Detailed information for compound 1203231

Basic information

Technical information
  • TDR Targets ID: 1203231
  • Name: 1-[2-[(Z)-2-(2-fluorophenyl)-2-(2-methylpheny l)ethenoxy]ethyl]-5,6-dihydro-2H-pyridine-3-c arboxylic acid
  • MW: 381.44 | Formula: C23H24FNO3
  • H donors: 1 H acceptors: 2 LogP: 2.36 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1=CCCN(C1)CCO/C=C(\c1ccccc1F)/c1ccccc1C
  • InChi: 1S/C23H24FNO3/c1-17-7-2-3-9-19(17)21(20-10-4-5-11-22(20)24)16-28-14-13-25-12-6-8-18(15-25)23(26)27/h2-5,7-11,16H,6,12-15H2,1H3,(H,26,27)/b21-16-
  • InChiKey: FWBPFHQSHFUAPS-PGMHBOJBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0126 0.1129 0.1882
Loa Loa (eye worm) raf kinase 0.0418 0.5451 0.5451
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0108 0.0863 0.4512
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0403 0.0439
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0064 0.021 0.021
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0438 0.5752 0.5752
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0205 0.0223
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0108 0.0863 0.4512
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0108 0.0863 0.1234
Schistosoma mansoni lipoxygenase 0.0114 0.0951 0.1037
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0267 0.3219 0.5597
Trichomonas vaginalis CMGC family protein kinase 0.0267 0.3219 0.543
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0064 0.021 0.0229
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0165 0.17 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0108 0.0863 0.4512
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0071 0.0311 0.0339
Echinococcus multilocularis musashi 0.0081 0.0459 0.05
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0056 0.0094 0.0102
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0122 0.1061 0.1157
Schistosoma mansoni serine/threonine protein kinase 0.042 0.5481 0.5977
Schistosoma mansoni protein kinase 0.0126 0.1121 0.1222
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0167 0.1735 0.1735
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0438 0.5752 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0108 0.0863 0.4512
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0311 0.0339
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0126 0.1129 0.1659
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0459 0.0459
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0725 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0064 0.021 0.001
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.0311 0.0339
Giardia lamblia Kinase, CMGC CLK 0.0438 0.5752 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0122 0.1061 0.1591
Echinococcus granulosus serine:threonine protein kinase mig 15 0.017 0.177 0.1931
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0108 0.0863 0.4512
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0205 0.0223
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0108 0.0863 0.3666
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0108 0.0863 0.4512
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0438 0.5752 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.4258 0.7305
Loa Loa (eye worm) hypothetical protein 0.0081 0.0459 0.0459
Echinococcus granulosus mitogen activated protein kinase 0.0267 0.3219 0.351
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0562 0.7595 0.8282
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0077 0.0403 0.041
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0108 0.0863 0.4512
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0108 0.0863 0.3666
Leishmania major protein kinase, putative 0.0438 0.5752 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0108 0.0863 0.3666
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0403 0.0439
Echinococcus multilocularis 0.0432 0.5658 0.617
Schistosoma mansoni serine/threonine protein kinase 0.0438 0.5752 0.6272
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0108 0.0863 0.3666
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0106 0.0834 0.0834
Giardia lamblia Kinase, CMGC MAPK 0.0267 0.3219 0.5274
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0108 0.0863 0.3666
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0108 0.0863 0.4512
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0205 0.0356
Trypanosoma brucei cytochrome P450, putative 0.0189 0.2052 0.3568
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0165 0.17 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0221 0.2539 0.2539
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0205 0.0055
Loa Loa (eye worm) hypoxia-induced factor 1 0.0297 0.3666 0.3666
Trichomonas vaginalis CMGC family protein kinase 0.0267 0.3219 0.543
Trichomonas vaginalis CMGC family protein kinase 0.0267 0.3219 0.543
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0056 0.0094 0.0094
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0122 0.1061 0.1157
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0122 0.1061 0.5816
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0126 0.1129 0.1129
Echinococcus granulosus hypothetical protein 0.0432 0.5658 0.617
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0403 0.0701
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0165 0.17 0.8123
Onchocerca volvulus 0.0071 0.0311 0.6778
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0395 0.5116 0.8896
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0126 0.1129 0.1882
Echinococcus granulosus raf serine:threonine protein kinase 0.042 0.5481 0.5977
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0174 0.019
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0267 0.3219 0.5459
Trypanosoma cruzi cytochrome P450, putative 0.0189 0.2052 0.3568
Leishmania major cytochrome p450-like protein 0.0108 0.0863 0.1234
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0122 0.1061 0.1061
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.917 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0108 0.0863 0.15
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0267 0.3219 0.5597
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0108 0.0863 0.4512
Schistosoma mansoni hypothetical protein 0.0108 0.0863 0.0941
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0108 0.0863 0.15
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0108 0.0863 0.3666
Leishmania major cytochrome p450-like protein 0.0108 0.0863 0.1234
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0077 0.0403 0.0403
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0221 0.2539 0.2769
Loa Loa (eye worm) hypothetical protein 0.008 0.0446 0.0446
Echinococcus granulosus microtubule associated protein 2 0.0669 0.917 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.021 0.0064
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0267 0.3219 0.5597
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0381 0.49 0.9559
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0267 0.3219 0.3219
Loa Loa (eye worm) cytochrome P450 family protein 0.0189 0.2052 0.2052
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0205 0.0356
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0064 0.021 0.0064
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0126 0.1121 0.1121
Loa Loa (eye worm) hypothetical protein 0.0432 0.5658 0.5658
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.4258 0.7305
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0064 0.021 0.0229
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0108 0.0863 0.3666
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0056 0.0094 0.0102
Schistosoma mansoni cytochrome P450 0.0108 0.0863 0.0941
Brugia malayi hypoxia-induced factor 1 0.0297 0.3666 0.3666
Toxoplasma gondii cytochrome p450 superfamily protein 0.0108 0.0863 0.1234
Brugia malayi MAP kinase sur-1 0.0267 0.3219 0.3219
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0108 0.0863 0.3666
Brugia malayi Cytochrome P450 family protein 0.0189 0.2052 0.2052
Loa Loa (eye worm) cytochrome P450 family protein 0.0246 0.2907 0.2907
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0108 0.0863 0.3666
Schistosoma mansoni intermediate filament proteins 0.0081 0.0459 0.05
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0064 0.021 0.001
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0205 0.0223
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0395 0.5116 0.8854
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0108 0.0863 0.3666
Brugia malayi Raf kinase 0.0405 0.5264 0.5264
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0403 0.0701
Loa Loa (eye worm) CYP4Cod1 0.0189 0.2052 0.2052
Echinococcus multilocularis lamin dm0 0.0081 0.0459 0.05
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0108 0.0863 0.3666
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.4258 0.7305
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0108 0.0863 0.3666
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.4258 0.7305
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0064 0.021 0.0364
Brugia malayi Protein kinase domain containing protein 0.0438 0.5752 0.5752
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0562 0.7595 0.8282
Echinococcus granulosus cytochrome P450 2K1 0.0108 0.0863 0.0941
Onchocerca volvulus 0.0081 0.0459 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.2539 0.2539
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0174 0.019
Mycobacterium ulcerans putative regulatory protein 0.0071 0.0311 0.0728
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0108 0.0863 0.4512
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0112 0.0912 0.1586
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0438 0.5752 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0108 0.0863 0.4512
Leishmania major cytochrome p450-like protein 0.0189 0.2052 0.3367
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0403 0.0439
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.4258 0.7305
Echinococcus multilocularis lamin 0.0081 0.0459 0.05
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0064 0.021 0.0364
Treponema pallidum fructose-bisphosphate aldolase 0.0337 0.4258 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0126 0.1129 0.1659
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0108 0.0863 0.3666
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0438 0.5752 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0174 0.019
Echinococcus granulosus lamin 0.0081 0.0459 0.05
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.03 0.3707 0.631
Echinococcus multilocularis mitogen activated protein kinase 3 0.0267 0.3219 0.351
Leishmania major protein kinase, putative 0.0438 0.5752 1
Brugia malayi cytochrome P450 0.0108 0.0863 0.0863
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0064 0.021 0.0229
Echinococcus multilocularis mitogen activated protein kinase 0.0267 0.3219 0.351
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0108 0.0863 0.3666
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0267 0.3219 0.5459
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0238 0.2787 0.4468
Brugia malayi Cytochrome P450 family protein 0.0189 0.2052 0.2052
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0077 0.0403 0.0019
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0951 0.1037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0122 0.1061 0.4725
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0071 0.0311 0.0339
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.03 0.3707 0.631
Schistosoma mansoni lamin 0.0081 0.0459 0.05
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0403 0.0439
Echinococcus multilocularis 0.0126 0.1121 0.1222
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0108 0.0863 0.3666
Schistosoma mansoni aryl hydrocarbon receptor 0.0096 0.0681 0.0743
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0064 0.021 0.0064
Echinococcus multilocularis 0.0108 0.0863 0.0941
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0395 0.5116 0.8854
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0108 0.0863 0.15
Loa Loa (eye worm) hypothetical protein 0.0077 0.0403 0.0403
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0126 0.1129 0.1659
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0395 0.5116 0.8896
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0077 0.0403 0.0439
Echinococcus granulosus protein kinase 0.0126 0.1121 0.1222
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0337 0.4258 0.8252
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0077 0.0403 0.0439
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0159 0.1619 0.288
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0108 0.0863 0.4512
Schistosoma mansoni lipoxygenase 0.008 0.0441 0.0481
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.4258 0.7305
Brugia malayi Cytochrome P450 family protein 0.0246 0.2907 0.2907
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0064 0.021 0.0229
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0438 0.5752 1
Schistosoma mansoni single-minded 0.0096 0.0681 0.0743
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0403 0.0349
Loa Loa (eye worm) hypothetical protein 0.0174 0.1834 0.1834
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0108 0.0863 0.4512
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0108 0.0863 0.3666
Echinococcus multilocularis raf serine:threonine protein kinase 0.042 0.5481 0.5977
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0064 0.021 0.021
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0064 0.021 0.0364
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0205 0.0205
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0108 0.0863 0.4512
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0205 0.0205
Brugia malayi hypothetical protein 0.0322 0.4036 0.4036
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0108 0.0863 0.4512
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0122 0.1061 0.4725
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0459 0.0459
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0562 0.7595 0.8282
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0438 0.5752 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0108 0.0863 0.3666
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0395 0.5116 0.8854
Brugia malayi PAS domain containing protein 0.0096 0.0681 0.0681
Trichomonas vaginalis CMGC family protein kinase 0.0438 0.5752 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0437 0.0437
Brugia malayi probable protein kinase 0.0176 0.1864 0.1864
Entamoeba histolytica hypothetical protein 0.0333 0.4197 0.8128
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0267 0.3219 0.5597
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0108 0.0863 0.3666
Echinococcus granulosus single minded 2 0.0071 0.0311 0.0339
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0395 0.5116 0.5116
Plasmodium vivax serine/threonine kinase-1, putative 0.0438 0.5752 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0108 0.0863 0.4512
Brugia malayi Protein kinase domain containing protein 0.0056 0.0094 0.0094
Schistosoma mansoni protein kinase 0.0056 0.0094 0.0102
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0174 0.019
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0064 0.021 0.0229
Echinococcus granulosus dual specificity protein kinase clk2 0.0438 0.5752 0.6272
Giardia lamblia Fructose-bisphosphate aldolase 0.0337 0.4258 0.7213
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0267 0.3219 0.5597
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0337 0.4258 0.8252
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0077 0.0403 0.0403
Trypanosoma cruzi cytochrome P450, putative 0.0189 0.2052 0.3568
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.3219 0.351
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0403 0.0349
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0311 0.0339
Brugia malayi Cytochrome P450 family protein 0.0108 0.0863 0.0863
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0108 0.0863 0.4512
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0108 0.0863 0.4512
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0056 0.0094 0.0102
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0108 0.0863 0.3666
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0108 0.0863 0.3666
Loa Loa (eye worm) cytochrome P450 family protein 0.0189 0.2052 0.2052
Loa Loa (eye worm) phosphatidylinositol 3 0.05 0.6675 0.6675
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0459 0.0459
Echinococcus multilocularis Zinc finger, PHD finger 0.0064 0.021 0.0229
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0126 0.1129 0.1963
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0238 0.2786 0.2786
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0056 0.0094 0.0102
Echinococcus granulosus lamin dm0 0.0081 0.0459 0.05
Schistosoma mansoni protein kinase 0.0176 0.1864 0.2033
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0126 0.1129 0.1963
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0189 0.2052 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0077 0.0403 0.0439
Loa Loa (eye worm) phosphatidylinositol 3 0.0112 0.0912 0.0912
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0333 0.4197 0.8128
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0108 0.0863 0.15
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.4258 0.7305
Trypanosoma brucei protein kinase, putative 0.0267 0.3219 0.5597
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0122 0.1061 0.1157
Loa Loa (eye worm) hypothetical protein 0.0322 0.4036 0.4036
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.917 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0403 0.0701
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0221 0.2539 0.2769
Echinococcus granulosus intermediate filament protein 0.0081 0.0459 0.05
Plasmodium falciparum protein serine/threonine kinase-1 0.0438 0.5752 1
Brugia malayi bHLH-PAS transcription factor 0.0071 0.0311 0.0311
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0267 0.3219 0.5459
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0108 0.0863 0.4512
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0108 0.0863 0.4512
Schistosoma mansoni lamin 0.0081 0.0459 0.05
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 0.4258 0.7305
Trichomonas vaginalis CMGC family protein kinase 0.0267 0.3219 0.543
Loa Loa (eye worm) cytochrome P450 0.0108 0.0863 0.0863
Leishmania major phosphatidylinositol 3-kinase, putative 0.0064 0.021 0.0064
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0205 0.0356
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0403 0.0349
Onchocerca volvulus 0.0081 0.0459 1
Echinococcus multilocularis dual specificity protein kinase clk2 0.0438 0.5752 0.6272
Echinococcus granulosus ubiquitin specific protease 41 0.0077 0.0403 0.0439
Echinococcus granulosus mitogen activated protein kinase 3 0.0267 0.3219 0.351
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0395 0.5116 1
Loa Loa (eye worm) hypothetical protein 0.017 0.177 0.177
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0438 0.5752 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0126 0.1129 0.1231
Schistosoma mansoni serine/threonine protein kinase 0.0438 0.5752 0.6272
Brugia malayi intermediate filament protein 0.0081 0.0459 0.0459
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0951 0.1037

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.