Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0141 | 0.3413 | 0.3103 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0345 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0141 | 0.3413 | 1 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0059 | 0.0761 | 0.223 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.152 | 0.1119 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0129 | 0.3032 | 0.8883 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0129 | 0.3032 | 0.2743 |
Onchocerca volvulus | 0.0157 | 0.3925 | 1 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0129 | 0.3032 | 0.2743 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0059 | 0.0761 | 0.223 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.3925 | 0.3639 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0059 | 0.0761 | 0.223 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0059 | 0.0761 | 0.223 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0141 | 0.3413 | 0.2871 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0262 | 0.7327 | 0.7201 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0141 | 0.3413 | 0.3103 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0059 | 0.0761 | 0.223 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0059 | 0.0761 | 0.223 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0059 | 0.0761 | 0.223 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.0761 | 0.0761 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0147 | 0.3604 | 0.3302 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0129 | 0.3032 | 0.3032 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0345 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0059 | 0.0761 | 0.5 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0345 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0059 | 0.0761 | 0.223 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0345 | 1 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.0147 | 0.3604 | 0.3604 |
Schistosoma mansoni | cytochrome P450 | 0.0059 | 0.0761 | 0.0378 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0059 | 0.0761 | 0.223 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0345 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0129 | 0.3032 | 0.8883 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0059 | 0.0761 | 0.223 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0129 | 0.3032 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0141 | 0.3413 | 0.3103 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0345 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0141 | 0.3413 | 0.2871 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0345 | 1 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0059 | 0.0761 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0129 | 0.3032 | 0.8883 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0345 | 1 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0059 | 0.0761 | 0.0761 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0345 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0059 | 0.0761 | 0.223 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0129 | 0.3032 | 1 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0059 | 0.0761 | 0.223 |
Brugia malayi | Cytochrome P450 family protein | 0.0137 | 0.3297 | 0.3297 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0059 | 0.0761 | 0.223 |
Leishmania major | cytochrome p450-like protein | 0.0141 | 0.3413 | 0.2871 |
Brugia malayi | hypothetical protein | 0.0157 | 0.3925 | 0.3925 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 0.0761 | 0.0378 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0451 | 0.0451 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0059 | 0.0761 | 0.223 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 1 | 1 |
Brugia malayi | cytochrome P450 | 0.0059 | 0.0761 | 0.0761 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0059 | 0.0761 | 0.223 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.4002 | 0.3719 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0345 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0129 | 0.3032 | 0.3032 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0137 | 0.3297 | 0.2981 |
Brugia malayi | hypothetical protein | 0.0159 | 0.4002 | 0.4002 |
Brugia malayi | Cytochrome P450 family protein | 0.0141 | 0.3413 | 0.3413 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0059 | 0.0761 | 0.223 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.0398 | 0.0398 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0345 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0451 | 0.0451 |
Brugia malayi | Cytochrome P450 family protein | 0.0141 | 0.3413 | 0.3413 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0345 | 1 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0129 | 0.3032 | 0.2458 |
Echinococcus multilocularis | 0.0059 | 0.0761 | 0.0761 | |
Loa Loa (eye worm) | cytochrome P450 | 0.0059 | 0.0761 | 0.0325 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0059 | 0.0761 | 0.223 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0059 | 0.0761 | 0.223 |
Brugia malayi | follicle stimulating hormone receptor | 0.0262 | 0.7327 | 0.7327 |
Trypanosoma brucei | cytochrome P450, putative | 0.0141 | 0.3413 | 0.2871 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0059 | 0.0761 | 0.223 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0059 | 0.0761 | 0.223 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0345 | 1 | 1 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0345 | 1 | 1 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0345 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0345 | 1 | 1 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0345 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.