Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0041 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.1577 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.