Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0076 | 0.489 | 0.888 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0084 | 0.5507 | 0.5 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0084 | 0.5507 | 0.5507 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0084 | 0.5507 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0084 | 0.5507 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4963 | 0.4963 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 0.9012 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 0.9012 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4963 | 0.4963 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4963 | 0.9012 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.5507 | 0.5507 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 0.9012 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0084 | 0.5507 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 0.9012 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4963 | 0.4963 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0084 | 0.5507 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0084 | 0.5507 | 0.5 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0084 | 0.5507 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4963 | 0.9012 |
Echinococcus granulosus | lysosomal protective protein | 0.0084 | 0.5507 | 1 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0084 | 0.5507 | 0.5 |
Echinococcus multilocularis | lysosomal protective protein | 0.0084 | 0.5507 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0084 | 0.5507 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4963 | 0.4963 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0084 | 0.5507 | 1 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0076 | 0.489 | 0.888 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4963 | 0.4963 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0084 | 0.5507 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4963 | 0.9012 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4963 | 0.4963 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.