Detailed information for compound 1205593

Basic information

Technical information
  • TDR Targets ID: 1205593
  • Name: [2-(furan-2-ylmethylamino)-2-oxoethyl] 2-(3,4 ,5-trimethoxyphenyl)acetate
  • MW: 363.362 | Formula: C18H21NO7
  • H donors: 1 H acceptors: 2 LogP: 1.57 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CC(=O)OCC(=O)NCc2ccco2)cc(c1OC)OC
  • InChi: 1S/C18H21NO7/c1-22-14-7-12(8-15(23-2)18(14)24-3)9-17(21)26-11-16(20)19-10-13-5-4-6-25-13/h4-8H,9-11H2,1-3H3,(H,19,20)
  • InChiKey: RBDQVOHJFRYOCE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(2-furylmethylamino)-2-oxo-ethyl] 2-(3,4,5-trimethoxyphenyl)acetate
  • 2-(3,4,5-trimethoxyphenyl)acetic acid [2-(2-furylmethylamino)-2-oxoethyl] ester
  • 2-(3,4,5-trimethoxyphenyl)acetic acid [2-(2-furylmethylamino)-2-keto-ethyl] ester
  • [2-(furan-2-ylmethylamino)-2-oxo-ethyl] 2-(3,4,5-trimethoxyphenyl)ethanoate
  • T0512-1706
  • ZINC03301993

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glutaminase 2 0.0299 0.3171 0.6286
Echinococcus granulosus tm gpcr rhodopsin 0.011 0.1021 0.1205
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011 0.1021 0.1205
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Onchocerca volvulus 0.011 0.1021 0.1735
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0031 0.012 0.0238
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0464 0.5045 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0066 0.0514 1
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus multilocularis transfer RNA-Gly 0.0026 0.0065 0.0065
Schistosoma mansoni lamin 0.0033 0.0141 0.0166
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0141 0.028
Loa Loa (eye worm) hypothetical protein 0.0078 0.0653 0.1293
Leishmania major histone deacetylase, putative 0.0136 0.1312 0.26
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0017 0.0034
Plasmodium vivax SET domain protein, putative 0.0066 0.0513 0.3723
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1021 0.1021
Echinococcus granulosus potassium voltage gated channel protein 0.0026 0.0065 0.0076
Echinococcus granulosus tissue type plasminogen activator 0.0024 0.0039 0.0046
Onchocerca volvulus 0.011 0.1021 0.1735
Entamoeba histolytica hypothetical protein 0.0065 0.0508 0.1006
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0464 0.5045 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.011 0.1021 0.1205
Echinococcus multilocularis lamin 0.0033 0.0141 0.0141
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.012 0.0142
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.011 0.1021 0.1205
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0377 0.0748
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0078 0.0653 0.077
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0026 0.0065 0.0076
Leishmania major hypothetical protein, unknown function 0.0026 0.0065 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1021 0.1205
Echinococcus multilocularis geminin 0.0371 0.3984 0.3984
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.011 0.1021 0.1735
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0065 0.0508 0.0599
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0017 0.0034
Onchocerca volvulus 0.011 0.1021 0.1735
Echinococcus multilocularis histone deacetylase 0.0039 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Loa Loa (eye worm) carboxylesterase 0.0461 0.5018 0.9947
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0026 0.0065 0.0128
Echinococcus multilocularis mitogen activated protein kinase 0.0031 0.012 0.012
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.003 0.0109 0.1666
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1021 0.1205
Echinococcus granulosus cytochrome P450 2K1 0.003 0.0109 0.0128
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0078
Echinococcus multilocularis serotonin receptor 0.011 0.1021 0.1021
Brugia malayi Histone deacetylase family protein 0.0039 0.0206 0.0409
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.046
Brugia malayi Histone deacetylase 1 0.0136 0.1312 0.26
Brugia malayi Carboxylesterase family protein 0.0078 0.0653 0.1293
Echinococcus multilocularis histone deacetylase 6 0.0039 0.0206 0.0206
Echinococcus granulosus hyperpolarization activated cyclic 0.0026 0.0065 0.0076
Onchocerca volvulus 0.011 0.1021 0.1735
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0022 0.0017 0.0034
Loa Loa (eye worm) histone deacetylase 11 0.0039 0.0206 0.0409
Echinococcus granulosus biogenic amine 5HT receptor 0.011 0.1021 0.1205
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Schistosoma mansoni 60S ribosomal protein L21 0.0026 0.0065 0.0076
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0141 0.028
Plasmodium falciparum histone deacetylase 1 0.0136 0.1312 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1021 0.1205
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0026 0.0065 0.0065
Onchocerca volvulus 0.011 0.1021 0.1735
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0026 0.0065 0.0128
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus granulosus intermediate filament protein 0.0033 0.0141 0.0166
Brugia malayi Melatonin receptor type 1A 0.011 0.1021 0.2024
Leishmania major histone deacetylase, putative 0.0136 0.1312 0.26
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0513 0.0986
Loa Loa (eye worm) hypothetical protein 0.0075 0.0619 0.1228
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.011 0.1021 0.1205
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus granulosus high affinity choline transporter 1 0.0372 0.3998 0.4718
Echinococcus granulosus transient receptor potential cation channel 0.0026 0.0065 0.0076
Echinococcus multilocularis neuroligin 0.0078 0.0653 0.0653
Toxoplasma gondii histone deacetylase HDAC2 0.0136 0.1312 0.2575
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Loa Loa (eye worm) melatonin receptor type 1A 0.011 0.1021 0.2024
Echinococcus multilocularis conserved hypothetical protein 0.0026 0.0065 0.0065
Trichomonas vaginalis histone deacetylase, putative 0.0136 0.1312 0.2301
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.0109 0.0215
Brugia malayi hypothetical protein 0.0026 0.0065 0.0128
Echinococcus granulosus potassium voltage gated channel protein 0.0026 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.0053 0.0372 0.0737
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.052 0.0614
Echinococcus multilocularis histone deacetylase 6 0.0039 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Loa Loa (eye worm) carboxylesterase 0.0078 0.0653 0.1293
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0022 0.0017 0.003
Brugia malayi GnHR receptor homolog 0.011 0.1021 0.2024
Brugia malayi G protein-coupled receptor 0.011 0.1021 0.2024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0087 0.0758 0.0895
Schistosoma mansoni biogenic amine (5HT) receptor 0.011 0.1021 0.1205
Onchocerca volvulus 0.0033 0.0141 0.018
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.017 0.0337
Brugia malayi Dopamine receptor protein 1 0.011 0.1021 0.2024
Trypanosoma cruzi histone deacetylase 1, putative 0.0136 0.1312 0.26
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0377 0.0748
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0065 0.0114
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Schistosoma mansoni histone deacetylase 1 2 3 0.0039 0.0206 0.0243
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0078 0.0653 1
Schistosoma mansoni cytochrome P450 0.003 0.0109 0.0128
Schistosoma mansoni histone deacetylase 0.0136 0.1312 0.1548
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Echinococcus multilocularis dro:myosuppressin receptor 0.011 0.1021 0.1021
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.011 0.1021 0.1205
Trichomonas vaginalis histone deacetylase, putative 0.0136 0.1312 0.2301
Loa Loa (eye worm) hypothetical protein 0.0054 0.0377 0.0748
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.1088 0.2156
Brugia malayi hypothetical protein 0.011 0.1021 0.2024
Mycobacterium ulcerans hypothetical protein 0.0054 0.0377 0.0748
Echinococcus multilocularis tachykinin peptides receptor 99D 0.011 0.1021 0.1021
Brugia malayi hypothetical protein 0.0078 0.0653 0.1293
Echinococcus multilocularis voltage gated potassium channel 0.0026 0.0065 0.0065
Echinococcus granulosus neutral alpha glucosidase AB 0.0022 0.0017 0.002
Schistosoma mansoni transient receptor potential channel 4 0.0026 0.0065 0.0076
Echinococcus multilocularis musashi 0.0033 0.0141 0.0141
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0026 0.0065 0.0076
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0464 0.5045 1
Schistosoma mansoni histone deacetylase 0.0136 0.1312 0.1548
Echinococcus multilocularis potassium large conductance calcium activated 0.0026 0.0065 0.0065
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0026 0.0065 0.0045
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.011 0.1021 0.1021
Schistosoma mansoni glutaminase 0.0299 0.3171 0.3742
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0464 0.5045 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0072 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1021 0.1021
Echinococcus granulosus g protein coupled receptor 0.011 0.1021 0.1205
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0072 0.0143
Giardia lamblia Histone deacetylase 0.0136 0.1312 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0026 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.1006
Echinococcus granulosus sodium leak channel non selective protein 0.0026 0.0065 0.0076
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.003 0.0109 0.1666
Loa Loa (eye worm) hypothetical protein 0.0464 0.5045 1
Echinococcus granulosus acetylcholinesterase 0.0461 0.5018 0.5921
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.011 0.1021 0.1205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0377 0.5784
Loa Loa (eye worm) hypothetical protein 0.0055 0.0389 0.0771
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0072 0.0143
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0066 0.0514 0.0607
Schistosoma mansoni hypothetical protein 0.011 0.1021 0.1205
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0031 0.012 0.0205
Echinococcus multilocularis thymidylate synthase 0.0066 0.0514 0.0514
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.003 0.0109 0.0215
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0026 0.0065 0.0128
Echinococcus granulosus neuropeptide receptor A26 0.011 0.1021 0.1205
Echinococcus multilocularis ryanodine receptor 44f 0.0026 0.0065 0.0065
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0031 0.012 0.0238
Loa Loa (eye worm) voltage-gated potassium channel 0.0026 0.0065 0.0128
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0026 0.0065 0.0076
Schistosoma mansoni transient receptor potential channel 0.0026 0.0065 0.0076
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0026 0.0065 0.0128
Schistosoma mansoni transient receptor potential channel 0.0026 0.0065 0.0076
Leishmania major cytochrome p450-like protein 0.003 0.0109 0.0215
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1021 0.1205
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.011 0.1021 0.2024
Brugia malayi histone deacetylase 1 (HD1) 0.0136 0.1312 0.26
Loa Loa (eye worm) hypothetical protein 0.0136 0.1312 0.26
Trichomonas vaginalis histone deacetylase, putative 0.0136 0.1312 0.2301
Loa Loa (eye worm) ryanodine receptor 0.0026 0.0065 0.0128
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0026 0.0065 0.0076
Echinococcus multilocularis histone deacetylase 6 0.0039 0.0206 0.0206
Echinococcus multilocularis histone deacetylase 8 0.0039 0.0206 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.0075 0.0619 0.1228
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0377 0.0748
Echinococcus multilocularis two pore calcium channel protein 2 0.0026 0.0065 0.0065
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.0377 0.6919
Echinococcus granulosus 7TM GPCR rhodopsin 0.011 0.1021 0.1205
Brugia malayi Kringle domain containing protein 0.0024 0.0039 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0377 0.0748
Brugia malayi hypothetical protein 0.011 0.1021 0.2024
Schistosoma mansoni microtubule-associated protein tau 0.0765 0.8475 1
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1021 0.1205
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.017 0.0337
Loa Loa (eye worm) hypothetical protein 0.0078 0.0653 0.1293
Brugia malayi Cytochrome P450 family protein 0.0116 0.1088 0.2156
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.011 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus granulosus sodium:myo inositol cotransporter 0.0041 0.0232 0.0274
Trichomonas vaginalis sucrase-isomaltase, putative 0.0022 0.0017 0.003
Onchocerca volvulus 0.0078 0.0653 0.1084
Loa Loa (eye worm) voltage-gated potassium channel 0.0026 0.0065 0.0128
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0508 0.3681
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0407 0.4398 0.519
Echinococcus multilocularis serotonin receptor 0.011 0.1021 0.1021
Trypanosoma brucei protein kinase, putative 0.0031 0.012 0.0238
Trypanosoma cruzi histone deacetylase, putative 0.0039 0.0206 0.0409
Echinococcus granulosus neuropeptide Y receptor 0.011 0.1021 0.1205
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0026 0.0065 0.0065
Echinococcus multilocularis G-protein coupled receptor, putative 0.011 0.1021 0.1021
Onchocerca volvulus 0.0055 0.0389 0.0618
Plasmodium vivax polyprenol reductase, putative 0.0065 0.0508 0.3681
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0461 0.5018 0.5921
Loa Loa (eye worm) hypothetical protein 0.0078 0.0653 0.1293
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0026 0.0065 0.0128
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.011 0.1021 0.1021
Loa Loa (eye worm) G-protein coupled receptor 0.011 0.1021 0.2024
Schistosoma mansoni alpha-glucosidase 0.0086 0.0743 0.0876
Loa Loa (eye worm) carboxylesterase 0.0078 0.0653 0.1293
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0136 0.1312 0.2301
Trichomonas vaginalis CMGC family protein kinase 0.0031 0.012 0.0211
Schistosoma mansoni neuropeptide F-like receptor 0.011 0.1021 0.1205
Onchocerca volvulus 0.0066 0.0513 0.0837
Trichomonas vaginalis alpha-glucosidase, putative 0.0022 0.0017 0.003
Echinococcus granulosus somatostatin receptor 0.011 0.1021 0.1205
Entamoeba histolytica hypothetical protein 0.0039 0.0212 0.0421
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0026 0.0065 0.0128
Brugia malayi hypothetical protein 0.011 0.1021 0.2024
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0026 0.0065 0.0076
Echinococcus granulosus lamin 0.0033 0.0141 0.0166
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Schistosoma mansoni neuropeptide F-like receptor 0.011 0.1021 0.1205
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0031 0.012 0.0238
Schistosoma mansoni neuropeptide receptor 0.011 0.1021 0.1205
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1021 0.1205
Schistosoma mansoni intermediate filament proteins 0.0033 0.0141 0.0166
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0026 0.0065 0.0065
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0458 0.498 0.9871
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0065 0.0508 0.0599
Echinococcus granulosus transient receptor potential cation channel 0.0026 0.0065 0.0076
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.052 0.1
Echinococcus granulosus histone deacetylase 6 0.0039 0.0206 0.0243
Echinococcus granulosus voltage gated potassium channel 0.0026 0.0065 0.0076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1021 0.1205
Echinococcus multilocularis two pore calcium channel protein 1 0.0026 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Brugia malayi Serotonin/octopamine receptor family protein 7 0.011 0.1021 0.2024
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Trypanosoma brucei histone deacetylase, putative 0.0039 0.0206 0.0409
Echinococcus multilocularis microtubule associated protein 2 0.0765 0.8475 0.8475
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1021 0.1205
Echinococcus multilocularis biogenic amine (5HT) receptor 0.011 0.1021 0.1021
Mycobacterium ulcerans carboxylesterase, LipT 0.0078 0.0653 0.1293
Schistosoma mansoni neuropeptide receptor 0.011 0.1021 0.1205
Brugia malayi Tachykinin-like peptides receptor 99D 0.011 0.1021 0.2024
Loa Loa (eye worm) G-protein coupled receptor 0.011 0.1021 0.2024
Echinococcus multilocularis 0.003 0.0109 0.0109
Brugia malayi Dopamine receptor protein 2 0.011 0.1021 0.2024
Echinococcus multilocularis neuropeptides capa receptor 0.011 0.1021 0.1021
Echinococcus multilocularis short transient receptor potential channel 6 0.0026 0.0065 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.003 0.0109 0.1666
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Onchocerca volvulus 0.011 0.1021 0.1735
Toxoplasma gondii histone deacetylase HDAC3 0.0136 0.1312 0.2575
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Onchocerca volvulus 0.0058 0.0422 0.0676
Echinococcus granulosus microtubule associated protein 2 0.0765 0.8475 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.052 0.1031
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.003 0.0109 0.0215
Brugia malayi Pre-SET motif family protein 0.0066 0.0513 0.1017
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.0508 0.089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.0758 0.0895
Schistosoma mansoni inositol transporter 0.0041 0.0232 0.0274
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0198 0.3029
Onchocerca volvulus 0.0078 0.0653 0.1084
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0041 0.0232 0.0274
Echinococcus multilocularis lysosomal alpha glucosidase 0.01 0.0901 0.0901
Echinococcus multilocularis mitogen activated protein kinase 3 0.0031 0.012 0.012
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0136 0.1312 0.2301
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0026 0.0065 0.0076
Echinococcus granulosus potassium voltage gated channel protein 0.0026 0.0065 0.0076
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0464 0.5045 0.885
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0087 0.0758 0.1503
Trypanosoma brucei histone deacetylase 2 0.0039 0.0206 0.0409
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0031 0.012 0.0238
Schistosoma mansoni hypothetical protein 0.0371 0.3984 0.4701
Echinococcus granulosus histone deacetylase 3 0.0136 0.1312 0.1548
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.0653 0.077
Echinococcus granulosus transient receptor potential cation channel 0.0026 0.0065 0.0076
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 0.0065 0.0076
Entamoeba histolytica hypothetical protein 0.0039 0.0212 0.0421
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0026 0.0065 0.0076
Echinococcus granulosus potassium voltage gated channel protein 0.0026 0.0065 0.0076
Echinococcus granulosus shaker cognate 0.0026 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.0078 0.0653 0.1293
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Echinococcus multilocularis neuropeptide receptor A26 0.011 0.1021 0.1021
Echinococcus multilocularis solute carrier family 5 0.0041 0.0232 0.0232
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.003 0.0109 0.1666
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0078 0.0653 0.0653
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.003 0.0109 0.0215
Echinococcus granulosus lysosomal alpha glucosidase 0.01 0.0901 0.1063
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0072 0.0109
Schistosoma mansoni voltage-dependent calcium channel 0.0026 0.0065 0.0076
Trypanosoma cruzi histone deacetylase, putative 0.0039 0.0206 0.0409
Leishmania major hypothetical protein, conserved 0.0027 0.0072 0.0143
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0026 0.0065 0.0076
Schistosoma mansoni BC026374 protein (S09 family) 0.0078 0.0653 0.077
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0041 0.0232 0.0232
Schistosoma mansoni hypothetical protein 0.0039 0.0212 0.0251
Echinococcus multilocularis hyperpolarization activated cyclic 0.0026 0.0065 0.0065
Onchocerca volvulus Huntingtin homolog 0.0075 0.0619 0.1025
Brugia malayi RE15519p 0.011 0.1021 0.2024
Loa Loa (eye worm) histone deacetylase 1 0.0136 0.1312 0.26
Leishmania major alpha glucosidase II subunit, putative 0.0022 0.0017 0.0034
Echinococcus multilocularis potassium voltage gated channel protein 0.0026 0.0065 0.0065
Echinococcus multilocularis neuropeptides capa receptor 0.011 0.1021 0.1021
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0026 0.0065 0.0076
Echinococcus multilocularis carboxylesterase 5A 0.0461 0.5018 0.5018
Mycobacterium leprae putative cytochrome p450 0.003 0.0109 0.0862
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.003 0.0109 0.0215
Schistosoma mansoni opsin-like receptor 0.011 0.1021 0.1205
Echinococcus granulosus sodium:glucose cotransporter 2 0.0041 0.0232 0.0274
Echinococcus multilocularis neutral alpha glucosidase AB 0.0022 0.0017 0.0017
Trypanosoma cruzi histone deacetylase, putative 0.0039 0.0206 0.0409
Trichomonas vaginalis maltase-glucoamylase, putative 0.0022 0.0017 0.003
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0464 0.5045 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0653 0.1293
Echinococcus multilocularis hyperpolarization activated cyclic 0.0026 0.0065 0.0065
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0026 0.0065 0.0128
Echinococcus multilocularis transient receptor potential cation channel 0.0026 0.0065 0.0065
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0026 0.0065 0.0065
Onchocerca volvulus 0.0078 0.0653 0.1084
Schistosoma mansoni hypothetical protein 0.0024 0.0039 0.0046
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 0.0065 0.0076
Trypanosoma brucei histone deacetylase 4 0.0039 0.0206 0.0409
Echinococcus granulosus histone deacetylase 1 0.0136 0.1312 0.1548
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0087 0.0758 0.0895
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0027 0.007 0.014
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.011 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.003 0.0109 0.0215
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.003 0.0109 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0513 0.0605
Loa Loa (eye worm) TYRA-2 protein 0.011 0.1021 0.2024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Echinococcus multilocularis g-protein coupled receptor 0.011 0.1021 0.1021
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0065 0.0508 0.1006
Echinococcus granulosus mitogen activated protein kinase 0.0031 0.012 0.0142
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.003 0.0109 0.1666
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.052 0.0614
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Trypanosoma brucei histone deacetylase 1 0.0136 0.1312 0.26
Echinococcus multilocularis calcium activated potassium channel 0.0027 0.0068 0.0068
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.003 0.0109 0.0215
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Echinococcus granulosus g protein coupled receptor 0.011 0.1021 0.1205
Echinococcus granulosus histone deacetylase 6 0.0039 0.0206 0.0243
Loa Loa (eye worm) ion channel NompC 0.0026 0.0065 0.0128
Onchocerca volvulus 0.011 0.1021 0.1735
Brugia malayi cation channel family protein 0.0026 0.0065 0.0128
Schistosoma mansoni amine GPCR 0.011 0.1021 0.1205
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.018 0.0357
Onchocerca volvulus 0.011 0.1021 0.1735
Toxoplasma gondii histone deacetylase HDAC5 0.0039 0.0206 0.0376
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Giardia lamblia Kinase, CMGC MAPK 0.0031 0.012 0.0917
Trichomonas vaginalis glutaminase, putative 0.0299 0.3171 0.5563
Echinococcus granulosus biogenic amine 5HT receptor 0.011 0.1021 0.1205
Schistosoma mansoni alpha glucosidase 0.0022 0.0017 0.002
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0026 0.0065 0.0065
Echinococcus multilocularis tissue type plasminogen activator 0.0024 0.0039 0.0039
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0041 0.0232 0.0232
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.011 0.1021 0.1205
Trichomonas vaginalis histone deacetylase, putative 0.0136 0.1312 0.2301
Schistosoma mansoni hypothetical protein 0.0053 0.0374 0.0441
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Onchocerca volvulus 0.0066 0.0514 0.0839
Echinococcus multilocularis BC026374 protein (S09 family) 0.0078 0.0653 0.0653
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Entamoeba histolytica histone deacetylase, putative 0.0136 0.1312 0.26
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0121 0.0213
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0026 0.0065 0.0076
Brugia malayi intermediate filament protein 0.0033 0.0141 0.028
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.003 0.0109 0.1666
Brugia malayi Glycosyl hydrolases family 31 protein 0.01 0.0901 0.1786
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0072 0.0258
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.011 0.1021 0.1205
Echinococcus multilocularis dihydrofolate reductase 0.0027 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Schistosoma mansoni growth hormone secretagogue receptor 0.011 0.1021 0.1205
Echinococcus granulosus voltage dependent calcium channel 0.0026 0.0065 0.0076
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.003 0.0109 0.1666
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Leishmania major histone deacetylase, putative 0.0039 0.0206 0.0409
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0093 0.082 0.1596
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0041 0.0232 0.0232
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0026 0.0065 0.0128
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Schistosoma mansoni histone deacetylase 4 5 0.0039 0.0206 0.0243
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.011 0.1021 0.2024
Loa Loa (eye worm) cytochrome P450 0.003 0.0109 0.0215
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.052 0.0614
Trichomonas vaginalis alpha-glucosidase, putative 0.0022 0.0017 0.003
Brugia malayi MAP kinase sur-1 0.0031 0.012 0.0238
Schistosoma mansoni histamine h1 receptor 0.011 0.1021 0.1205
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Echinococcus granulosus calcium activated potassium channel 0.0027 0.0068 0.008
Brugia malayi Serotonin receptor 0.011 0.1021 0.2024
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0513 0.0513
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.0461 0.5018 0.9947
Loa Loa (eye worm) hypothetical protein 0.004 0.0223 0.0441
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0464 0.5045 1
Onchocerca volvulus 0.011 0.1021 0.1735
Echinococcus granulosus dro:myosuppressin receptor 0.011 0.1021 0.1205
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Brugia malayi Cytochrome P450 family protein 0.0036 0.017 0.0337
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Brugia malayi histone deacetylase 3 (HD3) 0.0136 0.1312 0.26
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0054 0.0377 0.0748
Toxoplasma gondii hypothetical protein 0.0026 0.0065 0.0095
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0031 0.012 0.0238
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1021 0.1205
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Echinococcus granulosus thymidylate synthase 0.0066 0.0514 0.0607
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0198 0.3029
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0026 0.0065 0.0128
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0031 0.0121 0.0241
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0464 0.5045 1
Echinococcus granulosus neuropeptide s receptor 0.011 0.1021 0.1205
Brugia malayi Dihydrofolate reductase 0.0027 0.007 0.014
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0212 0.0212
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.0653 0.077
Loa Loa (eye worm) hypothetical protein 0.0372 0.3998 0.7925
Echinococcus granulosus TRP transient receptor potential channel 0.0026 0.0065 0.0076
Trichomonas vaginalis alpha-glucosidase, putative 0.0022 0.0017 0.003
Brugia malayi putative neuropeptide receptor 0.011 0.1021 0.2024
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.01 0.0901 0.1786
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0508 0.089
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.003 0.0109 0.0215
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0374 0.0741
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.011 0.1021 0.2024
Schistosoma mansoni inositol transporter 0.0041 0.0232 0.0274
Trichomonas vaginalis histone deacetylase, putative 0.0136 0.1312 0.2301
Echinococcus multilocularis histone deacetylase 1 0.0136 0.1312 0.1312
Onchocerca volvulus 0.011 0.1021 0.1735
Plasmodium vivax histone deacetylase, putative 0.0039 0.0206 0.1313
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0026 0.0065 0.0128
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Brugia malayi cytochrome P450 0.003 0.0109 0.0215
Loa Loa (eye worm) hypothetical protein 0.004 0.0223 0.0441
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.275 0.3244
Echinococcus granulosus transient receptor potential cation channel 0.0026 0.0065 0.0076
Echinococcus granulosus BC026374 protein S09 family 0.0078 0.0653 0.077
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Plasmodium falciparum polyprenol reductase, putative 0.0065 0.0508 0.3681
Echinococcus multilocularis transient receptor potential cation channel 0.0026 0.0065 0.0065
Echinococcus multilocularis alpha 1A adrenergic receptor 0.011 0.1021 0.1021
Echinococcus granulosus allatostatin A receptor 0.011 0.1021 0.1205
Echinococcus multilocularis transient receptor potential cation channel 0.0026 0.0065 0.0065
Echinococcus granulosus 7tm_1 domain containing protein 0.011 0.1021 0.1205
Onchocerca volvulus 0.0053 0.0374 0.0591
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0065 0.0508 0.0508
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0377 0.0748
Loa Loa (eye worm) hypothetical protein 0.0036 0.018 0.0357
Echinococcus multilocularis short transient receptor potential channel 6 0.0026 0.0065 0.0065
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0026 0.0065 0.0065
Brugia malayi larval opioid receptor 0.011 0.1021 0.2024
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0026 0.0065 0.0128
Echinococcus multilocularis neuropeptide FF receptor 2 0.011 0.1021 0.1021
Leishmania major histone deacetylase, putative 0.0039 0.0206 0.0409
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0065 0.0076
Brugia malayi GH02984p 0.0372 0.3998 0.7925
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.011 0.1021 0.1021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.0758 0.0895
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0377 0.0748
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.011 0.1021 0.1205
Echinococcus multilocularis tumor protein p63 0.0375 0.403 0.403
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.011 0.1021 0.2024
Toxoplasma gondii kringle domain-containing protein 0.0024 0.0039 0.0044
Brugia malayi G-protein coupled receptor 0.011 0.1021 0.2024
Echinococcus multilocularis transient receptor potential cation channel 0.0026 0.0065 0.0065
Brugia malayi Carboxylesterase family protein 0.0078 0.0653 0.1293
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.003 0.0109 0.0215
Plasmodium falciparum histone deacetylase 2 0.0039 0.0206 0.1313
Schistosoma mansoni hypothetical protein 0.011 0.1021 0.1205
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0026 0.0065 0.0065
Schistosoma mansoni neuropeptide f receptor 76f 0.011 0.1021 0.1205
Brugia malayi Carboxylesterase family protein 0.0461 0.5018 0.9947
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0389 0.0459
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Echinococcus granulosus short transient receptor potential channel 6 0.0026 0.0065 0.0076
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.0223 0.0441
Schistosoma mansoni acetylcholinesterase 0.0078 0.0653 0.077
Echinococcus multilocularis G protein coupled receptor 139 0.028 0.2957 0.2957
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0054 0.0377 0.0748
Schistosoma mansoni histone deacetylase hda2 0.0039 0.0206 0.0243
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0508 0.3681
Onchocerca volvulus 0.0054 0.0377 0.0598
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.004 0.0223 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0372 0.0737
Echinococcus granulosus histone deacetylase 8 0.0039 0.0206 0.0243
Echinococcus granulosus hypothetical protein 0.0026 0.0065 0.0076
Loa Loa (eye worm) voltage-gated calcium channel 0.0026 0.0065 0.0128
Schistosoma mansoni gliotactin 0.0078 0.0653 0.077
Echinococcus granulosus sex peptide receptor 0.011 0.1021 0.1205
Echinococcus multilocularis g protein coupled receptor 0.011 0.1021 0.1021
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.017 0.0337
Echinococcus multilocularis voltage gated potassium channel 0.0026 0.0065 0.0065
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.003 0.0109 0.1666
Trichomonas vaginalis CMGC family protein kinase 0.0031 0.012 0.0211
Echinococcus granulosus two pore calcium channel protein 1 0.0026 0.0065 0.0076
Leishmania major cytochrome p450-like protein 0.0036 0.017 0.0337
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Echinococcus granulosus tachykinin peptides receptor 99D 0.011 0.1021 0.1205
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0026 0.0065 0.0076
Brugia malayi Carboxylesterase family protein 0.0078 0.0653 0.1293
Brugia malayi Serotonin receptor 0.011 0.1021 0.2024
Trypanosoma brucei histone deacetylase 3 0.0039 0.0206 0.0409
Schistosoma mansoni voltage-gated ion channel 0.0026 0.0065 0.0076
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0065 0.0076
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.003 0.0109 0.1666
Loa Loa (eye worm) glutaminase 0.0299 0.3171 0.6286
Brugia malayi hypothetical protein 0.0027 0.0072 0.0143
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0093 0.082 0.1625
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0212 0.0251
Loa Loa (eye worm) neuropeptide F receptor 0.011 0.1021 0.2024
Echinococcus multilocularis lysosomal alpha glucosidase 0.01 0.0901 0.0901
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0026 0.0065 0.0128
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.003 0.0109 0.1666
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0041 0.0232 0.0427
Brugia malayi Sodium:solute symporter family protein 0.0041 0.0232 0.046
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.011 0.1021 0.1205
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.003 0.0109 0.0215
Brugia malayi voltage-dependent calcium channel 0.0026 0.0065 0.0128
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0464 0.5045 0.885
Brugia malayi hypothetical protein 0.0262 0.275 0.545
Brugia malayi thymidylate synthase 0.0066 0.0514 0.1019
Schistosoma mansoni neuroligin 3 (S09 family) 0.0078 0.0653 0.077
Loa Loa (eye worm) hypothetical protein 0.0054 0.0377 0.0748
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.003 0.0109 0.0215
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0072 0.0258
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Trichomonas vaginalis set domain proteins, putative 0.0521 0.5701 1
Schistosoma mansoni sodium/solute symporter 0.0041 0.0232 0.0274
Mycobacterium tuberculosis Carboxylesterase LipT 0.0078 0.0653 1
Brugia malayi Cytochrome P450 family protein 0.0036 0.017 0.0337
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.003 0.0109 0.0215
Trichomonas vaginalis alpha-glucosidase, putative 0.0022 0.0017 0.003
Schistosoma mansoni survival motor neuron protein 0.0053 0.0374 0.0441
Echinococcus granulosus histone deacetylase 7 0.0039 0.0206 0.0243
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0026 0.0065 0.0076
Echinococcus granulosus sodium:glucose cotransporter 0.0041 0.0232 0.0274
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.003 0.0109 0.0215
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0022 0.0017 0.0034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0141 0.028
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.003 0.0109 0.0215
Loa Loa (eye worm) hypothetical protein 0.0065 0.0508 0.1006
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.003 0.0109 0.0215
Brugia malayi glutaminase DH11.1 0.0299 0.3171 0.6286
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0026 0.0065 0.0114
Echinococcus multilocularis para nitrobenzyl esterase 0.0078 0.0653 0.0653
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0072 0.0143
Echinococcus granulosus acetylcholinesterase 0.0461 0.5018 0.5921
Giardia lamblia Synaptic glycoprotein SC2 0.0065 0.0508 0.387
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0065 0.0508 0.0976
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.003 0.0109 0.0215
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.011 0.1021 0.1205
Echinococcus multilocularis synaptic glycoprotein sc2 0.0065 0.0508 0.0508
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.003 0.0109 0.1666
Echinococcus granulosus neuropeptides capa receptor 0.011 0.1021 0.1205
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0078 0.0653 0.1145
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.003 0.0109 0.1666
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0026 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Schistosoma mansoni amine GPCR 0.011 0.1021 0.1205
Trichomonas vaginalis CMGC family protein kinase 0.0031 0.012 0.0211
Entamoeba histolytica acyl-coA synthetase, putative 0.0054 0.0377 0.0748
Echinococcus granulosus dihydrofolate reductase 0.0027 0.007 0.0083
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1021 0.1021
Schistosoma mansoni calcium-activated potassium channel 0.0026 0.0065 0.0076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.052 0.1031
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0026 0.0065 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0377 0.0748
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Brugia malayi hypothetical protein 0.0075 0.0619 0.1228
Brugia malayi putative neuropeptide receptor NPR1 0.011 0.1021 0.2024
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.003 0.0109 0.1666
Echinococcus granulosus hypothetical protein 0.011 0.1021 0.1205
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0377 0.0748
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0407 0.4398 0.8718
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus multilocularis high affinity choline transporter 1 0.0372 0.3998 0.3998
Schistosoma mansoni biogenic amine receptor 0.011 0.1021 0.1205
Schistosoma mansoni alpha-glucosidase 0.0086 0.0743 0.0876
Echinococcus multilocularis orexin receptor type 2 0.011 0.1021 0.1021
Echinococcus granulosus transient receptor potential cation channel 0.0026 0.0065 0.0076
Schistosoma mansoni neuropeptide receptor 0.011 0.1021 0.1205
Echinococcus multilocularis voltage dependent calcium channel 0.0026 0.0065 0.0065
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0039 0.0078
Echinococcus multilocularis g protein coupled receptor 0.011 0.1021 0.1021
Brugia malayi neuropeptide F receptor 0.011 0.1021 0.2024
Entamoeba histolytica hypothetical protein 0.0039 0.0212 0.0421
Loa Loa (eye worm) hypothetical protein 0.0078 0.0653 0.1293
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011 0.1021 0.1205
Onchocerca volvulus Neuropeptide F receptor homolog 0.011 0.1021 0.1735
Brugia malayi Carboxylesterase family protein 0.0461 0.5018 0.9947
Entamoeba histolytica hypothetical protein 0.0039 0.0212 0.0421
Onchocerca volvulus 0.0033 0.0141 0.018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1021 0.1021
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0026 0.0065 0.0128
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.052 0.797
Echinococcus multilocularis voltage dependent calcium channel 0.0026 0.0065 0.0065
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0027 0.007 0.108
Onchocerca volvulus 0.0078 0.0653 0.1084
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0026 0.0065 0.0065
Loa Loa (eye worm) calcium channel 0.0026 0.0065 0.0128
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0026 0.0065 0.0128
Echinococcus granulosus serotonin receptor 0.011 0.1021 0.1205
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0026 0.0065 0.0065
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.017 0.0337
Brugia malayi Transient-receptor-potential like protein 0.0026 0.0065 0.0128
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0065 0.0508 0.0976
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0513 0.0513
Trypanosoma cruzi histone deacetylase 1, putative 0.0136 0.1312 0.26
Echinococcus granulosus alpha 1A adrenergic receptor 0.011 0.1021 0.1205
Onchocerca volvulus 0.0026 0.0065 0.0045
Brugia malayi gonadotropin-releasing hormone receptor 2 0.011 0.1021 0.2024
Schistosoma mansoni myosin xvIII 0.011 0.1021 0.1205
Brugia malayi neuropeptide F receptor 0.011 0.1021 0.2024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0026 0.0065 0.0065
Echinococcus multilocularis acetylcholinesterase 0.0461 0.5018 0.5018
Schistosoma mansoni amine GPCR 0.011 0.1021 0.1205
Brugia malayi Histone deacetylase family protein 0.0039 0.0206 0.0409
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0031 0.012 0.0238
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.011 0.1021 0.1205
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Trichomonas vaginalis histone deacetylase, putative 0.0136 0.1312 0.2301
Schistosoma mansoni amine GPCR 0.011 0.1021 0.1205
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011 0.1021 0.1021
Schistosoma mansoni hypothetical protein 0.011 0.1021 0.1205
Echinococcus granulosus sodium channel protein 0.0407 0.4398 0.519
Echinococcus multilocularis sodium channel protein 0.0407 0.4398 0.4398
Schistosoma mansoni adenoreceptor 0.011 0.1021 0.1205
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1021 0.1205
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1021 0.1021
Plasmodium vivax histone deacetylase 1, putative 0.0136 0.1312 1
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.003 0.0109 0.0215
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0087 0.0758 0.0758
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1021 0.1205
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0065 0.0508 0.1006
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0026 0.0065 0.0128
Leishmania major lanosterol 14-alpha-demethylase, putative 0.003 0.0109 0.0215
Brugia malayi Protein kinase domain containing protein 0.0024 0.0039 0.0078
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0066 0.0514 0.788
Echinococcus granulosus g-protein coupled receptor 0.011 0.1021 0.1205
Echinococcus multilocularis neuropeptide s receptor 0.011 0.1021 0.1021
Echinococcus multilocularis g protein coupled receptor 0.011 0.1021 0.1021
Brugia malayi ion channel NompC 0.0026 0.0065 0.0128
Echinococcus multilocularis transient receptor potential cation channel 0.0026 0.0065 0.0065
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0508 0.1006
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1021 0.1021
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0377 0.0748
Brugia malayi follicle stimulating hormone receptor 0.011 0.1021 0.2024
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0026 0.0065 0.0076
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.011 0.1021 0.1205
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0136 0.1312 0.2301
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0026 0.0065 0.0065
Brugia malayi Cytochrome P450 family protein 0.003 0.0109 0.0215
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0054 0.0377 0.5784
Schistosoma mansoni voltage-gated cation channel 0.0026 0.0065 0.0076
Echinococcus granulosus solute carrier family 5 0.0041 0.0232 0.0274
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.003 0.0109 0.0215
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0513 0.0605
Echinococcus multilocularis potassium voltage gated channel protein 0.0026 0.0065 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1021 0.1205
Onchocerca volvulus 0.0041 0.0232 0.034
Brugia malayi AKH receptor 0.011 0.1021 0.2024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0143
Echinococcus granulosus transient receptor potential gamma protein 0.0026 0.0065 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0513 0.0605
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Trypanosoma brucei glucosidase, putative 0.0022 0.0017 0.0034
Loa Loa (eye worm) neuropeptide F receptor 0.011 0.1021 0.2024
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0026 0.0065 0.0065
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0026 0.0065 0.0076
Onchocerca volvulus 0.011 0.1021 0.1735
Brugia malayi dihydrofolate reductase family protein 0.0027 0.007 0.014
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.0653 0.077
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0065 0.0508 0.0599
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0513 0.0605
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0212 0.0251
Onchocerca volvulus 0.0078 0.0653 0.1084
Leishmania major cytochrome p450-like protein 0.003 0.0109 0.0215
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0022 0.0017 0.003
Echinococcus granulosus lamin dm0 0.0033 0.0141 0.0166
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011 0.1021 0.1021
Loa Loa (eye worm) acetylcholinesterase 1 0.0461 0.5018 0.9947
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.004 0.0223 0.3412
Schistosoma mansoni dihydrofolate reductase 0.0027 0.007 0.0083
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0054 0.0377 0.0748
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.003 0.0109 0.1666
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.011 0.1021 0.1205
Loa Loa (eye worm) hypothetical protein 0.0039 0.0206 0.0409
Loa Loa (eye worm) hypothetical protein 0.0461 0.5018 0.9947
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.0109 0.0182
Schistosoma mansoni lamin 0.0033 0.0141 0.0166
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus multilocularis potassium voltage gated channel protein 0.0026 0.0065 0.0065
Trypanosoma cruzi histone deacetylase, putative 0.0039 0.0206 0.0409
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0026 0.0065 0.0065
Trichomonas vaginalis spcc417.12 protein, putative 0.0078 0.0653 0.1145
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0026 0.0065 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0377 0.0748
Toxoplasma gondii transporter, cation channel family protein 0.0026 0.0065 0.0095
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.0508 0.089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1021 0.1205
Schistosoma mansoni biogenic amine receptor 0.011 0.1021 0.1205
Onchocerca volvulus 0.0065 0.0508 0.0827
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Toxoplasma gondii histone deacetylase HDAC1 0.0039 0.0206 0.0376
Echinococcus granulosus potassium voltage gated channel protein 0.0026 0.0065 0.0076
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.275 0.275
Echinococcus multilocularis sex peptide receptor 0.011 0.1021 0.1021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0065 0.0095
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0026 0.0065 0.0128
Brugia malayi Synaptic glycoprotein SC2 0.0065 0.0508 0.1006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0087 0.0758 0.0758
Brugia malayi hypothetical protein 0.011 0.1021 0.2024
Echinococcus multilocularis shaker cognate 0.0026 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Echinococcus multilocularis potassium voltage gated channel protein 0.0026 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0026 0.0065 0.0095
Loa Loa (eye worm) hypothetical protein 0.0078 0.0653 0.1293
Echinococcus granulosus voltage gated potassium channel 0.0026 0.0065 0.0076
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.003 0.0109 0.1666
Schistosoma mansoni histone deacetylase 4 5 0.0039 0.0206 0.0243
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.011 0.1021 0.1021
Schistosoma mansoni peptide (allatostatin)-like receptor 0.011 0.1021 0.1205
Echinococcus multilocularis rhodopsin orphan GPCR 0.011 0.1021 0.1021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.0377 0.6919
Onchocerca volvulus 0.011 0.1021 0.1735
Echinococcus granulosus short transient receptor potential channel 6 0.0026 0.0065 0.0076
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Echinococcus granulosus tm gpcr rhodopsin 0.011 0.1021 0.1205
Brugia malayi ORL1-like opioid receptor 0.011 0.1021 0.2024
Onchocerca volvulus 0.011 0.1021 0.1735
Echinococcus multilocularis acetylcholinesterase 0.0461 0.5018 0.5018
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0377 0.0748
Schistosoma mansoni alpha-1 adrenergic receptor 0.011 0.1021 0.1205
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0078 0.0653 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 0.0065 0.0076
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0026 0.0065 0.0128
Plasmodium falciparum histone deacetylase, putative 0.0039 0.0206 0.1313
Schistosoma mansoni opsin-like receptor 0.011 0.1021 0.1205
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0508 0.1006
Mycobacterium leprae Conserved hypothetical protein 0.003 0.0109 0.0862
Echinococcus granulosus tumor protein p63 0.0375 0.403 0.4755
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.003 0.0109 0.0215
Brugia malayi sulfakinin receptor protein 0.011 0.1021 0.2024
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0464 0.5045 0.885
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.052 0.1031
Schistosoma mansoni biogenic amine receptor 0.011 0.1021 0.1205
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.003 0.0109 0.1666
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.0485 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0508 0.089
Echinococcus multilocularis allatostatin A receptor 0.011 0.1021 0.1021
Toxoplasma gondii histone deacetylase HDAC4 0.0039 0.0206 0.0376
Trypanosoma brucei cytochrome P450, putative 0.0036 0.017 0.0337
Echinococcus granulosus G protein coupled receptor 139 0.011 0.1021 0.1205
Mycobacterium tuberculosis Hypothetical protein 0.0031 0.0121 0.186
Echinococcus granulosus voltage gated hydrogen channel 1 0.0026 0.0065 0.0076
Schistosoma mansoni hypothetical protein 0.0371 0.3984 0.4701
Toxoplasma gondii transporter, cation channel family protein 0.0026 0.0065 0.0095
Loa Loa (eye worm) follicle stimulating hormone receptor 0.011 0.1021 0.2024
Schistosoma mansoni ryanodine receptor related 0.0026 0.0065 0.0076
Echinococcus multilocularis fmrfamide receptor 0.011 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.011 0.1021 0.2024
Echinococcus multilocularis neuropeptide receptor 0.011 0.1021 0.1021
Schistosoma mansoni two-pore calcium channel 0.0026 0.0065 0.0076
Echinococcus granulosus neuropeptides capa receptor 0.011 0.1021 0.1205
Echinococcus multilocularis histone deacetylase 3 0.0136 0.1312 0.1312
Echinococcus granulosus geminin 0.0371 0.3984 0.4701
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0026 0.0065 0.0076
Echinococcus multilocularis neuropeptide Y receptor 0.011 0.1021 0.1021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0087 0.0758 0.0895
Leishmania major hypothetical protein, conserved 0.0026 0.0065 0.0128
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0026 0.0065 0.0128
Schistosoma mansoni biogenic amine (5HT) receptor 0.011 0.1021 0.1205
Schistosoma mansoni rhodopsin-like orphan GPCR 0.011 0.1021 0.1205
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.011 0.1021 0.1021
Mycobacterium ulcerans thymidylate synthase 0.0066 0.0514 0.1019
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0026 0.0065 0.0065
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0372 0.0737
Brugia malayi Dopamine receptor 0.011 0.1021 0.2024
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 0.0065 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0508 0.089
Loa Loa (eye worm) histone deacetylase 3 0.0136 0.1312 0.26
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0031 0.012 0.0238
Schistosoma mansoni amine GPCR 0.011 0.1021 0.1205
Plasmodium falciparum acyl-CoA synthetase 0.004 0.0223 0.1442
Mycobacterium ulcerans hypothetical protein 0.0464 0.5045 1
Echinococcus granulosus orexin receptor type 2 0.011 0.1021 0.1205
Echinococcus granulosus peptide allatostatin:somatostatin 0.011 0.1021 0.1205
Brugia malayi hypothetical protein 0.011 0.1021 0.2024
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0026 0.0065 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Loa Loa (eye worm) histone deacetylase 7A 0.0039 0.0206 0.0409
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0093 0.082 0.1625
Brugia malayi Cyclic-nucleotide gated cation channel 0.0026 0.0065 0.0128
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.011 0.1021 0.2024
Loa Loa (eye worm) thymidylate synthase 0.0066 0.0514 0.1019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0134 0.0266
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.011 0.1021 0.1205
Toxoplasma gondii hypothetical protein 0.0026 0.0065 0.0095
Brugia malayi hypothetical protein 0.011 0.1021 0.2024
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1021 0.1205
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0026 0.0065 0.0128
Plasmodium vivax histone deacetylase, putative 0.0039 0.0206 0.1313
Echinococcus granulosus para nitrobenzyl esterase 0.0078 0.0653 0.077
Echinococcus multilocularis transient receptor potential cation channel 0.0026 0.0065 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0039 0.0078
Schistosoma mansoni neuropeptide receptor 0.028 0.2957 0.3489
Leishmania major hypothetical protein, conserved 0.0024 0.0039 0.0078
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0128
Loa Loa (eye worm) hypothetical protein 0.004 0.0223 0.0441
Echinococcus granulosus ryanodine receptor 44f 0.0026 0.0065 0.0076
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.0508 0.089
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0372 0.0737
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0026 0.0065 0.0128
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0026 0.0065 0.0076
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.003 0.0109 0.1666
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.052 0.1031
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0093 0.082 0.1625
Onchocerca volvulus 0.011 0.1021 0.1735
Loa Loa (eye worm) hypothetical protein 0.004 0.0223 0.0441
Loa Loa (eye worm) histone deacetylase 0.0039 0.0206 0.0409
Brugia malayi olfactory channel protein osm-9 0.0026 0.0065 0.0128
Echinococcus granulosus neuropeptide receptor 0.028 0.2957 0.3489
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0109 0.0215
Echinococcus granulosus rhodopsin orphan GPCR 0.011 0.1021 0.1205
Trichomonas vaginalis CMGC family protein kinase 0.0031 0.012 0.0211
Echinococcus granulosus neuropeptide receptor 0.011 0.1021 0.1205
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0093 0.082 0.6134
Echinococcus multilocularis histone deacetylase 7 0.0039 0.0206 0.0206
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0026 0.0065 0.0076
Echinococcus multilocularis somatostatin receptor 0.011 0.1021 0.1021
Echinococcus granulosus carboxylesterase 5A 0.0461 0.5018 0.5921
Loa Loa (eye worm) hypothetical protein 0.0066 0.0513 0.1017
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.017 0.0337
Echinococcus granulosus transient receptor potential cation channel 0.0026 0.0065 0.0076
Echinococcus granulosus voltage dependent calcium channel 0.0026 0.0065 0.0076
Brugia malayi Pre-SET motif family protein 0.0458 0.498 0.9871
Echinococcus multilocularis fmrfamide receptor 0.011 0.1021 0.1021
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0141 0.028
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0026 0.0065 0.0128
Echinococcus granulosus two pore calcium channel protein 2 0.0026 0.0065 0.0076
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.011 0.1021 0.1021
Brugia malayi cation channel family protein 0.0026 0.0065 0.0128
Echinococcus granulosus synaptic glycoprotein sc2 0.0065 0.0508 0.0599
Echinococcus granulosus g protein coupled receptor 0.011 0.1021 0.1205
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.011 0.1021 0.2024
Loa Loa (eye worm) hypothetical protein 0.0054 0.0377 0.0748
Brugia malayi hypothetical protein 0.0039 0.0212 0.0421
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0026 0.0065 0.0076
Echinococcus granulosus hyperpolarization activated cyclic 0.0026 0.0065 0.0076
Schistosoma mansoni opsin-like receptor 0.011 0.1021 0.1205
Brugia malayi Glycosyl hydrolases family 31 protein 0.0022 0.0017 0.0034
Loa Loa (eye worm) hypothetical protein 0.0262 0.275 0.545
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.003 0.0109 0.1666
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0026 0.0065 0.0076
Brugia malayi hypothetical protein 0.011 0.1021 0.2024
Brugia malayi histone deacetylase 11 0.0039 0.0206 0.0409
Brugia malayi Carboxylesterase family protein 0.0078 0.0653 0.1293
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0026 0.0065 0.0076
Onchocerca volvulus 0.011 0.1021 0.1735
Onchocerca volvulus 0.0521 0.5701 1
Echinococcus multilocularis neuropeptide Y receptor 0.011 0.1021 0.1021
Schistosoma mansoni high-affinity choline transporter 0.0372 0.3998 0.4718
Echinococcus granulosus fmrfamide receptor 0.011 0.1021 0.1205
Echinococcus multilocularis lamin dm0 0.0033 0.0141 0.0141
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0377 0.0748
Brugia malayi hypothetical protein 0.011 0.1021 0.2024
Brugia malayi hypothetical protein 0.0031 0.0121 0.0241
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 0.0065 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.003 0.0109 0.1666
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.003 0.0109 0.0215
Echinococcus multilocularis neuropeptide receptor 0.028 0.2957 0.2957
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0087 0.0758 0.1503
Echinococcus granulosus histone deacetylase 6 0.0039 0.0206 0.0243
Loa Loa (eye worm) hypothetical protein 0.004 0.0223 0.0441
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Onchocerca volvulus Histone deacetylase 10 homolog 0.0039 0.0206 0.0295
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Schistosoma mansoni hypothetical protein 0.0036 0.018 0.0212
Echinococcus granulosus histone deacetylase 0.0039 0.0206 0.0243
Trypanosoma cruzi cytochrome p450-like protein, putative 0.003 0.0109 0.0215
Schistosoma mansoni hypothetical protein 0.0026 0.0065 0.0076
Trichomonas vaginalis alpha-glucosidase, putative 0.0022 0.0017 0.003
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0065 0.0076
Brugia malayi G-protein coupled receptor 0.011 0.1021 0.2024
Echinococcus granulosus neuropeptide FF receptor 2 0.011 0.1021 0.1205
Schistosoma mansoni vesicular amine transporter 0.0026 0.0065 0.0076
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.003 0.0109 0.1666
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0031 0.012 0.0238
Brugia malayi G protein-coupled receptor F59B2.13 0.011 0.1021 0.2024
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0026 0.0065 0.0128
Schistosoma mansoni hypothetical protein 0.011 0.1021 0.1205
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.011 0.1021 0.1205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0513 0.0605
Loa Loa (eye worm) CYP4Cod1 0.0036 0.017 0.0337
Echinococcus granulosus mitogen activated protein kinase 3 0.0031 0.012 0.0142
Schistosoma mansoni transient receptor potential channel 0.0026 0.0065 0.0076
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0022 0.0017 0.0034
Toxoplasma gondii transporter, cation channel family protein 0.0026 0.0065 0.0095
Echinococcus multilocularis transient receptor potential gamma protein 0.0026 0.0065 0.0065
Brugia malayi hypothetical protein 0.011 0.1021 0.2024
Trypanosoma cruzi histone deacetylase, putative 0.0039 0.0206 0.0409
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0093 0.082 0.6134
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.011 0.1021 0.1021
Echinococcus granulosus neuroligin 0.0078 0.0653 0.077
Loa Loa (eye worm) hypothetical protein 0.011 0.1021 0.2024
Plasmodium vivax acyl-CoA synthetase, putative 0.004 0.0223 0.1442
Echinococcus granulosus potassium large conductance calcium activated 0.0026 0.0065 0.0076
Schistosoma mansoni histone deacetylase hda2 0.0039 0.0206 0.0243
Loa Loa (eye worm) dihydrofolate reductase 0.0027 0.007 0.014
Plasmodium vivax histone deacetylase 2, putative 0.0039 0.0206 0.1313
Brugia malayi hypothetical protein 0.011 0.1021 0.2024
Echinococcus granulosus neuropeptide Y receptor 0.011 0.1021 0.1205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0198 0.3029
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0109 0.0215
Schistosoma mansoni hypothetical protein 0.003 0.0109 0.0128
Onchocerca volvulus 0.011 0.1021 0.1735
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0026 0.0065 0.0076
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0026 0.0065 0.0065
Echinococcus multilocularis sodium leak channel non selective protein 0.0026 0.0065 0.0065
Schistosoma mansoni biogenic amine (dopamine) receptor 0.011 0.1021 0.1205
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0026 0.0065 0.0076
Onchocerca volvulus Huntingtin homolog 0.0075 0.0619 0.1025
Echinococcus granulosus tm gpcr rhodopsin 0.011 0.1021 0.1205
Loa Loa (eye worm) voltage-dependent calcium channel 0.0026 0.0065 0.0128
Mycobacterium ulcerans glutaminase 0.0299 0.3171 0.6286
Onchocerca volvulus 0.011 0.1021 0.1735
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0198 0.3029

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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