Detailed information for compound 1205171

Basic information

Technical information
  • TDR Targets ID: 1205171
  • Name: [(2S,3S,6S)-3-(4-methylphenoxy)-6-(2-phenylet hynyl)-3,6-dihydro-2H-pyran-2-yl]methyl (4E)- 4-[2-[(2R,5S,6S)-5-acetyloxy-6-(acetyloxymeth yl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]pen tanoate
  • MW: 673.749 | Formula: C38H43NO10
  • H donors: 0 H acceptors: 3 LogP: 4.95 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(OC[C@@H]1O[C@H](C#Cc2ccccc2)C=C[C@@H]1Oc1ccc(cc1)C)CC/C(=N/OCC[C@@H]1C=C[C@@H]([C@@H](O1)COC(=O)C)OC(=O)C)/C
  • InChi: 1S/C38H43NO10/c1-26-10-14-31(15-11-26)47-35-20-17-32(16-13-30-8-6-5-7-9-30)48-37(35)25-44-38(42)21-12-27(2)39-45-23-22-33-18-19-34(46-29(4)41)36(49-33)24-43-28(3)40/h5-11,14-15,17-20,32-37H,12,21-25H2,1-4H3/b39-27+/t32-,33+,34+,35+,36+,37+/m1/s1
  • InChiKey: VASUPCKMVCFTTK-KKBMKLACSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2S,3S,6S)-3-(4-methylphenoxy)-6-(2-phenylethynyl)-3,6-dihydro-2H-pyran-2-yl]methyl (4E)-4-[2-[(2R,5S,6S)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]pentanoate
  • (4E)-4-[2-[(2R,5S,6S)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]pentanoic acid [(2S,3S,6S)-3-(4-methylphenoxy)-6-(2-phenylethynyl)-3,6-dihydro-2H-pyran-2-yl]methyl ester
  • (4E)-4-[2-[(2R,5S,6S)-5-acetoxy-6-(acetoxymethyl)-5,6-dihydro-2H-pyran-2-yl]ethoxyimino]valeric acid [(2S,3S,6S)-3-(4-methylphenoxy)-6-(2-phenylethynyl)-3,6-dihydro-2H-pyran-2-yl]methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0035 0.0026
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0096
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0371 0.0363
Echinococcus multilocularis peregrin 0.0036 0.0249 0.0241
Echinococcus multilocularis zinc finger protein 0.0025 0.0119 0.011
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1622 0.447
Brugia malayi hypothetical protein 0.0024 0.0108 0.0177
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.011 0.0303
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0305 0.1186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0071 0.0062
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0047 0.013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.1585 0.1577
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0071 0.0115
Echinococcus multilocularis tar DNA binding protein 0.0533 0.6116 0.6112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1585 0.1577
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0047 0.013
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0048 0.0131
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0047 0.1327
Echinococcus multilocularis snurportin 1 0.0357 0.4039 0.4034
Brugia malayi Cytochrome P450 family protein 0.0019 0.0045 0.0074
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0071 0.0062
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0035 0.0057
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0132 0.1498
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0448 0.044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0071 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0305 0.0841
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0355 0.0977
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0071 0.0062
Loa Loa (eye worm) hypothetical protein 0.0047 0.0373 0.0609
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0018 0.001
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0047 0.013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0373 0.0364
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0448 0.044
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0045 0.0124
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0047 0.1327
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0071 0.0274
Brugia malayi mbt repeat family protein 0.0047 0.0371 0.0607
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0305 0.1186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0047 0.013
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0371 0.1445
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0472 0.13
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.2009 0.2002
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0305 0.0297
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0088 0.0244
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.2039 0.2033
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0071 0.0115
Entamoeba histolytica hypothetical protein 0.0027 0.0132 0.373
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0653 0.0645
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0047 0.019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0071 0.0062
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0305 0.1186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0047 0.013
Brugia malayi RNA binding protein 0.0533 0.6116 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0035 0.0057
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0071 0.0062
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0071 0.0062
Onchocerca volvulus 0.0233 0.2571 1
Brugia malayi CXXC zinc finger family protein 0.0033 0.0213 0.0348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.1622 0.447
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0026
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.2009 0.3285
Loa Loa (eye worm) hypothetical protein 0.0071 0.0653 0.1068
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.2238 0.3659
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0653 0.254
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0305 0.0841
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0686 0.0678
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0132 0.0365
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0374
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.011 0.018
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0229 0.0374
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.011 0.0303
Schistosoma mansoni hypothetical protein 0.0288 0.3221 0.3215
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0173 0.0164
Brugia malayi beta-lactamase 0.0071 0.0653 0.1068
Loa Loa (eye worm) hypothetical protein 0.0071 0.0653 0.1068
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0355 0.0977
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0373 0.0364
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0371 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0071 0.0062
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0371 0.0607
Brugia malayi jmjC domain containing protein 0.0098 0.0978 0.1599
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0105 0.0096
Mycobacterium tuberculosis Conserved protein 0.0071 0.0653 0.1209
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0071 0.0062
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0071 0.0062
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0315 0.0869
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.3628 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0161 0.0444
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0071 0.0062
Onchocerca volvulus 0.003 0.0173 0.0674
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.055 0.0899
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0315 0.8886
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0653 1
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0653 0.18
Entamoeba histolytica hypothetical protein 0.0027 0.014 0.3934
Giardia lamblia GTOR 0.0019 0.0047 0.0386
Brugia malayi Importin beta-1 subunit 0.0033 0.0214 0.035
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0071 0.0062
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0448 0.044
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0292 0.0284
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0009 0.0014
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0045 0.0074
Loa Loa (eye worm) beta-lactamase 0.0071 0.0653 0.1068
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0071 0.0062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0071 0.0115
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0047 0.013
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0047 0.013
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0315 0.0307
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0451 0.5147 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Loa Loa (eye worm) hypothetical protein 0.0033 0.0214 0.035
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0653 0.1209
Brugia malayi beta-lactamase family protein 0.0071 0.0653 0.1068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Leishmania major cytochrome p450-like protein 0.0019 0.0045 0.0124
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0305 0.0499
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.009 0.0147
Schistosoma mansoni hypothetical protein 0.0474 0.5427 0.5423
Onchocerca volvulus Alhambra homolog 0.003 0.0173 0.0673
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0047 0.0038
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0047 0.013
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0355 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0071 0.0115
Schistosoma mansoni alpha glucosidase 0.0041 0.0305 0.0297
Schistosoma mansoni hypothetical protein 0.002 0.006 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0373 0.0364
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0173 0.0164
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0047 0.013
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0035 0.0026
Brugia malayi PHD-finger family protein 0.0031 0.0181 0.0297
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.1456 0.238
Schistosoma mansoni ran 0.0025 0.011 0.0101
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0071 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Echinococcus granulosus snurportin 1 0.0357 0.4039 0.4034
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0045 0.0124
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0052 0.0431 0.6087
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0247 0.0239
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0305 0.1186
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.014 0.0543
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0315 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0047 0.0038
Brugia malayi Cytochrome P450 family protein 0.0032 0.0192 0.0315
Onchocerca volvulus 0.0071 0.0653 0.254
Echinococcus granulosus tar DNA binding protein 0.0533 0.6116 0.6112
Loa Loa (eye worm) hypothetical protein 0.0071 0.0653 0.1068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0071 0.0062
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.2009 0.2002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0047 0.0077
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0132 0.0124
Schistosoma mansoni hypothetical protein 0.003 0.0173 0.0164
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0047 0.013
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0105 0.0096
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.1585 0.1577
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0071 0.0062
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0355 1
Loa Loa (eye worm) MBCTL1 0.0053 0.0448 0.0732
Loa Loa (eye worm) hypothetical protein 0.0042 0.0315 0.0515
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0048 0.0131
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0305 0.86
Plasmodium vivax hypothetical protein, conserved 0.003 0.0173 0.2236
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0071 0.0062
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0588 0.058
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0132 0.0124
Mycobacterium leprae Probable lipase LipE 0.0071 0.0653 0.5
Trypanosoma brucei glucosidase, putative 0.0041 0.0305 0.0841
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0071 0.0062
Loa Loa (eye worm) hypothetical protein 0.0024 0.0108 0.0177
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0071 0.0115
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1585 0.1577
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0071 0.0115
Leishmania major hypothetical protein, conserved 0.0071 0.0653 0.18
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0686 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.017 0.1834 0.1827
Leishmania major DNA polymerase eta, putative 0.0042 0.0315 0.0869
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0108 0.2294
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0305 0.0841
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Schistosoma mansoni cpg binding protein 0.0037 0.0257 0.0249
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0239 0.0231
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.017 0.1834 0.1827
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0653 0.3453
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0035 0.0096
Schistosoma mansoni tar DNA-binding protein 0.0533 0.6116 0.6112
Echinococcus granulosus zinc finger protein 0.0025 0.0119 0.011
Trichomonas vaginalis bromodomain-containing protein, putative 0.0052 0.0431 0.1676
Toxoplasma gondii hypothetical protein 0.0052 0.0433 0.6123
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0132 0.0124
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0047 0.0038
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0173 0.0164
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0047 0.013
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0355 0.0977
Brugia malayi Pre-SET motif family protein 0.003 0.0173 0.0283
Brugia malayi nuclear hormone receptor 0.0021 0.0071 0.0115
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0448 0.044
Schistosoma mansoni tar DNA-binding protein 0.0533 0.6116 0.6112
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0315 0.1566
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0419 0.0684
Brugia malayi acetyltransferase, GNAT family protein 0.017 0.1834 0.2998
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0173 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0071 0.0115
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0315 0.0869
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.1585 0.1577
Echinococcus multilocularis cpg binding protein 0.0037 0.0257 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0653 0.1209
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0018 0.001
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0214 0.0591
Onchocerca volvulus 0.0033 0.0213 0.0827
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0149 0.1585 0.2591
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0108 0.1128
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0173 0.2123
Echinococcus granulosus dna polymerase kappa 0.0042 0.0315 0.0307
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0322 0.3628 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0071 0.0115
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0653 0.1209
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.011 0.1155
Echinococcus granulosus histone acetyltransferase KAT2B 0.0052 0.0431 0.0423
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.011 0.2351
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0018 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0149 0.1585 0.2591
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.011 0.1217
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0047 0.0038
Onchocerca volvulus 0.0047 0.0371 0.1445
Echinococcus granulosus cpg binding protein 0.0037 0.0257 0.0249
Echinococcus multilocularis dna polymerase eta 0.0042 0.0315 0.0307
Echinococcus granulosus dna polymerase eta 0.0042 0.0315 0.0307
Brugia malayi Pre-SET motif family protein 0.0205 0.2238 0.3659
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0161 0.0444
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0419 0.0684
Echinococcus granulosus peregrin 0.0036 0.0249 0.0241
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0018 0.001
Schistosoma mansoni alpha-glucosidase 0.0159 0.1704 0.1697
Schistosoma mansoni DNA polymerase eta 0.0042 0.0315 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0071 0.0115
Trichomonas vaginalis esterase, putative 0.0071 0.0653 0.254
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0653 0.0645
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0312 0.0303
Loa Loa (eye worm) hypothetical protein 0.003 0.0173 0.0283
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0653 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Schistosoma mansoni importin beta-1 0.0033 0.0214 0.0206
Schistosoma mansoni ran 0.0025 0.011 0.0101
Trypanosoma brucei unspecified product 0.0029 0.0161 0.0444
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0108 0.0298
Trypanosoma brucei DNA polymerase eta, putative 0.0042 0.0315 0.0869
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0071 0.0062
Loa Loa (eye worm) hypothetical protein 0.007 0.0646 0.1056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0071 0.0115
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0653 0.0645
Leishmania major GTP-binding protein, putative 0.0025 0.011 0.0303
Leishmania major mitochondrial DNA polymerase beta 0.0322 0.3628 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0292 0.0478
Mycobacterium tuberculosis Conserved hypothetical protein 0.017 0.1825 0.3502
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0653 0.1209
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0315 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0686 0.3636
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0132 0.0365
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0052 0.0431 0.1676
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0071 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0355 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0035 0.0979
Brugia malayi Bromodomain containing protein 0.008 0.0767 0.1254
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0239 0.0231
Brugia malayi RNA recognition motif domain containing protein 0.0533 0.6116 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0071 0.0115
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0315 0.0549
Schistosoma mansoni alpha-glucosidase 0.0159 0.1704 0.1697
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0448 0.044
Loa Loa (eye worm) hypothetical protein 0.0048 0.0389 0.0636
Plasmodium falciparum importin beta, putative 0.0033 0.0214 0.5613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0074 0.0121
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0045 0.0124
Loa Loa (eye worm) RNA binding protein 0.0533 0.6116 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0653 0.1068
Schistosoma mansoni bromodomain containing protein 0.0069 0.063 0.0622
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0315 0.0515
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0653 0.254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0071 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0071 0.0115
Schistosoma mansoni hypothetical protein 0.0035 0.0229 0.022
Brugia malayi hypothetical protein 0.0016 0.0006 0.0009
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0071 0.0274
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0686 0.189
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0214 0.0591
Trichomonas vaginalis importin beta-1, putative 0.0027 0.014 0.0543
Brugia malayi MH2 domain containing protein 0.0138 0.1456 0.238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Brugia malayi PHD-finger family protein 0.003 0.0173 0.0283
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0047 0.0077
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0653 0.3453
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0047 0.0038
Brugia malayi Bromodomain containing protein 0.0042 0.0315 0.0516
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.0115
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0052 0.0431 0.641
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0686 0.1273
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0315 0.1566
Brugia malayi jmjC domain containing protein 0.004 0.0292 0.0478
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0686 0.3636
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0653 0.254
Loa Loa (eye worm) hypothetical protein 0.0038 0.0268 0.0438
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0071 0.0062
Mycobacterium ulcerans hypothetical protein 0.017 0.1825 1
Onchocerca volvulus 0.0107 0.1086 0.4223
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0071 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0071 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0315 0.0869
Plasmodium falciparum phd finger protein, putative 0.003 0.0173 0.432
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0653 0.254
Leishmania major hypothetical protein, conserved 0.0024 0.0108 0.0298
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0132 0.0216
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0653 0.18
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0071 0.0062
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0152 0.0143
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0047 0.013
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0071 0.0115
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0292 0.0284
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0315 0.0869
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0071 0.0062
Loa Loa (eye worm) hypothetical protein 0.0071 0.0653 0.1068
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.1456 0.238
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0686 0.0678
Brugia malayi Bromodomain containing protein 0.0036 0.0249 0.0408
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0686 0.3636
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0371 0.0363
Echinococcus granulosus importin subunit beta 1 0.0033 0.0214 0.0206
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0035 0.0135
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0071 0.0062
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0071 0.0062
Mycobacterium ulcerans lipase LipD 0.0071 0.0653 0.3453
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0047 0.013
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0371 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0047 0.013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.014 0.0543
Schistosoma mansoni hypothetical protein 0.0861 1 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0371 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Schistosoma mansoni hypothetical protein 0.0357 0.4039 0.4034
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0419 0.0684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Loa Loa (eye worm) hypothetical protein 0.0051 0.0426 0.0696
Schistosoma mansoni jumonji domain containing protein 0.0078 0.074 0.0732
Loa Loa (eye worm) TAR-binding protein 0.0533 0.6116 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0533 0.6116 0.6112
Loa Loa (eye worm) hypothetical protein 0.0044 0.0344 0.0562
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0533 0.6116 1
Schistosoma mansoni eyes absent homolog 0.009 0.0887 0.0879
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0315 0.0515
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1622 0.447
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0653 0.254
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0071 0.0115
Loa Loa (eye worm) hypothetical protein 0.0051 0.0419 0.0684
Loa Loa (eye worm) PHD-finger family protein 0.002 0.006 0.0098
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0653 0.18
Mycobacterium ulcerans hypothetical protein 0.0071 0.0653 0.3453
Trichomonas vaginalis set domain proteins, putative 0.0233 0.2571 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0047 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0071 0.0115
Plasmodium vivax SET domain protein, putative 0.003 0.0173 0.2242
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0305 0.1186
Schistosoma mansoni zinc finger protein 0.0025 0.0119 0.011
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0173 0.0283
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0355 0.0977
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0214 0.2758
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0588 0.058
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0192 0.0315
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0305 0.1186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0132 0.0514
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0305 0.4152
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0653 0.1209
Schistosoma mansoni hypothetical protein 0.0861 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0315 0.1226
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.0115
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0305 0.1186
Trypanosoma brucei unspecified product 0.0029 0.0161 0.0444
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Schistosoma mansoni cpg binding protein 0.0037 0.0257 0.0249
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0371 0.0363
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0045 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.3628 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0305 0.0297
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.0115
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0653 0.1068
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0014
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.2039 0.2033
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0047 0.013
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0373 0.0364
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0653 0.1209
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.0115
Onchocerca volvulus 0.0071 0.0653 0.254
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0145
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0071 0.0062
Loa Loa (eye worm) hypothetical protein 0.009 0.0887 0.145
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.011 0.0303
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0071 0.0062
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0315 0.0549
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0035 0.5
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0071 0.0062
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0173 0.2123
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0357 0.4039 0.6604
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0653 0.1209
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0096
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0315 0.1226
Loa Loa (eye worm) hypothetical protein 0.009 0.0887 0.145
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0071 0.0115
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0173 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0108 0.1187
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0035 0.0096
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0035 0.0135
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0071 0.0062
Brugia malayi nuclear receptor NHR-88 0.0021 0.0071 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0071 0.0115
Echinococcus multilocularis geminin 0.0861 1 1
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0312 0.0303
Mycobacterium tuberculosis Conserved protein 0.0071 0.0653 0.1209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Echinococcus granulosus histone acetyltransferase KAT2B 0.0163 0.175 0.1743
Schistosoma mansoni coup transcription factor 0.0021 0.0071 0.0062
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0978 0.097
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0108 0.0298
Echinococcus granulosus dnaJ subfamily B 0.0474 0.5427 0.5423
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.011 0.2351
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0686 0.0678
Onchocerca volvulus 0.0071 0.0653 0.254
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0315 0.0307
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.0654 0.9512
Leishmania major DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Brugia malayi beta-lactamase family protein 0.0071 0.0653 0.1068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0071 0.0115
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0214 0.0206
Toxoplasma gondii ABC1 family protein 0.0071 0.0653 0.9496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Mycobacterium tuberculosis Conserved protein 0.0071 0.0653 0.1209
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0686 0.0678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Plasmodium vivax importin-beta 2, putative 0.0033 0.0214 0.2905
Brugia malayi steroid hormone receptor 0.0021 0.0071 0.0115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.1585 0.1577
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0371 0.0363
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0978 0.097
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0105 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0071 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.0115
Brugia malayi TAR-binding protein 0.0533 0.6116 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0315 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0071 0.0062
Schistosoma mansoni cpg binding protein 0.0033 0.0213 0.0204
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0315 0.0307
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0213 0.0348
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0009 0.0014
Echinococcus multilocularis dnaJ subfamily B 0.0474 0.5427 0.5423
Schistosoma mansoni tar DNA-binding protein 0.0533 0.6116 0.6112
Giardia lamblia DINP protein human, muc B family 0.0042 0.0315 0.8765
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.011 0.018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0071 0.0115
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0448 0.0732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0071 0.0115
Loa Loa (eye worm) acetyltransferase 0.017 0.1834 0.2998
Schistosoma mansoni tar DNA-binding protein 0.0533 0.6116 0.6112
Loa Loa (eye worm) hypothetical protein 0.0047 0.0371 0.0607
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0047 0.0077
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0653 0.0645
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0071 0.0115
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0052 0.0431 0.6087
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0305 0.1186
Brugia malayi RNA, U transporter 1 0.0095 0.0943 0.1542
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0315 0.0869
Leishmania major importin beta-1 subunit, putative 0.0027 0.014 0.0385
Entamoeba histolytica Ran family GTPase 0.0025 0.011 0.31
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0173 0.0165
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0305 0.86
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0071 0.0062
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0667 0.0659
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0305 0.1186
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0292 0.0284
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0108 0.0298
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0035 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.2009 0.2002
Brugia malayi mbt repeat family protein 0.0047 0.0371 0.0607
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0161 0.0444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0047 0.0077
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0045 0.0037
Loa Loa (eye worm) hypothetical protein 0.0071 0.0653 0.1068
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.014 0.0385
Brugia malayi ecdysteroid receptor 0.0021 0.0071 0.0115
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0173 0.2129
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0045 0.0074
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0108 0.2294
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.011 0.0101
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.2009 0.3285
Trichomonas vaginalis ran, putative 0.0025 0.011 0.0428
Brugia malayi hypothetical protein 0.009 0.0887 0.145
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0045 0.0058
Mycobacterium ulcerans beta-lactamase 0.0071 0.0653 0.3453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Giardia lamblia PHD finger protein 15 0.003 0.0173 0.432
Brugia malayi Cytochrome P450 family protein 0.0019 0.0045 0.0074
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.011 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0315 0.0869
Loa Loa (eye worm) hypothetical protein 0.0071 0.0653 0.1068
Loa Loa (eye worm) hypothetical protein 0.0053 0.0448 0.0732
Onchocerca volvulus 0.0021 0.0071 0.0274
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0305 0.0499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0047 0.0183
Trypanosoma brucei unspecified product 0.0042 0.0315 0.0869
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0009 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.1585 0.1577

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.16227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 6.309573445 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (ADMET) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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