Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0024 | 0.0509 | 0.0509 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0126 | 0.6528 | 0.6528 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0126 | 0.6528 | 0.6528 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.7586 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0126 | 0.6528 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.7586 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.005 | 0.2024 | 0.2024 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1089 | 0.1089 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0024 | 0.0509 | 0.0509 |
Brugia malayi | isocitrate dehydrogenase | 0.005 | 0.2024 | 0.2668 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.7586 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.005 | 0.2024 | 0.2024 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1089 | 0.1436 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.3667 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2028 | 0.2673 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0055 | 0.2288 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0126 | 0.6528 | 0.6528 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.005 | 0.2024 | 0.2024 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0509 | 0.0509 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0055 | 0.2288 | 0.0587 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0126 | 0.6528 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2028 | 0.2673 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.2024 | 0.2024 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0055 | 0.2288 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0126 | 0.6528 | 0.6528 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0126 | 0.6528 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2288 | 0.3017 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0126 | 0.6528 | 1 |
Echinococcus multilocularis | geminin | 0.0185 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0126 | 0.6528 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.2288 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.2024 | 0.2024 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.005 | 0.2024 | 0.2024 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.3667 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.005 | 0.2024 | 0.2024 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2028 | 0.2673 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.2288 | 0.0587 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.3667 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.3667 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.3667 | 0.3667 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1089 | 0.1436 |
Brugia malayi | hypothetical protein | 0.0055 | 0.2288 | 0.3017 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0078 | 0.3667 | 0.3667 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0078 | 0.3667 | 0.3667 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2028 | 0.2673 |
Brugia malayi | Isocitrate dehydrogenase | 0.005 | 0.2024 | 0.2668 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0078 | 0.3667 | 0.3667 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1145 | 0.1509 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.005 | 0.2024 | 0.2668 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0126 | 0.6528 | 0.5 |
Brugia malayi | hypothetical protein | 0.0078 | 0.3667 | 0.4835 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.2288 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.2288 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.2288 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.