TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 408.426 | Formula: C18H20N2O7S
H donors: 2 H acceptors: 6 LogP: 1.31 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C(C(=O)OC)(Cc1ccncc1)Cc1ccc(cc1)NS(=O)(=O)O
InChi: 1S/C18H20N2O7S/c1-26-16(21)18(17(22)27-2,12-14-7-9-19-10-8-14)11-13-3-5-15(6-4-13)20-28(23,24)25/h3-10,20H,11-12H2,1-2H3,(H,23,24,25)
InChiKey: AWNSCXPWDCOPCA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0007	0.0231	0.02
Loa Loa (eye worm)	myotactin form A	0.0006	0.0119	0.0087
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0007	0.0231	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.2763	0.5378
Onchocerca volvulus		0.0096	0.7553	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0262	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.4943	0.9622
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0007	0.0231	0.045
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0013	0.0708	0.0679
Entamoeba histolytica	hypothetical protein	0.0038	0.2763	1
Brugia malayi	MH2 domain containing protein	0.0009	0.0347	0.0316
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.5138	0.5122
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Schistosoma mansoni	factor for adipocyte differentiation	0.0006	0.0119	0.0231
Brugia malayi	myotactin form A	0.0006	0.0119	0.0087
Schistosoma mansoni	cell adhesion molecule	0.0006	0.0119	0.0231
Schistosoma mansoni	cpg binding protein	0.003	0.2141	0.4167
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0007	0.0231	0.045
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.5138	1
Echinococcus multilocularis		0.0007	0.0231	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0006	0.0119	0.0087
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0007	0.0231	0.0224
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Schistosoma mansoni	Smad4	0.0009	0.0347	0.0676
Brugia malayi	Lethal protein 805	0.0006	0.0119	0.0087
Loa Loa (eye worm)	hypothetical protein	0.009	0.7076	0.7067
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087
Onchocerca volvulus		0.0007	0.0231	0.0151
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0007	0.0231	0.02
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0262	0.0286
Loa Loa (eye worm)	transcription factor SMAD2	0.0126	1	1
Echinococcus granulosus	smad	0.0009	0.0347	0.0455
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0415	0.059
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0006	0.0119	0.0087
Schistosoma mansoni	ephrin receptor	0.0006	0.0119	0.0231
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0007	0.0231	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0007	0.0231	0.045
Schistosoma mansoni	hypothetical protein	0.0038	0.2763	0.5378
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0013	0.0708	0.1379
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0262	0.0286
Entamoeba histolytica	hypothetical protein	0.0038	0.2763	1
Brugia malayi	protein unc-22	0.0006	0.0119	0.0087
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0006	0.0119	0.0087
Onchocerca volvulus		0.0007	0.0231	0.0151
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0347	0.0455
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Onchocerca volvulus		0.0007	0.0231	0.0151
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0013	0.0708	0.1175
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0007	0.0231	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0013	0.0708	0.1175
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0347	0.0676
Loa Loa (eye worm)	hypothetical protein	0.009	0.7076	0.7067
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0007	0.0231	1
Onchocerca volvulus		0.0007	0.0231	0.0151
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0006	0.0119	0.0087
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0007	0.0231	0.0224
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.5138	0.5122
Entamoeba histolytica	hypothetical protein	0.0038	0.2763	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0007	0.0231	0.045
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.5138	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0007	0.0231	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0013	0.0708	0.1175
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0347	0.0676
Schistosoma mansoni	serine/threonine protein kinase	0.0006	0.0119	0.0231
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0347	0.0316
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0007	0.0231	0.0224
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0006	0.0119	0.0087
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.2763	0.5269
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	hypothetical protein	0.009	0.7076	0.7067
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0013	0.0708	0.1175
Brugia malayi	TAR-binding protein	0.0067	0.5138	0.5122
Onchocerca volvulus		0.0007	0.0231	0.0151
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0006	0.0119	0.0087
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0262	0.0511
Brugia malayi	Smad1	0.0009	0.0347	0.0316
Brugia malayi	RNA binding protein	0.0067	0.5138	0.5122
Giardia lamblia	Protein tyrosine phosphatase	0.0007	0.0231	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.5138	1
Brugia malayi	Fibronectin type III domain containing protein	0.0006	0.0119	0.0087
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0007	0.0231	0.0224
Brugia malayi	Protein-tyrosine phosphatase	0.0007	0.0231	0.02
Onchocerca volvulus		0.003	0.2141	0.272
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0347	0.0316
Onchocerca volvulus		0.0007	0.0231	0.0151
Onchocerca volvulus		0.0007	0.0231	0.0151
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0007	0.0231	0.0224
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0007	0.0231	0.045
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0007	0.0231	0.0224
Schistosoma mansoni	factor for adipocyte differentiation	0.0006	0.0119	0.0231
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Schistosoma mansoni	factor for adipocyte differentiation	0.0006	0.0119	0.0231
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0415	0.059
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.2763	0.5269
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0007	0.0231	0.045
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0007	0.0231	0.0224
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087
Schistosoma mansoni	protein tyrosine phosphatase	0.0007	0.0231	0.045
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0347	0.0455
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0007	0.0231	0.0224
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0007	0.0231	0.045
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Brugia malayi	MH2 domain containing protein	0.0009	0.0347	0.0316
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0007	0.0231	0.0224
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.2141	0.2116
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0007	0.0231	0.02
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.5138	1
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0007	0.0231	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Schistosoma mansoni	cell adhesion molecule	0.0006	0.0119	0.0231
Brugia malayi	hypothetical protein	0.0038	0.2763	0.274
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0006	0.0119	0.0087
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0405	0.0374
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.4377	0.5
Brugia malayi	hypothetical protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Trichomonas vaginalis	pten, drome, putative	0.0007	0.0231	1
Onchocerca volvulus		0.0007	0.0231	0.0151
Onchocerca volvulus		0.0007	0.0231	0.0151
Brugia malayi	SPRY domain containing protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	RNA binding protein	0.0067	0.5138	0.5122
Schistosoma mansoni	myosin-binding protein-related	0.0006	0.0119	0.0231
Brugia malayi	hypothetical protein	0.0007	0.0231	0.02
Schistosoma mansoni	smad	0.0009	0.0347	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0007	0.0231	0.0224
Schistosoma mansoni	nephrin	0.0006	0.0119	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0006	0.0119	0.0087
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.5138	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0007	0.0231	0.0224
Brugia malayi	hypothetical protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0007	0.0231	0.02
Schistosoma mansoni	cell adhesion molecule	0.0006	0.0119	0.0231
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0007	0.0231	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Onchocerca volvulus		0.0007	0.0231	0.0151
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Schistosoma mansoni	titin	0.0006	0.0119	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0007	0.0231	0.0224
Onchocerca volvulus		0.0007	0.0231	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Brugia malayi	hypothetical protein	0.0007	0.0231	0.02
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0007	0.0231	0.0224
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0007	0.0231	0.045
Brugia malayi	hypothetical protein	0.0006	0.0119	0.0087
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0013	0.0708	0.1175
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087
Echinococcus multilocularis	cpg binding protein	0.0032	0.2284	0.4313
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0347	0.0455
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0007	0.0231	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0097	0.7666	0.7659
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0006	0.0119	0.0087
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0007	0.0231	0.02
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0007	0.0231	0.0224
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0013	0.0708	0.1379
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0007	0.0231	0.0224
Brugia malayi	Protein-tyrosine phosphatase	0.0103	0.8143	0.8137
Echinococcus multilocularis	smad	0.0009	0.0347	0.0455
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0007	0.0231	0.0224
Schistosoma mansoni	protein tyrosine phosphatase	0.0013	0.0708	0.1379
Brugia malayi	CXXC zinc finger family protein	0.003	0.2141	0.2116
Onchocerca volvulus		0.0007	0.0231	0.0151
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0007	0.0231	0.02
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0007	0.0231	0.045
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Schistosoma mansoni	titin	0.0006	0.0119	0.0231
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0007	0.0231	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Brugia malayi	MH1 domain containing protein	0.0009	0.0347	0.0316
Schistosoma mansoni	tripartite motif protein trim9	0.0006	0.0119	0.0231
Brugia malayi	hypothetical protein	0.0006	0.0119	0.0087
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0347	0.0455
Brugia malayi	Fibronectin type III domain containing protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	MH2 domain-containing protein	0.0126	1	1
Echinococcus multilocularis	Smad4	0.0009	0.0347	0.0455
Brugia malayi	Fibronectin type III domain containing protein	0.0006	0.0119	0.0087
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Schistosoma mansoni	nephrin	0.0006	0.0119	0.0231
Echinococcus granulosus	cpg binding protein	0.0032	0.2284	0.4313
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0013	0.0708	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0007	0.0231	0.0224
Loa Loa (eye worm)	UNCoordinated family member	0.0006	0.0119	0.0087
Schistosoma mansoni	hypothetical protein	0.0006	0.0119	0.0231
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0007	0.0231	0.045
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Brugia malayi	Fibronectin type III domain containing protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0006	0.0119	0.0087
Echinococcus granulosus	tar DNA binding protein	0.0067	0.5138	1
Onchocerca volvulus		0.0007	0.0231	0.0151
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0007	0.0231	0.0224
Schistosoma mansoni	titin	0.0006	0.0119	0.0231
Onchocerca volvulus		0.0007	0.0231	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Onchocerca volvulus		0.0007	0.0231	0.0151
Onchocerca volvulus		0.0007	0.0231	0.0151
Schistosoma mansoni	hemicentin	0.0006	0.0119	0.0231
Brugia malayi	Fibronectin type III domain containing protein	0.0006	0.0119	0.0087
Brugia malayi	Lethal protein 805	0.0006	0.0119	0.0087
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0007	0.0231	0.0224
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Schistosoma mansoni	pcd6 interacting protein-related	0.0007	0.0231	0.045
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0007	0.0231	0.0224
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0013	0.0708	0.1175
Brugia malayi	MH1 domain containing protein	0.0009	0.0347	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0013	0.0708	0.1379
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0007	0.0231	0.0224
Brugia malayi	Fibronectin type III domain containing protein	0.0006	0.0119	0.0087
Onchocerca volvulus		0.0007	0.0231	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Brugia malayi	hypothetical protein	0.0007	0.0231	0.02
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0013	0.0708	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Leishmania major	tyrosine specific protein phosphatase, putative	0.0007	0.0231	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0415	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	projectin	0.0006	0.0119	0.0087
Entamoeba histolytica	hypothetical protein	0.0038	0.2763	1
Loa Loa (eye worm)	lethal protein 805	0.0006	0.0119	0.0087
Onchocerca volvulus	4.1 G protein, putative homolog	0.0007	0.0231	0.0151
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0347	0.0676
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.5138	0.5122
Onchocerca volvulus		0.0007	0.0231	0.0151
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Echinococcus granulosus	Smad4	0.0009	0.0347	0.0455
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0006	0.0119	0.0087
Brugia malayi	Protein-tyrosine phosphatase 1	0.0007	0.0231	0.02
Echinococcus multilocularis	hypothetical protein	0.0007	0.0231	0.0224
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0007	0.0231	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Onchocerca volvulus		0.0007	0.0231	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Schistosoma mansoni	neuroglian	0.0006	0.0119	0.0231
Brugia malayi	myotactin form B	0.0006	0.0119	0.0087
Onchocerca volvulus		0.0007	0.0231	0.0151
Loa Loa (eye worm)	CAMK protein kinase	0.0006	0.0119	0.0087
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0013	0.0708	0.1175
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0013	0.0708	0.1379
Schistosoma mansoni	hypothetical protein	0.0006	0.0119	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0347	0.0676
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0013	0.0708	0.1175
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0007	0.0231	0.0224
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0231	0.02
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087
Schistosoma mansoni	cpg binding protein	0.0032	0.2284	0.4445
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.5138	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0013	0.0708	0.1379
Onchocerca volvulus		0.0007	0.0231	0.0151
Schistosoma mansoni	protein tyrosine phosphatase	0.0007	0.0231	0.045
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0007	0.0231	1
Onchocerca volvulus		0.0007	0.0231	0.0151
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0231	0.02
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0262	0.0286
Schistosoma mansoni	cell adhesion molecule	0.0006	0.0119	0.0231
Schistosoma mansoni	cpg binding protein	0.0032	0.2284	0.4445
Schistosoma mansoni	hypothetical protein	0.0006	0.0119	0.0231
Loa Loa (eye worm)	Smad1	0.0009	0.0347	0.0316
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0007	0.0231	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0231	0.02
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0007	0.0231	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0119	0.0087
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0007	0.0231	0.0224
Onchocerca volvulus		0.0007	0.0231	0.0151
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087
Schistosoma mansoni	cell adhesion molecule	0.0006	0.0119	0.0231
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0006	0.0119	0.0087

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1182120

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1202510