Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0543 | 0.151 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.205 | 0.1944 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0321 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1907 | 0.1799 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1547 | 0.4427 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0132 | 0.0366 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1729 | 0.1619 |
Trypanosoma brucei | ISWI complex protein | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.1547 | 0.4427 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.04 | 0.0272 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2282 | 0.6345 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0177 | 0.0047 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0321 | 0.0891 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0132 | 0.0366 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0543 | 0.1287 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2282 | 0.1683 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0543 | 0.1287 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.1724 | 0.1081 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.3597 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.4154 | 0.4076 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.3328 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.3328 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2282 | 0.6727 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2282 | 0.6727 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2282 | 0.6345 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.04 | 0.1112 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2282 | 0.6727 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0132 | 0.0366 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2282 | 0.6727 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2282 | 0.2179 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0132 | 0.0366 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2282 | 0.6345 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.4475 | 0.4046 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0321 | 0.0592 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.