0001 0.0001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0071 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0171 0.0161
Plasmodium falciparum zinc finger protein, putative 0.0013 0.0011 0.0296
Schistosoma mansoni transcription factor LCR-F1 0.0152 0.1008 0.109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0242 0.1651 0.1785
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0211 0.0228
Entamoeba histolytica hypothetical protein 0.0013 0.0011 0.0101
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0052 0.0056
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0001 0.0001
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0233 0.0252
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0024 0.0014
Echinococcus granulosus snurportin 1 0.0634 0.446 0.4822
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0233 0.6744
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0204 0.1311
Trichomonas vaginalis penicillin-binding protein, putative 0.022 0.1498 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0185 0.1232
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0069 0.0454
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.022 0.1498 0.3358
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0045 0.0101
Schistosoma mansoni cpg binding protein 0.0098 0.0626 0.0677
Schistosoma mansoni hypothetical protein 0.0523 0.3668 0.3965
Schistosoma mansoni alpha glucosidase 0.004 0.0204 0.0221
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0204 0.136
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0054 0.0058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0469 0.3279 0.7352
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0065 0.0145
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0071 0.0077
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0024 0.0102
Schistosoma mansoni cpg binding protein 0.0091 0.0575 0.0622
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.004 0.0043
Brugia malayi hypothetical protein 0.0148 0.0978 0.2983
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.1201 0.1298
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0033 0.0035
Brugia malayi hypothetical protein 0.0027 0.011 0.0337
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0275 0.17
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0275 0.17
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0152 0.1008 0.109
Brugia malayi steroid hormone receptor 0.0021 0.0071 0.0217
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0275 0.1831
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0204 0.136
Echinococcus multilocularis geminin 0.0523 0.3668 0.3965
Schistosoma mansoni coup transcription factor 0.0021 0.0071 0.0077
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0052 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0211 0.0473
Schistosoma mansoni hypothetical protein 0.0012 0.0006 0.0006
Echinococcus granulosus geminin 0.0523 0.3668 0.3965
Brugia malayi RNA binding protein 0.0469 0.3279 1
Echinococcus granulosus expressed protein 0.0018 0.0048 0.0051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.022 0.1498 0.1619
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0071 0.0077
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0345 0.2303
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0058
Loa Loa (eye worm) beta-lactamase 0.022 0.1498 0.3358
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0071 0.0077
Loa Loa (eye worm) hypothetical protein 0.0117 0.0759 0.1701
Schistosoma mansoni hypothetical protein 0.0152 0.1008 0.109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0069 0.0454
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0042 0.0094
Echinococcus granulosus translational activator gcn1 0.0011 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0015 0.0027 0.0029
Schistosoma mansoni alpha-glucosidase 0.0154 0.1022 0.1105
Brugia malayi intermediate filament protein 0.0033 0.0154 0.0468
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0275 0.17
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0204 0.0623
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0024 0.0026
Onchocerca volvulus 0.0021 0.0071 0.0319
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0204 0.2021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0071 0.0217
Echinococcus multilocularis zinc finger protein 0.0024 0.0095 0.0102
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.1201 0.3661
Loa Loa (eye worm) hypothetical protein 0.0032 0.0149 0.0335
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.022 0.1498 0.1619
Echinococcus granulosus beta LACTamase domain containing family member 0.022 0.1498 0.1619
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.1706 0.3826
Loa Loa (eye worm) hypothetical protein 0.0033 0.0157 0.0351
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0152 0.1008 0.109
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0233 0.1553
Brugia malayi hypothetical protein 0.0152 0.1008 0.3075
Leishmania major GTP-binding protein, putative 0.0044 0.0233 0.1553
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0024 0.0026
Schistosoma mansoni ap endonuclease 0.0018 0.0052 0.0056
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0265 0.1766
Echinococcus granulosus zinc finger protein 0.0024 0.0095 0.0102
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0024 0.0026
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0026 0.0012
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0204 0.2021
Loa Loa (eye worm) hypothetical protein 0.022 0.1498 0.3358
Schistosoma mansoni ferritin light chain 0.0018 0.0048 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0071 0.0217
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0115 0.0125
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0052 0.0187
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0042 0.0045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.003 0.0032
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0024 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0071 0.0217
Onchocerca volvulus 0.0049 0.0275 0.17
Brugia malayi ecdysteroid receptor 0.0021 0.0071 0.0217
Mycobacterium tuberculosis Probable lipase LipE 0.022 0.1498 0.149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0242 0.1651 0.1785
Mycobacterium tuberculosis Probable conserved lipoprotein 0.022 0.1498 0.149
Schistosoma mansoni tar DNA-binding protein 0.0469 0.3279 0.3545
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0071 0.0217
Brugia malayi kap beta 3 protein 0.0011 0.0001 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0054 0.0058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0204 0.136
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.1201 0.1298
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0634 0.446 1
Schistosoma mansoni smad 0.0017 0.0042 0.0045
Schistosoma mansoni ran 0.0044 0.0233 0.0252
Trichomonas vaginalis D-aminoacylase, putative 0.022 0.1498 1
Leishmania major hypothetical protein, conserved 0.0027 0.011 0.0734
Loa Loa (eye worm) hypothetical protein 0.022 0.1498 0.3358
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0071 0.0077
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0042 0.0094
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0275 0.17
Toxoplasma gondii histone lysine methyltransferase SET1 0.0175 0.1178 0.7862
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0083 0.009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0014 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.022 0.1498 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0071 0.0217
Echinococcus multilocularis lamin 0.0033 0.0154 0.0166
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0157 0.0478
Brugia malayi PHD-finger family protein 0.003 0.0132 0.0402
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0071 0.0217
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0024 0.0158
Mycobacterium ulcerans lipase LipD 0.022 0.1498 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0242 0.1651 0.5035
Onchocerca volvulus 0.022 0.1498 1
Entamoeba histolytica hypothetical protein 0.0048 0.0265 0.2624
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0275 0.0838
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0071 0.0077
Brugia malayi Latrophilin receptor protein 2 0.0015 0.003 0.009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0071 0.0077
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0087 0.0264
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0052 0.0116
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0071 0.0077
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0071 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0171 0.0161
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0069 0.0454
Loa Loa (eye worm) hypothetical protein 0.0033 0.0154 0.0344
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0071 0.0077
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0024 0.0158
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0069 0.0454
Plasmodium vivax hypothetical protein, conserved 0.022 0.1498 1
Trypanosoma cruzi ISWI complex protein 0.0015 0.0027 0.0122
Loa Loa (eye worm) CXXC zinc finger family protein 0.0091 0.0575 0.129
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0204 0.136
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0071 0.0077
Mycobacterium tuberculosis Probable lipase LipD 0.022 0.1498 0.149
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.016
Echinococcus multilocularis Smad4 0.0017 0.0042 0.0045
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0154 0.0344
Schistosoma mansoni tar DNA-binding protein 0.0469 0.3279 0.3545
Mycobacterium tuberculosis Conserved protein 0.022 0.1498 0.149
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.004 0.0043
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0009 0.0085
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0211 0.2086
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.022 0.1498 0.149
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0071 0.0077
Schistosoma mansoni ap endonuclease 0.0018 0.0052 0.0056
Schistosoma mansoni lamin 0.0033 0.0154 0.0166
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0052 0.0342
Mycobacterium leprae Probable lipase LipE 0.022 0.1498 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0048 0.0038
Echinococcus granulosus GPCR family 2 0.0015 0.003 0.0032
Schistosoma mansoni ferritin 0.0018 0.0048 0.0051
Entamoeba histolytica hypothetical protein 0.0152 0.1008 1
Schistosoma mansoni apoferritin-2 0.0018 0.0048 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0071 0.016
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0185 0.5
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0014
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0042 0.0045
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.0032
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0233 0.1553
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0024 0.0014
Loa Loa (eye worm) hypothetical protein 0.022 0.1498 0.3358
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0071 0.0319
Loa Loa (eye worm) hypothetical protein 0.0037 0.0189 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0071 0.0217
Echinococcus granulosus ferritin 0.0018 0.0048 0.0051
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0044 0.0098
Brugia malayi beta-lactamase family protein 0.022 0.1498 0.4568
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0066 0.1911
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0242 0.1651 0.1785
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0115 0.0125
Trypanosoma brucei ISWI complex protein 0.0015 0.0027 0.0178
Trichomonas vaginalis esterase, putative 0.022 0.1498 1
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0185 0.5351
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0172 0.0186
Echinococcus multilocularis smad 0.0017 0.0042 0.0045
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0204 0.136
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0052 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.016
Echinococcus multilocularis ferritin 0.0018 0.0048 0.0051
Echinococcus granulosus smad 0.0017 0.0042 0.0045
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0185 0.1091
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0042 0.0045
Echinococcus multilocularis musashi 0.0033 0.0154 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0069 0.0454
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0026 0.0079
Loa Loa (eye worm) hypothetical protein 0.0027 0.011 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0069 0.0454
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0275 0.272
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0069 0.0454
Toxoplasma gondii ABC1 family protein 0.022 0.1498 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0035 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.92 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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