TDR Targets

Basic information

Technical information

TDR Targets ID: 1202606
Name: MLS001007469
MW: 453.511 | Formula: C23H23N3O5S
H donors: 0 H acceptors: 5 LogP: 2.51 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N(C1CCS(=O)(=O)C1)C)COC(=O)c1cn(nc1c1ccccc1)c1ccccc1
InChi: 1S/C23H23N3O5S/c1-25(19-12-13-32(29,30)16-19)21(27)15-31-23(28)20-14-26(18-10-6-3-7-11-18)24-22(20)17-8-4-2-5-9-17/h2-11,14,19H,12-13,15-16H2,1H3
InChiKey: ATEZSLAFDQKFQN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

SMR000352671
T5232095

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Saccharomyces cerevisiae	Rce1p	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	Get druggable targets OG5_129169	All targets in OG5_129169
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Entamoeba histolytica	CAAX prenyl protease family	Get druggable targets OG5_129169	All targets in OG5_129169
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	Clan U, family U48, CaaX prenyl peptidase 2-like	Get druggable targets OG5_129169	All targets in OG5_129169
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	expressed protein	Get druggable targets OG5_129169	All targets in OG5_129169
Brugia malayi	CAAX amino terminal protease family protein	Get druggable targets OG5_129169	All targets in OG5_129169
Leishmania donovani	CAAX prenyl protease 2, putative	Get druggable targets OG5_129169	All targets in OG5_129169
Candida albicans	ras and a-factor terminal proteolysis	Get druggable targets OG5_129169	All targets in OG5_129169
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei gambiense	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48), putative	Get druggable targets OG5_129169	All targets in OG5_129169
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania infantum	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	Get druggable targets OG5_129169	All targets in OG5_129169
Leishmania mexicana	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	Get druggable targets OG5_129169	All targets in OG5_129169
Trypanosoma cruzi	CAAX prenyl protease 2, putative	Get druggable targets OG5_129169	All targets in OG5_129169
Trypanosoma congolense	CAAX amino terminal protease, putative	Get druggable targets OG5_129169	All targets in OG5_129169
Trypanosoma cruzi	peptidase with unknown catalytic mechanism (family U48)	Get druggable targets OG5_129169	All targets in OG5_129169
Giardia lamblia	Hypothetical protein	Get druggable targets OG5_129169	All targets in OG5_129169
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129169	All targets in OG5_129169
Echinococcus granulosus	CAAX prenyl protease 2	Get druggable targets OG5_129169	All targets in OG5_129169
Schistosoma japonicum	ko:K08658 prenyl protein peptidase, putative	Get druggable targets OG5_129169	All targets in OG5_129169
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	Get druggable targets OG5_129169	All targets in OG5_129169
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei	CAAX amino terminal protease, putative	Get druggable targets OG5_129169	All targets in OG5_129169
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania major	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	Get druggable targets OG5_129169	All targets in OG5_129169
Leishmania braziliensis	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	Get druggable targets OG5_129169	All targets in OG5_129169
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	CAAX prenyl protease 2	Get druggable targets OG5_129169	All targets in OG5_129169
Candida albicans	ras and a-factor terminal proteolysis	Get druggable targets OG5_129169	All targets in OG5_129169
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0023	0.0023
Brugia malayi	Carboxylesterase family protein	0.0263	0.1606	0.1606
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0207	0.0207
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0023	0.0023
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0023	0.0023
Onchocerca volvulus		0.0263	0.1606	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0432	0.0432
Brugia malayi	Carboxylesterase family protein	0.1554	1	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0082	0.0432	0.0432
Echinococcus granulosus	acetylcholinesterase	0.1554	1	1
Loa Loa (eye worm)	hypothetical protein	0.0263	0.1606	0.1606
Loa Loa (eye worm)	acetylcholinesterase 1	0.1554	1	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0263	0.1606	1
Echinococcus granulosus	carbonic anhydrase II	0.0175	0.1033	0.1033
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0082	0.0432	0.0432
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0175	0.1033	0.1033
Loa Loa (eye worm)	hypothetical protein	0.0263	0.1606	0.1606
Echinococcus granulosus	carbonic anhydrase	0.0082	0.0432	0.0432
Giardia lamblia	Hypothetical protein	0.0111	0.0618	0.5
Schistosoma mansoni	hypothetical protein	0.0164	0.0965	0.0965
Brugia malayi	hypothetical protein	0.0232	0.1408	0.1408
Brugia malayi	hypothetical protein	0.0263	0.1606	0.1606
Trypanosoma cruzi	peptidase with unknown catalytic mechanism (family U48)	0.0111	0.0618	0.5982
Plasmodium falciparum	carbonic anhydrase	0.0082	0.0432	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0023	0.0023
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0263	0.1606	0.1606
Echinococcus multilocularis	carbonic anhydrase	0.0082	0.0432	0.0432
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0111	0.0618	0.0618
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0263	0.1606	0.1606
Schistosoma mansoni	hypothetical protein	0.0019	0.0023	0.0023
Trypanosoma cruzi	CAAX prenyl protease 2, putative	0.0111	0.0618	0.5982
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0175	0.1033	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.029	0.029
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0111	0.0618	0.0618
Echinococcus multilocularis	carbonic anhydrase	0.0082	0.0432	0.0432
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0023	0.0023
Chlamydia trachomatis	hypothetical protein	0.0023	0.0048	0.5
Echinococcus granulosus	carbonic anhydrase	0.0082	0.0432	0.0432
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0258	0.0258
Entamoeba histolytica	CAAX prenyl protease family	0.0111	0.0618	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0082	0.0432	0.0432
Echinococcus granulosus	BC026374 protein S09 family	0.0263	0.1606	0.1606
Toxoplasma gondii	CAAX amino terminal protease family protein	0.0023	0.0048	0.1101
Toxoplasma gondii	hypothetical protein	0.0082	0.0432	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0454	0.2849	0.2849
Schistosoma mansoni	hypothetical protein	0.0019	0.0023	0.0023
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0263	0.1606	0.1606
Loa Loa (eye worm)	carbonic anhydrase 3	0.0175	0.1033	0.1033
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0023	0.0023
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0082	0.0432	0.0432
Brugia malayi	Carboxylesterase family protein	0.0263	0.1606	0.1606
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0023	0.0023
Echinococcus granulosus	acetylcholinesterase	0.1554	1	1
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.1408	0.1408
Schistosoma mansoni	gliotactin	0.0263	0.1606	0.1606
Loa Loa (eye worm)	hypothetical protein	0.1554	1	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0263	0.1606	1
Echinococcus multilocularis	geminin	0.0164	0.0965	0.0965
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1554	1	1
Trypanosoma brucei	carbonic anhydrase-like protein	0.0175	0.1033	1
Mycobacterium ulcerans	carboxylesterase, LipT	0.0263	0.1606	1
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1408	0.1408
Echinococcus granulosus	neuropeptide receptor A26	0.0454	0.2849	0.2849
Mycobacterium tuberculosis	Probable conserved integral membrane protein	0.0023	0.0048	0.0296
Echinococcus multilocularis	carbonic anhydrase	0.0082	0.0432	0.0432
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0263	0.1606	0.1606
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0258	0.0258
Trypanosoma brucei	CAAX amino terminal protease, putative	0.0111	0.0618	0.5982
Onchocerca volvulus		0.0263	0.1606	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0258	0.0258
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0263	0.1606	0.1606
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0263	0.1606	0.1606
Schistosoma mansoni	BC026374 protein (S09 family)	0.0263	0.1606	0.1606
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0175	0.1033	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0175	0.1033	0.1033
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0175	0.1033	0.1033
Toxoplasma gondii	hypothetical protein	0.0023	0.0048	0.1101
Plasmodium vivax	protease, putative	0.0023	0.0048	1
Plasmodium falciparum	protease, putative	0.0023	0.0048	0.1101
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0258	0.0258
Echinococcus granulosus	GPCR family 2	0.0019	0.0023	0.0023
Schistosoma mansoni	carbonic anhydrase	0.0082	0.0432	0.0432
Echinococcus multilocularis	neuroligin	0.0263	0.1606	0.1606
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.029	0.029
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0263	0.1606	1
Schistosoma mansoni	carbonic anhydrase-related	0.0082	0.0432	0.0432
Echinococcus multilocularis	carbonic anhydrase II	0.0175	0.1033	0.1033
Brugia malayi	CAAX amino terminal protease family protein	0.0111	0.0618	0.0618
Echinococcus multilocularis	para nitrobenzyl esterase	0.0263	0.1606	0.1606
Echinococcus granulosus	neuroligin	0.0263	0.1606	0.1606
Echinococcus granulosus	carboxylesterase 5A	0.1554	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0258	0.0258
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0258	0.0258
Loa Loa (eye worm)	hypothetical protein	0.006	0.029	0.029
Toxoplasma gondii	hypothetical protein	0.0023	0.0048	0.1101
Mycobacterium tuberculosis	Probable integral membrane protein	0.0023	0.0048	0.0296
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0258	0.0258
Echinococcus granulosus	carbonic anhydrase	0.0082	0.0432	0.0432
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0263	0.1606	0.1606
Trichomonas vaginalis	spcc417.12 protein, putative	0.0263	0.1606	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0048	0.0296
Onchocerca volvulus		0.0263	0.1606	1
Loa Loa (eye worm)	hypothetical protein	0.0263	0.1606	0.1606
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0258	0.0258
Schistosoma mansoni	hypothetical protein	0.0082	0.0432	0.0432
Onchocerca volvulus		0.0263	0.1606	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0023	0.0023
Schistosoma mansoni	carbonic anhydrase-related	0.0082	0.0432	0.0432
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.029	0.029
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0082	0.0432	0.0432
Brugia malayi	Carboxylesterase family protein	0.0263	0.1606	0.1606
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0263	0.1606	1
Echinococcus multilocularis	CAAX prenyl protease 2	0.0111	0.0618	0.0618
Schistosoma mansoni	hypothetical protein	0.0164	0.0965	0.0965
Loa Loa (eye worm)	hypothetical protein	0.1554	1	1
Treponema pallidum	hypothetical protein	0.0023	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0023	0.0023
Echinococcus multilocularis	neuropeptide s receptor	0.0454	0.2849	0.2849
Loa Loa (eye worm)	carboxylesterase	0.0263	0.1606	0.1606
Echinococcus multilocularis	acetylcholinesterase	0.1554	1	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0082	0.0432	0.0432
Echinococcus granulosus	geminin	0.0164	0.0965	0.0965
Schistosoma mansoni	acetylcholinesterase	0.0263	0.1606	0.1606
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0263	0.1606	0.1606
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0175	0.1033	0.1033
Echinococcus multilocularis	acetylcholinesterase	0.1554	1	1
Mycobacterium tuberculosis	Probable conserved integral membrane protein	0.0023	0.0048	0.0296
Leishmania major	carbonic anhydrase-like protein	0.0175	0.1033	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0432	0.0432
Brugia malayi	Carboxylesterase family protein	0.0263	0.1606	0.1606
Echinococcus granulosus	neuropeptide s receptor	0.0454	0.2849	0.2849
Loa Loa (eye worm)	carboxylesterase	0.0263	0.1606	0.1606
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0167	0.0167
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0258	0.0258
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0167	0.0167
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0263	0.1606	0.1606
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0175	0.1033	0.1033
Leishmania major	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	0.0111	0.0618	0.5982
Echinococcus granulosus	CAAX prenyl protease 2	0.0111	0.0618	0.0618
Schistosoma mansoni	hypothetical protein	0.0041	0.0167	0.0167
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.1408	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0618	0.0618
Schistosoma mansoni	carbonic anhydrase-related	0.0082	0.0432	0.0432
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0263	0.1606	0.1606
Loa Loa (eye worm)	carboxylesterase	0.1554	1	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0263	0.1606	0.1606
Echinococcus multilocularis	carboxylesterase 5A	0.1554	1	1
Onchocerca volvulus		0.0263	0.1606	1
Loa Loa (eye worm)	hypothetical protein	0.0263	0.1606	0.1606
Schistosoma mansoni	hypothetical protein	0.0047	0.0207	0.0207

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (binding)	= 0.6788 uM	PUBCHEM_BIOASSAY: Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618]	ChEMBL.	No reference
AC50 (binding)	= 25.09 uM	PUBCHEM_BIOASSAY: Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618]	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	37.933 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1299782

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1202606